TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced Endosomes
Open accessAbstract
Class E vacuolar protein sorting (vps) proteins are required for appropriate sorting of receptors within the yeast endocytic pathway, and most probably function in the biogenesis of multivesicular bodies. We have identified the mammalian orthologue of Vps28p as a 221- amino acid cytosolic protein that interacts with TSG101/mammalian VPS23 to form part of a multiprotein complex. Co-immunoprecipitation and cross-linking experiments demonstrated that hVPS28 and TSG101 interact directly and that binding requires structural information within the conserved C-terminal portion of TSG101. TSG101 and hVPS28 are predominantly cytosolic. However, when endosomal vacuolization was induced by the expression of a dominant-negative mutant of another class E vps protein, human VPS4, a portion of both TSG101 and hVPS28 translocated to the surface of these vacuoles. We conclude that TSG101 and its interacting components are directly involved in endosomal sorting.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A triple mutant (K55D, K59D, D60A) within 54EKAYIKD60 prevented VPS28-TSG101 subcomplex from forming higher order assemblies and prevented autophagosome closure.
“a triple mutant (K55D, K59D, and D60A, termed TM) within the 54EKAYIKD60 motif, that prevented the VPS28-TSG101 subcomplex from forming higher order assemblies in solution, which also prevented autophagosome closure [36].”
From Budding of a Retrovirus: Some Assemblies Required (2020) · cites this paper as [36]
Flower and colleagues confirmed 54EKAYIKD60 motif as critical mediator of ESCRT-I helical assembly.
“Flower and colleagues crystallized the human ESCRT-I complex and remarkably confirmed the 54EKAYIKD60 motif as a critical mediator of ESCRT-I helical assembly.”
From Budding of a Retrovirus: Some Assemblies Required (2020) · cites this paper as [36]
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684 · see citing works
Thompson, J. D., Higgins, D. G., & Gibson, T. J. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4673 · Cited by 64,617 · see citing works
Garnier, J., Osguthorpe, D. J., & Robson, B. (1978) · Journal of Molecular Biology · doi:10.1016/0022-2836(78)90297-8 · Cited by 4,523 · see citing works
Wessel, D., & Flügge, U. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90782-6 · Cited by 3,997 · see citing works
Predicting coiled coils from protein sequences.
Lupas, A., Van Dyke, M., & Stock, J. (1991) · Science · doi:10.1126/science.252.5009.1162 · Cited by 3,953 · see citing works
Prediction of Protein Secondary Structure at Better than 70% Accuracy
Rost, B., & Sander, C. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1413 · Cited by 2,927 · see citing works
Geourjon, C., & Deléage, G. (1995) · Computer applications in the biosciences · doi:10.1093/bioinformatics/11.6.681 · Cited by 2,137 · see citing works
[22] Using CLUSTAL for multiple sequence alignments
Higgins, D. G., Thompson, J., & Gibson, T. J. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66024-8 · Cited by 1,571 · see citing works
ENDOCYTOSIS AND MOLECULAR SORTING
Mellman, I. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.575 · Cited by 1,521 · see citing works
[32] GOR method for predicting protein secondary structure from amino acid sequence
Garnier, J., Gibrat, J.-F., & Robson, B. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66034-0 · Cited by 1,260 · see citing works
The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression
Lennon, G., Auffray, C., Polymeropoulos, M. H., & Soares, M. B. (1996) · Genomics · doi:10.1006/geno.1996.0177 · Cited by 1,123 · see citing works
Levkowitz, G., Waterman, H., Ettenberg, S. A., Katz, M., Tsygankov, A. Y., Alroy, I., Lavi, S., Iwaï, K., Reiss, Y., Ciechanover, A. J., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80231-2 · Cited by 1,003 · see citing works
Raymond, C. K., Howald-Stevenson, I., Vater, C. A., & Stevens, T. H. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.12.1389 · Cited by 840 · see citing works
Babst, M., Wendland, B., Estepa, E. J., & Emr, S. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.2982 · Cited by 770 · see citing works
Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body
Odorizzi, G., Babst, M., & Emr, S. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81707-9 · Cited by 656 · see citing works
Further developments of protein secondary structure prediction using information theory
Gibrat, J.-F., Garnier, J., & Robson, B. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90292-0 · Cited by 572 · see citing works
King, R. D., & Sternberg, M. J. E. (1996) · Protein Science · doi:10.1002/pro.5560051116 · Cited by 460 · see citing works
Endosomal transport function in yeast requires a novel AAA‐type ATPase, Vps4p
