Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion
Open accessAbstract
The cell surface receptor tyrosine kinase HER2/neu enhances tumor metastasis. Recent studies suggest that deregulated microRNA (miRNA) expression promotes invasion and metastasis of cancer cells; we therefore explored the possibility that HER2/neu signaling induces the expression of specific miRNAs involved in this process. We identified a putative oncogenic miRNA, miR-21, whose expression is correlated with HER2/neu up-regulation and is functionally involved in HER2/neu-induced cell invasion. We show that miR-21 is up-regulated via the MAPK (ERK1/2) pathway upon stimulation of HER2/neu signaling in breast cancer cells, and overexpression of other ERK1/2 activators such as RASV12 or ID-1 is sufficient to induce miR-21 up-regulation in HER2/neu-negative breast cancer cells. Furthermore, the metastasis suppressor protein PDCD4 (programmed cell death 4) is down-regulated by miR-21 in breast cancer cells expressing HER2/neu. Our data reveal a mechanism for HER2/neu-induced cancer cell invasion via miRNA deregulation. In addition, our results identify miR-21 as a potential therapeutic target for the prevention of breast cancer invasion and metastasis.
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EGFR and HER2/neu signaling positively regulates miR-21 expression in human lung and breast carcinoma cell lines, respectively.
“As well, epidermal growth factor receptor (EGFR) and HER2/neu signaling positively regulates miR-21 expression in human lung and breast carcinoma cell lines, respectively (Huang et al., 2009; Seike et al., 2009).”
From Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21 (2010) · cites this paper as Huang et al., 2009
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Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038 · see citing works
Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer
Slamon, D. J., Godolphin, W. J., Jones, L. A., Holt, J. A., Wong, S., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J. A., Ullrich, A., et al. (1989) · Science · doi:10.1126/science.2470152 · Cited by 6,817 · see citing works
Real-time quantification of microRNAs by stem-loop RT-PCR
Chen, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni178 · Cited by 4,931 · see citing works
Exploring the metabolic and genetic control of gene expression on a genomic scale.
Derisi, J., Iyer, V., & Brown, P. (1997) · Science · doi:10.1126/science.278.5338.680 · Cited by 4,832 · see citing works
miRBase: microRNA sequences, targets and gene nomenclature
Griffiths‐Jones, S. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj112 · Cited by 4,713 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
A microRNA polycistron as a potential human oncogene
He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,520 · see citing works
MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
Meng, F., Henson, R., Wehbe–Janek, H., Ghoshal, K., Jacob, S. T., & Patel, T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.022 · Cited by 2,773 · see citing works
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605 · see citing works
MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells
Chan, J. A., Krichevsky, A. M., & Kosik, K. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0137 · Cited by 2,557 · see citing works
Asangani, I. A., Rasheed, S. A. K., Nikolova, D. A., Leupold, J. H., Colburn, N. H., Post, S., & Allgayer, H. (2008) · Oncogene · doi:10.1038/sj.onc.1210856 · Cited by 1,882 · see citing works
Si, M.-L., Zhu, S., Wu, H., Lu, Z., Wu, F., & Mo, Y.-Y. (2007) · Oncogene · doi:10.1038/sj.onc.1210083 · Cited by 1,600 · see citing works
Self-citationVentura, A., Young, A. G., Winslow, M. M., Lintault, L., Meissner, A., Erkeland, S. J., Newman, J. J., Bronson, R. T., Crowley, D. G., Stone, J. R., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.019 · Cited by 1,592 · see citing works
Filardo, E. J., Quinn, J. A., Bland, K. I., & Frackelton, A. R. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.10.0532 · Cited by 1,387 · see citing works
Xiao, C., Srinivasan, L., Calado, D. P., Patterson, H. C., Zhang, B., Wang, J., Henderson, J., Kutok, J. L., & Rajewsky, K. (2008) · Nature Immunology · doi:10.1038/ni1575 · Cited by 1,225 · see citing works
