Biogenesis and Function of Multivesicular Bodies

THE UBIQUITIN SYSTEM

Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840 · see citing works

Global analysis of protein localization in budding yeast

Huh, W.-K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., & O'Shea, E. K. (2003) · Nature · doi:10.1038/nature02026 · Cited by 4,248 · cited 1× · see citing works

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042 · see citing works

Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

Théry, C., Boussac, M., Véron, P., Ricciardi‐Castagnoli, P., Raposo, G., Garin, J., & Amigorena, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7309 · Cited by 1,564 · see citing works

Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

Heijnen, H. F. G., Schiel, A. E., Fijnheer, R., Geuze, H. J., & Sixma, J. J. (1999) · Blood · doi:10.1182/blood.v94.11.3791 · Cited by 1,488 · see citing works

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

Katzmann, D. J., Babst, M., & Emr, S. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00434-2 · Cited by 1,430 · see citing works

Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes

Escola, J.-M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O., & Geuze, H. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20121 · Cited by 1,228 · see citing works

Receptor downregulation and multivesicular-body sorting

Katzmann, D. J., Odorizzi, G., & Emr, S. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm973 · Cited by 1,201 · see citing works

Localization of phosphatidylinositol 3‐phosphate in yeast and mammalian cells

Gillooly, D. J., Morrow, I. C., Lindsay, M. R., Gould, R., Bryant, N. J., Gaullier, J., Parton, R. G., & Stenmark, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4577 · Cited by 1,125 · see citing works

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

Hicke, L., & Dunn, R. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.110701.154617 · Cited by 1,106 · see citing works

A SMALL PARTICULATE COMPONENT OF THE CYTOPLASM

Palade, G. E. (1955) · The Journal of Cell Biology · doi:10.1083/jcb.1.1.59 · Cited by 1,014 · see citing works

Exosomes: A Common Pathway for a Specialized Function

van Niel, G., Porto-Carreiro, I., Simoes, S., & Raposo, G. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj128 · Cited by 922 · see citing works

Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes

Wubbolts, R., Leckie, R. S., Veenhuizen, P. T. M., Schwarzmann, G., Möbius, W., Hoernschemeyer, J., Slot, J.-W., Geuze, H. J., & Stoorvogel, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207550200 · Cited by 886 · see citing works

Escrt-III

Babst, M., Katzmann, D. J., Estepa, E. J., Meerloo, T., & Emr, S. D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00220-4 · Cited by 875 · see citing works

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

Raymond, C. K., Howald-Stevenson, I., Vater, C. A., & Stevens, T. H. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.12.1389 · Cited by 840 · see citing works

Tetraspanin Proteins Mediate Cellular Penetration, Invasion, and Fusion Events and Define a Novel Type of Membrane Microdomain

Hemler, M. E. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.153609 · Cited by 831 · see citing works

The Protein Network of HIV Budding

von Schwedler, U. K., Stuchell‐Brereton, M. D., Müller, B., Ward, D. M., Chung, H.-Y., Morita, E., Wang, H. E., Davis, T., He, G.-P., Cimbora, D. M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00714-1 · Cited by 815 · see citing works

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

Haglund, K., Sigismund, S., Polo, S., Szymkiewicz, I., Fiore, P. P. D., & Đikić, I. (2003) · Nature Cell Biology · doi:10.1038/ncb983 · Cited by 813 · see citing works

A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

Kobayashi, T., Stang, E., Fang, K. S., de Moerloose, P., Parton, R. G., & Gruenberg, J. (1998) · Nature · doi:10.1038/32440 · Cited by 787 · see citing works

The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function

Babst, M., Wendland, B., Estepa, E. J., & Emr, S. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.2982 · Cited by 770 · see citing works

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

Raiborg, C., Bache, K. G., Gillooly, D. J., Madshus, I. H., Stang, E., & Stenmark, H. (2002) · Nature Cell Biology · doi:10.1038/ncb791 · Cited by 717 · see citing works

Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

Matsuo, H., Chevallier, J., Mayran, N., Le Blanc, I., Ferguson, C., Fauré, J., Blanc, N. S., Matile, S., Dubochet, J., Sadoul, R., et al. (2004) · Science · doi:10.1126/science.1092425 · Cited by 705 · see citing works

Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Body

Babst, M., Katzmann, D. J., Snyder, W. B., Wendland, B., & Emr, S. D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00219-8 · Cited by 662 · see citing works

Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body

Odorizzi, G., Babst, M., & Emr, S. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81707-9 · Cited by 656 · see citing works

Membrane transport in the endocytic pathway

Gruenberg, J. E., & Maxfield, F. R. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80013-1 · Cited by 645 · see citing works

Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies

Subra, C., Laulagnier, K., Perret, B., & Record, M. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.014 · Cited by 623 · see citing works

Ubiquitin-binding domains

Hurley, J. H., Lee, S., & Prag, G. (2006) · Biochemical Journal · doi:10.1042/bj20061138 · Cited by 601 · see citing works

RETROVIRUS BUDDING

Morita, E., & Sundquist, W. I. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.102350 · Cited by 574 · see citing works

Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane

Booth, A. M., Fang, Y., Fallon, J. K., Yang, J.-M., Hildreth, J. E. K., & Gould, S. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508014 · Cited by 562 · see citing works

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.

Haigler, H. T., McKanna, J. A., & Cohen, S. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.81.2.382 · Cited by 530 · see citing works

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

Mayor, S., Presley, J. F., & Maxfield, F. R. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.6.1257 · Cited by 520 · see citing works

Protein sorting into multivesicular endosomes

Raiborg, C., Rusten, T. E., & Stenmark, H. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00080-2 · Cited by 500 · see citing works

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

Bache, K. G., Brech, A., Mehlum, A., & Stenmark, H. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302131 · Cited by 470 · see citing works

PRINCIPLES OF LYSOSOMAL MEMBRANE DIGESTION: Stimulation of Sphingolipid Degradation by Sphingolipid Activator Proteins and Anionic Lysosomal Lipids

Kolter, T., & Sandhoff, K. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.120013 · Cited by 464 · see citing works

Vps27 recruits ESCRT machinery to endosomes during MVB sorting

Katzmann, D. J., Stefan, C. J., Babst, M., & Emr, S. D. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302136 · Cited by 455 · see citing works

Recycling Compartments and the Internal Vesicles of Multivesicular Bodies Harbor Most of the Cholesterol Found in the Endocytic Pathway

Möbius, W., van Donselaar, E. G., Ohno‐Iwashita, Y., Shimada, Y., Heijnen, H. F. G., Slot, J. W., & Geuze, H. J. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00072.x · Cited by 453 · see citing works

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

Felder, S., Miller, K., Moehren, G., Ullrich, A., Schlessinger, J., & Hopkins, C. R. (1990) · Cell · doi:10.1016/0092-8674(90)90474-s · Cited by 445 · see citing works

Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila

Lloyd, T. E., Atkinson, R., Wu, M. N., Zhou, Y., Pennetta, G., & Bellen, H. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00611-6 · Cited by 423 · see citing works

Separation and Characterization of Late Endosomal Membrane Domains

Kobayashi, T., Beuchat, M.-H., Chevallier, J., Makino, A., Mayran, N., Escola, J.-M., Lebrand, C., Cosson, P., Kobayashi, T., & Gruenberg, J. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202838200 · Cited by 409 · see citing works

