The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.
Interleukin-4 Reversibly Inhibits Osteoclastogenesis via Inhibition of NF-κB and Mitogen-activated Protein Kinase Signaling
Open accessAbstract
To define the molecular mechanism(s) by which interleukin (IL)-4 reversibly inhibits formation of osteoclasts (OCs) from bone marrow macrophages (BMMs), we examined the capacity of this T cell-derived cytokine to impact signals known to modulate osteoclastogenesis, which include those initiated by macrophage colony-stimulating factor (M-CSF), receptor for activation of NF-kappa B ligand (RANKL), tumor necrosis factor (TNF), and IL-1. We find that although pretreatment of BMMs with IL-4 does not alter M-CSF signaling, it reversibly blocks RANKL-dependent activation of the NF-kappa B, JNK, p38, and ERK signals. IL-4 also selectively inhibits TNF signaling, while enhancing that of IL-1. Contrary to previous reports, we find that MEK inhibitors dose-dependently inhibit OC differentiation. To identify more proximal signals mediating inhibition of OC formation by IL-4, we used mice lacking STAT6 or SHIP1, two adapter proteins that bind the IL-4 receptor. IL-4 fails to inhibit RANKL/M-CSF-induced osteoclastogenesis by BMMs derived from STAT6-, but not SHIP1-, knockout mice. Consistent with this observation, the inhibitory effects of IL-4 on RANKL-induced NF-kappa B and mitogen-activated protein kinase activation are STAT6-dependent. We conclude that IL-4 reversibly arrests osteoclastogenesis in a STAT6-dependent manner by 1) preventing I kappa B phosphorylation and thus NF-kappa B activation, and 2) blockade of the JNK, p38, and ERK mitogen-activated protein kinase pathways.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Wei and associates found that IL-4 inhibited osteoclastogenesis by blocking the JNK, p38, and ERK protein kinase pathways, which are upstream of NFATc1 [40].”
From Osteoclasts and Microgravity (2020) · cites this paper as [40]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962
Self-citationA homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290
The IL-4 receptor: signaling mechanisms and biologic functions
Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J., & Paul, W. E. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.701 · Cited by 1,545
Lam, J., Takeshita, S., Barker, J. E., Kanagawa, O., Ross, F. P., & Teitelbaum, S. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11176 · Cited by 1,440
Self-citationKobayashi, K., Takahashi, N., Jimi, E., Udagawa, N., Takami, M., Kotake, S., Nakagawa, N., Kinosaki, M., Yamaguchi, K., Shima, N., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.2.275 · Cited by 1,309
TRAF6 is a signal transducer for interleukin-1
Cao, Z., Xiong, J., Takeuchi, M., Kurama, T., & Goeddel, D. V. (1996) · Nature · doi:10.1038/383443a0 · Cited by 1,305
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- McNally, 1995, Am. J. Pathol., 147, 1487
Cited by
Sorted by citations
Items 101–200 of 202
Lindberg, M. K., Movérare, S., Eriksson, A.-L., Skrtic, S., Gao, H., Dahlman‐Wright, K., Gustafsson, J.-Α., & Ohlsson, C. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.12.2183 · Cited by 41
Teng, Y.-T. A. (2002) · Infection and Immunity · doi:10.1128/iai.70.9.5269-5273.2002 · Cited by 40
Harnessing the power of macrophages/monocytes for enhanced bone tissue engineering
Dong, L., & Wang, C. (2013) · Trends in biotechnology · doi:10.1016/j.tibtech.2013.04.001 · Cited by 39
Bone Malformations in Interleukin-18 Transgenic Mice
