Ultraviolet radiation-mediated damage to cellular DNA
Abstract
Emphasis is placed in this review article on recent aspects of the photochemistry of cellular DNA in which both the UVB and UVA components of solar radiation are implicated individually or synergistically. Interestingly, further mechanistic insights into the UV-induced formation of DNA photoproducts were gained from the application of new accurate and sensitive chromatographic and enzymic assays aimed at measuring base damage. Thus, each of the twelve possible dimeric photoproducts that are produced at the four main bipyrimidine sites can now be singled out as dinucleoside monophosphates that are enzymatically released from UV-irradiated DNA. This was achieved using a recently developed high-performance liquid chromatography-tandem mass spectrometry assay (HPLC-MS/MS) assay after DNA extraction and appropriate enzymic digestion. Interestingly, a similar photoproduct distribution pattern is observed in both isolated and cellular DNA upon exposure to low doses of either UVC or UVB radiation. This applies more specifically to the DNA of rodent and human cells, the cis-syn cyclobutadithymine being predominant over the two other main photolesions, namely thymine-cytosine pyrimidine (6-4) pyrimidone adduct and the related cyclobutyl dimer. UVA-irradiation was found to generate cyclobutane dimers at TT and to a lower extent at TC sites as a likely result of energy transfer mechanism involving still unknown photoexcited chromophore(s). Oxidative damage to DNA is also induced although less efficiently by UVA-mediated photosensitization processes that mostly involved 1O2 together with a smaller contribution of hydroxyl radical-mediated reactions through initially generated superoxide radicals.
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UVB-induced DNA damage is dominated by bipyrimidine photoproducts.
“DNA damage induced by UVB radiation is dominated by bipyrimidine photoproducts (22).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [22]
Cyclobutadithymine is the predominant DNA photoproduct induced in cellular DNA by UVB and solar irradiation.
“T< >T has been shown later to be the predominant DNA photoproduct induced in cellular DNA upon UVB and solar irradiation (22).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [22]
UVA-mediated oxidation reactions to cellular DNA are initiated by interaction of long-wavelength UV radiation with endogenous chromophores.
“The UVA-mediated oxidation reactions to cellular DNA have suggested to be initiated by the interaction of incident long UV wavelength radiation with endogenous chromophores (7,22,34).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [22]
Cites
Toxic effects of ultraviolet radiation on the skin
Matsumura, Y., & Ananthaswamy, H. N. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.08.019 · Cited by 1,270 · see citing works
Direct and indirect effects of UV radiation on DNA and its components
Ravanat, J.-L., Douki, T., & Cadet, J. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00206-8 · Cited by 980 · see citing works
Self-citationWavelengths effective in induction of malignant melanoma.
Setlow, R. B., Grist, E., Thompson, K. H., & Woodhead, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6666 · Cited by 718 · see citing works
Oxidative damage to DNA: formation, measurement and biochemical features
Cadet, J., Douki, T., Gasparutto, D., & Ravanat, J. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.09.001 · Cited by 698 · see citing works
Self-citationWavelength dependence of oxidative DNA damage induced by UV and visible light
Kielbassa, C. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.811 · Cited by 616 · see citing works
Oxy radicals, lipid peroxidation and DNA damage
Marnett, L. J. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00448-1 · Cited by 563 · see citing works
Douki, T., Reynaud-Angelin, A., Cadet, J., & Sage, E. (2003) · Biochemistry · doi:10.1021/bi034593c · Cited by 452 · see citing works
Self-citationOxidative damage to DNA: Formation, measurement, and biological significance
Cadet, J., Berger, M., Douki, T., & Ravanat, J. (1997) · Springer eBooks · doi:10.1007/3-540-61992-5_5 · Cited by 431 · see citing works
Self-citationMori, T., Nakane, M., Hattori, T., Matsunaga, T., Ihara, M., & Nikaido, O. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02010.x · Cited by 410 · see citing works
Vile, G. F., & Tyrrell, R. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82386-9 · Cited by 406 · see citing works
Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation
Kvam, E. (1997) · Carcinogenesis · doi:10.1093/carcin/18.12.2379 · Cited by 344 · see citing works
Douki, T., & Cadet, J. (2001) · Biochemistry · doi:10.1021/bi0022543 · Cited by 337 · see citing works
Self-citationSinglet Oxygen Induces Oxidation of Cellular DNA
Ravanat, J., Mascio, P. D., Martinez, G. R., de Medeiros, M. H. G., & Cadet, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006681200 · Cited by 327 · see citing works
Self-citationYou, Y.-H., Lee, D.-H., Yoon, J.-H., Nakajima, S., Yasui, A., & Pfeifer, G. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107696200 · Cited by 314 · see citing works
Freeman, S. E., Hacham, H., Gange, R. W., Maytum, D. J., Sutherland, J. C., & Sutherland, B. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5605 · Cited by 311 · see citing works
Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin
Stege, H., Roza, L., Vink, A. A., Grewe, M., Ruzicka, T., Grether-Beck, S., & Krutmann, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.030528897 · Cited by 292 · see citing works
[33] Photocarcinogenesis: UVA vs UVB
de Gruijl, F. R. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)19035-4 · Cited by 285 · see citing works
Unraveling the Molecular Pathway from Sunlight to Skin Cancer
Taylor, J. (1994) · Accounts of Chemical Research · doi:10.1021/ar00039a003 · Cited by 283 · see citing works
Pouget, J.-P., Douki, T., Richard, M.-J., & Cadet, J. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000020e · Cited by 274 · see citing works
Self-citationNew trends in photobiology the interaction of UVA radiation with cultured cells
Tyrrell, R. M., & Keyse, S. M. (1990) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(90)85014-n · Cited by 273 · see citing works
Frelon, S., Douki, T., Ravanat, J.-L., Pouget, J.-P., Tornabene, C., & Cadet, J. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000085h · Cited by 271 · see citing works
Self-citationTechnologies for Detection of DNA Damage and Mutations
Pfeifer, G. P. (1996) · Springer eBooks · doi:10.1007/978-1-4899-0301-3 · Cited by 262 · see citing works
A role for ultraviolet A in solar mutagenesis.