Accumulation of Major Histocompatibility Complex Class II Molecules in Mast Cell Secretory Granules and Their Release upon Degranulation

Raposo, G., Tenza, D., Mecheri, S., Péronet, R., Bonnerot, C., & Desaymard, C. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.12.2631 · Cited by 406 · see citing works

Mammalian Tumor Susceptibility Gene 101 (TSG101) and the Yeast Homologue, Vps23p, Both Function in Late Endosomal Trafficking

Babst, M., Odorizzi, G., Estepa, E. J., & Emr, S. D. (2000) · Traffic · doi:10.1034/j.1600-0854.2000.010307.x · Cited by 402 · see citing works

An Electron Microscope Study of the Rat Ovum

Sotelo, J. R., & Porter, K. R. (1959) · The Journal of Cell Biology · doi:10.1083/jcb.5.2.327 · Cited by 388 · see citing works

The E3 Ubiquitin Ligase AIP4 Mediates Ubiquitination and Sorting of the G Protein-Coupled Receptor CXCR4

Marchese, A., Raiborg, C., Santini, F., Keen, J. H., Stenmark, H., & Benovic, J. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00321-6 · Cited by 386 · see citing works

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

Longva, K. E., Blystad, F. D., Stang, E., Larsen, A. M., Johannessen, L. E., & Madshus, I. H. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200106056 · Cited by 385 · see citing works

VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae.

Piper, R. C., Cooper, A. A., Yang, H., & Stevens, T. H. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.3.603 · Cited by 382 · see citing works

AMSH is an endosome-associated ubiquitin isopeptidase

McCullough, J., Clague, M. J., & Urbé, S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200401141 · Cited by 369 · see citing works

EGF stimulates annexin 1‐dependent inward vesiculation in a multivesicular endosome subpopulation

White, I. J., Bailey, L. M., Aghakhani, M. R., Moss, S. E., & Futter, C. E. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600759 · Cited by 367 · see citing works

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

Görden, P., Carpentier, J. L., Cohen, S., & Orci, L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.5025 · Cited by 351 · see citing works

Proteomic Analysis of Exosomes Secreted by Human Mesothelioma Cells

Hegmans, J. P., Bard, M. P. L., Hemmes, A., Luider, T. M., Kleijmeer, M. J., Prins, J., Zitvogel, L., Burgers, S. A., Hoogsteden, H. C., & Lambrecht, B. N. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63739-x · Cited by 350 · see citing works

The Vps27p–Hse1p complex binds ubiquitin and mediates endosomal protein sorting

Bilodeau, P. S., Urbanowski, J. L., Winistorfer, S. C., & Piper, R. C. (2002) · Nature Cell Biology · doi:10.1038/ncb815 · Cited by 346 · see citing works

Bilayered Clathrin Coats on Endosomal Vacuoles Are Involved in Protein Sorting toward Lysosomes

Sachse, M., Urbé, S., Oorschot, V. M. J., Strous, G. J., & Klumperman, J. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-10-0525 · Cited by 345 · see citing works

Endosome-to-cytosol transport of viral nucleocapsids

Blanc, I., Luyet, P., Pons, V., Ferguson, C., Emans, N., Petiot, A., Mayran, N., Demaurex, N., Fauré, J., Sadoul, R., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1269 · Cited by 324 · see citing works

Sorting of proteins into multivesicular bodies: ubiquitin‐dependent and ‐independent targeting

Reggiori, F., & Pelham, H. R. B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5176 · Cited by 324 · see citing works

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

Lu, Q., Hope, L. W., Brasch, M. A., Reinhard, C., & Cohen, S. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0932599100 · Cited by 319 · see citing works

β-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System

Almeida, C. G., Takahashi, R. H., & Gouras, G. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5078-05.2006 · Cited by 316 · see citing works

Regulation of ubiquitin-binding proteins by monoubiquitination

Hoeller, D., Crosetto, N., Blagoev, B., Raiborg, C., Tikkanen, R., Wagner, S., Kowanetz, K., Rainer Breitling, A., Mann, M., Stenmark, H., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1354 · Cited by 314 · see citing works

The Doa4 Deubiquitinating Enzyme Is Functionally Linked to the Vacuolar Protein-sorting and Endocytic Pathways

Amerik, A. Y., Nowak, J. A., Swaminathan, S., & Hochstrasser, M. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.10.3365 · Cited by 298 · see citing works

A Lumenal Domain-Dependent Pathway for Sorting to Intralumenal Vesicles of Multivesicular Endosomes Involved in Organelle Morphogenesis

Theos, A. C., Truschel, S. T., Tenza, D., Hurbain, I., Harper, D. C., Berson, J. F., Thomas, P. C., Raposo, G., & Marks, M. S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.01.012 · Cited by 289 · see citing works

Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis

Berson, J. F., Theos, A. C., Harper, D. C., Tenza, D., Raposo, G., & Marks, M. S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302072 · Cited by 288 · see citing works

The Tetraspanin CD63/lamp3 Cycles between Endocytic and Secretory Compartments in Human Endothelial Cells

Kobayashi, T., Vischer, U. M., Rosnoblet, C., Lebrand, C., Lindsay, M. R., Parton, R. G., Kruithof, E. K. O., & Gruenberg, J. E. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1829 · Cited by 283 · see citing works

Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant.

Rieder, S., Banta, L. M., Köhrer, K., McCaffery, J. M., & Emr, S. D. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.6.985 · Cited by 280 · see citing works

Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination

Shin, J., Ebersold, M. W., Pypaert, M., Delamarre, L., Hartley, A., & Mellman, I. (2006) · Nature · doi:10.1038/nature05261 · Cited by 262 · see citing works

Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1

Nydegger, S., Khurana, S., Krementsov, D. N., Foti, M., & Thali, M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508165 · Cited by 257 · see citing works

Distinct Roles for Tsg101 and Hrs in Multivesicular Body Formation and Inward Vesiculation

Razi, M., & Futter, C. E. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-11-1054 · Cited by 255 · see citing works

The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation

Row, P. E., Prior, I. A., McCullough, J., Clague, M. J., & Urbé, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512615200 · Cited by 253 · see citing works

ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking

Bishop, N. E., & Woodman, P. G. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.1.227 · Cited by 250 · see citing works

Structural Basis for Budding by the ESCRT-III Factor CHMP3

Muzioł, T. M., Pineda‐Molina, E., Ravelli, R. B. G., Zamborlini, A., Usami, Y., Göttlinger, H. G., & Weissenhorn, W. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.013 · Cited by 250 · see citing works

Human VPS34 is required for internal vesicle formation within multivesicular endosomes

Futter, C. E., Collinson, L., Backer, J., & Hopkins, C. R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108152 · Cited by 248 · see citing works

Ubiquitin interactions of NZF zinc fingers

Alam, S. L., Sun, J., Payne, M., Welch, B. D., Blake, B. K., Davis, D. R., Meyer, H. H., Emr, S. D., & Sundquist, W. I. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600114 · Cited by 248 · see citing works

ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes

Teo, H., Gill, D. J., Sun, J., Perisic, O., Veprintsev, D. B., Vallis, Y., Emr, S. D., & Williams, R. L. (2006) · Cell · doi:10.1016/j.cell.2006.01.047 · Cited by 242 · see citing works

Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesisPreprint

Komada, M., & Soriano, P. M. (1999) · Genes & Development · doi:10.1101/gad.13.11.1475 · Cited by 238 · see citing works

ESCRT-II, an Endosome-Associated Complex Required for Protein Sorting

Teo, H., Perišić, O., González, B., & Williams, R. L. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.003 · Cited by 238 · see citing works

Endosomal and non-endosomal functions of ESCRT proteins

Slagsvold, T., Pattni, K., Malerød, L., & Stenmark, H. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.04.004 · Cited by 238 · see citing works

bicoid RNA localization requires specific binding of an endosomal sorting complex

Irion, U., & Johnston, D. S. (2007) · Nature · doi:10.1038/nature05503 · Cited by 236 · see citing works

Ubiquitin Recognition by the Human TSG101 Protein

Sundquist, W. I., Schubert, H., Kelly, B. N., Hill, G. C., Holton, J. M., & Hill, C. P. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00129-7 · Cited by 235 · see citing works

A physical and functional link between cholesterol and tetraspanins

Charrin, S., Manié, S. N., Thiele, C., Billard, M., Gerlier, D., Boucheix, C., & Rubinstein, E. (2003) · European Journal of Immunology · doi:10.1002/eji.200323884 · Cited by 232 · see citing works

Interactions of GGA3 with the ubiquitin sorting machinery

Puertollano, R., & Bonifacino, J. S. (2004) · Nature Cell Biology · doi:10.1038/ncb1106 · Cited by 231 · see citing works

Structural and mechanistic studies of VPS4 proteins

Scott, A., Chung, H.-Y., Gonciarz-Swiatek, M., Hill, G. C., Whitby, F. G., Gaspar, J., Holton, J. M., Viswanathan, R., Ghaffarian, S., Hill, C. P., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600818 · Cited by 218 · see citing works

Degradation of AP2 During Reticulocyte Maturation Enhances Binding of Hsc70 and Alix to a Common Site on TfR for Sorting into Exosomes

Géminard, C., Gassart, A. D., Blanc, L., & Vidal, M. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.0167.x · Cited by 217 · see citing works

Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

Abrami, L., Lindsay, M. R., Parton, R. G., Leppla, S. H., & van der Goot, F. G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312072 · Cited by 214 · see citing works

Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes

Luhtala, N., & Odorizzi, G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403139 · Cited by 201 · see citing works

Protein–Protein Interactions of ESCRT Complexes in the Yeast Saccharomyces cerevisiae

Bowers, K., Lottridge, J. M., Helliwell, S. B., Goldthwaite, L. M., Luzio, J. P., & Stevens, T. H. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00169.x · Cited by 198 · see citing works

Dendritic Cells Regulate Exposure of MHC Class II at Their Plasma Membrane by Oligoubiquitination

van Niel, G., Wubbolts, R., ten Broeke, T., Buschow, S. I., OSSENDORP, F. A., Melief, C. J. M., Raposo, G., van Balkom, B. W. M., & Stoorvogel, W. (2006) · Immunity · doi:10.1016/j.immuni.2006.11.001 · Cited by 195 · see citing works

Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome

Bilodeau, P. S., Winistorfer, S. C., Kearney, W. R., Robertson, A. D., & Piper, R. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305007 · Cited by 193 · see citing works

Molecular mechanisms of coupled monoubiquitination

Woelk, T., Oldrini, B., Maspero, E., Confalonieri, S., Cavallaro, E. C., Fiore, P. P. D., & Polo, S. (2006) · Nature Cell Biology · doi:10.1038/ncb1484 · Cited by 192 · see citing works

Exploring the ESCRTing machinery in eukaryotes

Ibl, V., & Hauser, M. (2006) · Trends in Plant Science · doi:10.1016/j.tplants.2006.01.008 · Cited by 191 · see citing works

Hrs Interacts with Sorting Nexin 1 and Regulates Degradation of Epidermal Growth Factor Receptor

Chin, L., Raynor, M., Wei, X., Chen, H.-Q., & Li, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004129200 · Cited by 191 · see citing works

The Mouse SKD1, a Homologue of Yeast Vps4p, Is Required for Normal Endosomal Trafficking and Morphology in Mammalian Cells

Yoshimori, T., Yamagata, F., Yamamoto, A., Mizushima, N., Kabeya, Y., Nara, A., Miwako, I., Ohashi, M., Ohsumi, M., & Ohsumi, Y. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.2.747 · Cited by 190 · see citing works

Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces

Villadangos, J., Schnorrer, P., & Wilson, N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00317.x · Cited by 189 · see citing works

TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced Endosomes

Bishop, N., & Woodman, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009863200 · Cited by 187 · see citing works

Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII

Bowers, K., Piper, S. C., Edeling, M. A., Gray, S. R., Owen, D. J., Lehner, P. J., & Luzio, J. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508632200 · Cited by 187 · see citing works

Exosomes contain ubiquitinated proteins

Buschow, S. I., Liefhebber, J. M. P., Wubbolts, R., & Stoorvogel, W. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.08.005 · Cited by 185 · see citing works

Aggregation reroutes molecules from a recycling to a vesicle-mediated secretion pathway during reticulocyte maturation

Vidal, M., Mangeat, P. H., & Hoekstra, D. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.16.1867 · Cited by 184 · see citing works

The multiple personalities of Alix

Odorizzi, G. (2006) · Journal of Cell Science · doi:10.1242/jcs.03072 · Cited by 184 · see citing works

Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A

Scott, A., Gaspar, J., Stuchell‐Brereton, M. D., Alam, S. L., Skalicky, J. J., & Sundquist, W. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502165102 · Cited by 183 · see citing works

Depletion of TSG101 forms a mammalian `Class E' compartment: a multicisternal early endosome with multiple sorting defects

Doyotte, A., Russell, M. R. G., Hopkins, C. R., & Woodman, P. G. (2005) · Journal of Cell Science · doi:10.1242/jcs.02421 · Cited by 175 · see citing works

Multivesicular Body-ESCRT Components Function in pH Response Regulation in Saccharomyces cerevisiae and Candida albicans

Xu, W., Smith, F. J., Subaran, R. L., & Mitchell, A. P. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0666 · Cited by 167 · see citing works

The ESCRT-III Subunit hVps24 Is Required for Degradation but Not Silencing of the Epidermal Growth Factor Receptor

Bache, K. G., Stuffers, S., Malerød, L., Slagsvold, T., Raiborg, C., Lechardeur, D., Wälchli, S., Lukács, G. L., Brech, A., & Stenmark, H. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-10-0915 · Cited by 166 · see citing works

Human ESCRT-II Complex and Its Role in Human Immunodeficiency Virus Type 1 Release

Langelier, C., von Schwedler, U. K., Fisher, R. D., De Domenico, I., White, P. L., Hill, C. P., Kaplan, J., Ward, D., & Sundquist, W. I. (2006) · Journal of Virology · doi:10.1128/jvi.01049-06 · Cited by 166 · see citing works

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

Li, L., Liao, J., Ruland, J., Mak, T. W., & Cohen, S. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1619 · Cited by 159 · see citing works

