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Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor

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Razani, Babak, Zhang, Xiao Lan, Bitzer, Markus, von Gersdorff, Gero, Böttinger, Erwin P., Lisanti, Michael P.·2001·Journal of Biological Chemistry
DOI 10.1074/jbc.m008340200
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Abstract

Transforming growth factor-beta (TGF-beta) signaling proceeds from the cell membrane to the nucleus through the cooperation of the type I and II serine/threonine kinase receptors and their downstream SMAD effectors. Although various regulatory proteins affecting TGF-beta-mediated events have been described, relatively little is known about receptor interactions at the level of the plasma membrane. Caveolae are cholesterol-rich membrane microdomains that, along with their marker protein caveolin-1 (Cav-1), have been implicated in the compartmentalization and regulation of certain signaling events. Here, we demonstrate that specific components of the TGF-beta cascade are associated with caveolin-1 in caveolae and that Cav-1 interacts with the Type I TGF-beta receptor. Additionally, Cav-1 is able to suppress TGF-beta-mediated phosphorylation of Smad-2 and subsequent downstream events. We localize the Type I TGF-beta receptor interaction to the scaffolding domain of Cav-1 and show that it occurs in a physiologically relevant time frame, acting to rapidly dampen signaling initiated by the TGF-beta receptor complex.

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Research works printed but not linked: 84