Kawase, Y., Hoshino, T., Yokota, K., Kuzuhara, A., Nakamura, M., Maeda, Y., Nishiwaki, E., Zenmyo, M., Hiraoka, K., Aizawa, H., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.6.975 · Cited by 39
Liu, Y. F., Shi, Z., Silveira, A. C., Liu, J., Sawadogo, M., Yang, H., & Feng, X. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212093200 · Cited by 39
Osteoimmunology: A View from the Bone
David, J. (2007) · Advances in immunology · doi:10.1016/s0065-2776(07)95005-1 · Cited by 38
Eaton, G. J., Zhang, Q.-S., Diallo, C., Matsuzawa, A., Ichijo, H., Steinbeck, M. J., & Freeman, T. A. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.480 · Cited by 37
IL-37 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption in vivo
Saeed, J., Kitaura, H., Kimura, K., Ishida, M., Sugisawa, H., Ochi, Y., Kishikawa, A., & Takano‐Yamamoto, T. (2016) · Immunology Letters · doi:10.1016/j.imlet.2016.04.004 · Cited by 36
Cell-Autonomous CCL5 Transcription by Memory CD8 T Cells Is Regulated by IL-4
Marçais, A., Coupet, C., Walzer, T., Tomkowiak, M., Ghittoni, R., & Marvel, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4451 · Cited by 33
Zhu, X. Y., Gao, J., Landao‐Bassonga, E., Pavlos, N. J., Qin, A., Steer, J. H., Zheng, M., Dong, Y., & Cheng, T. S. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.02.013 · Cited by 33
Lin, X., Yuan, G., Li, Z., Zhou, M., Hu, X., Song, F., Shao, S., Fu, F., Zhao, J., Xu, J., et al. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29520 · Cited by 33
Current perspectives of osteoclastogenesis through estrogen modulated immune cell cytokines
Uehara, I. A., Soldi, L. R., & Silva, M. J. B. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117921 · Cited by 34
Cytokines and Bone: Osteoimmunology
Lorenzo, J. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2019_346 · Cited by 32
Hasegawa, H., Kido, S., Tomomura, M., Fujimoto, K., Ohi, M., Kiyomura, M., Kanegae, H., Inaba, A., Sakagami, H., & Tomomura, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.068742 · Cited by 32
Exercise and osteoimmunology in bone remodeling
Zhao, Z., Du, Y., Yan, K., Zhang, L., & Guo, Q. (2024) · The FASEB Journal · doi:10.1096/fj.202301508rrr · Cited by 34
Pathophysiology of interleukin-1 receptor-associated kinase-M: implications in refractory state
López‐Collazo, E., Fuentes‐Prior, P., Arnalich, F., & del Fresno, C. (2006) · Current Opinion in Infectious Diseases · doi:10.1097/01.qco.0000224817.35105.7d · Cited by 31
Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma
Xu, L., Mohammad, K. S., Wu, H., Crean, C., Poteat, B. A., Cheng, Y., Cardoso, A. A., Machal, C., Hanenberg, H., Abonour, R., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0517 · Cited by 31
Robaee, A. A. A., Alzolibani, A. A., Shobaili, H. A. A., & Settin, A. (2012) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2012.349 · Cited by 28
Kitaura, H., Nagata, N., Fujimura, Y., Hotokezaka, H., Tatamiya, M., Nakao, N., Yoshida, N., & Nakayama, K. (2003) · Immunology Letters · doi:10.1016/s0165-2478(03)00082-8 · Cited by 33
Complex Regulation of Tartrate-resistant Acid Phosphatase (TRAP) Expression by Interleukin 4 (IL-4)
Yu, M., Moreno, J. L., Stains, J. P., & Keegan, A. D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.001016 · Cited by 29
PD98059 enhances C2 myoblast differentiation through p38 MAPK activation: a novel role for PD98059
Al‐Shanti, N., & Stewart, C. E. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0151 · Cited by 28
Lin, T., Pajarinen, J., Kohno, Y., Maruyama, M., Romero-López, M., Huang, J., Nathan, K., Khan, T. N., Yao, Z., & Goodman, S. B. (2018) · Cytotherapy · doi:10.1016/j.jcyt.2018.06.009 · Cited by 27
