Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

Nagai, Taku; Takuma, Kazuhiro; Kamei, Hiroyuki; Ito, Yukio; Nakamichi, Noritaka; Ibi, Daisuke; Nakanishi, Yutaka; Murai, Masaaki; Mizoguchi, Hiroyuki; Nabeshima, Toshitaka; Yamada, Kiyofumi

doi:10.1101/lm.461407

PreprintCited by 184Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

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Nagai, Taku, Takuma, Kazuhiro, Kamei, Hiroyuki, Ito, Yukio, Nakamichi, Noritaka, Ibi, Daisuke, Nakanishi, Yutaka, Murai, Masaaki +3 more·2007·Learning & Memory

DOI 10.1101/lm.461407PMC PMC1838552

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Abstract

Several lines of evidence suggest that extracellular signal-regulated kinase1/2 (ERK1/2) and dopaminergic system is involved in learning and memory. However, it remains to be determined if the dopaminergic system and ERK1/2 pathway contribute to cognitive function in the prefrontal cortex (PFC). The amount of phosphorylated ERK1/2 was increased in the PFC immediately after exposure to novel objects in the training session of the novel object recognition test. An inhibitor of ERK kinase impaired long-term recognition memory 24 h after the training although short-term memory tested 1 h after the training was not affected by the treatment. The dopamine D1 receptor agonist increased ERK1/2 phosphorylation in the PFC in vivo as well as in cortical neurons in vitro. Microinjection of the dopamine D1 receptor antagonist into the PFC impaired long-term recognition memory whereas the D2 receptor antagonist had no effect. Immunohistochemistry revealed that exposure to novel objects resulted in an increase in c-Fos expression in the PFC. Microinjection of the protein synthesis inhibitor anisomycin into the PFC impaired the long-term recognition memory. These results suggest that the activation of ERK1/2 following the stimulation of dopamine D1 receptors is necessary for the protein synthesis-dependent long-term retention of recognition memory in the PFC.

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Pre- or post-sample infusions of anisomycin into the mPFC disrupt long-term NOP memory in mice.
“Pre- (Nagai et al., 2007) or post-sample (Tanimizu et al., 2018) infusions of anisomycin, a protein synthesis inhibitor, into the mPFC disrupted long-term NOP memory in mice.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Nagai et al., 2007
Pre-sample microinjections into the mPFC of the DA D1/5-R agonist SKF81297 facilitate, and its antagonist SCH23390 disrupt, NOP memory tested 24 hours later.
“When administrated prior to the sample trial, microinjections into the mPFC of the DA D1/5-R agonist SKF81297 facilitated, and its antagonist SCH23390 disrupted, NOP memory tested 24 hours later (De Bundel et al., 2013; Nagai et al., 2007).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Nagai et al., 2007
Intra-hippocampal infusions of PD98059, a selective MEK inhibitor, disrupted long-term NOP memory in mice.
“Intra-hippocampal infusions of PD98059, a selective MEK inhibitor, disrupted long-term NOP memory in mice”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Nagai et al., 2007