Interaction of the Mammalian Endosomal Sorting Complex Required for Transport (ESCRT) III Protein hSnf7-1 with Itself, Membranes, and the AAA+ ATPase SKD1

Lin, Y., Kimpler, L. A., Naismith, T. V., Lauer, J. M., & Hanson, P. I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413968200 · Cited by 157 · see citing works

A systematic analysis of human CHMP protein interactions: Additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex

Tsang, H. T. H., Connell, J. W., Brown, S. E., Thompson, A., Reid, E., & Sanderson, C. M. (2006) · Genomics · doi:10.1016/j.ygeno.2006.04.003 · Cited by 156 · see citing works

Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains

Raiborg, C., Wesche, J., Malerød, L., & Stenmark, H. (2006) · Journal of Cell Science · doi:10.1242/jcs.02978 · Cited by 155 · see citing works

Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1

Azmi, I. F., Davies, B. A., Dimaano, C., Payne, J. A., Eckert, D. M., Babst, M., & Katzmann, D. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508166 · Cited by 155 · see citing works

Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding

Blot, V., Perugi, F., Gay, B., Prévost, M., Briant, L., Tangy, F., Abriel, H., Staub, O., Dokhelar, M., & Pique, C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01095 · Cited by 155 · see citing works

Ubiquitin Sorts Proteins into the Intralumenal Degradative Compartment of the Late‐Endosome/Vacuole

Urbanowski, J. L., & Piper, R. C. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.20905.x · Cited by 151 · see citing works

Structural insight into the ESCRT‐I/‐II link and its role in MVB trafficking

Gill, D. J., Teo, H., Sun, J., Perišić, O., Veprintsev, D. B., Emr, S. D., & Williams, R. L. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601501 · Cited by 150 · see citing works

Multivesicular bodies in HEp-2 cells are maturing endosomes.

van Deurs, B., Holm, P. K., Kayser, L., Sandvig, K., & Hansen, S. H. (1993) · PubMed · Cited by 150 · see citing works

Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus buddingPreprint

Amit, I., Yakir, L., Katz, M., Zwang, Y., Marmor, M. D., Citri, A., Shtiegman, K., Alroy, I., Tuvia, S., Reiss, Y., et al. (2004) · Genes & Development · doi:10.1101/gad.294904 · Cited by 148 · see citing works

Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities

Wurmser, A. E., & Emr, S. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.4930 · Cited by 148 · see citing works

Intracellular Trafficking of Interleukin-1 Receptor I Requires Tollip

Brissoni, B., Agostini, L., Kropf, M., Martinon, F., Swoboda, V., Lippens, S., Everett, H., Aebi, N., Janssens, S., Meylan, E., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.062 · Cited by 148 · see citing works

Endosomal compartmentalization in three dimensions: Implications for membrane fusion

Murk, J., Humbel, B. M., Ziese, U., Griffith, J. M., Posthuma, G., Slot, J. W., Koster, A. J., Verkleij, A. J., Geuze, H. J., & Kleijmeer, M. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232379100 · Cited by 145 · see citing works

Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites

Silvie, O., Charrin, S., Billard, M., Franetich, J., Clark, K. L., van Gemert, G., Sauerwein, R. W., Dautry, F., Boucheix, C., Mazier, D., et al. (2006) · Journal of Cell Science · doi:10.1242/jcs.02911 · Cited by 138 · see citing works

Spongiform Neurodegeneration-associated E3 Ligase Mahogunin Ubiquitylates TSG101 and Regulates Endosomal Trafficking

Kim, B. Y., Olzmann, J. A., Barsh, G. S., Chin, L., & Li, L. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0787 · Cited by 137 · see citing works

Structural Insights into Endosomal Sorting Complex Required for Transport (ESCRT-I) Recognition of Ubiquitinated Proteins

Teo, H., Veprintsev, D. B., & Williams, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400023200 · Cited by 132 · see citing works

CART: An Hrs/Actinin-4/BERP/Myosin V Protein Complex Required for Efficient Receptor Recycling

Yan, Q., Sun, W., Kujala, P., Lotfi, Y., Vida, T. A., & Bean, A. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-11-1014 · Cited by 128 · see citing works

Rapid Ca 2+ -dependent decrease of protein ubiquitination at synapses

Chen, H., Polo, S., Fiore, P. P. D., & Camilli, P. V. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2136625100 · Cited by 121 · see citing works

A Deubiquitinating Enzyme UBPY Regulates the Level of Protein Ubiquitination on Endosomes

Mizuno, E., Kobayashi, K., Yamamoto, A., Kitamura, N., & Komada, M. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00452.x · Cited by 120 · see citing works

Proteasome Inhibitors Block a Late Step in Lysosomal Transport of Selected Membrane but not Soluble Proteins

van Kerkhof, P., dos Santos, C. M. A., Sachse, M., Klumperman, J., Bu, G., & Strous, G. J. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2556 · Cited by 114 · see citing works

VESICLE FUSION AND FORMATION AT THE SURFACE OF PINOCYTIC VACUOLES IN MACROPHAGES

Hirsch, J. G., Fedorko, M. E., & Cohn, Z. A. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.38.3.629 · Cited by 113 · see citing works

Involvement of the Ubiquitin/Proteasome System in Sorting of the Interleukin 2 Receptor β Chain to Late Endocytic Compartments

Rocca, A., Lamaze, C., Subtil, A., & Dautry‐Varsat, A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.5.1293 · Cited by 113 · see citing works

Evidence of Cholesterol Accumulated in High Curvature Regions: Implication to the Curvature Elastic Energy for Lipid Mixtures

Wang, W., Yang, L., & Huang, H. W. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.097923 · Cited by 109 · see citing works

Endosomal Dynamics of Met Determine Signaling Output

Hammond, D. E., Carter, S., McCullough, J., Urbé, S., Woude, G. V., & Clague, M. J. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-09-0578 · Cited by 103 · see citing works

Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation

Delaguillaumie, A., Harriague, J., Kohanna, S., Bismuth, G., Rubinstein, E., Seigneuret, M., & Conjeaud, H. (2004) · Journal of Cell Science · doi:10.1242/jcs.01380 · Cited by 103 · see citing works

Isolation and characterization of multivesicular bodies from rat hepatocytes: an organelle distinct from secretory vesicles of the Golgi apparatus.