Drobetsky, E. A., Turcotte, J., & Châteauneuf, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.2350 · Cited by 255 · see citing works
Distribution and Repair of Bipyrimidine Photoproducts in Solar UV-irradiated Mammalian Cells
Perdiz, D., Gróf, P., Mezzina, M., Nikaido, O., Moustacchi, E., & Sage, E. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61437-7 · Cited by 248 · see citing works
Self-citationDouki, T., Court, M., Sauvaigo, S., Odin, F., & Cadet, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11678 · Cited by 239 · see citing works
Self-citationSunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.
Tommasi, S., Denissenko, M. F., & Pfeifer, G. P. (1997) · PubMed · Cited by 237 · see citing works
Sage, É. (1993) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1993.tb02273.x · Cited by 235 · see citing works
Rochette, P. J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg402 · Cited by 231 · see citing works
INDUCTION OF PYRIMIDINE DIMERS IN BACTERIAL DNA BY 365 nm RADIATION*
TYRRELL, R. M. (1973) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1973.tb06334.x · Cited by 203 · see citing works
Effects of UV and visible radiation on DNA-final base damage.
Cadet, J., Berger, M., Douki, T., Morin, B., Raoul, S., Ravanat, J., & Spinelli, S. (1997) · PubMed · Cited by 197 · see citing works
Self-citationRadiation-induced Decomposition of the Purine Bases within DNA and Related Model Compounds
Cadet, J., & Berger, M. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514550201 · Cited by 194 · see citing works
Self-citationPourzand, C., Watkin, R. D., Brown, J. E., & Tyrrell, R. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6751 · Cited by 176 · see citing works
The DNA damage spectrum produced by simulated sunlight
Yoon, J., Lee, C.-S., O'Connor, T. R., Yasui, A., & Pfeifer, G. P. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3771 · Cited by 163 · see citing works
Tornaletti, S., Rozek, D., & Pfeifer, G. P. (1993) · PubMed · Cited by 151 · see citing works
Roza, L., Kj, V. D. W., MacFarlane, S. J., Lohman, P. H. M., & Baan, R. A. (1988) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1988.tb02873.x · Cited by 136 · see citing works
Stewart, M. S., Cameron, G. S., & Pence, B. C. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12339344 · Cited by 134 · see citing works
Oxidation of Guanine in Cellular DNA by Solar UV Radiation: Biological Role†
Douki, T., Perdiz, D., Grof, P., Kuluncsics, Z., Moustacchi, E., Cadet, J., & Sage, E. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb07988.x · Cited by 133 · see citing works
Self-citationde Laat, A. (1997) · Carcinogenesis · doi:10.1093/carcin/18.5.1013 · Cited by 133 · see citing works
Zhang, X., Rosenstein, B. S., Wang, Y., Lebwohl, M., Mitchell, D. M., & Wei, H. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb01886.x · Cited by 129 · see citing works
Pflaum, M., Kielbassa, C., Garmyn, M., & Epe, B. (1998) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(98)00029-9 · Cited by 122 · see citing works
Mutagenic specificity of solar UV light in nucleotide excision repair-deficient rodent cells.