  1. Heldin, 1997, Nature, 390, 465, 10.1038/37284 · DOI · Paper page
  2. Massague, 1998, Annu. Rev. Biochem., 67, 753, 10.1146/annurev.biochem.67.1.753 · DOI · Paper page
  3. Franzen, 1993, Cell, 75, 681, 10.1016/0092-8674(93)90489-D · DOI · Paper page
  4. Lin, 1992, Cell, 68, 775, 10.1016/0092-8674(92)90152-3 · DOI · Paper page
  5. Wrana, 1994, Nature, 370, 341, 10.1038/370341a0 · DOI · Paper page
  6. Chen, 1995, Proc. Natl. Acad. Sci. U. S. A., 92, 1565, 10.1073/pnas.92.5.1565 · DOI
  7. Macias-Silva, 1996, Cell, 87, 1215, 10.1016/S0092-8674(00)81817-6 · DOI · Paper page
  8. Zhang, 1996, Nature, 383, 168, 10.1038/383168a0 · DOI · Paper page
  9. Nakao, 1997, EMBO J., 16, 5353, 10.1093/emboj/16.17.5353 · DOI · Paper page
  10. Kretzschmar, 1997, Nature, 389, 618, 10.1038/39348 · DOI · Paper page
  11. Kretzschmar, 1999, Genes Dev., 13, 804, 10.1101/gad.13.7.804 · DOI · Paper page
  12. Ulloa, 1999, Nature, 397, 710, 10.1038/17826 · DOI · Paper page
  13. Luo, 1999, Genes Dev., 13, 2196, 10.1101/gad.13.17.2196 · DOI · Paper page
  14. Bitzer, 2000, Genes Dev., 14, 187, 10.1101/gad.14.2.187 · DOI · Paper page
  15. Stroschein, 1999, Science, 286, 771, 10.1126/science.286.5440.771 · DOI · Paper page
  16. Imamura, 1997, Nature, 389, 622, 10.1038/39355 · DOI · Paper page
  17. Nakao, 1997, Nature, 389, 631, 10.1038/39369 · DOI · Paper page
  18. Hayashi, 1997, Cell, 89, 1165, 10.1016/S0092-8674(00)80303-7 · DOI · Paper page
  19. Chen, 1997, EMBO J., 16, 3866, 10.1093/emboj/16.13.3866 · DOI · Paper page
  20. Pawson, 1997, Science, 278, 2075, 10.1126/science.278.5346.2075 · DOI · Paper page
  21. Gilboa, 1998, J. Cell Biol., 140, 767, 10.1083/jcb.140.4.767 · DOI
  22. Wells, 1999, J. Biol. Chem., 274, 5716, 10.1074/jbc.274.9.5716 · DOI
  23. Tsukazaki, 1998, Cell, 95, 779, 10.1016/S0092-8674(00)81701-8 · DOI · Paper page
  24. Fra, 1995, FEBS Lett., 375, 11, 10.1016/0014-5793(95)95228-O · DOI · Paper page
  25. Li, 1996, J. Biol. Chem., 271, 568, 10.1074/jbc.271.1.568 · DOI · Paper page
  26. Murata, 1995, Proc. Natl. Acad. Sci. U. S. A., 92, 10339, 10.1073/pnas.92.22.10339 · DOI · Paper page
  27. Glenney, 1992, Proc. Natl. Acad. Sci. U. S. A., 89, 10517, 10.1073/pnas.89.21.10517 · DOI · Paper page
  28. Kurzchalia, 1992, J. Cell Biol., 118, 1003, 10.1083/jcb.118.5.1003 · DOI · Paper page
  29. Rothberg, 1992, Cell, 68, 673, 10.1016/0092-8674(92)90143-Z · DOI · Paper page
  30. Scherer, 1995, J. Biol. Chem., 270, 16395, 10.1074/jbc.270.27.16395 · DOI · Paper page
  31. Anderson, 1992, Science, 255, 410, 10.1126/science.1310359 · DOI · Paper page
  32. Razani, 2000, J. Cell Sci., 113, 2103, 10.1242/jcs.113.12.2103 · DOI
  33. Couet, 1997, Trends Cardiovascular Med., 7, 103, 10.1016/S1050-1738(97)00001-7 · DOI
  34. Lisanti, 1994, Trends Cell Biol., 4, 231, 10.1016/0962-8924(94)90114-7 · DOI · Paper page
  35. Li, 1996, J. Biol. Chem., 271, 29182, 10.1074/jbc.271.46.29182 · DOI · Paper page
  36. Song, 1996, J. Biol. Chem., 271, 9690, 10.1074/jbc.271.16.9690 · DOI · Paper page
  37. Song, 1997, Cell. Mol. Biol., 43, 293
  38. Garcia-Cardena, 1996, Proc. Natl. Acad. Sci. U. S. A., 93, 6448, 10.1073/pnas.93.13.6448 · DOI · Paper page
  39. Shaul, 1996, J. Biol. Chem., 271, 6518, 10.1074/jbc.271.11.6518 · DOI · Paper page
  40. Li, 1995, J. Biol. Chem., 270, 15693, 10.1074/jbc.270.26.15693 · DOI · Paper page
  41. Okamoto, 1998, J. Biol. Chem., 273, 5419, 10.1074/jbc.273.10.5419 · DOI · Paper page
  42. Scherer, 1996, Proc. Natl. Acad. Sci. U. S. A., 93, 131, 10.1073/pnas.93.1.131 · DOI · Paper page
  43. Tang, 1996, J. Biol. Chem., 271, 2255, 10.1074/jbc.271.4.2255 · DOI · Paper page
  44. Sargiacomo, 1993, J. Cell Biol., 122, 789, 10.1083/jcb.122.4.789 · DOI · Paper page
  45. Song, 1997, J. Biol. Chem., 272, 4398, 10.1074/jbc.272.7.4398 · DOI · Paper page
  46. Carcamo, 1994, Mol. Cell. Biol., 14, 3810
  47. Wieser, 1995, EMBO J., 14, 2199, 10.1002/j.1460-2075.1995.tb07214.x · DOI · Paper page
