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cAMP-dependent Protein Kinase Induces cAMP-response Element-binding Protein Phosphorylation via an Intracellular Calcium Release/ERK-dependent Pathway in Striatal Neurons
Open accessAbstract
Activation of the cAMP-dependent protein kinase A (PKA) pathway may induce cAMP-response element-binding protein (CREB) phosphorylation either directly or via cross-talk mechanisms with other signal transduction pathways. In this study, we have investigated in striatal primary cultures the mechanism by which activation of the cAMP/PKA-dependent pathway leads to CREB phosphorylation via the extracellular signal-regulated kinase (ERK)-dependent pathway. We have found that PKA-induced CREB phosphorylation and CREB-dependent transcription are mediated by calcium (Ca(2+)) release from intracellular stores and are blocked by inhibitors of the protein kinase C and ERK pathways. This mechanism appears to be mediated by the small G-protein Rap1, whose activation appears to be primed by PKA-induced Ca(2+) release but not further induced by direct or indirect PKA- or protein kinase C-dependent phosphorylation. These results suggest that, in striatal neurons, intracellular Ca(2+) release, Rap1, and ERK pathway play a crucial role in the PKA-induced CREB phosphorylation and CREB-dependent transcription.
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Martin, K. C., Michael, D., Rose, J. C., Barad, M., Casadio, A., Zhu, H., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80330-x · Cited by 545
Cited by
Nagai, T., Takuma, K., Kamei, H., Ito, Y., Nakamichi, N., Ibi, D., Nakanishi, Y., Murai, M., Mizoguchi, H., Nabeshima, T., et al. (2007) · Learning & Memory · doi:10.1101/lm.461407 · Cited by 184
Methamphetamine-Induced Neuronal Damage: Neurotoxicity and Neuroinflammation
Kim, B., Yun, J., & Park, B. (2020) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2020.044 · Cited by 116
Ca2+- and CaMKII-mediated processes in early LTP
Byth, L. A. (2014) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.210408 · Cited by 18
Metadata
- Authors
- Zanassi, P., Paolillo, M., Feliciello, A., Avvedimento, E. V., Gallo, V., & Schinelli, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 276
- Issue
- 15
- Pages
- 11487-11495
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2016399806
- Cited by
- 162
- References
- 1
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: cAMP-dependent Protein Kinase Induces cAMP-response Element-binding Protein Phosphorylation via an Intracellular Calcium Release/ERK-dependent Pathway in Striatal Neurons. https://app.cochat.ai/papers/10.1074/jbc.m007631200
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- Zanassi, P., Paolillo, M., Feliciello, A., Avvedimento, E. V., Gallo, V., & Schinelli, S. (2001). cAMP-dependent Protein Kinase Induces cAMP-response Element-binding Protein Phosphorylation via an Intracellular Calcium Release/ERK-dependent Pathway in Striatal Neurons. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m007631200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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