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Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity
Molina-Luna, K., Pekanovic, A., Röhrich, S., Hertler, B., Schubring-Giese, M., Rioult-Pedotti, M.-S., & Luft, A. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007082 · Cited by 350 · see citing works
Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females
Almey, A., Milner, T. A., & Brake, W. G. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.010 · Cited by 315 · see citing works
Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia
Young, J. W., Powell, S. B., Risbrough, V. B., Marston, H. M., & Geyer, M. A. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.004 · Cited by 299 · see citing works
Behavioral abnormality and pharmacologic response in social isolation-reared mice
Koike, H., Ibi, D., Mizoguchi, H., Nagai, T., Nitta, A., Takuma, K., Nabeshima, T., Yoneda, Y., & Yamada, K. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.028 · Cited by 221 · see citing works
Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortexPreprint
Sui, L., Wang, J., & Li, B.-M. (2008) · Learning & Memory · doi:10.1101/lm.1067808 · Cited by 195 · see citing works
The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer’s disease
Mita, T., Furukawa‐Hibi, Y., Takeuchi, H., Hattori, H., Yamada, K., Hibi, H., Ueda, M., & Yamamoto, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.043 · Cited by 160 · see citing works
Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex
Watson, D. J., Loiseau, F., Ingallinesi, M., Millan, M. J., Marsden, C. A., & Fone, K. C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.254 · Cited by 151 · see citing works
Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice
Furukawa‐Hibi, Y., Alkam, T., Nitta, A., Matsuyama, A., Mizoguchi, H., Suzuki, K., Moussaoui, S. M., Yu, Q.-S., Greig, N. H., Nagai, T., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.035 · Cited by 150 · see citing works
Nobiletin, a Citrus Flavonoid, Improves Cognitive Impairment and Reduces Soluble Aβ Levels in a Triple Transgenic Mouse Model of Alzheimer’s Disease (3XTg-AD)
Nakajima, A., Aoyama, Y., Shin, E.-J., Nam, Y., Kim, H.-C., Nagai, T., Yokosuka, A., Mimaki, Y., Yokoi, T., Ohizumi, Y., et al. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.028 · Cited by 138 · see citing works
Self-citation
Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors
Nagai, T., Murai, R., Matsui, K., Kamei, H., Noda, Y., Furukawa, H., & Nabeshima, T. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1240-6 · Cited by 137 · see citing works
Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood
Ibi, D., Nagai, T., Kitahara, Y., Mizoguchi, H., Koike, H., Shiraki, A., Takuma, K., Kamei, H., Noda, Y., Nitta, A., et al. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.03.015 · Cited by 135 · see citing works
Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse
Kuroda, K., Yamada, S., Tanaka, M., Iizuka, M., Yano, H., Mori, D., Tsuboi, D., Nishioka, T., Namba, T., Iizuka, Y., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr400 · Cited by 135 · see citing works
Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer’s disease
Guzmán-Ramos, K., Moreno-Castilla, P., Castro-Cruz, M., McGaugh, J. L., Martínez-Coria, H., LaFerla, F. M., & Bermúdez-Rattoni, F. (2012) · Learning & Memory · doi:10.1101/lm.026070.112 · Cited by 127 · see citing works
The Dopamine and Cannabinoid Interaction in the Modulation of Emotions and Cognition: Assessing the Role of Cannabinoid CB1 Receptor in Neurons Expressing Dopamine D1 Receptors
Terzian, A. L. B., Drago, F., Wotjak, C. T., & Micale, V. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00049 · Cited by 127 · see citing works
The Effects of Fluoxetine Treatment in a Chronic Mild Stress Rat Model on Depression-Related Behavior, Brain Neurotrophins and ERK Expression
First, M., Gil‐Ad, I., Taler, M., Tarasenko, I., Novak, N., & Weizman, A. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9515-5 · Cited by 127 · see citing works
Microinfusion of the D1 receptor antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning
Hikind, N., & Maroun, M. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.03.003 · Cited by 124 · see citing works
Medial prefrontal cortex role in recognition memory in rodents
Morici, J. F., Bekinschtein, P., & Weisstaub, N. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.030 · Cited by 119 · see citing works
