The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis
Open accessAbstract
The serine/threonine kinase PAK4 was identified first as an effector molecule for the Rho GTPase Cdc42. PAK4 differs from other members of the PAK family both in sequence and function. Previously we have shown that an important function of this kinase is to mediate the induction of filopodia in response to activated Cdc42. Studies with a constitutively active PAK4 mutant have shown that it also has a role in promoting anchorage-independent growth, an important hallmark of oncogenic transformation. Here we show that another function of PAK4 is to protect cells against apoptotic cell death. Expression of wild-type or constitutively active PAK4 delays the onset of apoptosis in response to tumor necrosis factor alpha stimulation, UV irradiation, and serum starvation. Consistent with an antiapoptotic function, expression of PAK4 leads to an increase in phosphorylation of the proapoptotic protein Bad and an inhibition of caspase activation.
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Cites
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
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A role for Rho in Ras transformation
Qiu, R. G., Chen, J., McCormick, F., & Symons, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11781 · Cited by 533
Rho family proteins and Ras transformation: the RHOad less traveled gets congested
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Cited by
Frisch, S. M., & Screaton, R. A. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00251-9 · Cited by 1,249
Fernald, K., & Kurokawa, M. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.006 · Cited by 579
p21-Activated kinases: three more join the Pak
Jaffer, Z. M., & Chernoff, J. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00158-3 · Cited by 373
Arias‐Romero, L. E., & Chernoff, J. (2008) · Biology of the Cell · doi:10.1042/bc20070109 · Cited by 364
Global Proteome Analysis of the NCI-60 Cell Line Panel
Gholami, A. M., Hahne, H., Wu, Z., Auer, F. J., Meng, C., Wilhelm, M., & Kuster, B. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.018 · Cited by 302
Metadata
- Authors
- Gnesutta, N., Qu, J., & Minden, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 276
- Issue
- 17
- Pages
- 14414-14419
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1826874877
- Cited by
- 200
- References
- 4
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gnesutta, N., Qu, J., & Minden, A. (2001). The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m011046200
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