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Lipid Droplet Binding and Oligomerization Properties of the Parkinson's Disease Protein α-Synuclein
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α-Synuclein oligomers induce cellular stress responses, including aberrant autophagy-lysosome pathways, dysregulation of lipid metabolism, and a reduction in membrane trafficking.
“α-Synuclein oligomers are known to induce cellular stress responses, including aberrant autophagy-lysosome pathways [161,162], dysregulation of lipid metabolism [163,164], and a reduction in membrane trafficking [4].”
From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [164]
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Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
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Toll‐like receptor 4 is required for α‐synuclein dependent activation of microglia and astroglia
Fellner, L., Irschick, R., Schanda, K., Reindl, M., Klimaschewski, L., Poewe, W., Wenning, G. K., & Stefanova, N. (2013) · Glia · doi:10.1002/glia.22437 · Cited by 697
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Metadata
- Authors
- Cole, N. B., Murphy, D. D., Grider, T., Rueter, S., Brasaemle, D., & Nussbaum, R. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 277
- Issue
- 8
- Pages
- 6344-6352
- ISSN
- 0021-9258
- Cited by
- 430
- References
- 2
- Language
- en
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