Nobiletin, a Citrus Flavonoid, Ameliorates Cognitive Impairment, Oxidative Burden, and Hyperphosphorylation of Tau in Senescence-Accelerated Mouse
Nakajima, A., Aoyama, Y., Nguyen, T.-T. L., Shin, E.-J., Kim, H.-C., Yamada, S., Nakai, T., Nagai, T., Yokosuka, A., Mimaki, Y., et al. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.025 · Cited by 115 · see citing works
Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus
Gafford, G. M., Parsons, R. G., & Helmstetter, F. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.023 · Cited by 110 · see citing works
Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism
Pilorge, M., Fassier, C., Le Corronc, H., Potey, A., Bai, J., De Gois, S., Delaby, E., Assouline, B., Guinchat, V, Devillard, F., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.139 · Cited by 110 · see citing works
Dopamine Receptor Signaling and Current and Future Antipsychotic Drugs
Boyd, K. N., & Mailman, R. B. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25761-2_3 · Cited by 107 · see citing works
Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR Signaling and Beyond
Groß, C., Berry‐Kravis, E., & Bassell, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.137 · Cited by 103 · see citing works
Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice
Shinohara, R., Taniguchi, M., Ehrlich, A. T., Yokogawa, K., Deguchi, Y., Chérasse, Y., Lazarus, M., Urade, Y., Ogawa, A., Kitaoka, S., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.177 · Cited by 103 · see citing works
Modulatory influence of dopamine receptors on consolidation of object recognition memory
de Lima, M. N. M., Presti-Torres, J., Dornelles, A. D. S., Scalco, F. S., Roesler, R., Garcia, V. A., & Schröder, N. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.12.007 · Cited by 102 · see citing works
Sex differences in the activity of signalling pathways and expression of G-protein-coupled receptor kinases in the neonatal ventral hippocampal lesion model of schizophrenia
Бычков, Э. Р., Ahmed, M. R., & Gurevich, E. V. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000118 · Cited by 99 · see citing works
Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus
Canto‐de‐Souza, L., Provensi, G., Vullo, D., Carta, F., Scozzafava, A., Costa, A., Schmidt, S. D., Passani, M. B., Supuran, C. T., & Blandina, P. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.009 · Cited by 98 · see citing works
Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders
Niwa, M., Matsumoto, Y., Mouri, A., Ozaki, N., & Nabeshima, T. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001239 · Cited by 98 · see citing works
Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment
Lü, P., Mamiya, T., Lu, L., Mouri, A., Niwa, M., Kim, H., Zou, L.-B., Nagai, T., Yamada, K., Ikejima, T., et al. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.10.024 · Cited by 97 · see citing works
Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice
Mizoguchi, H., Takuma, K., Fukakusa, A., Ito, Y., Nakatani, A., Ibi, D., Kim, H., & Yamada, K. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0955-0 · Cited by 92 · see citing works
Girdin Phosphorylation Is Crucial for Synaptic Plasticity and Memory: A Potential Role in the Interaction of BDNF/TrkB/Akt Signaling with NMDA Receptor
NAKAI, T., Nagai, T., Tanaka, M., Itoh, N., Asai, N., Enomoto, A., Asai, M., Yamada, S., Saifullah, A. B., Sokabe, M., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2228-14.2014 · Cited by 88 · see citing works
Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR
Schicknick, H., Schott, B. H., Budinger, E., Smalla, K., Riedel, A., Seidenbecher, C. I., Scheich, H., Gundelfinger, E. D., & Tischmeyer, W. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn026 · Cited by 88 · see citing works
What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory
Brown, M. W., Barker, G. R. I., Aggleton, J. P., & Warburton, E. C. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.07.034 · Cited by 85 · see citing works
Effects of betaine on lipopolysaccharide-induced memory impairment in mice and the involvement of GABA transporter 2
Miwa, M., Tsuboi, M., Noguchi, Y., Enokishima, A., Nabeshima, T., & Hiramatsu, M. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-153 · Cited by 82 · see citing works
Contingent negative variation as a dopaminergic biomarker: evidence from dose-related effects of methylphenidate
