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Apolipoprotein E: From lipid transport to neurobiology

Hauser, P. S., Narayanaswami, V., & Ryan, R. O. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.09.001 · Cited by 320 · see citing works

ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias

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Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

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Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

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APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis

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Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

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ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease

Lane-Donovan, C., & Herz, J. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.12.001 · Cited by 157 · see citing works

Apolipoprotein E and cholesterol in aging and disease in the brain

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Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

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Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

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Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure

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ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes

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APOE in the normal brain

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Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities

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Diabetes as a risk factor for Alzheimer’s disease in the Middle East and its shared pathological mediators

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Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

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Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and Insulin

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Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights

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APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease

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Mass spectrometry-based protein footprinting characterizes the structures of oligomeric apolipoprotein E2, E3, and E4

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Dissecting Complex and Multifactorial Nature of Alzheimer’s Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective

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The Association−Dissociation Behavior of the ApoE Proteins: Kinetic and Equilibrium Studies

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Apolipoprotein C-II Amyloid Fibrils Assemble via a Reversible Pathway that Includes Fibril Breaking and Rejoining

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Apolipoproteins and amyloid fibril formation in atherosclerosis

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Apolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation

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Interactions of metals and Apolipoprotein E in Alzheimer’s disease

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Molecular Insight into the Therapeutic Promise of TargetingAPOE4for Alzheimer’s Disease

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Serum amyloid P colocalizes with apolipoproteins in human atheroma: functional implications

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The Glymphatic System in Diabetes-Induced Dementia

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A differential association of Apolipoprotein E isoforms with the amyloid‐β oligomer in solution

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APOE: The New Frontier in the Development of a Therapeutic Target towards Precision Medicine in Late-Onset Alzheimer’s

Yang, A., Kantor, B., & Chiba‐Falek, O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031244 · Cited by 50 · see citing works

A Structural Model for Apolipoprotein C-II Amyloid Fibrils: Experimental Characterization and Molecular Dynamics Simulations

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The fibrillogenic L178H variant of apolipoprotein A-I forms helical fibrils

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The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

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Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer’s Disease

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Effects of different isoforms of apoE on aggregation of the α‐synuclein protein implicated in Parkinson’s disease

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Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) risk

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Chemical Cross-Linking/Mass Spectrometry Maps the Amyloid β Peptide Binding Region on Both Apolipoprotein E Domains

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Multi-functional role of apolipoprotein E in neurodegenerative diseases

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Native Mass Spectrometry, Ion Mobility, Electron-Capture Dissociation, and Modeling Provide Structural Information for Gas-Phase Apolipoprotein E Oligomers

Wang, H., Eschweiler, J. D., Cui, W., Zhang, H., Frieden, C., Ruotolo, B. T., & Gross, M. L. (2019) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-019-02148-z · Cited by 36 · see citing works

APOE expression and secretion are modulated by mitochondrial dysfunction

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The Role of Upregulated APOE in Alzheimer's Disease Etiology

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TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer's disease

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Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer

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Trends and challenges of AAV-delivered gene editing therapeutics for CNS disorders: Implications for neurodegenerative disease

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The dark side of Alzheimer’s disease: unstructured biology of proteins from the amyloid cascade signaling pathway

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Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits

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Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

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Olfactory ERPs in an odor/visual congruency task differentiate ApoE ε4 carriers from non-carriers

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Insight on the Molecular Envelope of Lipid-Bound Apolipoprotein E from Electron Paramagnetic Resonance Spectroscopy

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Structural Basis for the Recognition and Cross-linking of Amyloid Fibrils by Human Apolipoprotein E

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Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

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Self-Association and Stability of the ApoE Isoforms at Low pH: Implications for ApoE–Lipid Interactions

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Biochemical and biophysical characterization of recombinant rat apolipoprotein E: Similarities to human apolipoprotein E3

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Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease

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An Updated Review and Meta Analysis of Lipoprotein Glomerulopathy

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Atomistic Insights into Structural Differences between E3 and E4 Isoforms of Apolipoprotein E

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Structural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments

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Thermodynamic destabilization and aggregation propensity as the mechanism behind the association of apoE3 mutants and lipoprotein glomerulopathy

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Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity

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Lessons from genome‐wide association studies findings in Alzheimer's disease

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Putting Huntingtin “Aggregation” in View with Windows into the Cellular Milieu

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Tissue transglutaminase‐catalysed cross‐linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E's protective effects towards amyloid‐beta‐induced toxicity

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Age and apolipoprotein E ε4 effects on neural correlates of odor memory.