Sage, É., Lamolet, B., Brulay, E., Moustacchi, E., Chteauneuf, A., & Drobetsky, E. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.176 · Cited by 121 · see citing works
Young, A. R., Potten, C. S., Nikaido, O., Parsons, P. G., Boenders, J., Ramsden, J. M., & Chadwick, C. A. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00435.x · Cited by 117 · see citing works
Martinez, G. R., Ravanat, J., de Medeiros, M. H. G., Cadet, J., & Mascio, P. D. (2000) · Journal of the American Chemical Society · doi:10.1021/ja0016452 · Cited by 111 · see citing works
Self-citationClimate change and skin cancer
van der Leun, J. C., & de Gruijl, F. D. (2002) · Photochemical and Photobiological Sciences · doi:10.1039/b201025a · Cited by 107 · see citing works
Bykov, V. J. N., Hemminki, K., Sheehan, J. M., & Young, A. R. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00523.x · Cited by 105 · see citing works
Kimura, S. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh591 · Cited by 103 · see citing works
You, Y.-H. (2000) · Carcinogenesis · doi:10.1093/carcin/21.11.2113 · Cited by 102 · see citing works
The C-C (6-4) UV photoproduct is mutagenic in Escherichia coli.
Glickman, B. W., Schaaper, R. M., Haseltine, W. A., Dunn, R. L., & Brash, D. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.6945 · Cited by 101 · see citing works
Vonarx, E. J., Mitchell, H. L., Karthikeyan, R., Chatterjee, I., & Kunz, B. A. (1998) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(98)00043-8 · Cited by 100 · see citing works
You, Y.-H., & Pfeifer, G. P. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4322 · Cited by 99 · see citing works
Inter-strand photoproducts are produced in high yield within A-DNA exposed to UVC radiation
Douki, T. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg408 · Cited by 96 · see citing works
Self-citationDouki, T., Odin, F., Caillat, S., Favier, A. E., & Cadet, J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.013 · Cited by 92 · see citing works
Self-citationReelfs, O., Tyrrell, R. M., & Pourzand, C. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22620.x · Cited by 92 · see citing works
Therrien, J., Drouin, R., Baril, C., & Drobetsky, E. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15038 · Cited by 92 · see citing works
Mizuno, T., Matsunaga, T., Ihara, M., & Nikaido, O. (1991) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(91)90009-e · Cited by 88 · see citing works
Pelle, E., Mammone, T., MARENUS, K. D., Maes, D. H., Huang, X., & Frenkel, K. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12330.x · Cited by 87 · see citing works
Reaction mechanism of thymine dimer formation in DNA induced by UV light
Durbeej, B., & Eriksson, L. A. (2002) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/s1010-6030(02)00180-6 · Cited by 86 · see citing works
Ravanat, J., Sauvaigo, S., Caillat, S., Martinez, G. R., de Medeiros, M. H. G., Mascio, P. D., Favier, A. E., & Cadet, J. (2004) · Biological Chemistry · doi:10.1515/bc.2004.003 · Cited by 84 · see citing works
Self-citationBernerd, F., Asselineau, D., Vioux, C., Chevallier, O., Bouadjar, B., Sarasin, A. R., & Magnaldo, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141221998 · Cited by 83 · see citing works
Photochemistry and the nucleic acids
Morrison, H. A. (1990) · Medical Entomology and Zoology · Cited by 82 · see citing works
Mechanistic aspects of the oxidation of DNA constituents mediated by singlet molecular oxygen
Ravanat, J., Martinez, G. R., de Medeiros, M. H. G., Mascio, P. D., & Cadet, J. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.10.018 · Cited by 82 · see citing works
Self-citationEffects of chronic low-dose ultraviolet B radiation on DNA damage and repair in mouse skin.
Mitchell, D. L., Greinert, R., de Gruijl, F. R., Guikers, K. L. H., Breitbart, E. W., Byrom, M., Gallmeier, M. M., Lowery, M. G., & Volkmer, B. (1999) · PubMed · Cited by 81 · see citing works
In vitro Photooxidation of Nucleic Acids by Ultraviolet A Radiation
Warner, W. G., & Wei, R. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb08605.x · Cited by 79 · see citing works
The development of a radioimmunoassay for the detection of photoproducts in mammalian cell DNA
Mitchell, D. L., & Clarkson, J. M. (1981) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(81)90066-6 · Cited by 77 · see citing works
Douki, T., Court, M., & Cadet, J. (2000) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(00)00009-9 · Cited by 75 · see citing works
Self-citationGoukassian, D. A., Helms, E., STEEG, H. V., van Oostrom, C., Bhawan, J., & Gilchrest, B. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306389101 · Cited by 74 · see citing works
Douki, T., & Cadet, J. (1994) · Biochemistry · doi:10.1021/bi00205a033 · Cited by 72 · see citing works
Self-citationNiggli, H. J., & Cerutti, P. (1983) · Biochemistry · doi:10.1021/bi00275a011 · Cited by 69 · see citing works
Rosen, J. E., Prahalad, A. K., & Williams, G. M. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb02430.x · Cited by 68 · see citing works
Otoshi, E., Yagi, T., Mori, T., Matsunaga, T., Nikaido, O., Kim, S. T., Hitomi, K., Ikenaga, M., & Todo, T. (2000) · PubMed · Cited by 67 · see citing works
Radioimmunoassay of DNA Damaged by Ultraviolet Light
Mitchell, D. L. (1996) · Springer eBooks · doi:10.1007/978-1-4899-0301-3_6 · Cited by 66 · see citing works
Effect of age on the formation and repair of UV photoproducts in human skin in situ
Xu, G., Snellman, E., Bykov, V. J. N., Jansén, C. T., & Hemminki, K. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00069-5 · Cited by 65 · see citing works
Matsunaga, T., HATAKEYAMA, Y., Ohta, M., Mori, T., & Nikaido, O. (1993) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1993.tb02952.x · Cited by 65 · see citing works
Deleterious effects of ultraviolet A radiation in human cells
Stary, A., Robert, C., & Sarasin, A. R. (1997) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(96)00041-9 · Cited by 62 · see citing works
Low incidence of p53 mutations in UVA (365-nm)-induced skin tumors in hairless mice.
