The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Singlet Oxygen Induces Oxidation of Cellular DNA
Open accessAbstract
The aim of the present work was to evaluate the potential for (1)O(2) to induce oxidation of cellular DNA. For this purpose cells were incubated in the presence of a water-soluble endoperoxide whose thermal decomposition leads to the formation of singlet oxygen. Thereafter, DNA was extracted and the level of several modified DNA bases was determined by HPLC analysis coupled to a tandem mass spectrometric detection. A significant increase in the level of 8-oxo-7,8-dihydro-2'-deoxyguanosine was observed upon incubation of the cells with the chemical generator of (1)O(2), whereas the level of the other DNA bases measured remained unchanged. To demonstrate that singlet oxygen is directly involved in the formation of 8-oxo-7, 8-dihydro-2'-deoxyguanosine, the corresponding (18)O-labeled endoperoxide was used. Incubation of the cells with such a generator of (18)O-labeled singlet oxygen results in the formation of (18)O-labeled 8-oxo-7,8-dihydro-2'-deoxyguanosine in the nuclear DNA. This result clearly demonstrates that singlet oxygen, when released within cells, is able to directly oxidize cellular DNA.
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Cites
Oxidative DNA damage through long-range electron transfer
Hall, D. B., Holmlin, R. E., & Barton, J. K. (1996) · Nature · doi:10.1038/382731a0 · Cited by 825
Kasai, H., Yamaizumi, Z., Berger, M., & Cadet, J. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00050a078 · Cited by 300
Self-citationFrelon, S., Douki, T., Ravanat, J.-L., Pouget, J.-P., Tornabene, C., & Cadet, J. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000085h · Cited by 271
Self-citationCADENAS, E., SIES, H., NASTAINCZYK, W., & ULLRICH, V. (1983) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1983.364.1.519 · Cited by 108
Cited by
Direct and indirect effects of UV radiation on DNA and its components
Ravanat, J.-L., Douki, T., & Cadet, J. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00206-8 · Cited by 980
Self-citationFree radical-induced damage to DNA: mechanisms and measurement
Dizdaroglu, M., Jaruga, P., Birincioglu, M., & Rodriguez, H. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00826-2 · Cited by 953
Ultraviolet radiation-mediated damage to cellular DNA
Cadet, J., Sage, E., & Douki, T. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.09.012 · Cited by 932
Self-citationDNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
Cadet, J., & Wagner, J. R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012559 · Cited by 903
Self-citationMouret, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604213103 · Cited by 684
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Metadata
- Authors
- Ravanat, J.-L., Di Mascio, P., Martinez, G. R., Medeiros, M. H. G., & Cadet, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 275
- Issue
- 51
- Pages
- 40601-40604
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1989261646
- Cited by
- 326
- References
- 4
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ravanat, J.-L., Di Mascio, P., Martinez, G. R., Medeiros, M. H. G., & Cadet, J. (2000). Singlet Oxygen Induces Oxidation of Cellular DNA. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m006681200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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