Yamaguchi, M., Ukai, T., Kaneko, T., Yoshinaga, M., Yokoyama, M., Ozaki, Y., & Hara, Y. (2008) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2008.01083.x · Cited by 26
Park, C., Kim, H.-M., Kim, D. H., Han, H.-J., Noh, H., Jang, J., Park, S.-H., Chae, H., Chae, S., Ryu, E. K., et al. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.0111 · Cited by 25
Pajarinen, J., Lin, T., Nabeshima, A., Sato, T., Gibon, E., Jämsen, E., Khan, T. N., Yao, Z., & Goodman, S. B. (2020) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37142 · Cited by 27
Interleukin-10-Producing B Cells Help Suppress Ovariectomy-Mediated Osteoporosis
Wang, Y., Zhang, W., Lim, S.-M., Xu, L., & Jin, J. (2020) · Immune Network · doi:10.4110/in.2020.20.e50 · Cited by 24
Nardelli, B., Zaritskaya, L., McAuliffe, W. J., Ni, Y., Lincoln, C., Cho, Y. H., Birse, C. E., Halpern, W., Ullrich, S. J., & Moore, P. A. (2005) · Endocrinology · doi:10.1210/en.2005-0518 · Cited by 24
Iannitti, T., Rosini, S., Lodi, D., Frediani, B., Rottigni, V., & Palmieri, B. (2012) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e318247148f · Cited by 21
Direct and indirect effects of estrogen on osteoclasts.
Oursler, M. J. (2003) · PubMed · Cited by 21
New perspectives on traumatic bone infections
Tang, R., Yang, J., & Fei, J. (2020) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2020.05.009 · Cited by 21
Huang, W., Drissi, M., O'Keefe, R. J., & Schwarz, E. M. (2003) · Calcified Tissue International · doi:10.1007/s00223-003-0059-8 · Cited by 21
p38 MAPK as a Potential Therapeutic Target for Inflammatory Osteolysis
Shi, W., & Siegal, G. P. (2006) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e31802ef4f2 · Cited by 19
IL1β and TNFα promote RANKL-dependent adseverin expression and osteoclastogenesis
Wang, Y., Galli, M., Silver, A. S., Lee, W., Song, Y., Mei, Y., Bachus, C., Glogauer, M., & McCulloch, C. A. (2018) · Journal of Cell Science · doi:10.1242/jcs.213967 · Cited by 21
Reduced cortical bone mass in mice with inactivation of interleukin‐4 and interleukin‐13
Silfverswärd, C., Larsson, S., Ohlsson, C., Frost, A., & Nilsson, O. (2007) · Journal of Orthopaedic Research® · doi:10.1002/jor.20361 · Cited by 19
Silfverswärd, C., Frost, A., Brändström, H., Nilsson, O., & Ljunggren, Ö. (2004) · Journal of Orthopaedic Research® · doi:10.1016/j.orthres.2004.02.008 · Cited by 19
Peroxidase enzymes inhibit osteoclast differentiation and bone resorption
Panagopoulos, V., Liapis, V., Zinonos, I., Hay, S., Leach, D. A., Ingman, W., DeNichilo, M. O., Atkins, G. J., Findlay, D. M., Zannettino, A. C. W., et al. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.007 · Cited by 18
The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells
Lorenzo, J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800571-2.00009-8 · Cited by 20
Hu, Y., Ek‐Rylander, B., Wendel, M., & Andersson, G. N. (2013) · Oral Diseases · doi:10.1111/odi.12189 · Cited by 18
Oh, J., Lee, J. Y., Park, J. H., No, J. H., & Lee, N. K. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.2340 · Cited by 17
Tsubaki, M., Takeda, T., Matsuda, T., Yamamoto, Y., Higashinaka, A., Yamamoto, K., Tsurushima, K., Ishizaka, T., & Nishida, S. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155591 · Cited by 17
Molstad, D. H. H., Zars, E., Norton, A., Mansky, K., Westendorf, J., & Bradley, E. W. (2020) · Scientific Reports · doi:10.1038/s41598-020-78364-5 · Cited by 16
Chen, B., Liang, Y., Song, Y., Liang, Y., Jiao, J., Bai, H., & Li, Y. (2022) · Materials · doi:10.3390/ma15175962 · Cited by 13