van Kranen, H. J., de Laat, A., van de Ven, J., Wester, P. W., de Vries, A., Berg, R. J. W., van Kreijl, C. F., & de Gruijl, F. R. (1997) · PubMed · Cited by 61 · see citing works
Morin, B., & Cadet, J. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00155a005 · Cited by 61 · see citing works
Self-citationDouki, T., & Cadet, J. (2003) · Photochemical & Photobiological Sciences · doi:10.1039/b300173c · Cited by 61 · see citing works
Self-citationDany, A.-L., Douki, T., Triantaphylidès, C., & Cadet, J. (2001) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(01)00254-8 · Cited by 60 · see citing works
Self-citationCadet, J., Gentner, N. E., Rózga, B., & Paterson, M. C. (1983) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)91543-7 · Cited by 59 · see citing works
Self-citationSpivak, G., Itoh, T., Matsunaga, T., Nikaido, O., Hanawalt, P. C., & Yamaizumi, M. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00056-3 · Cited by 59 · see citing works
Effects of Duplex Stability on Charge-Transfer Efficiency within DNA
Douki, T., Ravanat, J., Angelov, D., Wagner, J. R., & Cadet, J. (2012) · Topics in current chemistry · doi:10.1007/b94409 · Cited by 57 · see citing works
Self-citationMeasurement of UVB-Induced DNA damage and its consequences in models of immunosuppression
Yarosh, D. B., Boumakis, S., Brown, A. B., Canning, M. T., Galvin, J. W., Both, D., Kraus, E., O’Connor, A., & Brown, D. A. (2002) · Methods · doi:10.1016/s1046-2023(02)00209-8 · Cited by 54 · see citing works
Sauvaigo, S., Serres, C., Signorini, N., Emonet‐Piccardi, N., Richard, M., & Cadet, J. (1998) · Analytical Biochemistry · doi:10.1006/abio.1998.2628 · Cited by 54 · see citing works
Self-citationReproductive factors and breast cancer in New Zealand
McCredie, M. R. E., Paul, C., Skegg, D. C. G., & Williams, S. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980413)76:2 · Cited by 54 · see citing works
DNA−Protein Cross-Linking via Guanine Oxidation: Dependence upon Protein and Photosensitizer
Kurbanyan, K., Nguyen, K. L., To, P., Rivas, E. V., Lueras, A. M. K., Kosinski, C., Steryo, M., González, A., Mah, D. A., & Stemp, E. D. A. (2003) · Biochemistry · doi:10.1021/bi020713p · Cited by 53 · see citing works
Liuzzi, M., Weinfeld, M., & Paterson, M. C. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83356-7 · Cited by 52 · see citing works
Durbeej, B., & Eriksson, L. A. (2003) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)0780159otfocp2.0.co2 · Cited by 52 · see citing works
Fischer‐Nielsen, A., Loft, S. H., & Jensen, K. G. (1993) · Carcinogenesis · doi:10.1093/carcin/14.11.2431 · Cited by 52 · see citing works
Effects of UV and Visible Radiations on Cellular DNA
Cadet, J., Douki, T., Pouget, J., et al. (2000) · Current Problems in Dermatology · doi:10.1159/000060654 · Cited by 51 · see citing works
Self-citationLuo, J. L., Tong, W., Yoon, J. H., et al. (2001) · PubMed · Cited by 51 · see citing works
Differential repair of the two major UV-induced photolesions in trichothiodystrophy fibroblasts
Riou, L., Eveno, E., van Hoffen, A., van Zeeland, A. A., Sarasin, A., & Mullenders, L. H. F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2070 · Cited by 46 · see citing works
[39] DNA damage induced by ultraviolet and visible light and its wavelength dependence
Kielbassa, C., & Epe, B. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)19041-x · Cited by 45 · see citing works
Frelon, S., Douki, T., & Cadet, J. (2002) · Free Radical Research · doi:10.1080/10715760290025889 · Cited by 45 · see citing works
Self-citationSinglet oxygen sensitisation by excited state DNA
Bishop, S. M., Malone, M. E., Phillips, D., Parker, A. W., & Symons, M. C. R. (1994) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39940000871 · Cited by 44 · see citing works
Far‐UV‐lnduced Dimeric Photoproducts in Short Oligonucleotides: Sequence Effects
Douki, T., Zalizniak, T., & Cadet, J. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb08639.x · Cited by 43 · see citing works
Self-citationImmunochemical detection of UV-induced DNA damage and repair
Cooke, M. S., Podmore, I. D., Mistry, N., Evans, M. D., Herbert, K. E., Griffiths, H. R., & Lunec, J. (2003) · Journal of Immunological Methods · doi:10.1016/s0022-1759(03)00269-2 · Cited by 42 · see citing works