Linssen, A. M. W., Vuurman, E. F. P. M., Sambeth, A., Navé, S., Spooren, W. P. J. M., Vargas, G. A., Santarelli, L., & Riedel, W. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2345-x · Cited by 82 · see citing works
Fluoride exposure during development affects both cognition and emotion in mice
Liu, F., Ma, J., Zhang, H., Liu, P., Liu, Y., Xing, B., & Dang, Y. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.10.027 · Cited by 80 · see citing works
Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats
Liu, A., Jain, N. K., Vyas, A., & Lim, L. W. (2015) · eLife · doi:10.7554/elife.04803 · Cited by 78 · see citing works
GABAA Receptor Blockade Enhances Memory Consolidation by Increasing Hippocampal BDNF Levels
Kim, D. H., Kim, J. M., Park, S. J., Cai, M., Liu, X., Lee, S., Shin, C. Y., & Ryu, J. H. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.189 · Cited by 75 · see citing works
Facilitation of fear extinction by novelty depends on dopamine acting on D1-subtype dopamine receptors in hippocampus
Menezes, J., Alves, N., Borges, S., Roehrs, R., Myskiw, J. D. C., Furini, C. R. G., Izquierdo, I., & Mello‐Carpes, P. B. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502295112 · Cited by 73 · see citing works
Activation of calcium/calmodulin-dependent protein kinase IIα in the striatum by the heteromeric D1-D2 dopamine receptor complex
Ng, J., Rashid, A. J., So, C. H., O’Dowd, B. F., & George, S. R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.10.017 · Cited by 70 · see citing works
Nociceptin Receptor Impairs Recognition Memory via Interaction with NMDA Receptor-Dependent Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in the Hippocampus
Goeldner, C., Reiss, D. J., Wichmann, J., Méziane, H., Kieffer, B. L., & Ouagazzal, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3711-07.2008 · Cited by 70 · see citing works
The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes
Drago, A., Crisafulli, C., Sidoti, A., & Serretti, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.009 · Cited by 68 · see citing works
Adolescent nicotine exposure induces dysregulation of mesocorticolimbic activity states and depressive and anxiety-like prefrontal cortical molecular phenotypes persisting into adulthood
Jobson, C. L. M., Renard, J., Szkudlarek, H., Rosen, L. G., Pereira, B., Wright, D. J., Rushlow, W., & Laviolette, S. R. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy179 · Cited by 64 · see citing works
Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice
González, B., Raineri, M., Cadet, J. L., García‐Rill, E., Urbano, F. J., & Bisagno, V. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.02.002 · Cited by 58 · see citing works
Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes
Sobue, A., Ito, N., Nagai, T., Wei, S., Hada, K., Nakajima, A., Murakami, Y., Mouri, A., Yamamoto, Y., Nabeshima, T., et al. (2018) · Glia · doi:10.1002/glia.23299 · Cited by 58 · see citing works
Fustin flavonoid attenuates β‐amyloid (1–42)‐induced learning impairment
Jin, C., Shin, E., Park, J., Jang, C., Li, Z., Kim, M. S., Koo, K. H., Yoon, H., Park, S., Choi, W., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22159 · Cited by 57 · see citing works
Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice
Ibi, D., Nagai, T., Nakajima, A., Mizoguchi, H., Kawase, T., Tsuboi, D., Kano, S., Sato, Y., Hayakawa, M., Lange, U. C., et al. (2013) · Glia · doi:10.1002/glia.22461 · Cited by 56 · see citing works
Background Dopamine Concentration Dependently Facilitates Long-term Potentiation in Rat Prefrontal Cortex through Postsynaptic Activation of Extracellular Signal-Regulated Kinases
Kolomiets, B. P., Marzo, A., Caboche, J., Vanhoutte, P., & Otani, S. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp047 · Cited by 56 · see citing works
Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice
Hara, Y., Ago, Y., Taruta, A., Hasebe, S., Kawase, H., Tanabe, W., Tsukada, S., Nakazawa, T., Hashimoto, H., Matsuda, T., et al. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4703-9 · Cited by 56 · see citing works
Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model
Hara, Y., Takuma, K., Takano, E., Katashiba, K., Taruta, A., Higashino, K., Hashimoto, H., Ago, Y., & Matsuda, T. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.022 · Cited by 55 · see citing works
Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: Involvement of ERK1/2 signaling