Osteoprotective effect by interleukin-4 (IL-4) on lipoprotein-induced periodontitis
Teixeira, J. F. L., Henning, P., Magalhães, F. A. C., Coletto-Nunes, G., Marcelino, T. F., Westerlund, A., Movérare‐Skrtic, S., de Oliveira, G. J. P. L., Lerner, U. H., & de Souza, P. C. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156399 · Cited by 13
Inflammatory Arthritis and Bone Metabolism Regulated by Type 2 Innate and Adaptive Immunity
Omata, Y., Frech, M., Saito, T., Schett, G. A., Zaiss, M. M., & Tanaka, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031104 · Cited by 12
Roux, S., & Brown, J. P. (2009) · Current Rheumatology Reviews · doi:10.2174/157339709788298428 · Cited by 12
Role of Muramyl Dipeptide in Lipopolysaccharide-Mediated Biological Activity and Osteoclast Activity
Kitaura, H., Ishida, M., Kimura, K., Sugisawa, H., Kishikawa, A., Shima, K., Ogawa, S., Qi, J., & Shen, W.-R. (2018) · Analytical Cellular Pathology · doi:10.1155/2018/8047610 · Cited by 14
Biomaterial-based osteoimmunomodulatory strategies via the TLR4-NF-κB signaling pathway: A review
Xing, H., Li, R., Qing, Y., Ying, B., & Qin, Y. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.100969 · Cited by 13
Zhang, N. N., Huang, N. Y., Zhou, X. K., Luo, X. L., Liu, C. Y., Zhang, Y., Qiu, J., Zhang, Y. B., Teng, X., Luo, C., et al. (2011) · Inflammation Research · doi:10.1007/s00011-011-0383-9 · Cited by 11
The Role of Jak/STAT Pathways in Osteoclast Differentiation
Lee, Y., & Kim, H. H. (2011) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2011.19.2.141 · Cited by 10
IL-4 absence triggers distinct pathways in apical periodontitis development
Freire, M. S., Oliveira-Júnior, N. G., Lima, S. M. D. F., Porto, W. F., Martins, D. C. M., Silva, O. N., Chaves, S. B., de Sousa, M. V., Ricart, C. A. O., Castro, M. S., et al. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.104080 · Cited by 10
Xu, D., Shi, Z.-Q., Mcdonald, J., Pan, G., Cao, X.-M., Yu, X.-Q., & Feng, X. (2004) · Biochemical Journal · doi:10.1042/bj20040961 · Cited by 12
Bone Tissue Engineering: Growth Factors and Cytokines
Hollinger, J. O., Srinivasan, A., Alvarez, P., Hsu, E., McBride, S., Eppell, S. J., Baskin, J. Z., Waters, H., & Gruber, R. (2011) · Comprehensive Biomaterials · doi:10.1016/b978-0-08-055294-1.00160-4 · Cited by 10
Shehabeldin, M., Kobyra, J. A., Cho, Y., Gao, J., Chong, R., Tabib, T., Lafyatis, R., Little, S. R., & Sfeir, C. S. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2400332 · Cited by 9
Morishita, K., Tatsukawa, E., Shibata, Y., Suehiro, F., Kamitakahara, M., Yokoi, T., Ioku, K., Umeda, M., Nishimura, M., & Ikeda, T. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.05.002 · Cited by 9
Regulation of Osteoclast Activity
Baron, R., & Horne, W. C. (2005) · Springer eBooks · doi:10.1007/1-84628-016-8_3 · Cited by 9
Suramin interacts with RANK and inhibits RANKL-induced osteoclast differentiation
Regmi, A., Fuson, T. R., Yang, X., Kays, J. S., Moxham, C., Zartler, E. R., Chandrashekhar, S., & Galvin, R. J. S. (2005) · Bone · doi:10.1016/j.bone.2004.09.022 · Cited by 9
Chen, D., Li, Y., Guo, F., Lü, Z., Hei, C., Li, P., & Jin, Q. (2015) · Genetics and Molecular Research · doi:10.4238/2015.january.15.6 · Cited by 8
Sims, N. A., & Lorenzo, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00050-6 · Cited by 7
Ma, H., Guo, M., Shan, B., & Xia, Z. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.03.009 · Cited by 8
Mechanisms of bone resorption and new bone formation in spondyloarthropathies
