The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Molecular Cloning and Characterization of a Novel Type of Histamine Receptor Preferentially Expressed in Leukocytes
Open accessAbstract
Recently cDNA encoding the histamine H3 receptor was isolated after 15 years of considerable research. However, several studies have proposed heterogeneity of the H3 receptor. We report here the molecular cloning and characterization of a novel type of histamine receptor. A novel orphan G-protein-coupled receptor named GPRv53 was obtained through a search of the human genomic DNA data base and analyzed by rapid amplification of cDNA ends (RACE). GPRv53 possessed the features of biologic amine receptors and had the highest homology with H3 receptor among known G-protein-coupled receptors. Mammalian cells expressing GPRv53 were demonstrated to bind and respond to histamine in a concentration-dependent manner. In functional assays, not only an H3 receptor agonist, R-(alpha)-methylhistamine, but also a H3 receptor antagonist, clobenpropit, and a neuroleptic, clozapine, activated GPRv53-expressing cells. Tissue distribution analysis revealed that expression of GPRv53 is localized in the peripheral blood leukocytes, spleen, thymus, and colon, which was totally different from the H3 receptor, whose expression was restricted to the brain. The discovery of the GPRv53 receptor will open a new phase of research on the physiological role of histamine.
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Histamine and H1-antihistamines: Celebrating a century of progress
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Molecular Cloning and Characterization of a New Human Histamine Receptor, HH4R
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Histamine, histamine receptors and their role in immune pathology
Jutel, M., Akdis, M., & Akdis, C. A. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03374.x · Cited by 329
Regulation of the immune response and inflammation by histamine and histamine receptors
O’Mahony, L., Akdis, M., & Akdis, C. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.06.051 · Cited by 313
Metadata
- Authors
- Oda, T., Morikawa, N., Saito, Y., Masuho, Y., & Matsumoto, S.-I.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 275
- Issue
- 47
- Pages
- 36781-36786
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2085577426
- Cited by
- 608
- References
- 19
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Oda, T., Morikawa, N., Saito, Y., Masuho, Y., & Matsumoto, S.-I. (2000). Molecular Cloning and Characterization of a Novel Type of Histamine Receptor Preferentially Expressed in Leukocytes. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m006480200
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