Mohammad, T., & Morrison, H. A. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9519187 · Cited by 40 · see citing works
Kan, L. S., Voituriez, L., & Cadet, J. (1992) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(92)85040-2 · Cited by 39 · see citing works
Self-citationWei, H. (1998) · Carcinogenesis · doi:10.1093/carcin/19.6.1013 · Cited by 36 · see citing works
Nishiwaki, Y., Kobayashi, N., Imoto, K., Iwamoto, T., Yamamoto, A., Katsumi, S., Shirai, T., Sugiura, S., Nakamura, Y., Sarasin, A. R., et al. (2004) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2004.22226.x · Cited by 35 · see citing works
Yokoyama, H., Mizutani, R., Satow, Y., Komatsu, Y., Ohtsuka, E., & Nikaido, O. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3772 · Cited by 31 · see citing works
Douki, T., Voituriez, L., & Cadet, J. (1995) · Chemical Research in Toxicology · doi:10.1021/tx00044a010 · Cited by 29 · see citing works
Self-citationDecreased Levels of (6-4) Photoproduct Excision Repair in Hybrid Fish of the Genus Xiphophorus¶
Mitchell, D. L., Nairn, R. S., Johnston, D. A., et al. (2004) · Photochemistry and Photobiology · doi:10.1562/ca-03-14.1 · Cited by 29 · see citing works
Photodynamic DNA damage mediated by δ-aminolevulinic acid-induced porphyrins
Duez, P., Hanocq, M., & Dubois, J. (2001) · Carcinogenesis · doi:10.1093/carcin/22.5.771 · Cited by 28 · see citing works
Didier, C., Emonet‐Piccardi, N., Béani, J., Cadet, J., & Richard, M. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.13.1817 · Cited by 26 · see citing works
Self-citationApplegate, L. A., Scaletta, C., Panizzon, R., Niggli, H. J., & Frenk, E. (1999) · International Journal of Molecular Medicine · doi:10.3892/ijmm.3.5.467 · Cited by 26 · see citing works
Tommasi, S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.20.3991 · Cited by 26 · see citing works
Berg, R. J. W., de Gruijl, F. R., Roza, L., & van der Leun, J. C. (1993) · Carcinogenesis · doi:10.1093/carcin/14.1.103 · Cited by 24 · see citing works
Jen, J., Mitchell, D. L., Cunningham, R. P., Smith, C. A., Taylor, J., & Cleaver, J. E. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb08565.x · Cited by 23 · see citing works
Rouabhia, M., Mitchell, D. L., Rhainds, M., Claveau, J., & Drouin, R. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b107894c · Cited by 23 · see citing works
UV-induced photoproducts in human skin explants analysed by TLC and HPLC-radioactivity detection
Bykov, V. J. N., & Hemminki, K. (1995) · Carcinogenesis · doi:10.1093/carcin/16.12.3015 · Cited by 23 · see citing works
Therrien, J., Rouabhia, M., Drobetsky, E. A., et al. (1999) · PubMed · Cited by 22 · see citing works
Douki, T., Vadesne-Bauer, G., & Cadet, J. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b201612e · Cited by 22 · see citing works
Self-citationvan der Wees, C. G. C., Vreeswijk, M. P. G., Persoon, M., van der Laarse, A., van Zeeland, A. A., & Mullenders, L. H. F. (2003) · DNA repair · doi:10.1016/j.dnarep.2003.06.001 · Cited by 21 · see citing works
Freeman, S. E., & Ryan, S. L. (1990) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(90)90072-d · Cited by 19 · see citing works
Higurashi, M., Ohtsuki, T., Inase, A., Kusumoto, R., Masutani, C., Hanaoka, F., & Iwai, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307186200 · Cited by 17 · see citing works
Snellman, E., Strozyk, M., Segerbäck, D., et al. (2003) · Photodermatology Photoimmunology & Photomedicine · doi:10.1046/j.1600-0781.2003.00063.x · Cited by 12 · see citing works
Courdavault, S., Baudouin, C., Sauvaigo, S., Mouret, S., Candéias, S., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2004) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2004.tb00004.x · Cited by 12 · see citing works
Self-citationImmunochemical study of DNA modifications in the nuclei of UV-damaged lymphocytes
Снопов, С. А., de Gruijl, F. R., Roza, L., & van der Leun, J. C. (2004) · Photochemical & Photobiological Sciences · doi:10.1039/b305135h · Cited by 11 · see citing works
Torizawa, T., Kato, K., Kato, J., et al. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2926 · Cited by 8 · see citing works
How Fast Are UV-Dimers Repaired in Human Skin DNA In Situ?