Babst, M., Sato, T. K., Banta, L. M., & Emr, S. D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1820 · Cited by 424 · see citing works
Babst, M., Odorizzi, G., Estepa, E. J., & Emr, S. D. (2000) · Traffic · doi:10.1034/j.1600-0854.2000.010307.x · Cited by 402 · see citing works
Piper, R. C., Cooper, A. A., Yang, H., & Stevens, T. H. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.3.603 · Cited by 382 · see citing works
Frishman, D., & Argos, P. (1996) · Protein Engineering Design and Selection · doi:10.1093/protein/9.2.133 · Cited by 370 · see citing works
Li, L.-M., & Cohen, S. N. (1996) · Cell · doi:10.1016/s0092-8674(00)81111-3 · Cited by 354 · see citing works
An algorithm for protein secondary structure prediction based on class prediction
Deléage, G., & Roux, B. (1987) · Protein Engineering Design and Selection · doi:10.1093/protein/1.4.289 · Cited by 352 · see citing works
A 200‐amino acid ATPase module in search of a basic function
Confalonieri, F., & Duguet, M. (1995) · BioEssays · doi:10.1002/bies.950170710 · Cited by 338 · see citing works
Krieg, U. C., Walter, P., & Johnson, A. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.22.8604 · Cited by 338 · see citing works
SOPM: a self-optimized method for protein secondary structure prediction
Geourjon, C., & Deléage, G. (1994) · Protein Engineering Design and Selection · doi:10.1093/protein/7.2.157 · Cited by 336 · see citing works
An algorithm for secondary structure determination in proteins based on sequence similarity
Levin, J. M., Robson, B., & Garnier, J. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80917-6 · Cited by 303 · see citing works
Vacuole Biogenesis in Saccharomyces cerevisiae : Protein Transport Pathways to the Yeast Vacuole
Bryant, N. J., & Stevens, T. H. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.230-247.1998 · Cited by 283 · see citing works
Rieder, S., Banta, L. M., Köhrer, K., McCaffery, J. M., & Emr, S. D. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.6.985 · Cited by 280 · see citing works
Hittelman, A. B., Burakov, D., Iñiguez-Lluhı́, J. A., Freedman, L. P., & Garabedian, M. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5380 · Cited by 276 · see citing works
Stathmin: a relay phosphoprotein for multiple signal transduction?
Sobel, A. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90123-d · Cited by 269 · see citing works
Simmerman, H. K. B., Kobayashi, Y. M., Autry, J. M., & Jones, L. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5941 · Cited by 257 · see citing works
Munn, A. L., & Riezman, H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.2.373 · Cited by 253 · see citing works
ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking
Bishop, N. E., & Woodman, P. G. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.1.227 · Cited by 250 · see citing works
Self-citationChaperone-like activity of the AAA domain of the yeast Yme1 AAA protease
Leonhard, K., Stiegler, A., Neupert, W., & Langer, T. (1999) · Nature · doi:10.1038/18704 · Cited by 233 · see citing works
Improved performance in protein secondary structure prediction by inhomogeneous score combination.
Guermeur, Y., Geourjon, C., Gallinari, P., & Del√©age, G. (1999) · Bioinformatics · doi:10.1093/bioinformatics/15.5.413 · Cited by 224 · see citing works
Yoshimori, T., Yamagata, F., Yamamoto, A., Mizushima, N., Kabeya, Y., Nara, A., Miwako, I., Ohashi, M., Ohsumi, M., & Ohsumi, Y. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.2.747 · Cited by 190 · see citing works
The ubiquitin-proteasome system and endocytosis
Strous, G. J., & Govers, R. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.10.1417 · Cited by 189 · see citing works
Fernández‐Silva, P., Martínez‐Azorín, F., Micol, V., & Attardi, G. M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.1066 · Cited by 183 · see citing works
Hyman, J., Chen, H., Di Fiore, P. P., De Camilli, P., & Brunger, A. T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.537 · Cited by 158 · see citing works
Endocytosis and mitogenic signaling
Fiore, P. P. D., & Gillt, G. N. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80069-6 · Cited by 128 · see citing works
Yeast Mutants Affecting Possible Quality Control of Plasma Membrane Proteins
Li, Y., Kane, T., Tipper, C. H., Spatrick, P., & Jenness, D. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3588 · Cited by 120 · see citing works
TSG101 may be the prototype of a class of dominant negative ubiquitin regulators
Koonin, E. V., & Abagyan, R. A. (1997) · Nature Genetics · doi:10.1038/ng0897-330 · Cited by 118 · see citing works
Xie, W., Li, L., & Cohen, S. N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1595 · Cited by 105 · see citing works
Stathmin interaction with a putative kinase and coiled-coil-forming protein domains.