Guy, C. T., Webster, M. A., Schaller, M. D., Parsons, T. J., Cardiff, R. D., & Muller, W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10578 · Cited by 1,193 · see citing works
Frankel, L. B., Christoffersen, N. R., Jacobsen, A., Lindow, M., Krogh, A., & Lund, A. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707224200 · Cited by 1,141 · see citing works
MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)
Zhu, S., Si, M.-L., Wu, H., & Mo, Y.-Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611393200 · Cited by 1,090 · see citing works
Self-citationMicroRNA-21 targets tumor suppressor genes in invasion and metastasis
Zhu, S., Wu, H., Wu, F., Nie, D., Sheng, S., & Mo, Y.-Y. (2008) · Cell Research · doi:10.1038/cr.2008.24 · Cited by 1,051 · see citing works
Self-citationPhylogenetic Shadowing and Computational Identification of Human microRNA Genes
Berezikov, E., Guryev, V., van de Belt, J., Wienholds, E., Plasterk, R. H. A., & Cuppen, E. (2005) · Cell · doi:10.1016/j.cell.2004.12.031 · Cited by 1,008 · see citing works
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype
Blenkiron, C., Goldstein, L. D., Thorne, N., Spiteri, I., Chin, S., Dunning, M., Barbosa‐Morais, N. L., Teschendorff, A. E., Green, A. R., Ellis, I. O., et al. (2007) · Genome biology · doi:10.1186/gb-2007-8-10-r214 · Cited by 955 · see citing works
A custom microarray platform for analysis of microRNA gene expression
Thomson, J. M., Parker, J. S., Perou, C. M., & Hammond, S. M. (2004) · Nature Methods · doi:10.1038/nmeth704 · Cited by 742 · see citing works
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Yang, J.-Y., Zong, C. S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J.-Y., Lai, C., Chang, C. J., Huang, W., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1676 · Cited by 698 · see citing works
Löffler, D., Brocke-Heidrich, K., Pfeifer, G., Stocsits, C., Hackermüller, J., Kretzschmar, A. K., Burger, R., Gramatzki, M., Blumert, C., Bauer, K., et al. (2007) · Blood · doi:10.1182/blood-2007-03-081133 · Cited by 637 · see citing works
Migliaccio, A., Piccolo, D., Castoria, G., Domenico, M. D., Bilancio, A., Lombardi, M., Gong, W., Beato, M., & Auricchio, F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.7.2008 · Cited by 627 · see citing works
Cre-lox-regulated conditional RNA interference from transgenes
Ventura, A., Meissner, A., Dillon, C. P., McManus, M. T., Sharp, P. A., Parijs, L. V., Jaenisch, R., & Jacks, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403954101 · Cited by 623 · see citing works
Self-citationAltered MicroRNA Expression Confined to Specific Epithelial Cell Subpopulations in Breast Cancer
Sempere, L. F., Christensen, M., Silahtaroglu, A., Bak, M., Heath, C. V., Schwartz, G. N., Wells, W. A., Kauppinen, S., & Cole, C. N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-5019 · Cited by 570 · see citing works
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis
Li, Y. M., Pan, Y., Wei, Y., Cheng, X., Zhou, B. P., Tan, M., Zhou, X., Xia, W., Hortobágyi, G. N., Yu, D., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.027 · Cited by 537 · see citing works
miR-21 Gene Expression Triggered by AP-1 Is Sustained through a Double-Negative Feedback Mechanism
Fujita, S., Ito, T., Mizutani, T., Minoguchi, S., Yamamichi, N., Sakurai, K., & Iba, H. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.03.015 · Cited by 432 · see citing works
Overexpression of ErbB2 in cancer and ErbB2-targeting strategies
Yu, D., & Hung, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203972 · Cited by 431 · see citing works
Regulation of Raf-Akt Cross-talk
Moelling, K., Schad, K., Bosse, M., Zimmermann, S., & Schweneker, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111974200 · Cited by 389 · see citing works
Hellawell, G. O., Turner, G. D. H., Davies, D. R., Poulsom, R., BREWSTER, S. F., & Macaulay, V. M. (2002) · PubMed · Cited by 376 · see citing works
A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
Smalley, K. S. M. (2003) · International Journal of Cancer · doi:10.1002/ijc.10978 · Cited by 325 · see citing works
Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
Goga, A., Yang, D., Tward, A. D., Morgan, D. O., & Bishop, J. M. (2007) · Nature Medicine · doi:10.1038/nm1606 · Cited by 324 · see citing works
Self-citationCyclooxygenase-2 Is Overexpressed in HER-2/neu-positive Breast Cancer