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Endogenous Human Proteins Interfering with Amyloid Formation

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Alzheimer’s Disease: Causal Effect between Obesity and APOE Gene Polymorphisms

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Hidden Aggregation Hot-Spots on Human Apolipoprotein E: A Structural Study

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Amyloid-peptide β 42 Enhances the Oligomerization and Neurotoxicity of apoE4: The C-terminal Residues Leu279, Lys282 and Gln284 Modulate the Structural and Functional Properties of apoE4

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Diagnostics for Amyloid Fibril Formation: Where to Begin?

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Fruquintinib/HMPL-013 ameliorates cognitive impairments and pathology in a mouse model of cerebral amyloid angiopathy (CAA)

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Elucidation of the Aggregation Pathways of Helix–Turn–Helix Peptides: Stabilization at the Turn Region Is Critical for Fibril Formation

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Apolipoprotein E Genotype: The Innocent Bystander or Active Bridge Between Metabolic Syndrome and Cognitive Impairment?

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Apolipoprotein E Expression and Purification

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ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9

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Alzheimer's Disease; Mechanism, Mutations, and Applications of Nano-Medicine

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Molecular crowding impacts the structure of apolipoprotein A‐I with potential implications on in vivo metabolism and function

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Molecular basis of the association between transcription regulators nuclear respiratory factor 1 and inhibitor of DNA binding protein 3 and the development of microvascular lesions

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Apolipoprotein E isoforms differentially affect LCAT-dependent cholesterol esterification

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Stimulus-Based ApoE Alzheimer’s Disease Induction Model Using Microglia-Containing Brain Organoids for Drug Discovery

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Functional Connectivity Change Associated With Apolipoprotein E Allotypes Precedes Structural Connectivity and Neurodegeneration in Cognitive Normal Older Adults Without Cerebral Aβ Deposition

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Imaging the Morphology and Structure of Apolipoprotein Amyloid Fibrils

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Domino-like Effect of C112R Mutation on ApoE4 Aggregation and Its Reduction by Alzheimer’s Disease Drug CandidatePreprint

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Influence of genetic variability and external regulating factors on amyloid-beta peptide aggregation

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Lipases and their interaction partners in Gallus gallus

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Mass Spectrometry and Protein Analysis: Structure, Oligomerization and Interaction

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Genes, Aging, and Parkinson’s Disease

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Modelling the neurobiology of Alzheimer’s disease in vitro

Muñoz, S. S. (2019) · Research Online (University of Wollongong)

Title: Biochemical linkage of type 2 diabetes mellitus and Alzheimer’s disease

mahmoud, S., Abo–Elmatty, D. M., Mesbah, N. M., Mehanna, E. T., & Hafez, M. M. (2019) · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences · doi:10.21608/rpbs.2019.12031.1031

Reduced Binding of Apolipoprotein E4 Isoform to Complement Factor H Promotes Amyloid-Β Induced Neuroinflammation in vitro and in vivoPreprint

Chernyaeva, L., Ratti, G., Teirilä, L., Rankka, U., Fudo, S., Pelkonen, A., Korhonen, P., Leskinen, K., Keskitalo, S., Salokas, K., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4163140

Amyloid, Tau, and ApoE: Revisiting Hypotheses of Alzheimer's Disease

Yao, B., Kuang, M., Jiang, D. F., & Xu, C. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2024.19396

In Silico Design of APOE ɛ4 Interaction Inhibitor Peptides for Alzheimer’s DiseasePreprint

Ji, J., Han, E., Park, J., Son, A., & Kim, H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.03.673973

Additional file 1 of Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease

Turri, M., Conti, E., Pavanello, C., Gastoldi, F., Palumbo, M., Bernini, F., Aprea, V., Re, F., Barbiroli, A. G., Emide, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23001925

The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

Raulin, A.-C., Kraft, L., Al-Hilaly, Y. K., Xue, W.-F., McGeehan, J. E., Atack, J. R., & Serpell, L. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.04.019 · Cited by 47 · see citing works

P1‐478: Isoform‐specific effects of apolipoprotein E on the stability of Abeta protofibrils

Hori, Y., Hashimoto, T., Nomoto, H., & Iwatsubo, T. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.1061

Amyloid-peptide β 42 Enhances the Oligomerization and Neurotoxicity of apoE4: The C-terminal Residues Leu279, Lys282 and Gln284 Modulate the Structural and Functional Properties of apoE4

Dafnis, I., Argyri, L., & Chroni, A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.10.026 · Cited by 12 · see citing works

High ability of apolipoprotein E4 to stabilize amyloid‐β peptide oligomers, the pathological entities responsible for Alzheimer's disease

Cerf, E., Gustot, A., Goormaghtigh, E., Ruysschaert, J., & Raussens, V. (2011) · The FASEB Journal · doi:10.1096/fj.10-175976 · Cited by 94 · see citing works

The structure of Apolipoprotein E isoforms and their role in Alzheimer's disease

Williams, B. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/zwrw-h146