Maucuer, A., Camonis, J., & Sobel, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3100 · Cited by 105 · see citing works
The Newly Identified Yeast GRD Genes Are Required for Retention of Late-Golgi Membrane Proteins
Nothwehr, S. F., Bryant, N. J., & Stevens, T. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2700 · Cited by 85 · see citing works
Watanabe, M., Yanagi, Y., Masuhiro, Y., Yano, T., Yoshikawa, H., Yanagisawa, J., & Kato, S. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8547 · Cited by 57 · see citing works
Perturbation of TSG101 protein affects cell cycle progression.
Zhong, Q., Chen, Y., Jones, D., & Lee, W. (1998) · PubMed · Cited by 50 · see citing works
Use of photocrosslinkers in cell biology
Brunner, J. (1996) · Trends in Cell Biology · doi:10.1016/0962-8924(96)40001-0 · Cited by 49 · see citing works
Trimerization Specificity in HIV-1 gp41: Analysis with a GCN4 Leucine Zipper Model,
Shu, W., Ji, H., & Lu, M. (1999) · Biochemistry · doi:10.1021/bi990199w · Cited by 48 · see citing works
Absence of rearrangements in the tumour susceptibility gene TSG101 in human breast cancer
Steiner, P., Barnes, D. M., Harris, W. H., & Weinberg, R. A. (1997) · Nature Genetics · doi:10.1038/ng0897-332 · Cited by 46 · see citing works
Périer, F., Coulter, K. L., Liang, H., Radeke, C. M., Gaber, R. F., & Vandenberg, C. A. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00879-5 · Cited by 43 · see citing works
Čapková, P., Driessen, R. A. J., Schenk, H., & Weiss, Z. (1997) · Journal of Molecular Modeling · doi:10.1007/s008940050064 · Cited by 34 · see citing works
Chapter 11 Probing the Molecular Environment of Translocating Polypeptide Chains by Cross-Linking
Görlich, D., Kurzchalia, T. V., Wiedmann, M., & Rapoport, T. A. (1991) · Methods in cell biology · doi:10.1016/s0091-679x(08)61684-2 · Cited by 32 · see citing works
MPSA: integrated system for multiple protein sequence analysis with client/server capabilities
Blanchet, C., Combet, C., Geourjon, C., & Deléage, G. (2000) · Bioinformatics · doi:10.1093/bioinformatics/16.3.286 · Cited by 28 · see citing works
Swanton, E., Sheehan, J. K., Bishop, N. E., High, S., & Woodman, P. G. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.7.1633 · Cited by 18 · see citing works
Self-citationEvidence ThatTSG101Aberrant Transcripts Are PCR Artifacts
Hampl, M., Hampl, J. A., Plaschke, J., Fitze, G., Schackert, G., Saeger, H., & Schackert, H. K. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9038 · Cited by 15 · see citing works
Ferrer, M., López-Borges, S., & Lazo, P. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202551 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Identification and proteomic profiling of exosomes in human urine
Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162 · see citing works
Abels, E. R., & Breakefield, X. O. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0366-z · Cited by 1,685 · see citing works
Henne, W. M., Buchkovich, N. J., & Emr, S. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.05.015 · Cited by 1,505 · see citing works
Katzmann, D. J., Babst, M., & Emr, S. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00434-2 · Cited by 1,430 · see citing works
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