Subbaramaiah, K., Norton, L., Gerald, W. L., & Dannenberg, A. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111415200 · Cited by 315 · see citing works
Tan, M., Yao, J., & Yu, D. (1997) · PubMed · Cited by 222 · see citing works
Carvalho, I. P., Milanezi, F., Martins, A. M., Reis, R. M., & Schmitt, F. C. (2005) · Breast Cancer Research · doi:10.1186/bcr1304 · Cited by 207 · see citing works
Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
Fong, S., Itahana, Y., Sumida, T., Singh, J., Coppé, J., Liu, Y., Richards, P. C., Bennington, J. L., Lee, N. M., Debs, R. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2230238100 · Cited by 206 · see citing works
Paumelle, R., Tulasne, D., Kherrouche, Z., Plaza, S., Leroy, C., Reveneau, S., Vandenbunder, B., & Fafeur, V. (2002) · Oncogene · doi:10.1038/sj.onc.1205297 · Cited by 158 · see citing works
Higashi, Y., Kanekura, T., & Kanzaki, T. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000601)86:5 · Cited by 155 · see citing works
A Novel Pathway for Mammary Epithelial Cell Invasion Induced by the Helix-Loop-Helix Protein Id-1
Desprez, P., Lin, C. Q., Thomasset, N., Sympson, C. J., Bissell, M. J., & Campisi, J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4577 · Cited by 148 · see citing works
HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1
Bosc, D. G., Goueli, B. S., & Janknecht, R. (2001) · Oncogene · doi:10.1038/sj.onc.1204820 · Cited by 108 · see citing works
The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA
Böhm, M., Sawicka, K., Siebrasse, J. P., Brehmer-Fastnacht, A., Peters, R., & Klempnauer, K.-H. (2003) · Oncogene · doi:10.1038/sj.onc.1206710 · Cited by 101 · see citing works
Ling, M., Wang, X., Ouyang, X., Lee, T. K., Fan, T., Xu, K., Tsao, S., & Wong, Y. C. (2002) · Oncogene · doi:10.1038/sj.onc.1206007 · Cited by 98 · see citing works
Nieves-Alicea, R., Colburn, N. H., Simeone, A., & Tari, A. M. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-9993-5 · Cited by 86 · see citing works
HER2 expression in cervical cancer as a potential therapeutic target
Chávez-Blanco, A. D., Pérez-Sánchez, V. M., González‐Fierro, A., Vela-Chávez, T., Candelaria, M., Cetina, L., Vidal, S., & Dueñas‐González, A. (2004) · BMC Cancer · doi:10.1186/1471-2407-4-59 · Cited by 69 · see citing works
Huang, T.-H., & Morrison, S. L. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.095513 · Cited by 29 · see citing works
Self-citationGam1-associated alterations of drug responsiveness through activation of apoptosis
Wu, F., Chiocca, S., Beck, W. T., & Mo, Y.-Y. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0771 · Cited by 29 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- Guy, C. T., Webster, M. A., Schaller, M., Parsons, T. J., Cardiff, R. D., and Muller, W. J. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 10578 -10582
- Taganov, K. D., Boldin, M. P., Chang, K. J., and Baltimore, D. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 12481-12486
- Ventura, A., Meissner, A., Dillon, C. P., McManus, M., Sharp, P. A., Van Parijs, L., Jaenisch, R., and Jacks, T. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 10380 -10385
- Fong, S., Itahana, Y., Sumida, T., Singh, J., Coppe, J. P., Liu, Y., Richards, P. C., Bennington, J. L., Lee, N. M., Debs, R. J., and Desprez, P. Y. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 13543-13548
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MicroRNAs in Development and Disease
Sayed, D. H., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,074 · see citing works
Farazi, T. A., Spitzer, J., Morozov, P. S., & Tuschl, T. (2010) · The Journal of Pathology · doi:10.1002/path.2806 · Cited by 892 · see citing works
Farazi, T. A., Hoell, J. I., Morozov, P. S., & Tuschl, T. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-5590-1_1 · Cited by 699 · see citing works
Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21
Hatley, M. E., Patrick, D. M., Garcia, M. R., Richardson, J. A., Bassel-Duby, R., van Rooij, E., & Olson, E. N. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.013 · Cited by 626 · see citing works
“In addition, epidermal growth factor receptor (EGFR) and HER2/neu signaling positively regulates miR-21 expression in human lung and breast carcinoma cell lines, respectively (Huang et al., 2009; Seike et al., 2009).”