Hornick, C. A., Hamilton, R. L., Spaziani, E., Enders, G. H., & Havel, R. J. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.100.5.1558 · Cited by 102 · see citing works

Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex

Sun, W., Yan, Q., Vida, T. A., & Bean, A. J. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302083 · Cited by 94 · see citing works

Biogenesis of transport intermediates in the endocytic pathway

Gu, F., & Gruenberg, J. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00561-x · Cited by 92 · see citing works

Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body

Lottridge, J. M., Flannery, A. R., Vincelli, J. L., & Stevens, T. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601712103 · Cited by 89 · see citing works

Interactions of TOM1L1 with the Multivesicular Body Sorting Machinery

Puertollano, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412481200 · Cited by 80 · see citing works

Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain

Alam, S. L., Langelier, C., Whitby, F. G., Koirala, S., Robinson, H. H., Hill, C. P., & Sundquist, W. I. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1160 · Cited by 80 · see citing works

Membrane transport: Ubiquitylation in endosomal sorting

Dupré‐Crochet, S., Volland, C., & Haguenauer‐Tsapis, R. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00558-9 · Cited by 79 · see citing works

Hse1, a Component of the Yeast Hrs-STAM Ubiquitin-sorting Complex, Associates with Ubiquitin Peptidases and a Ligase to Control Sorting Efficiency into Multivesicular Bodies

Ren, J., Kee, Y., Huibregtse, J. M., & Piper, R. C. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0557 · Cited by 77 · see citing works

Targeting of AMSH to Endosomes Is Required for Epidermal Growth Factor Receptor Degradation

Ma, Y. M., Boucrot, E., Villén, J., Affar, E. B., Gygi, S. P., Göttlinger, H. G., & Kirchhausen, T. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611635200 · Cited by 77 · see citing works

Peripherin/rds Influences Membrane Vesicle Morphology

Wrigley, J. D. J., Ahmed, T., Nevett, C. L., & Findlay, J. B. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c900853199 · Cited by 76 · see citing works

Characterization of Vta1p, a Class E Vps Protein in Saccharomyces cerevisiae

Shiflett, S. L., Ward, D. M., Huynh, D., Vaughn, M. B., Simmons, J. C., & Kaplan, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312669200 · Cited by 75 · see citing works

Direct Binding to Rsp5 Mediates Ubiquitin-independent Sorting of Sna3 via the Multivesicular Body Pathway

McNatt, M. W., McKittrick, I., West, M., & Odorizzi, G. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0663 · Cited by 74 · see citing works

Efficient Cargo Sorting by ESCRT-I and the Subsequent Release of ESCRT-I from Multivesicular Bodies Requires the Subunit Mvb12

Curtiss, M., Jones, C. B., & Babst, M. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0588 · Cited by 73 · see citing works

Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation

Kanazawa, C., Morita, E., Yamada, M., Ishii, N., Miura, S., Asao, H., Yoshimori, T., & Sugamura, K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.078 · Cited by 71 · see citing works

Snf7p, a Component of the ESCRT-III Protein Complex, Is an Upstream Member of the RIM101 Pathway in Candida albicans

Kullas, A. L., Li, M., & Davis, D. A. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.6.1609-1618.2004 · Cited by 65 · see citing works

Recruitment of clathrin onto endosomes by the Tom1–Tollip complex

Katoh, Y., Imakagura, H., Futatsumori, M., & Nakayama, K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.156 · Cited by 64 · see citing works

Characterization of Multiple Multivesicular Body Sorting Determinants within Sna3: A Role for the Ubiquitin Ligase Rsp5

Oestreich, A. J., Aboian, M., Lee, J. R. E., Azmi, I. F., Payne, J. A., Issaka, R. B., Davies, B. A., & Katzmann, D. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0680 · Cited by 64 · see citing works

ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles

Sachse, M., Strous, G. J., & Klumperman, J. (2004) · Journal of Cell Science · doi:10.1242/jcs.00998 · Cited by 63 · see citing works

AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism

Wang, P., Zhang, Y., Li, H., Chieu, H. K., Munn, A. L., & Yang, H. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600764 · Cited by 63 · see citing works

The GAT Domains of Clathrin-associated GGA Proteins Have Two Ubiquitin Binding Motifs

Bilodeau, P. S., Winistorfer, S. C., Allaman, M. M., Surendhran, K., Kearney, W. R., Robertson, A. D., & Piper, R. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406654200 · Cited by 59 · see citing works

Old lysosomes, new tricks: MHC II dynamics in DCs

CHOW, A., & Mellman, I. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.11.008 · Cited by 55 · see citing works

Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain

Hirano, S., Suzuki, N., Slagsvold, T., Kawasaki, M., Trambaiolo, D. M., Kato, R., Stenmark, H., & Soichi Wakatsuki, A. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1163 · Cited by 55 · see citing works

Mvb12 Is a Novel Member of ESCRT-I Involved in Cargo Selection by the Multivesicular Body Pathway

Oestreich, A. J., Davies, B. A., Payne, J. A., & Katzmann, D. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0601 · Cited by 53 · see citing works

A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila.

Sevrioukov, E. A., Moghrabi, N., Kuhn, M., & Krämer, H. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-11-1013 · Cited by 51 · see citing works

The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation

Yang, M., Coppens, I., Wormsley, S., Baevova, P., Hoppe, H. C., & Joiner, K. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.01237 · Cited by 47 · see citing works

Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (HRS) Interacts with PELP1 and Activates MAPK

Rayala, S. K., den Hollander, P., Balasenthil, S., Molli, P. R., Bean, A. J., Vadlamudi, R. K., Wang, R., & Kumar, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510368200 · Cited by 45 · see citing works

Formation of multivesicular endosomes in Dictyostelium

Marchetti, A., Mercanti, V., Cornillon, S., Alibaud, L., Charette, S. J., & Cosson, P. (2004) · Journal of Cell Science · doi:10.1242/jcs.01524 · Cited by 30 · see citing works

Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability

Yogosawa, S., Kawasaki, M., Soichi Wakatsuki, A., Kominami, E., Shiba, Y., Nakayama, K., Kohsaka, S., & Akazawa, C. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.013 · Cited by 26 · see citing works

Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor

Myromslien, F. D., Grøvdal, L. M., Raiborg, C., Stenmark, H., Madshus, I. H., & Stang, E. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.06.004 · Cited by 22 · see citing works

Ubiquitin, lysosomes and neurodegenerative diseases

Mayer, R. J., László, L., MIDDLETON, A., Landon, M., Hope, J., & Lowe, J. S. (1992) · Biochemical Society Transactions · doi:10.1042/bst0200645 · Cited by 7 · see citing works

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,639 · see citing works

Endosome maturation

Huotari, J., & Helenius, A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.286 · Cited by 2,279 · see citing works

New Technologies for Analysis of Extracellular Vesicles

Shao, H., Im, H., Castro, C. M., Breakefield, X. O., Weissleder, R., & Lee, H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00534 · Cited by 1,672 · see citing works

Extracellular vesicles in cancer — implications for future improvements in cancer care

Xu, R., Rai, A., Chen, M., Suwakulsiri, W., Greening, D. W., & Simpson, R. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0036-9 · Cited by 1,435 · see citing works

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

Akers, J. C., Gonda, D., Kim, R., Carter, B. S., & Chen, C. C. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1084-8 · Cited by 1,423 · see citing works

Platelet α-granules: Basic biology and clinical correlates

Blair, P., & Flaumenhaft, R. (2009) · Blood Reviews · doi:10.1016/j.blre.2009.04.001 · Cited by 1,157 · see citing works

Virus Entry by Endocytosis

Mercer, J., Schelhaas, M., & Helenius, A. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-104626 · Cited by 1,057 · see citing works

Post-translational modifications in signal integration

Deribe, Y. L., Pawson, T., & Dikic, I. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1842 · Cited by 876 · see citing works

Molecular biology of hepatitis B virus infection

Seeger, C., & Mason, W. S. (2015) · Virology · doi:10.1016/j.virol.2015.02.031 · Cited by 868 · see citing works