Garrus, J. E., von Schwedler, U. K., Pornillos, O. W., Morham, S. G., Zavitz, K. H., Wang, H. E., Wettstein, D. A., Stray, K. M., Côté, M., Rich, R. L., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00506-2 · Cited by 1,369 · see citing works
Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes
Wubbolts, R., Leckie, R. S., Veenhuizen, P. T. M., Schwarzmann, G., Möbius, W., Hoernschemeyer, J., Slot, J.-W., Geuze, H. J., & Stoorvogel, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207550200 · Cited by 886 · see citing works
Babst, M., Katzmann, D. J., Estepa, E. J., Meerloo, T., & Emr, S. D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00220-4 · Cited by 875 · see citing works
The Biogenesis and Functions of Exosomes
Stoorvogel, W., Kleijmeer, M. J., Geuze, H. J., & Raposo, G. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30502.x · Cited by 848 · see citing works
The Protein Network of HIV Budding
von Schwedler, U. K., Stuchell‐Brereton, M. D., Müller, B., Ward, D. M., Chung, H.-Y., Morita, E., Wang, H. E., Davis, T., He, G.-P., Cimbora, D. M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00714-1 · Cited by 815 · see citing works
Biogenesis and Function of Multivesicular Bodies
Piper, R. C., & Katzmann, D. J. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123319 · Cited by 771 · see citing works
The emerging shape of the ESCRT machinery
Williams, R. L., & Urbé, S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2162 · Cited by 747 · see citing works
Martin-Serrano, J., Zang, T., & Bieniasz, P. D. (2001) · Nature Medicine · doi:10.1038/nm1201-1313 · Cited by 710 · see citing works
Lipid raft-associated protein sorting in exosomes
Gassart, A. D., Géminard, C., Février, B., Raposo, G., & Vidal, M. (2003) · Blood · doi:10.1182/blood-2003-03-0871 · Cited by 675 · see citing works
VerPlank, L., Bouamr, F., LaGrassa, T. J., Agresta, B., Kikonyogo, A., Leis, J., & Carter, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131059198 · Cited by 584 · see citing works
Morita, E., & Sundquist, W. I. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.102350 · Cited by 574 · see citing works
Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
Bache, K. G., Brech, A., Mehlum, A., & Stenmark, H. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302131 · Cited by 470 · see citing works
The melanosome: membrane dynamics in black and white
Marks, M. S., & Seabra, M. C. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096009 · Cited by 452 · see citing works
Vps27 recruits ESCRT machinery to endosomes during MVB sorting
Katzmann, D. J., Stefan, C. J., Babst, M., & Emr, S. D. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302136 · Cited by 455 · see citing works
Freed, E. (2002) · Journal of Virology · doi:10.1128/jvi.76.10.4679-4687.2002 · Cited by 444 · see citing works
Martin‐Serrano, J., Yaravoy, A., Pérez-Caballero, D., & Bieniasz, P. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2133846100 · Cited by 397 · see citing works
Marchese, A., Raiborg, C., Santini, F., Keen, J. H., Stenmark, H., & Benovic, J. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00321-6 · Cited by 386 · see citing works
Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases
Marmor, M. D., & Yarden, Y. (2004) · Oncogene · doi:10.1038/sj.onc.1207390 · Cited by 382 · see citing works
Late budding domains and host proteins in enveloped virus release.