Plasma exosome microRNAs are indicative of breast cancer
Hannafon, B. N., Trigoso, Y. D., Calloway, C. L., Zhao, Y. D., Lum, D. H., Welm, A. L., Zhao, Z. J., Blick, K. E., Dooley, W. C., & Ding, W. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0753-x · Cited by 603 · see citing works
The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics
Bautista-Sánchez, D., Arriaga-Canon, C., Pedroza-Torres, A., De La Rosa-Velázquez, I. A., González-Barrios, R., Contreras-Espinosa, L., Montiel-Manríquez, R., Castro-Hernández, C., Fragoso-Ontiveros, V., Álvarez-Gómez, R. M., et al. (2020) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2020.03.003 · Cited by 549 · see citing works
Negative regulation of lncRNA GAS5 by miR-21
Zhang, Z., Zhu, Z., Watabe, K., Zhang, X., Bai, C., Xu, M., Wu, F., & Mo, Y.-Y. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.110 · Cited by 416 · see citing works
Self-citationApoptosis and the target genes of microRNA-21
Buscaglia, L. E. B., & Li, Y. (2011) · 癌症:英文版 · doi:10.5732/cjc.011.10132 · Cited by 374 · see citing works
MicroRNAs in idiopathic pulmonary fibrosis
Pandit, K. V., Milošević, J., & Kaminski, N. (2011) · Translational research · doi:10.1016/j.trsl.2011.01.012 · Cited by 310 · see citing works
Up-regulation of miR-21 Mediates Resistance to Trastuzumab Therapy for Breast Cancer
Gong, C., Yao, Y., Wang, Y., Liu, B., Wu, W. G., Chen, J., Su, F., Yao, H., & Song, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.216887 · Cited by 310 · see citing works
The role of microRNAs in endometriosis and associated reproductive conditions
Ohlsson Teague, E. M. C., Print, C. G., & Hull, M. L. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp034 · Cited by 309 · see citing works
van Schooneveld, E., Wildiers, H. P. M. W., Vergote, I. B., Vermeulen, P. B., Dirix, L. Y., & Laere, S. V. (2015) · Breast Cancer Research · doi:10.1186/s13058-015-0526-y · Cited by 296 · see citing works
Mittal, S., Kaur, H., Gautam, N., & Mantha, A. K. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.08.028 · Cited by 295 · see citing works
MicroRNA control of epithelial–mesenchymal transition and metastasis
Zhang, J., & Ma, L. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9368-6 · Cited by 273 · see citing works
MicroRNAs in cancer — from research to therapy
Cho, W. C. S. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.11.003 · Cited by 234 · see citing works
Intracellular and Extracellular MicroRNAs in Breast Cancer
Corcoran, C., Friel, A. M., Duffy, M. J., Crown, J. P., & O’Driscoll, L. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.150730 · Cited by 226 · see citing works
MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer
Andorfer, C. A., Necela, B. M., Thompson, E. A., & Perez, E. A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.01.006 · Cited by 213 · see citing works
Micro RNA s play a central role in molecular dysfunctions linking inflammation with cancer
Tili, E., Michaille, J., & Croce, C. M. (2013) · Immunological Reviews · doi:10.1111/imr.12050 · Cited by 207 · see citing works
Aitken, S. J., Thomas, J. S. J., Langdon, S. P., Harrison, D. J., & Faratian, D. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp427 · Cited by 187 · see citing works
MicroRNAs in regulation of triple-negative breast cancer progression
Piasecka, D., Braun, M., Kordek, R., Sądej, R., & Romańska, H. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2689-2 · Cited by 187 · see citing works
Metastamirs: a stepping stone towards improved cancer management