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

Hsu, C., Morohashi, Y., Yoshimura, S., Manrique‐Hoyos, N., Jung, S., Lauterbach, M. A., Bakhti, M., Grønborg, M., Möbius, W., Rhee, J., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200911018 · Cited by 860 · see citing works

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

Wollert, T., & Hurley, J. H. (2010) · Nature · doi:10.1038/nature08849 · Cited by 804 · see citing works

Exosome Function: From Tumor Immunology to Pathogen Biology

Schorey, J. S., & Bhatnagar, S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00734.x · Cited by 758 · see citing works

Membrane budding and scission by the ESCRT machinery: it's all in the neck

Hurley, J. H., & Hanson, P. I. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2937 · Cited by 757 · see citing works

Mechanisms of regulated unconventional protein secretion

Nickel, W., & Rabouille, C. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2617 · Cited by 703 · see citing works

The regulation and function of Class III PI3Ks: novel roles for Vps34

Backer, J. (2008) · Biochemical Journal · doi:10.1042/bj20071427 · Cited by 659 · see citing works

Membrane scission by the ESCRT-III complex

Wollert, T., Wunder, C., Lippincott‐Schwartz, J., & Hurley, J. H. (2009) · Nature · doi:10.1038/nature07836 · Cited by 634 · see citing works

Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

Kou, M., Huang, L., Yang, J., Chiang, Z., Chen, S., Liu, J., Guo, L., Zhang, X., Zhou, X., Xu, X. M., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05034-x · Cited by 654 · see citing works

Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications

Hanyaloglu, A. C., & von Zastrow, M. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094830 · Cited by 610 · see citing works

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

Ghossoub, R., Lembo, F., Rubio, A., Baron, C. L., Bouchet, J., Vitale, N., Slavík, J., Machala, M., & Zimmermann, P. (2014) · Nature Communications · doi:10.1038/ncomms4477 · Cited by 601 · see citing works

Multivesicular Body Morphogenesis

Hanson, P. I., & Cashikar, A. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154152 · Cited by 583 · see citing works

Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

Li, X., Corbett, A. L., Taatizadeh, E., Tasnim, N., Little, J. P., Garnis, C., Daugaard, M., Guns, E. S. T., Hoorfar, M., & Li, I. T. S. (2019) · APL Bioengineering · doi:10.1063/1.5087122 · Cited by 575 · see citing works

The significance of exosomes in the development and treatment of hepatocellular carcinoma

Li, X., Li, C., Zhang, L., Wu, M. Y., Cao, K., Jiang, F., Chen, D., Li, N., & Li, W. (2020) · Molecular Cancer · doi:10.1186/s12943-019-1085-0 · Cited by 503 · see citing works

The emerging mechanisms and functions of microautophagy

Wang, L., Klionsky, D. J., & Shen, H. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00529-z · Cited by 473 · see citing works

Systems survey of endocytosis by multiparametric image analysis

Collinet, C., Stöter, M., Bradshaw, C. R., Samusik, N., Rink, J. C., Kenski, D. M., Habermann, B. H., Buchholz, F., Henschel, R., Mueller, M., et al. (2010) · Nature · doi:10.1038/nature08779 · Cited by 446 · see citing works

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

Alegre‐Abarrategui, J., Christian, H., Lufino, M. M., Dafinca, R., Venda, L. L., Ansorge, O., & Wade‐Martins, R. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp346 · Cited by 433 · see citing works

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell‐Induced Exosomes Via Distinct Multivesicular Body Pathways

Buschow, S. I., Hoen, E. N. M. N., van Niel, G., Pols, M. S., ten Broeke, T., Lauwen, M. M., OSSENDORP, F. A., Melief, C. J. M., Raposo, G., Wubbolts, R., et al. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00963.x · Cited by 430 · see citing works

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

Liao, W., Du, Y., Zhang, C., Pan, F., Yao, Y., Zhang, T., & Peng, Q. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.045 · Cited by 416 · see citing works

Mechanisms associated with biogenesis of exosomes in cancer

McAndrews, K. M., & Kalluri, R. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0963-9 · Cited by 394 · see citing works

Itinerant exosomes: emerging roles in cell and tissue polarity

Lakkaraju, A., & Rodriguez-Boulan, E. J. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.03.002 · Cited by 391 · see citing works

Protein quality control in the secretory pathway

Sun, Z., & Brodsky, J. L. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201906047 · Cited by 381 · see citing works

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

Taylor, D. D., & Gerçel-Taylor, Ç. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-010-0234-8 · Cited by 386 · see citing works

A Role for the ESCRT System in Cell Division in Archaea

Samson, R. Y., Obita, T., Freund, S. M. V., Williams, R. L., & Bell, S. D. (2008) · Science · doi:10.1126/science.1165322 · Cited by 368 · see citing works

Plaque formation and the intraneuronal accumulation of β‐amyloid in Alzheimer's disease

Takahashi, R. H., Nagao, T., & Gouras, G. K. (2017) · Pathology International · doi:10.1111/pin.12520 · Cited by 354 · see citing works

The ESCRT complexes

Hurley, J. H. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2010.502516 · Cited by 347 · see citing works

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

Teis, D., Saksena, S., & Emr, S. D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.08.013 · Cited by 338 · see citing works

Silencing by small RNAs is linked to endosomal trafficking

Lee, Y. S., Pressman, S., Andress, A. P., Kim, K., White, J. L., Cassidy, J. J., Li, X., Lubell, K., Lim, D., Cho, I. S., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1930 · Cited by 338 · see citing works

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

Kajimoto, T., Okada, T., Miya, S., Zhang, L., & Nakamura, S. (2013) · Nature Communications · doi:10.1038/ncomms3712 · Cited by 318 · see citing works

Plant secretome: Unlocking secrets of the secreted proteins

Agrawal, G. K., Jwa, N., Lebrun, M., Job, D., & Rakwal, R. (2009) · PROTEOMICS · doi:10.1002/pmic.200900514 · Cited by 314 · see citing works

Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains

Puthenveedu, M., Lauffer, B. E. L., Temkin, P., Vistein, R., Carlton, P., Thorn, K., Taunton, J., Weiner, O., Parton, R., & von Zastrow, M. (2010) · Cell · doi:10.1016/j.cell.2010.10.003 · Cited by 332 · see citing works

Characterization and proteomic analysis of ovarian cancer-derived exosomes

Liang, B., Peng, P., Chen, S., Li, L., Zhang, M., Cao, D., Yang, J., Li, H., Gui, T., Xialu Li, C., et al. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2012.12.029 · Cited by 309 · see citing works

Targeting the lysosome in cancer

Piao, S., & Amaravadi, R. K. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12953 · Cited by 303 · see citing works

Mechanism of amyloid plaque formation suggests an intracellular basis of Aβ pathogenicity

Friedrich, R. P., Tepper, K., Rönicke, R., Soom, M., Westermann, M., Reymann, K., Kaether, C., & Fändrich, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904532106 · Cited by 303 · see citing works

Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis

Zhang, Z., Li, X., Sun, W., Yue, S., Yang, J., Li, J., Ma, B., Wang, J., Yang, X., Pu, M., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.03.004 · Cited by 296 · see citing works

Signal transduction by protease‐activated receptors

Soh, U. J. K., Dores, M. R., Chen, B., & Trejo, J. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00705.x · Cited by 294 · see citing works