Huang, W., & Schwarz, E. (2002) · Current Rheumatology Reports · doi:10.1007/s11926-002-0059-0 · Cited by 9
Role of cytokines and chemokines in cartilage and bone destruction in arthritis
Goldring, M. B., & Goldring, S. R. (2002) · Current Opinion in Orthopedics · doi:10.1097/00001433-200210000-00005 · Cited by 8
Dynamic analysis of STAT6 signalling in living cells
Nelson, G., Wilde, G. J. C., Spiller, D. G., Sullivan, E., Unitt, J. F., & White, M. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03672-4 · Cited by 8
Pantaroto, H. N., de Almeida, A. B., Gomes, O. P., Matos, A. O., Landers, R., Casarin, R. C. V., da Silva, J. H. D., Nociti, F. H., & Barão, V. A. R. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111438 · Cited by 6
Emerging Roles of Eosinophils in Bone
Andreev, D., & Porschitz, P. (2025) · Current Osteoporosis Reports · doi:10.1007/s11914-025-00913-6 · Cited by 5
Kim, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015342 · Cited by 7
The Effect of Methyl‐β‐cyclodextrin on the Differentiation of RAW264 Cells into Osteoclasts
Ogawa, Y., Goda, S., & Morita, S. (2007) · Oral Science International · doi:10.1016/s1348-8643(08)80002-x · Cited by 5
6.2 Bone Tissue Engineering: Growth Factors and Cytokines ☆
Hollinger, J. O., Alvarez, P., Ducheyne, P., Srinivasan, A., Baskin, J. Z., Waters, H., & Gruber, R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803581-8.10205-x · Cited by 5
Systemic and Local Regulators of Bone Remodeling
Hurley, M. M., & Lorenzo, J. (2004) · Springer eBooks · doi:10.1007/978-1-4471-3777-1_3 · Cited by 4
The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells
Lorenzo, J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375670-1.10007-x · Cited by 4
Nouvelles cibles thérapeutiques dans l’ostéoporose
Roux, S. (2010) · Revue du Rhumatisme · doi:10.1016/j.rhum.2009.10.032 · Cited by 3
ThPOK Inhibits Osteoclast Formation Via NFATc1 Transcription and Function
Zou, W., Izawa, T., Rohatgi, N., Zou, S. Y., Li, Y., & Teitelbaum, S. L. (2022) · JBMR Plus · doi:10.1002/jbm4.10613 · Cited by 3
Self-citationExpression of Osteoclastogenesis-related Genes in Rheumatoid Arthritis Synovial Macrophages
Ji, J. D., Kim, T., Lee, B., Choi, S. J., Lee, Y. H., & Song, G. G. (2011) · Journal of Rheumatic Diseases · doi:10.4078/jrd.2011.18.1.11 · Cited by 3
Cytokines and the Pathogenesis of Osteoporosis
Lorenzo, J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00038-8 · Cited by 3
Kinins : important regulators in inflammation induced bone resorption
Brechter, A. B. (2006) · Cited by 3
Lerner, U. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11202-4 · Cited by 3
Canellada, A. M., Custidiano, A., Abraham, F., Rey, E., & Gentile, T. (2013) · Placenta · doi:10.1016/j.placenta.2012.12.015 · Cited by 2
Dougall, W. C. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374895-9.00032-3 · Cited by 2
Alzolibani, A. A., Robaee, A. A. A., Shobaili, H. A. A., Saif, G. A. B., Alsaif, F., Ali, A., & Settin, A. (2015) · Journal of the Egyptian Public Health Association · doi:10.1097/01.epx.0000461326.05328.d3 · Cited by 2
Osteoarthritis and the Immune System
Goldring, M. B., Dayer, J., & Goldring, S. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800571-2.00014-1 · Cited by 2
Pacifici, R., & Weitzmann, M. N. (2018) · Wiley eBooks · doi:10.1002/9781119266594.ch128 · Cited by 2
Hao, Y., Meng, Q., Chang, L., Qiu, M., Han, J., Wang, Z., Li, C., Ma, J., & Zhang, X. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.14088 · Cited by 1
Role of Calpain in Immunobiology of Neurodegenerative Diseases