White, N. M. A., Fatoohi, E., Metias, M., Jung, K., Stephan, C., & Yousef, G. M. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.173 · Cited by 185 · see citing works
Martínez, A. R., de Miguel‐Pérez, D., Ortega, F. G., García-Puche, J. L., Robles‐Fernandez, I., Expósito, J., Martorell‐Marugán, J., Carmona‐Sáez, P., Garrido-Navas, M. C., Rolfo, C. D., et al. (2019) · Breast Cancer Research · doi:10.1186/s13058-019-1109-0 · Cited by 180 · see citing works
MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation
Li, Q., Zhang, D., Wang, Y., Sun, P., Hou, X., Larner, J., Xiong, W., & Mi, J. (2013) · Scientific Reports · doi:10.1038/srep02038 · Cited by 176 · see citing works
Regulation of microRNAs in cancer metastasis
Bouyssou, J., Manier, S., Huynh, D., Issa, S., Roccaro, A. M., & Ghobrial, I. M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.02.002 · Cited by 174 · see citing works
Jin, L., Wessely, O., Marcusson, E. G., Ivan, C., Călin, G. A., & Alahari, S. K. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2162 · Cited by 175 · see citing works
Aigner, A. M. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0716-0 · Cited by 146 · see citing works
Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease
Wancket, L. M., Frazier, W. J., & Liu, Y. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.11.017 · Cited by 134 · see citing works
Han, M., Wang, Y., Liu, M., Bi, X., Bao, J., Zeng, N., Zhu, Z.-K., Mo, Z., Wu, C., & Chen, X. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02281.x · Cited by 129 · see citing works
Park, Y. M., Hwang, S. J., Masuda, K., Choi, K.-M., Jeong, M., Nam, D., Gorospe, M., & Kim, H. H. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00443-12 · Cited by 125 · see citing works
Aktas, B., Müller, V., Tewes, M., Zeitz, J., Kasimir‐Bauer, S., Loehberg, C. R., Rack, B. K., Schneeweiß, A., & Fehm, T. N. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.04.039 · Cited by 124 · see citing works
Magnetobiosensors Based on Viral Protein p19 for MicroRNA Determination in Cancer Cells and Tissues
Campuzano, S., Torrente-Rodríguez, R. M., López‐Hernández, E., Conzuelo, F., Granados, R., Sánchez-Puelles, J.-M., & Pingarrón, J. M. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403270 · Cited by 119 · see citing works
Ming-li, H., Liu, M., Wang, Y., Mo, Z., Bi, X., Liu, Z., Fan, Y., Chen, X., & Wu, C. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1195-5 · Cited by 114 · see citing works
The roles of oncogenic miRNAs and their therapeutic importance in breast cancer
O’Bryan, S. M., Dong, S., Mathis, J. M., & Alahari, S. K. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.11.004 · Cited by 112 · see citing works
MicroRNA regulation of innate immune responses in epithelial cells
Zhou, R., O’Hara, S. P., & Chen, X. (2011) · Cellular and Molecular Immunology · doi:10.1038/cmi.2011.19 · Cited by 111 · see citing works
MicroRNA expression in ovarian carcinoma and its correlation with clinicopathological features
Lee, H.-J., Park, C. S., Deftereos, G., Morihara, J. K., Stern, J., Hawes, S. E., Swisher, E. M., Kiviat, N. B., & Feng, Q. (2012) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-10-174 · Cited by 109 · see citing works
Metastasis-related miRNAs, active players in breast cancer invasion, and metastasis
Shi, M., Liu, D., Duan, H., Shen, B., & Guo, N. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9265-9 · Cited by 106 · see citing works
Zhao, J., Tang, N., Wu, K., Dai, W., Ye, C., Shi, J. G., Zhang, J., Ning, B., Zeng, X. Y., & Lin, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108005 · Cited by 106 · see citing works