Hemminki, K., & Snellman, E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.00289.x · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Protective Role of Melanin Against UV Damage in Human Skin <sup>†</sup>
Brenner, M., & Hearing, V. J. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00226.x · Cited by 1,741 · see citing works
Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair
Rastogi, R. P., Richa, Kumar, A., Tyagi, M. B., & Sinha, R. P. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/592980 · Cited by 1,329 · see citing works
Mouret, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604213103 · Cited by 684 · see citing works
Self-citationCentral role of p53 in the suntan response and pathologic hyperpigmentation
Cui, R., Widlund, H. R., Feige, E., Lin, J. Y., Wilensky, D. L., Igras, V. E., D'Orazio, J., Fung, C. Y., Schanbacher, C. F., Granter, S. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.045 · Cited by 657 · see citing works
Horneck, G., Klaus, D. M., & Mancinelli, R. L. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00016-09 · Cited by 619 · see citing works
Effects of solar UV radiation on aquatic ecosystems and interactions with climate change
Häder, D. P., Kumar, H. D., Smith, R. C., & Worrest, R. C. (2007) · Photochemical & Photobiological Sciences · doi:10.1039/b700020k · Cited by 601 · see citing works
Cadet, J., Douki, T., & Ravanat, J.-L. (2008) · Accounts of Chemical Research · doi:10.1021/ar700245e · Cited by 555 · see citing works
Self-citationKarran, P., & Attard, N. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2292 · Cited by 477 · see citing works
UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer
Pfeifer, G. P., & Besaratinia, A. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05144j · Cited by 473 · see citing works
Using deep learning to model the hierarchical structure and function of a cell
Ma, J., Yu, M. K., Fong, S., Ono, K., Sage, E., Demchak, B., Sharan, R., & Ideker, T. (2018) · Nature Methods · doi:10.1038/nmeth.4627 · Cited by 435 · see citing works
Self-citationFormation of UV-induced DNA damage contributing to skin cancer development
Cadet, J., & Douki, T. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00395a · Cited by 435 · see citing works
Self-citationCadet, J., Douki, T., & Ravanat, J. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12368 · Cited by 355 · see citing works
Self-citationSkin DNA photodamage and its biological consequences
Marrot, L., & Meunier, J.-R. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.12.007 · Cited by 343 · see citing works
Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup>
Cadet, J., Mouret, S., Ravanat, J., & Douki, T. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01200.x · Cited by 300 · see citing works
Self-citationHow DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis
Batista, L. F. Z., Kaina, B., Meneghini, R., & Menck, C. F. M. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.09.001 · Cited by 234 · see citing works
Oxidatively generated complex DNA damage: Tandem and clustered lesions
Cadet, J., Ravanat, J.-L., TavernaPorro, M., Menoni, H., & Angelov, D. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.005 · Cited by 233 · see citing works
Self-citationSensitized formation of oxidatively generated damage to cellular DNA by UVA radiation
Cadet, J., Douki, T., Ravanat, J.-L., & Di Mascio, P. (2009) · Photochemical & Photobiological Sciences · doi:10.1039/b905343n · Cited by 213 · see citing works
Self-citationSinglet Oxygen Oxidation of Isolated and Cellular DNA: Product Formation and Mechanistic Insights
Cadet, J., Ravanat, J., Martinez, G. R., Medeiros, M. H. G., & Mascio, P. D. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-06-09-ir-914 · Cited by 176 · see citing works
Self-citationCadet, J., & Wagner, J. R. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.001 · Cited by 169 · see citing works
Self-citationUnravelling UVA-induced mutagenesis
Sage, E., Girard, P.-M., & Francesconi, S. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05219e · Cited by 167 · see citing works
Besaratinia, A., Synold, T. W., Chen, H.-H., Chang, C., Xi, B., Riggs, A. D., & Pfeifer, G. P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502311102 · Cited by 156 · see citing works
Besaratinia, A., Yoon, J., Schroeder, C., Bradforth, S. E., Cockburn, M., & Pfeifer, G. P. (2011) · The FASEB Journal · doi:10.1096/fj.11-187336 · Cited by 155 · see citing works