Trager, N., Haque, A., Ray, S. K., Das, A., & Banik, N. L. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9099-9_1 · Cited by 1
Cytokines and the pathogenesis of osteoporosis
Lorenzo, J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00033-2 · Cited by 1
Origin and Differentiation of Osteoclasts
Sanjay, A., & Charles, J. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11161-4 · Cited by 1
Osteotropic cytokines : expression in human gingival fibroblasts and effects on bone
Palmqvist, P. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Cytokine regulation of bone destruction
Lubberts, E., & van den Berg, W. B. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7883-8_11
Osteopenia and osteoporosis in HIV-infected patients
Gołaszewska, D., & Racewicz, A. J. (2007) · HIV & AIDS Review · doi:10.1016/s1730-1270(10)60072-0
Arthritis and immune-mediated bone loss - role of estrogen signalling pathways
Engdahl, C. (2012) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Involvements of mitogen-activated protein kinase cascades in osteoclastogenesis
Hirata, K., & Sugita, T. (2011) · Inflammation and Regeneration · doi:10.2492/inflammregen.31.425
Baron, R., & Horne, W. C. (2005)
The Prevention and Treatment of Inflammation-Induced Bone Loss: Can It Be Done?
Romas, E. (2006) · Elsevier eBooks · doi:10.1016/b978-0-323-03437-1.50033-6
Trebec‐Reynolds, D. P. (2010) · TSpace (University of Toronto)
Regulation of bone and joint inflammation by type 2 innate lymphoid cells
Omata, Y., Zaiss, M. M., Frech, M., Schett, G. A., & Tanaka, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85831-1.00026-7
Immunomodulation of Bone Remodeling in Osteoporosis
Hazra, S., Chattopadhyay, S., & Goswami, R. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1003281
Huang, Y.-M., Fu, Y.-S., Chen, W., & Lu, H. (2024) · International journal of medicinal mushrooms · doi:10.1615/intjmedmushrooms.2024053977
Ofotokun, I., Titanji, K., Dabeer, S., Tripathi, A. K., Bedi, B., Kirkpatrick, C. M., Nguyen, T. B., & Weitzmann, M. N. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaf570
Bauler, T. J. (2009) · Deep Blue (University of Michigan)
Effects of interleukin-4 and interleukin-13 on bone.
Silfverswärd, C. (2008) · Uppsala University Publications (Uppsala University)
Basak, S., Hridayanka, K. S. N., & Duttaroy, A. K. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1774824
Metadata
- Authors
- Wei, S., Wang, M. W.-H., Teitelbaum, S. L., & Ross, F. P.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Ross, F. Patrick
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 277
- Issue
- 8
- Pages
- 6622-6630
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1998128158
- Cited by
- 202
- References
- 55
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 3 · 2020: 15 · 2019: 3 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 3 · 2013: 10 · 2012: 5
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- IL-4, osteoclastogenesis, NF-κB signaling, mitogen-activated protein kinase, STAT6, SHIP1, RANKL, macrophage colony-stimulating factor, TNF signaling, IL-1 signaling, MEK inhibitors, bone marrow-derived macrophages
- MeSH terms
- Animals, Bone Marrow Cells, Carrier Proteins, Cells, Cultured, Gene Expression Regulation, Kinetics, Macrophages, Membrane Glycoproteins, Mice, Inbred C57BL, Osteoclasts, Osteogenesis, Signal Transduction, Interleukin-4, Macrophage Colony-Stimulating Factor, NF-kappa B, Cell Culture Techniques, Reverse Transcriptase Polymerase Chain Reaction, MAP Kinase Signaling System, Mice, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review