Rivas, M. A., Venturutti, L., Huang, Y., Schillaci, R., Huang, T. H. ‐., & Elizalde, P. V. (2012) · Breast Cancer Research · doi:10.1186/bcr3187 · Cited by 105 · see citing works
Self-citationMa, Y., Li, C., Huang, Y., Wang, Y., Xia, X., & Zheng, J. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0418-3 · Cited by 105 · see citing works
Wang, X., Li, C., Ju, S., Wang, Y., Wang, H., & Zhong, R. (2011) · Leukemia & Lymphoma · doi:10.3109/10428194.2011.591004 · Cited by 103 · see citing works
miR-21 promotes EGF-induced pancreatic cancer cell proliferation by targeting Spry2
Zhao, Q., Chen, S., Zhu, Z., Yu, L., Ren, Y., Jiang, M., Weng, J., & Li, B. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1182-9 · Cited by 103 · see citing works
MicroRNA-mediated breast cancer metastasis: from primary site to distant organs
Wang, L., & Wang, J. (2011) · Oncogene · doi:10.1038/onc.2011.444 · Cited by 101 · see citing works
Huang, Y., Yang, Y. B., Zhang, X. H., Yu, X. L., Wang, Z. B., & Cheng, X. C. (2012) · Medical Oncology · doi:10.1007/s12032-012-0376-8 · Cited by 101 · see citing works
Dong, G., Liang, X., Wang, D., Gao, H., Wang, L., Wang, L., Liu, J., & Du, Z. (2014) · Medical Oncology · doi:10.1007/s12032-014-0057-x · Cited by 99 · see citing works
Zhao, Y., Zhao, L., Ischenko, I., Bao, Q., Schwarz, B., Nieß, H., Wang, Y., Renner, A., Mysliwietz, J., Jauch, K., et al. (2015) · Targeted Oncology · doi:10.1007/s11523-015-0360-2 · Cited by 98 · see citing works
Loayza‐Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., & Noda, M. (2010) · Oncogene · doi:10.1038/onc.2010.23 · Cited by 96 · see citing works
Markou, A. N., Yousef, G. M., Stathopoulos, E. N., Georgoulias, V., & Lianidou, E. S. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2013.210542 · Cited by 96 · see citing works
β2-AR signaling controls trastuzumab resistance-dependent pathway
Liu, D., Yang, Z., Wang, T., Yang, Z., Chen, H., Hu, Y., Hu, C., Guo, L., Deng, Q., Liu, Y., et al. (2015) · Oncogene · doi:10.1038/onc.2015.58 · Cited by 95 · see citing works
miRNAs and Other Epigenetic Changes as Biomarkers in Triple Negative Breast Cancer
Mathe, A., Scott, R. J., & Avery‐Kiejda, K. A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226090 · Cited by 95 · see citing works
Curcumin as tyrosine kinase inhibitor in cancer treatment
Golonko, A., Lewandowska, H., Świsłocka, R., Jasińska, U., Priebe, W., & Lewandowski, W. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.07.015 · Cited by 96 · see citing works
Anfossi, S., Giordano, A., Gao, H., Cohen, E. N., Tin, S., Wu, Q., Garza, R. J., Debeb, B. G., Álvarez, R. H., Valero, V., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083113 · Cited by 91 · see citing works
microRNAs in Cancer Cell Response to Ionizing Radiation
Czochor, J. R., & Glazer, P. M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5718 · Cited by 89 · see citing works
Therapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment
Esposito, S., Bianco, A., Russo, R., Maro, A. D., Isernia, C., & Pedone, P. V. (2019) · Molecules · doi:10.3390/molecules24152753 · Cited by 89 · see citing works
Venturutti, L., Russo, R. I. C., Rivas, M. A., Mercogliano, M. F., Izzo, F., Oakley, R. H., Pereyra, M. G., Martino, M. D., Proietti, C. J., Yankilevich, P., et al. (2016) · Oncogene · doi:10.1038/onc.2016.151 · Cited by 86 · see citing works
Self-citationJiang, Y., Chen, X., Tian, W., Yin, X., Wang, J., & Yang, H. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.368 · Cited by 85 · see citing works