  48. Engelman, 1998, FEBS Lett., 428, 205, 10.1016/S0014-5793(98)00470-0 · DOI · Paper page
  49. Engelman, 1998, J. Biol. Chem., 273, 20448, 10.1074/jbc.273.32.20448 · DOI · Paper page
  50. Schlegel, 1999, J. Biol. Chem., 274, 22660, 10.1074/jbc.274.32.22660 · DOI
  51. Weisberg, 1998, Mech. Dev., 79, 17, 10.1016/S0925-4773(98)00160-9 · DOI
  52. Wrana, 1992, Cell, 71, 1003, 10.1016/0092-8674(92)90395-S · DOI · Paper page
  53. Pestell, 1994, J. Biol. Chem., 269, 31090, 10.1016/S0021-9258(18)47394-2 · DOI
  54. Lechleider, 1996, J. Biol. Chem., 271, 17617, 10.1074/jbc.271.30.17617 · DOI
  55. Sargiacomo, 1995, Proc. Natl. Acad. Sci. U. S. A., 92, 9407, 10.1073/pnas.92.20.9407 · DOI · Paper page
  56. Frangioni, 1993, Anal. Biochem., 210, 179, 10.1006/abio.1993.1170 · DOI · Paper page
  57. Couet, 1997, J. Biol. Chem., 272, 30429, 10.1074/jbc.272.48.30429 · DOI · Paper page
  58. Oka, 1997, J. Biol. Chem., 272, 33416, 10.1074/jbc.272.52.33416 · DOI
  59. Koskinen, 1991, Growth Factors, 5, 283, 10.3109/08977199109000292 · doi:10.3109/08977199109000292
  60. Lisanti, 1994, J. Cell Biol., 126, 111, 10.1083/jcb.126.1.111 · DOI · Paper page
  61. Smart, 1999, Mol. Cell. Biol., 19, 7289, 10.1128/MCB.19.11.7289 · DOI · Paper page
  62. Lisanti, 1999, Methods Mol. Biol., 116, 51
  63. Smart, 1995, Proc. Natl. Acad. Sci. U. S. A., 92, 10104, 10.1073/pnas.92.22.10104 · DOI · Paper page
  64. Mastick, 1995, J. Cell Biol., 129, 1523, 10.1083/jcb.129.6.1523 · DOI
  65. Feron, 1997, J. Biol. Chem., 272, 17744, 10.1074/jbc.272.28.17744 · DOI · Paper page
  66. Igarashi, 2000, J. Biol. Chem., 275, 32363, 10.1074/jbc.M003075200 · DOI · Paper page
  67. Lasley, 2000, J. Biol. Chem., 275, 4417, 10.1074/jbc.275.6.4417 · DOI
  68. Liu, 1997, Proc. Natl. Acad. Sci. U. S. A., 94, 10669, 10.1073/pnas.94.20.10669 · DOI · Paper page
  69. Lagna, 1996, Nature, 383, 832, 10.1038/383832a0 · DOI · Paper page
  70. Razani, 1999, J. Biol. Chem., 274, 26353, 10.1074/jbc.274.37.26353 · DOI
  71. Li, 1998, FEBS Lett., 434, 127, 10.1016/S0014-5793(98)00945-4 · DOI
  72. Galbiati, 1998, EMBO J., 17, 6633, 10.1093/emboj/17.22.6633 · DOI · Paper page
  73. Onichtchouk, 1999, Nature, 401, 480, 10.1038/46794 · DOI · Paper page
  74. Wang, 1996, Cell, 86, 435, 10.1016/S0092-8674(00)80116-6 · DOI · Paper page
  75. Couet, 1997, J. Biol. Chem., 272, 6525, 10.1074/jbc.272.10.6525 · DOI · Paper page
  76. Carman, 1999, J. Biol. Chem., 274, 8858, 10.1074/jbc.274.13.8858 · DOI · Paper page
  77. Hanks, 1988, Science, 241, 42, 10.1126/science.3291115 · DOI · Paper page
  78. Yu, 2000, Genes Dev., 14, 163, 10.1101/gad.14.2.163 · DOI · Paper page
  79. Zhang, 2000, J. Biol. Chem., 275, 20717, 10.1074/jbc.M909895199 · DOI
  80. Liu, 1999, J. Biol. Chem., 274, 15781, 10.1074/jbc.274.22.15781 · DOI
  81. Moses, 1996, Curr. Opin. Genet. Dev., 6, 581, 10.1016/S0959-437X(96)80087-6 · DOI · Paper page
  82. Scherer, 1997, J. Biol. Chem., 272, 29337, 10.1074/jbc.272.46.29337 · DOI · Paper page
  83. Scherer, 1994, J. Cell Biol., 127, 1233, 10.1083/jcb.127.5.1233 · DOI · Paper page
  84. Ignotz, 1985, Proc. Natl. Acad. Sci. U. S. A., 82, 8530, 10.1073/pnas.82.24.8530 · DOI · Paper page

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Metadata

Authors
Razani, B., Zhang, X. L., Bitzer, M., von Gersdorff, G., Böttinger, E. P., & Lisanti, M. P.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2001-03
Volume
276
Issue
9
Pages
6727-6738
ISSN
0021-9258 (ISSN-L)
DOI
10.1074/jbc.m008340200
OpenAlex
W2023468848
Cited by
639
References
1
FWCI
9.26
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor. https://app.cochat.ai/papers/10.1074/jbc.m008340200
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Razani, B., Zhang, X. L., Bitzer, M., von Gersdorff, G., Böttinger, E. P., & Lisanti, M. P. (2001). Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m008340200

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