Roles of UVA radiation and DNA damage responses in melanoma pathogenesis
Khan, A. Q., Travers, J. B., & Kemp, M. G. (2018) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22176 · Cited by 152 · see citing works
Kozmin, S., Slezak, G., Reynaud-Angelin, A., Elie, C., de Rycke, Y., Boiteux, S., & Sage, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504497102 · Cited by 148 · see citing works
Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms
Dinkova-Kostova, A. (2008) · Planta Medica · doi:10.1055/s-2008-1081296 · Cited by 136 · see citing works
Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair
Rochette, P. J., & Brash, D. E. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000926 · Cited by 133 · see citing works
Douki, T. (2013) · Photochemical & Photobiological Sciences · doi:10.1039/c3pp25451h · Cited by 132 · see citing works
Self-citationMelanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts
Wang, H.-T., Choi, B., & Tang, M.-S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005244107 · Cited by 119 · see citing works
Oxidatively generated damage to DNA by UVA radiation in cells and human skin
Cadet, J., & Douki, T. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.51 · Cited by 116 · see citing works
Self-citationNanocosmetics and Nanomedicines
(2011) · doi:10.1007/978-3-642-19792-5 · Cited by 116 · see citing works
The Triplet Energy of Thymine in DNA
Bosca, F., Lhiaubet-Vallet, V., Cuquerella, M. C., Castell, J. V., & Miranda, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja060651g · Cited by 113 · see citing works
Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light
Zhang, X., Jeffs, G., Ren, X., O’Donovan, P., Montaner, B., Perrett, C. M., Karran, P., & Xu, Y.-Z. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.11.003 · Cited by 110 · see citing works
The role of ultraviolet radiation in melanomagenesis
Von Thaler, A., Kamenisch, Y., & Berneburg, M. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.01025.x · Cited by 100 · see citing works
Wischermann, K., Popp, S., Moshir, S., Scharfetter-Kochanek, K., Wlaschek, M., de Gruijl, F., Hartschuh, W., Greinert, R., Volkmer, B., Faust, A., et al. (2008) · Oncogene · doi:10.1038/onc.2008.70 · Cited by 99 · see citing works
Development of a DNA-dosimeter system for monitoring the effects of solar-ultraviolet radiation
Schuch, A. P., da Silva Galhardo, R., de Lima-Bessa, K. M., Schuch, N. J., & Menck, C. F. M. (2009) · Photochemical & Photobiological Sciences · doi:10.1039/b810085c · Cited by 97 · see citing works
Mouret, S., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2008) · DNA Repair · doi:10.1016/j.dnarep.2008.01.005 · Cited by 92 · see citing works
Self-citationMultiple forms of DNA Damage Caused by UVA Photoactivation of DNA 6‐Thioguanine
Brem, R., & Karran, P. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.01043.x · Cited by 76 · see citing works
Ultraviolet A does not induce melanomas in a <i>Xiphophorus</i> hybrid fish model
Mitchell, D. L., Fernandez, A. A., Nairn, R. S., Garcia, R., Paniker, L., Trono, D., Thames, H. D., & Gimenez-Conti, I. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000324107 · Cited by 75 · see citing works
Gordon-Thomson, C., Gupta, R., Tongkao-on, W., Ryan, A., Halliday, G. M., & Mason, R. S. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c2pp25202c · Cited by 73 · see citing works
Rünger, T. M., Farahvash, B., Hatvani, Z., & Rees, A. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05232b · Cited by 72 · see citing works
Ravi, S. K., Wu, T., Udayagiri, V. S., Vu, X. M., Wang, Y., Jones, M. R., & Tan, S. C. (2018) · Advanced Materials · doi:10.1002/adma.201802290 · Cited by 70 · see citing works
Brem, R., Li, F., & Karran, P. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp070 · Cited by 67 · see citing works
Ali, A., Rashid, M. A., Huang, Q. Y., & Lei, C.-L. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-8514-7 · Cited by 65 · see citing works
Shin, D., Lee, Y., Huang, Y.-H., Lim, H.-W., Jang, K., Kim, D.-D., & Lim, C.-J. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2194-9 · Cited by 57 · see citing works
Ren, X., Li, F., Jeffs, G., Zhang, X., Xu, Y.-Z., & Karran, P. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1165 · Cited by 55 · see citing works
Postreplication gaps at UV lesions are signals for checkpoint activation