The march of the PINs: developmental plasticity by dynamic polar targeting in plant cells

Grunewald, W., & Friml, J. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.181 · Cited by 278 · see citing works

Lysosomal degradation of membrane lipids

Kolter, T., & Sandhoff, K. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.021 · Cited by 276 · see citing works

Membrane Budding

Hurley, J. H., Bouřa, E., Carlson, L. A., & Różycki, B. (2010) · Cell · doi:10.1016/j.cell.2010.11.030 · Cited by 271 · see citing works

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

Minakaki, G., Menges, S., Kittel, A., Emmanouilidou, E., Schaeffner, I., Barkovits, K., Bergmann, A., Rockenstein, E., Adame, A., Marxreiter, F., et al. (2018) · Autophagy · doi:10.1080/15548627.2017.1395992 · Cited by 272 · see citing works

Unconventional Mechanisms of Protein Transport to the Cell Surface of Eukaryotic Cells

Nickel, W., & Seedorf, M. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175320 · Cited by 259 · see citing works

Multivesicular Bodies Mature from the Trans -Golgi Network/Early Endosome in Arabidopsis

Scheuring, D., Viotti, C., Krüger, F., Künzl, F., Sturm, S., Bubeck, J. A., Hillmer, S., Frigerio, L., Robinson, D. G., Pimpl, P., et al. (2011) · The Plant Cell · doi:10.1105/tpc.111.086918 · Cited by 257 · see citing works

Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications

Huda, M. N., Nafiujjaman, M., Deaguero, I. G., Okonkwo, J., Hill, M. L., Kim, T. H., & Nurunnabi, M. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00217 · Cited by 262 · see citing works

Rab GTPases and Membrane Trafficking in Neurodegeneration

Kiral, F. R., Kohrs, F. E., Jin, E. J., & Hiesinger, P. R. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.010 · Cited by 239 · see citing works

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF‐κB activation

Verweij, F. J., van Eijndhoven, M. A. J., Hopmans, E. S., Vendrig, T., Würdinger, T., Cahir-McFarland, E. D., Kieff, E. D., Geerts, D., van der Kant, R., Neefjes, J., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.123 · Cited by 230 · see citing works

Hrs‐ and CD63 ‐Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

Edgar, J. R., Eden, E. R., & Futter, C. E. (2013) · Traffic · doi:10.1111/tra.12139 · Cited by 224 · see citing works

Structural basis for ESCRT-III protein autoinhibition

Bajorek, M., Schubert, H., McCullough, J., Langelier, C., Eckert, D. M., Stubblefield, W. B., Uter, N. T., Myszka, D. G., Hill, C. P., & Sundquist, W. I. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1621 · Cited by 224 · see citing works

Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake

Zhao, X., Wu, D. L., Ma, X., Wang, J., Hou, W., & Zhang, W. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110237 · Cited by 220 · see citing works

The ESCRT-Related CHMP1A and B Proteins Mediate Multivesicular Body Sorting of Auxin Carriers in Arabidopsis and Are Required for Plant Development

Spitzer, C., Reyes, F. C., Buono, R. A., Sliwinski, M. K., Haas, T. J., & Otegui, M. S. (2009) · The Plant Cell · doi:10.1105/tpc.108.064865 · Cited by 202 · see citing works

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

von Bartheld, C. S., & Altick, A. L. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.003 · Cited by 197 · see citing works

Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities

Hassanzadeh, A., Rahman, H. S., Markov, A. A., Endjun, J. J., Zekiy, A. O., Chartrand, M. S., Beheshtkhoo, N., Kouhbanani, M. A. J., Marofi, F., Nikoo, M., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02378-7 · Cited by 190 · see citing works

Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly

Seguin, S. J., Morelli, F. F., Vinet, J., Amore, D., Biasi, S. D., Poletti, A., Rubinsztein, D. C., & Carra, S. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.103 · Cited by 188 · see citing works

Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles

Bost, J., Barriga, H. M. G., Holme, M. N., Gallud, A., Maugeri, M., Gupta, D., Lehto, T., Valadi, H., Esbjörner, E. K., Stevens, M. M., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c05099 · Cited by 187 · see citing works

MHC Class II Antigen Presentation by Dendritic Cells Regulated through Endosomal SortingPreprint

ten Broeke, T., Wubbolts, R., & Stoorvogel, W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016873 · Cited by 182 · see citing works

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

Polanco, J. C., Li, C., Durisic, N., Sullivan, R., & Götz, J. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0514-4 · Cited by 180 · see citing works

In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes

Schmidt, H. B., & Rohatgi, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.088 · Cited by 178 · see citing works

Horizontal transfer of RNAs: exosomes as mediators of intercellular communication

Ramachandran, S., & Palanisamy, V. (2011) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.115 · Cited by 176 · see citing works

How Ubiquitin Functions with ESCRTs

Shields, S. B., & Piper, R. C. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01242.x · Cited by 175 · see citing works

Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles

Dobrowolski, R., & Robertis, E. M. D. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3244 · Cited by 172 · see citing works

Extracellular Vesicle-Mediated Communication Within Host-Parasite Interactions

Wu, Z., Wang, L., Li, J., Wang, L., Wu, Z., & Sun, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03066 · Cited by 172 · see citing works

Exosomes and extracellular vesicles: Rethinking the essential values in cancer biology

Yokoi, A., & Ochiya, T. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.032 · Cited by 169 · see citing works

Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease

Reza-Zaldívar, E. E., Hernández-Sapiéns, M. A., Minjarez, B. D., Gutiérrez-Mercado, Y. K., Márquez-Aguirre, A. L., & Canales-Aguirre, A. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00317 · Cited by 168 · see citing works

An ESCRT–spastin interaction promotes fission of recycling tubules from the endosome

Allison, R. J., Lumb, J. H., Fassier, C., Connell, J. W., Martín, D. T., Seaman, M. N. J., Hazan, J., & Reid, E. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201211045 · Cited by 164 · see citing works

NEDD4L Overexpression Rescues the Release and Infectivity of Human Immunodeficiency Virus Type 1 Constructs Lacking PTAP and YPXL Late Domains

Chung, H.-Y., Morita, E., von Schwedler, U. K., Müller, B., Kräusslich, H., & Sundquist, W. I. (2008) · Journal of Virology · doi:10.1128/jvi.02667-07 · Cited by 161 · see citing works

Extracellular vesicles from infected cells: potential for direct pathogenesis

Schwab, A., Meyering, S. S., Lepene, B., Iordanskiy, S., van Hoek, M. L., Hakami, R. M., & Kashanchi, F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01132 · Cited by 160 · see citing works

Understanding extracellular vesicle diversity – current status

Greening, D. W., & Simpson, R. J. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1537788 · Cited by 160 · see citing works

PLD3 affects axonal spheroids and network defects in Alzheimer’s disease

Yuan, P., Zhang, M., Tong, L., Morse, T. M., McDougal, R. A., Ding, H., Chan, D., Cai, Y., & Grutzendler, J. (2022) · Nature · doi:10.1038/s41586-022-05491-6 · Cited by 155 · see citing works

In Vitro Budding of Intralumenal Vesicles into Late Endosomes Is Regulated by Alix and Tsg101