Sarantis, K., Matsokis, N. A., & Angelatou, F. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.056 · Cited by 55 · see citing works
Effects of S‐citalopram, citalopram, and R‐citalopram on the firing patterns of dopamine neurons in the ventral tegmental area,N‐methyl‐ D ‐aspartate receptor‐mediated transmission in the medial prefrontal cortex and cognitive function in the rat
Schilström, B., Konradsson‐Geuken, Å., Ivanov, V., Gertow, J., Feltmann, K., Marcus, M. M., Jardemark, K. E., & Svensson, T. H. (2010) · Synapse · doi:10.1002/syn.20853 · Cited by 54 · see citing works
The effect of catecholaminergic depletion within the prelimbic and infralimbic medial prefrontal cortex on recognition memory for recency, location, and objects
Nelson, A. J. D., Cooper, M. T., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2011) · Behavioral Neuroscience · doi:10.1037/a0023337 · Cited by 53 · see citing works
From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations
Cassaday, H. J. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00160 · Cited by 51 · see citing works
Roles of Fragile X Mental Retardation Protein in Dopaminergic Stimulation-induced Synapse-associated Protein Synthesis and Subsequent α-Amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) Receptor Internalization
Wang, H., Kim, S. S., & Zhuo, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.116293 · Cited by 52 · see citing works
Asenapine Increases Dopamine, Norepinephrine, and Acetylcholine Efflux in the Rat Medial Prefrontal Cortex and Hippocampus
Huang, M., Li, Z., Dai, J., Shahid, M., Wong, E. H. F., & Meltzer, H. Y. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.20 · Cited by 52 · see citing works
Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex
Pezze, M. A., Marshall, H. J., Fone, K. C. F., & Cassaday, H. J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.07.018 · Cited by 51 · see citing works
RNA interference‐mediated phosphodiesterase 4D splice variants knock‐down in the prefrontal cortex produces antidepressant‐like and cognition‐enhancing effects
Wang, Z., Zhang, Y., Liu, Y., Zhao, N., Zhang, Y., Li, Y., An, L., Li, J., Wang, X., Qin, J., et al. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02225.x · Cited by 51 · see citing works
Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice
Wang, Z., Yang, W., Zhang, Y., Zhao, N., Zhang, Y., Liu, Y., Xu, Y., Wilson, S. P., O’Donnell, J. M., Zhang, H., et al. (2015) · Scientific Reports · doi:10.1038/srep11332 · Cited by 51 · see citing works
Conversion of short-term to long-term memory in the novel object recognition paradigm
Moore, S. J., Deshpande, K. S., Stinnett, G. S., Seasholtz, A. F., & Murphy, G. G. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.06.014 · Cited by 49 · see citing works
Heterozygous Disruption of Autism susceptibility candidate 2 Causes Impaired Emotional Control and Cognitive Memory
Hori, K., Nagai, T., Shan, W., Sakamoto, A., Abe, M., Yamazaki, M., Sakimura, K., Yamada, K., & Hoshino, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145979 · Cited by 47 · see citing works
Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia
Sobue, A., Kushima, I., Nagai, T., Shan, W., Kohno, T., Aleksić, B., Aoyama, Y., Mori, D., Arioka, Y., Kawano, N., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31390-w · Cited by 48 · see citing works
Working memory deficits in neuronal nitric oxide synthase knockout mice: Potential impairments in prefrontal cortex mediated cognitive function
Zoubovsky, S. P., Pogorelov, V. M., Taniguchi, Y., Kim, S.-H., Yoon, P., Nwulia, E. A., Sawa, A., Pletnikov, M. V., & Kamiya, A. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.04.097 · Cited by 48 · see citing works
Cooperation of taurine uptake and dopamine D1 receptor activation facilitates the induction of protein synthesis-dependent late LTP
Suárez, L. M., Bustamante, J., Orensanz, L. M., del Rı́o, R. M., & Solís, J. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.035 · Cited by 46 · see citing works
Methamphetamine-sensitized mice are accompanied by memory impairment and reduction of N-methyl-d-aspartate receptor ligand binding in the prefrontal cortex and hippocampus
Lee, K.-W., Kim, H.-C., Lee, S., & Jang, C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.01.025 · Cited by 46 · see citing works
Exposure to novel environment is characterized by an interaction of D1/NMDA receptors underlined by phosphorylation of the NMDA and AMPA receptor subunits and activation of ERK1/2 signaling, leading to epigenetic changes and gene expression in rat hippocampus