miRNAs and regulation of cell signaling
Ichimura, A., Ruike, Y., Terasawa, K., & Tsujimoto, G. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08087.x · Cited by 84 · see citing works
The role of oncomirs in the pathogenesis and treatment of breast cancer
Hemmatzadeh, M., Mohammadi, H., Jadidi‐Niaragh, F., Asghari, F., & Yousefi, M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.01.026 · Cited by 83 · see citing works
Wang, D., Huang, J., & Hu, Z. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.011932 · Cited by 82 · see citing works
Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs
Velagapudi, S. P., Costales, M. G., Vummidi, B. R., Nakai, Y., Angelbello, A. J., Tran, T. A., Haniff, H. S., Matsumoto, Y., Wang, Z. F., Chatterjee, A. K., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.05.015 · Cited by 81 · see citing works
microRNAs in Gliomas: Small Regulators of a Big Problem
Silber, J., James, C. D., & Hodgson, J. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8087-9 · Cited by 80 · see citing works
Ando, W., Kikuchi, K., Uematsu, T., Yokomori, H., Takaki, T., Sogabe, M., Kohgo, Y., Otori, K., Ishikawa, S., & Okazaki, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-50084-5 · Cited by 80 · see citing works
Ren, J., Zhu, D., Liu, M., Sun, Y., & Tian, L. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.07.047 · Cited by 79 · see citing works
MicroRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases
Li, S., Liang, Z., Liu, X., & Zou, F. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1052-6 · Cited by 76 · see citing works
MiR-21 Is Required for the Epithelial–Mesenchymal Transition in MDA-MB-231 Breast Cancer Cells
Arısan, E. D., Rencüzoğulları, Ö., Cieza-Borrella, C., Miralles, F., Dwek, M. V., Lange, S., & Onganer, P. U. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041557 · Cited by 74 · see citing works
Sun, S.-S., Zhou, X., Huang, Y.-Y., Kong, L.-P., Mei, M., Guo, W.-Y., Zhao, M.-H., Ren, Y., Shen, Q., & Zhang, L. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0487-x · Cited by 72 · see citing works
Sareyeldin, R. M., Gupta, I., Al‐Hashimi, I., Al-Thawadi, H., Farsi, H. F. A., Vranić, S., & Moustafa, A. A. (2019) · Cancers · doi:10.3390/cancers11050646 · Cited by 71 · see citing works
Toraih, E. A., Mohammed, E. A.-M., Farrag, S. H., Ramsis, N., & Hosny, S. (2015) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-015-0143-6 · Cited by 69 · see citing works
Ismail, A., El‐Mahdy, H. A., Abulsoud, A. I., Sallam, A.-A. M., Eldeib, M. G., Elsakka, E. G. E., Zaki, M. B., & Doghish, A. S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.10.241 · Cited by 67 · see citing works
Venturutti, L., Romero, L., Urtreger, A., Chervo, M., Russo, R., Mercogliano, M., Inurrigarro, G., Pereyra, M., Proietti, C., Izzo, F., et al. (2016) · Oncogene · doi:10.1038/onc.2015.281 · Cited by 65 · see citing works
Petrović, N. (2016) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-016-0186-3 · Cited by 65 · see citing works
MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival
Mima, K., Nishihara, R., Yang, J., Dou, R., Masugi, Y., Shi, Y. X., da Silva, A., Cao, Y., Song, M., Nowak, J. A., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2173 · Cited by 65 · see citing works
MicroRNAs: Promising New Antiangiogenic Targets in Cancer
Gallach, S., Fariñas, S. C., Lewintre, E. J., & Camps, C. (2014) · BioMed Research International · doi:10.1155/2014/878450 · Cited by 64 · see citing works
ErbB-2 nuclear function in breast cancer growth, metastasis and resistance to therapy.