Falguières, T., Luyet, P., Bissig, C., Scott, C. C., Velluz, M., & Gruenberg, J. E. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0239 · Cited by 155 · see citing works

Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy

Tang, X., Sun, X., Huang, K.-M., Zhang, L., Yang, Z., Zou, D., Wang, B., Warnock, G. L., Dai, L., & Luo, J. D. (2015) · Oncotarget · doi:10.18632/oncotarget.6175 · Cited by 157 · see citing works

Large-scale identification ofLegionella pneumophilaDot/Icm substrates that modulate host cell vesicle trafficking pathways

Heidtman, M. I., Chen, E. J., Moy, M.-Y., & Isberg, R. R. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01249.x · Cited by 154 · see citing works

Viral escape from endosomes and host detection at a glance

Staring, J., Raaben, M., & Brummelkamp, T. R. (2018) · Journal of Cell Science · doi:10.1242/jcs.216259 · Cited by 154 · see citing works

Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines

Guo, J., Massaeli, H., Xu, J., Jia, Z., Wigle, J. T., Mesaeli, N., & Zhang, S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39027 · Cited by 152 · see citing works

Computational Model of Membrane Fission Catalyzed by ESCRT-III

Fabrikant, G., Lata, S., Riches, J. D., Briggs, J. A. G., Weissenhorn, W., & Kozlov, M. M. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000575 · Cited by 151 · see citing works

Molecular characterization of S. japonicum exosome-like vesicles reveals their regulatory roles in parasite-host interactions

Zhu, L., Liu, J., Dao, J., Ke, L., Li, H., Gu, H., Liu, J., Feng, X., & Cheng, G. (2016) · Scientific Reports · doi:10.1038/srep25885 · Cited by 151 · see citing works

Herpes Simplex Virus Type 1 Production Requires a Functional ESCRT-III Complex but Is Independent of TSG101 and ALIX Expression

Pawliczek, T., & Crump, C. M. (2009) · Journal of Virology · doi:10.1128/jvi.00574-09 · Cited by 150 · see citing works

Diagnostic and therapeutic potentials of exosomes in CNS diseases

Kawiková, I., & Askenase, P. W. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.070 · Cited by 144 · see citing works

A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination

Stringer, D. K., & Piper, R. C. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008121 · Cited by 144 · see citing works

ESCRT-III Family Members Stimulate Vps4 ATPase Activity Directly or via Vta1

Azmi, I. F., Davies, B. A., Xiao, J., Babst, M., Xu, Z., & Katzmann, D. J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.10.021 · Cited by 144 · see citing works

Biodistribution and function of extracellular miRNA-155 in mice

Bala, S., Csák, T., Momen‐Heravi, F., Lippai, D., Kodys, K., Catalano, D., Satishchandran, A., Ambros, V., & Szabó, G. (2015) · Scientific Reports · doi:10.1038/srep10721 · Cited by 141 · see citing works

Pharmacological Analysis Demonstrates Dramatic Alteration of D1Dopamine Receptor Neuronal Distribution in the Rat Analog of l-DOPA-Induced Dyskinesia

Berthet, A., Porras, G., Doudnikoff, É., Stark, H., Cador, M., Bézard, E., & Bloch, B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5884-08.2009 · Cited by 140 · see citing works

Secretory autophagy machinery and vesicular trafficking are involved in HMGB1 secretion

Kim, Y. H., Kwak, M. S., Lee, B., Shin, J. M., Aum, S., Park, I. H., Lee, M. G., & Shin, J. (2020) · Autophagy · doi:10.1080/15548627.2020.1826690 · Cited by 141 · see citing works

Forms of extracellular mitochondria and their impact in health

Miliotis, S., Nicolalde, B., Ortega, M., Yepez, J., & Caicedo, A. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.02.002 · Cited by 138 · see citing works

Diabetic Nephropathy: Perspective on Extracellular Vesicles

Lu, Y., Liu, D., Feng, Q., & Liu, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00943 · Cited by 138 · see citing works

Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling

Sugiyama, M. G., Fairn, G. D., & Antonescu, C. N. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00070 · Cited by 134 · see citing works

Ist1 Regulates Vps4 Localization and Assembly

Dimaano, C., Jones, C. B., Hanono, A., Curtiss, M., & Babst, M. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0747 · Cited by 137 · see citing works

On the cellular processing of non-viral nanomedicines for nucleic acid delivery: Mechanisms and methods

Vercauteren, D., Rejman, J., Martens, T., Demeester, J., Smedt, S. C. D., & Braeckmans, K. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.020 · Cited by 134 · see citing works

Lysosomes drive the piecemeal removal of mitochondrial inner membrane

Prashar, A., Bussi, C., Fearns, A., Capurro, M., Gao, X., Sesaki, H., Gutierrez, M. G., & Jones, N. L. (2024) · Nature · doi:10.1038/s41586-024-07835-w · Cited by 139 · see citing works

MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation

Eyster, C. A., Cole, N. B., Harrington, S. P., Viswanathan, K., Früh, K., & Donaldson, J. G. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-11-0874 · Cited by 130 · see citing works

ESCRT‐III and Vps4: a dynamic multipurpose tool for membrane budding and scission

Adell, M. A. Y., Migliano, S. M., & Teis, D. (2016) · FEBS Journal · doi:10.1111/febs.13688 · Cited by 126 · see citing works

pH-Lemon, a Fluorescent Protein-Based pH Reporter for Acidic Compartments

Burgstaller, S., Bischof, H., Gensch, T., Stryeck, S., Gottschalk, B., Ramadani‐Muja, J., Eroğlu, E., Rost, R., Balfanz, S., Baumann, A., et al. (2019) · ACS Sensors · doi:10.1021/acssensors.8b01599 · Cited by 128 · see citing works

Exosomes in diagnostic and therapeutic applications: biomarker, vaccine and RNA interference delivery vehicle

Lässer, C. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.977250 · Cited by 127 · see citing works

Intracellular Trafficking and Maturation of Herpes Simplex Virus Type 1 gB and Virus Egress Require Functional Biogenesis of Multivesicular Bodies

Calistri, A., Sette, P., Salata, C., Cancellotti, E., Forghieri, C., Comin, A., Göttlinger, H. G., Campadelli‐Fiume, G., Palù, G., & Parolin, C. (2007) · Journal of Virology · doi:10.1128/jvi.01364-07 · Cited by 124 · see citing works

Ubiquitin-Mediated Vacuolar Sorting and Degradation

Klionsky, D. J. (2003) · CRC Press eBooks · doi:10.1201/9781498713276-20

Multivesicular Bodies and Multivesicular Endosomes: The "Ins and Outs" of Endosomal Traffic

Stahl, P. D., & Barbieri, M. A. (2002) · Science Signaling · doi:10.1126/scisignal.1412002pe32 · Cited by 12 · see citing works

Biogenesis of Multivesicular Body and Protein Sorting: No One of ESCRT,Vps4 and Ubiquitination Can Be Missed

Heng, X. (2013) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

Multivesicular Body (MSB)

(2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_10962

Multivesicular bodies: co-ordinated progression to maturity

Woodman, P. G., & Futter, C. E. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.04.001 · Cited by 206 · see citing works