Bieniasz, P. (2006) · Virology · doi:10.1016/j.virol.2005.09.044 · Cited by 411 · see citing works
Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15
Okumura, A., Lu, G., Pitha, I., & Pitha, P. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510518103 · Cited by 363 · see citing works
Demirov, D., Ono, A., Orenstein, J., & Freed, E. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.032511899 · Cited by 381 · see citing works
The enigmatic endosome – sorting the ins and outs of endocytic trafficking
Naslavsky, N., & Caplan, S. (2018) · Journal of Cell Science · doi:10.1242/jcs.216499 · Cited by 349 · see citing works
ESCRT-III recognition by VPS4 ATPases
Stuchell‐Brereton, M. D., Skalicky, J. J., Kieffer, C., Karren, M. A., Ghaffarian, S., & Sundquist, W. I. (2007) · Nature · doi:10.1038/nature06172 · Cited by 329 · see citing works
STAM and Hrs Are Subunits of a Multivalent Ubiquitin-binding Complex on Early Endosomes
Bache, K. G., Raiborg, C., Mehlum, A., & Stenmark, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210843200 · Cited by 324 · see citing works
TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation
Lu, Q., Hope, L. W., Brasch, M. A., Reinhard, C., & Cohen, S. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0932599100 · Cited by 319 · see citing works
Structure and functional interactions of the Tsg101 UEV domain
Pornillos, O., Alam, S. L., Rich, R. L., Myszka, D. G., Davis, D. R., & Sundquist, W. I. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2397 · Cited by 301 · see citing works
Moberg, K. H., Schelble, S., Burdick, S. K., & Hariharan, I. K. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.018 · Cited by 296 · see citing works
ESCRTing proteins in the endocytic pathway
SAKSENA, S., Sun, J., Chu, T., & Emr, S. D. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.09.010 · Cited by 292 · see citing works
Sorting of proteins into multivesicular bodies: ubiquitin‐dependent and ‐independent targeting
Reggiori, F., & Pelham, H. R. B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5176 · Cited by 324 · see citing works
Evolution of the Multivesicular Body ESCRT Machinery; Retention Across the Eukaryotic Lineage
Leung, K. F., Dacks, J. B., & Field, M. C. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00797.x · Cited by 282 · see citing works
Bishop, N. E., Horman, A., & Woodman, P. G. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112080 · Cited by 266 · see citing works
Self-citationMechanisms of enveloped RNA virus budding.
Pornillos, O., Garrus, J., & Sundquist, W. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02402-9 · Cited by 277 · see citing works
Role of ESCRT-I in Retroviral Budding
Martin-Serrano, J., Zang, T., & Bieniasz, P. D. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4794-4804.2003 · Cited by 250 · see citing works
Teo, H., Gill, D. J., Sun, J., Perisic, O., Veprintsev, D. B., Vallis, Y., Emr, S. D., & Williams, R. L. (2006) · Cell · doi:10.1016/j.cell.2006.01.047 · Cited by 242 · see citing works
ESCRT-II, an Endosome-Associated Complex Required for Protein Sorting
Teo, H., Perišić, O., González, B., & Williams, R. L. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.003 · Cited by 238 · see citing works
Late Endosomes: Sorting and Partitioning in Multivesicular Bodies
Piper, R. C., & Luzio, J. P. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.20904.x · Cited by 215 · see citing works
HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway
Martin‐Serrano, J., Eastman, S. W., Chung, W., & Bieniasz, P. D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408155 · Cited by 201 · see citing works
Ebola Virus Matrix Protein VP40 Interaction with Human Cellular Factors Tsg101 and Nedd4
Timmins, J., Schoehn, G., Ricard‐Blum, S., Scianimanico, S., Vernet, T., Ruigrok, R. W. H., & Weissenhorn, W. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01406-7 · Cited by 192 · see citing works
Bowers, K., Piper, S. C., Edeling, M. A., Gray, S. R., Owen, D. J., Lehner, P. J., & Luzio, J. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508632200 · Cited by 187 · see citing works
Plunder and Stowaways: Incorporation of Cellular Proteins by Enveloped Viruses
Cantin, R., Méthot, S., & Tremblay, M. J. (2005) · Journal of Virology · doi:10.1128/jvi.79.11.6577-6587.2005 · Cited by 177 · see citing works
Doyotte, A., Russell, M. R. G., Hopkins, C. R., & Woodman, P. G. (2005) · Journal of Cell Science · doi:10.1242/jcs.02421 · Cited by 175 · see citing works