Sarantis, K., Antoniou, K., Matsokis, N. A., & Angelatou, F. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.10.018 · Cited by 46 · see citing works
Dendritic protein synthesis in the normal and diseased brain
Swanger, S. A., & Bassell, G. J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.003 · Cited by 47 · see citing works
The subchronic phencyclidine rat model: relevance for the assessment of novel therapeutics for cognitive impairment associated with schizophrenia
Janhunen, S. K., Svärd, H., Talpos, J., Kumar, G., Steckler, T., Plath, N., Lerdrup, L., Ruby, T., Haman, M., Wyler, R., et al. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3954-6 · Cited by 43 · see citing works
Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice
Grace, C. E., Schaefer, T. L., Herring, N. R., Graham, D. L., Skelton, M. R., Gudelsky, G. A., Williams, M. T., & Vorhees, C. V. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.01.006 · Cited by 42 · see citing works
Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway
McDonald, C. R., Cahill, L. S., Ho, K. T., Yang, J., Kim, H., Silver, K., Ward, P. A., Mount, H. T. J., Liles, W. C., Sled, J. G., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005140 · Cited by 42 · see citing works
Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning
Bureau, G., Carrier, M., Lebel, M., & Cyr, M. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.04.008 · Cited by 42 · see citing works
Dopamine modulates memory consolidation of discrimination learning in the auditory cortex
Schicknick, H., Reichenbach, N., Smalla, K., Scheich, H., Gundelfinger, E. D., & Tischmeyer, W. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.07994.x · Cited by 42 · see citing works
IL-6 attenuates trimethyltin-induced cognitive dysfunction via activation of JAK2/STAT3, M1 mAChR and ERK signaling network
Kim, B. K., Tran, H.-Y. P., Shin, E., Lee, C., Chung, Y. H., Jeong, J. H., Bach, J., Kim, W.-K., Park, D. H., Saito, K., et al. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.02.017 · Cited by 41 · see citing works
Dopaminergic mechanisms in memory consolidation and antidepressant reversal of a chronic mild stress-induced cognitive impairment`
Papp, M., Gruca, P., Lason-Tyburkiewicz, M., Litwa, E., Niemczyk, M., Tota-Glowczyk, K., & Willner, P. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4651-4 · Cited by 40 · see citing works
Contributions of extracellular-signal regulated kinase 1/2 activity to the memory trace
Ramos, S. O., Feld, M., & Fustiñana, M. S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.988790 · Cited by 41 · see citing works
Hippocampal and prefrontal dopamine D1/5 receptor involvement in the memory-enhancing effect of reboxetine
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FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia
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Authors: Nagai, T., Takuma, K., Kamei, H., Ito, Y., Nakamichi, N., Ibi, D., Nakanishi, Y., Murai, M., Mizoguchi, H., Nabeshima, T., & Yamada, K.
Affiliations: Kanazawa University (JP)
Nagoya University (JP)
ORCID: Nagai, Taku
Takuma, Kazuhiro
Kamei, Hiroyuki
Nakamichi, Noritaka
Mizoguchi, Hiroyuki
Nabeshima, Toshitaka
Yamada, Kiyofumi
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2007-03
Volume: 14
Issue: 3
Pages: 117-125
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.461407
PMC: PMC1838552
OpenAlex: W1991942710
Cited by: 184
References: 79
Citations by year: 2026: 4 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 13 · 2017: 11 · 2016: 2 · 2015: 18 · 2014: 9 · 2013: 12 · 2012: 8
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Smoking Research Foundation
Japan Society for the Promotion of Science (17790056)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine D1 receptor, ERK1/ERK2, novel object recognition, prefrontal cortex, protein synthesis, c-fos, anisomycin, dopaminergic system, memory consolidation
MeSH terms: Animals, Enzyme Activation, Male, Mice, Inbred ICR, Nerve Tissue Proteins, Phosphorylation, Time Factors, Proto-Oncogene Proteins c-fos, Prefrontal Cortex, Receptors, Dopamine D1, Mitogen-Activated Protein Kinase 1, Recognition, Psychology, Mitogen-Activated Protein Kinase 3, Mice

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Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

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