Lipid Association-induced N- and C-terminal Domain Reorganization in Human Apolipoprotein E3
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The apoE molecule comprises an N-terminal domain (amino acids 1-191), a hinge region (amino acids 192-215), and a C-terminal domain (amino acids 216-299).
“The apoE molecule comprises an N-terminal domain (NT; amino acids 1–191), a hinge region (amino acids 192–215), and a C-terminal domain (CT; amino acids 216–299).”
The hinge region plays an indispensable role in the binding of both domains.
“The hinge region plays an indispensable role in the binding of both domains [10].”
NT includes an LDL receptor and heparan sulfate proteoglycan-binding region, and CT is critical for lipid binding.
“NT includes an LDL receptor and heparan sulfate proteoglycan-binding region, and CT is critical for lipid binding [10].”
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Cites
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830 · see citing works
The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.
Innerarity, T. L., Friedlander, E. J., Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44180-9 · Cited by 276 · see citing works
Aggerbeck, L. P., Wetterau, J. R., Weisgraber, K. H., Wu, C. S., & Lindgren, F. T. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68779-4 · Cited by 229 · see citing works
Westerlund, J. A., & Weisgraber, K. H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82318-3 · Cited by 164 · see citing works
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Research works printed but not linked: 4
- Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L.-M., Salsesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., and Roses, A. D. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 8098 -8102
- Lakowicz, J. R. (1999) Principles of Fluorescence Spectroscopy, pp. 237-265, Plenum Press, New York
- Fo ¨rster, T. (1966) in Modern Quantum Chemistry (Sinanoglu, O., ed) pp. 93-137, Academic Press, New York
- Lakowicz, J. R. (1983) Principles of Fluorescence Spectroscopy, pp. 303-339, Plenum Press, New York
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Apolipoprotein E isoforms and lipoprotein metabolism
Phillips, M. C. (2014) · IUBMB Life · doi:10.1002/iub.1314 · Cited by 328 · see citing works
Apolipoprotein E and cholesterol in aging and disease in the brain
de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164 · see citing works
Self-citationAmino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils
Hatters, D. M., Zhong, N., Rutenber, E., & Weisgraber, K. H. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.06.080 · Cited by 105 · see citing works
Characterization of the Heparin Binding Sites in Human Apolipoprotein E
Saito, H., Dhanasekaran, P., Nguyen, D., Baldwin, F., Weisgraber, K. H., Wehrli, S., Phillips, M. C., & Lund-Katz, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213207200 · Cited by 90 · see citing works
Apolipoprotein E–related glomerular disorders
Saito, T., Matsunaga, A., Fukunaga, M., Nagahama, K., Hara, S., & Muso, E. (2020) · Kidney International · doi:10.1016/j.kint.2019.10.031 · Cited by 77 · see citing works
Sakamoto, T., Tanaka, M., Vedhachalam, C., Nickel, M., Nguyen, D., Dhanasekaran, P., Phillips, M. C., Lund-Katz, S., & Saito, H. (2008) · Biochemistry · doi:10.1021/bi701923h · Cited by 54 · see citing works
Effect of Carboxyl-Terminal Truncation on Structure and Lipid Interaction of Human Apolipoprotein E4
Tanaka, M., Vedhachalam, C., Sakamoto, T., Dhanasekaran, P., Phillips, M. C., Lund-Katz, S., & Saito, H. (2006) · Biochemistry · doi:10.1021/bi060023b · Cited by 43 · see citing works
Structural Analysis of Lipoprotein E Particles
Schneeweis, L. A., Koppaka, V., Lund-Katz, S., Phillips, M. C., & Axelsen, P. H. (2005) · Biochemistry · doi:10.1021/bi050872j · Cited by 39 · see citing works
Koshino, A., Takaeda, C., Matsuno, T., Kitajima, S., Iwata, Y., Sakai, N., Nagahama, K., Niida, Y., Saito, T., Yokoyama, H., et al. (2022) · Case Reports in Nephrology and Dialysis · doi:10.1159/000525086 · Cited by 2 · see citing works
- Authors
- Narayanaswami, V., Szeto, S. S. W., & Ryan, R. O.
- Venue
- Journal of Biological Chemistry
- Published
- 2001-10
- Volume
- 276
- Issue
- 41
- Pages
- 37853-37860
- ISSN
- 0021-9258
- Cited by
- 53
- References
- 4
- Language
- en
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