Self-citationThe Human Endosomal Sorting Complex Required for Transport (ESCRT-I) and Its Role in HIV-1 Budding
Stuchell‐Brereton, M. D., Garrus, J. E., Müller, B., Stray, K. M., Ghaffarian, S., McKinnon, R. S., Kräusslich, H., Morham, S. G., & Sundquist, W. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405226200 · Cited by 174 · see citing works
Human ESCRT-II Complex and Its Role in Human Immunodeficiency Virus Type 1 Release
Langelier, C., von Schwedler, U. K., Fisher, R. D., De Domenico, I., White, P. L., Hill, C. P., Kaplan, J., Ward, D., & Sundquist, W. I. (2006) · Journal of Virology · doi:10.1128/jvi.01049-06 · Cited by 166 · see citing works
Whitley, P. R., Reaves, B. J., Hashimoto, M., Riley, A. M., Potter, B. V. L., & Holman, G. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306864200 · Cited by 160 · see citing works
Dunn, R., Dehring, D. A. K., Adler, A. S., & Hicke, L. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200309026 · Cited by 160 · see citing works
Bache, K. G., Slagsvold, T., Cabezas, A., Rosendal, K. R., Raiborg, C., & Stenmark, H. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-03-0250 · Cited by 159 · see citing works
Lin, Y., Kimpler, L. A., Naismith, T. V., Lauer, J. M., & Hanson, P. I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413968200 · Cited by 157 · see citing works
Blot, V., Perugi, F., Gay, B., Prévost, M., Briant, L., Tangy, F., Abriel, H., Staub, O., Dokhelar, M., & Pique, C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01095 · Cited by 155 · see citing works
Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4
Wang, B., Alam, S. L., Meyer, H. H., Payne, M., Stemmler, T. L., Davis, D. R., & Sundquist, W. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300459200 · Cited by 153 · see citing works
Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus buddingPreprint
Amit, I., Yakir, L., Katz, M., Zwang, Y., Marmor, M. D., Citri, A., Shtiegman, K., Alroy, I., Tuvia, S., Reiss, Y., et al. (2004) · Genes & Development · doi:10.1101/gad.294904 · Cited by 148 · see citing works
Bouamr, F., Melillo, J. A., Wang, M. Q., Nagashima, K., Santos, M. D. L., Rein, A., & Goff, S. (2003) · Journal of Virology · doi:10.1128/jvi.77.22.11882-11895.2003 · Cited by 132 · see citing works
Shim, J., Xiao, C., Hayden, M. S., Lee, K., Trombetta, E. S., Pypaert, M., Nara, A., Yoshimori, T., Wilm, B., Erdjument‐Bromage, H., et al. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200509041 · Cited by 134 · see citing works
Teo, H., Veprintsev, D. B., & Williams, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400023200 · Cited by 132 · see citing works
The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin.
Wei, W.-S., Lu, Q., Chaudry, G., Leppla, S., & Cohen, S. N. (2006) · Cell · doi:10.1016/j.cell.2005.12.045 · Cited by 147 · see citing works
Bänfer, S., Schneider, D., Dewes, J., Strauss, M. T., Freibert, S., Heimerl, T., Maier, U. G., Elsässer, H., Jungmann, R., & Jacob, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718921115 · Cited by 130 · see citing works
Nagashima, S., Takahashi, M., Jirintai, S., Tanaka, T., Nishizawa, T., Yasuda, J., & Okamoto, H. (2011) · Journal of General Virology · doi:10.1099/vir.0.035378-0 · Cited by 128 · see citing works
Fujita, H., Yamanaka, M., Imamura, K., Tanaka, Y., Nara, A., Yoshimori, T., Yokota, S., & Himeno, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.00213 · Cited by 126 · see citing works
Mizuno, E., Kawahata, K., Kato, M., Kitamura, N., & Komada, M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-12-0823 · Cited by 125 · see citing works
UBAP1 Is a Component of an Endosome-Specific ESCRT-I Complex that Is Essential for MVB Sorting
Stefani, F., Zhang, L., Taylor, S., Donovan, J., Rollinson, S. J., Doyotte, A., Brownhill, K., Callister, J. B., Pickering-Brown, S. M., & Woodman, P. G. (2011) · Current Biology · doi:10.1016/j.cub.2011.06.028 · Cited by 119 · see citing works
Self-citationShaping development with ESCRTs
Rusten, T. E., Vaccari, T., & Stenmark, H. (2011) · Nature Cell Biology · doi:10.1038/ncb2381 · Cited by 122 · see citing works
Hislop, J. N., Marley, A., & von Zastrow, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311062200 · Cited by 117 · see citing works
Role of Ceramides and Lysosomes in Extracellular Vesicle Biogenesis, Cargo Sorting and Release
Horbay, R., Hamraghani, A., Ermini, L., Holcik, S., Beug, S. T., & Yeganeh, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315317 · Cited by 115 · see citing works
Hrs and Endocytic Sorting of Ubiquitinated Membrane Proteins.