Callegari, A. J., Clark, E., Pneuman, A., & Kelly, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003449107 · Cited by 54 · see citing works
UV irradiation induces a postreplication DNA damage checkpoint
Callegari, A. J., & Kelly, T. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607343103 · Cited by 51 · see citing works
No formation of DNA double-strand breaks and no activation of recombination repair with UVA
Rizzo, J. L., Dunn, J., Rees, A., & Rünger, T. M. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.365 · Cited by 50 · see citing works
Dietary Suberic Acid Protects Against UVB-Induced Skin Photoaging in Hairless Mice
Kang, W., Choi, D., & Park, T. (2019) · Nutrients · doi:10.3390/nu11122948 · Cited by 49 · see citing works
Jang, J., Ye, B.-R., Heo, S.-J., Oh, C., Kang, D.-H., Kim, J. H., Affan, A., Yoon, K.-T., Choi, Y.-U., Park, S. C., et al. (2012) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2012.08.003 · Cited by 42 · see citing works
Rolfsmeier, M. L., Laughery, M. F., & Haseltine, C. A. (2010) · Journal of Bacteriology · doi:10.1128/jb.00667-10 · Cited by 42 · see citing works
Brem, R., Li, F., Montaner, B., Reelfs, O., & Karran, P. (2010) · Oncogene · doi:10.1038/onc.2010.140 · Cited by 42 · see citing works
The Emerging Roles of ATP-Dependent Chromatin Remodeling Enzymes in Nucleotide Excision Repair
Czaja, W., Mao, P., & Smerdon, M. J. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130911954 · Cited by 40 · see citing works
Fernández-García, E., Carvajal-Lérida, I., & Pérez-Gálvez, A. (2016) · Photochemical & Photobiological Sciences · doi:10.1039/c6pp00134c · Cited by 40 · see citing works
Photolyases: Capturing the Light to Battle Skin Cancer
Garinis, G. A., Jans, J., & van der Horst, G. T. (2006) · Future Oncology · doi:10.2217/14796694.2.2.191 · Cited by 30 · see citing works
Discovery and Synthesis of New UV-Induced Intrastrand C(4−8)G and G(8−4)C Photolesions
Münzel, M., Szeibert, C., Glas, A. F., Globisch, D., & Carell, T. (2011) · Journal of the American Chemical Society · doi:10.1021/ja111304f · Cited by 28 · see citing works
Photosensitive human syndromes
Spivak, G., & Hanawalt, P. C. (2015) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2014.11.003 · Cited by 27 · see citing works
Enhancement of UVB-induced DNA damage repair after a chronic low-dose UVB pre-stimulation
Drigeard Desgarnier, M.-C., & Rochette, P. J. (2018) · DNA Repair · doi:10.1016/j.dnarep.2018.01.008 · Cited by 24 · see citing works
Buko, T., Tuczko, N., & Ishikawa, T. (2023) · BioTech · doi:10.3390/biotech12020044 · Cited by 21 · see citing works
“In vegetative cells, this UV irradiance leads to DNA mutations, such as cyclobutane pyrimidine dimers and pyrimidine–pyrimidone photo products [9].”
BackgroundUV-Induced TA Photoproducts: Formation and Hydrolysis in Double-Stranded DNA
Asgatay, S., Martinez, A., Coantic-Castex, S., Harakat, D., Philippe, C., Douki, T., & Clivio, P. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1023173 · Cited by 21 · see citing works
Self-citationMeador, J. A., Baldwin, A. J., Pakulski, J. D., Jeffrey, W. H., Mitchell, D. L., & Douki, T. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12414 · Cited by 17 · see citing works
Self-citationSerrentino, M.-E., Catalfo, A., Angelin, A.-R., de Guidi, G., & Sage, E. (2010) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2010.07.011 · Cited by 9 · see citing works
Self-citation
- Authors
- Cadet, J., Sage, E., & Douki, T.
- Affiliations
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Venue
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 571
- Issue
- 1-2
- Pages
- 3-17
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W2056826119
- Cited by
- 932
- References
- 121
- Citations by year
- 2026: 10 · 2025: 26 · 2024: 27 · 2023: 26 · 2022: 29 · 2021: 37 · 2020: 46 · 2019: 67 · 2018: 53 · 2017: 38 · 2016: 56 · 2015: 46 · 2014: 59 · 2013: 59 · 2012: 56
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Les Laboratories Pierre Fabre
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- ultraviolet radiation, DNA photoproducts, UV-B radiation, UVA, cyclobutane dimers, dinucleoside monophosphates, photosensitization, singlet oxygen, hydroxyl radicals, superoxide, oxidative DNA damage, energy transfer
- MeSH terms
- Animals, DNA, DNA Damage, Humans, Ultraviolet Rays
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