Raiborg, C., & Stenmark, H. (2002) · Cell Structure and Function · doi:10.1247/csf.27.403 · Cited by 107 · see citing works
Ouyang, Y., Bayer, A., Chu, T., Tyurin, V. A., Kagan, V. E., Morelli, A. E., Coyne, C. B., & Sadovsky, Y. (2016) · Placenta · doi:10.1016/j.placenta.2016.09.008 · Cited by 105 · see citing works
Leithe, E., Kjenseth, A., Sirnes, S., Stenmark, H., Brech, A., & Rivedal, E. (2009) · Journal of Cell Science · doi:10.1242/jcs.053801 · Cited by 103 · see citing works
Scheuring, S., Röhricht, R. A., Schöning-Burkhardt, B., Beyer, A., Müller, S., Abts, H. F., & Köhrer, K. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4917 · Cited by 101 · see citing works
Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TGS101 and VPS4A
Irie, T., Licata, J. M., McGettigan, J. P., Schnell, M. J., & Harty, R. N. (2004) · Journal of Virology · doi:10.1128/jvi.78.6.2657-2665.2004 · Cited by 101 · see citing works
Goila-Gaur, R., Demirov, D. G., Orenstein, J. M., Ono, A., & Freed, E. O. (2003) · Journal of Virology · doi:10.1128/jvi.77.11.6507-6519.2003 · Cited by 101 · see citing works
The Role of LIP5 and CHMP5 in Multivesicular Body Formation and HIV-1 Budding in Mammalian Cells
Ward, D. M., Vaughn, M. B., Shiflett, S. L., White, P. L., Pollock, A. L., Hill, J., Schnegelberger, R., Sundquist, W. I., & Kaplan, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413734200 · Cited by 99 · see citing works
Tsg101 Control of Human Immunodeficiency Virus Type 1 Gag Trafficking and Release
Goff, A., Ehrlich, L. S., Cohen, S. N., & Carter, C. (2003) · Journal of Virology · doi:10.1128/jvi.77.17.9173-9182.2003 · Cited by 105 · see citing works
The Role of Exosome and the ESCRT Pathway on Enveloped Virus Infection
Ju, Y., Bai, H., Ren, L., & Zhang, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169060 · Cited by 88 · see citing works
Eastman, S. W., Martin‐Serrano, J., Chung, W., Zang, T. M., & Bieniasz, P. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410384200 · Cited by 89 · see citing works
Alix regulates egress of hepatitis B virus naked capsid particles in an ESCRT-independent manner
Bardens, A., Döring, T., Stieler, J., & Prange, R. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01557.x · Cited by 87 · see citing works
Overexpression of tumor susceptibility gene TSG101 in human papillary thyroid carcinomas
Liu, R., Huang, C., You, H., Chou, F., Hu, C. A., Chao, F.-P., Chen, C.-M., & Cheng, J. (2002) · Oncogene · doi:10.1038/sj.onc.1205612 · Cited by 80 · see citing works
Pelham, H. R. B. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00352-6 · Cited by 77 · see citing works
Specificity of Interaction of INI1/hSNF5 with Retroviral Integrases and Its Functional Significance
Yung, E., Sorin, M., Wang, E., Perumal, S., Ott, D. E., & Kalpana, G. V. (2004) · Journal of Virology · doi:10.1128/jvi.78.5.2222-2231.2004 · Cited by 76 · see citing works
Katoh, K., Suzuki, H., Terasawa, Y., Mizuno, T., Yasuda, J., Shibata, H., & Maki, M. (2005) · Biochemical Journal · doi:10.1042/bj20050398 · Cited by 73 · see citing works
Regulation of Tsg101 Expression by the Steadiness Box: A Role of Tsg101-associated Ligase
McDonald, B., & Martin‐Serrano, J. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0957 · Cited by 72 · see citing works
Tu, C., Ortega-Cava, C. F., Winograd, P., Stanton, M. J., Reddi, A. L., Dodge, I. L., Arya, R., Dimri, M., Clubb, R. J., Naramura, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009471107 · Cited by 71 · see citing works
Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation
Kanazawa, C., Morita, E., Yamada, M., Ishii, N., Miura, S., Asao, H., Yoshimori, T., & Sugamura, K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.078 · Cited by 71 · see citing works
Jasenosky, L. D., & Kawaoka, Y. (2004) · Virus Research · doi:10.1016/j.virusres.2004.08.014 · Cited by 69 · see citing works
The molecular basis of HIV capsid assembly—five years of progress
Adamson, C. S., & Jones, I. M. (2004) · Reviews in Medical Virology · doi:10.1002/rmv.418 · Cited by 69 · see citing works
Irie, T., Shimazu, Y., Yoshida, T., & Sakaguchi, T. (2006) · Journal of Virology · doi:10.1128/jvi.02218-06 · Cited by 71 · see citing works
Bruce, E. A., Medcalf, L., Crump, C. M., Noton, S. L., Stuart, A. D., Wise, H. M., Elton, D. M., Bowers, K., & Digard, P. (2009) · Virology · doi:10.1016/j.virol.2009.05.016 · Cited by 65 · see citing works
Late Domain-Dependent Inhibition of Equine Infectious Anemia Virus Budding
Shehu-Xhilaga, M., Ablan, S. D., Demirov, D., Chen, C.-P., Montelaro, R., & Freed, E. (2004) · Journal of Virology · doi:10.1128/jvi.78.2.724-732.2004 · Cited by 62 · see citing works
Sachse, M., Strous, G. J., & Klumperman, J. (2004) · Journal of Cell Science · doi:10.1242/jcs.00998 · Cited by 63 · see citing works
Wrapping up the bad news – HIV assembly and release
Meng, B., & Lever, A. M. (2013) · Retrovirology · doi:10.1186/1742-4690-10-5 · Cited by 68 · see citing works
Ahmed, I., Akram, Z., Iqbal, H. M. N., & Munn, A. L. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.01.015 · Cited by 61 · see citing works
Basic Residues in the Nucleocapsid Domain of Gag Are Critical for Late Events of HIV-1 Budding
Dussupt, V., Sette, P., Bello, N. F., Javid, M. P., Nagashima, K., & Bouamr, F. (2011) · Journal of Virology · doi:10.1128/jvi.01562-10 · Cited by 60 · see citing works
Viral defense, carcinogenesis and ISG15: Novel roles for an old ISG
Pitha, I., & Pitha, P. M. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.06.017 · Cited by 60 · see citing works
Richardson, L. G. L., Howard, A. S. M., Khuu, N., Gidda, S. K., McCartney, A. W., Morphy, B. J., & Mullen, R. T. (2011) · Frontiers in Plant Science · doi:10.3389/fpls.2011.00020 · Cited by 60 · see citing works
Citron Kinase, a RhoA Effector, Enhances HIV‐1 Virion Production by Modulating Exocytosis
Loomis, R. J., Holmes, D. A., Elms, A. R., Solski, P. A., Der, C. J., & Su, L. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00503.x · Cited by 55 · see citing works
Myers, E. L., & Allen, J. F. (2002) · Journal of Virology · doi:10.1128/jvi.76.22.11226-11235.2002 · Cited by 68 · see citing works
Pineda‐Molina, E., Belrhali, H., Piefer, A. J., Akula, I., Bates, P. F., & Weissenhorn, W. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00440.x · Cited by 58 · see citing works
Medina, G., Zhang, Y., Tang, Y., Gottwein, E., Vana, M. L., Bouamr, F., Leis, J., & Carter, C. (2005) · Traffic : the International Journal of Intracellular Transport · doi:10.1111/j.1600-0854.2005.00323.x · Cited by 58 · see citing works
Tanzi, G., Piefer, A. J., & Bates, P. (2003) · Journal of Virology · doi:10.1128/jvi.77.15.8440-8447.2003 · Cited by 57 · see citing works
- Authors
- Bishop, N., & Woodman, P.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Woodman, Philip
- ORCID
- Woodman, Philip
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 276
- Issue
- 15
- Pages
- 11735-11742
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2102891026
- Cited by
- 187
- References
- 59
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- TSG101, VPS28, VPS4, endosomal sorting, multivesicular bodies, endocytic pathway, protein-protein interaction, dominant-negative mutant, vacuolization, receptor sorting
- MeSH terms
- Tsg101 Protein, Adenosine Triphosphatases, Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, DNA, DNA-Binding Proteins, Fungal Proteins, Humans, Molecular Sequence Data, Precipitin Tests, Protein Binding, Endosomes, Transcription Factors, Sequence Homology, Amino Acid, Protein Structure, Secondary, Saccharomyces cerevisiae Proteins, Vesicular Transport Proteins, Endosomal Sorting Complexes Required for Transport
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