Elizalde, P., Russo, R. C., Chervo, M. F., & Schillaci, R. (2016) · Endocrine-Related Cancer · doi:10.1530/erc-16-0360 · Cited by 54 · see citing works
Wang, T., Zhang, L., Shi, C., Sun, H., Wang, J., Li, R., Zou, Z., Ran, X., & Su, Y. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.11.012 · Cited by 62 · see citing works
MicroRNAs: a complex regulatory network drives the acquisition of malignant cell phenotype
Santarpia, L., Nicoloso, M. S., & Calin, G. A. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0222 · Cited by 62 · see citing works
The Role of MicroRNAs in Lung Cancer: Implications for Diagnosis and Therapy
Naeli, P., Yousefi, F., Ghasemi, Y., Savardashtaki, A., & Mirzaei, H. (2019) · Current Molecular Medicine · doi:10.2174/1566524019666191001113511 · Cited by 59 · see citing works
Chen, Z., Yuan, Y.-C., Wang, Y., Liu, Z., Chan, H. J., & Chen, S. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3446-8 · Cited by 59 · see citing works
Ho, C., Bar, E. E., Giannini, C., Marchionni, L., Karajannis, M. A., Zagzag, D., Gutmann, D. H., Eberhart, C. G., & Rodriguez, F. J. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos269 · Cited by 59 · see citing works
Weidle, U. H., Dickopf, S., Hintermair, C., Kollmorgen, G., Birzele, F., & Brinkmann, U. (2018) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20062 · Cited by 56 · see citing works
Luo, F., Ji, J., Liu, Y., Xu, Y., Zheng, G., Jing, J., Wang, B., Xu, W., Shi, L., Lü, X., et al. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.11.001 · Cited by 56 · see citing works
Han, M., Wang, F., Gu, Y., Pei, X., Guo, G., Yu, C., Li, L., Zhu, M., Xiong, Y., & Wang, Y. (2015) · Oncology Reports · doi:10.3892/or.2015.4360 · Cited by 54 · see citing works
TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
Chevalier, C., Collin, G., Descamps, S., Touaitahuata, H., Simon, V., Reymond, N., Fernandez, L., Milhiet, P., Georget, V., Urbach, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms10765 · Cited by 53 · see citing works
MicroRNAs and lung cancers: from pathogenesis to clinical implications
Qi, J., & Mu, D. (2012) · Frontiers of Medicine · doi:10.1007/s11684-012-0188-4 · Cited by 52 · see citing works
Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks.
Gomez, G. G., Wykosky, J., Zanca, C., Furnari, F. B., & Cavenee, W. K. (2013) · Europe PMC (PubMed Central) · doi:10.7497/j.issn.2095-3941.2013.04.003 · Cited by 52 · see citing works
Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival
Young, J. S., Kawaguchi, T., Yan, L., Qi, Q., Liu, S., & Takabe, K. (2017) · Oncotarget · doi:10.18632/oncotarget.21577 · Cited by 51 · see citing works
A comprehensive review on oncogenic miRNAs in breast cancer
Nurzadeh, M., Naemi, M., & Hasani, S. S. (2021) · Journal of Genetics · doi:10.1007/s12041-021-01265-7 · Cited by 49 · see citing works
Liu, F., Zheng, S., Liu, T., Liu, Q., Liang, M., Li, X., Sheyhidin, I., Lu, X., & Liu, W. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1693-8 · Cited by 46 · see citing works
Mehrgou, A., & Akouchekian, M. (2017) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_967_16 · Cited by 46 · see citing works
Huber, R. M., Rajski, M., Sivasankaran, B., Moncayo, G. E., Hemmings, B. A., & Merlo, A. U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057793 · Cited by 45 · see citing works
Schmitz, U., Wolkenhauer, O., & Vera, J. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-5590-1 · Cited by 56 · see citing works
Zhu, D., Gu, L., Li, Z., Jin, W., Lu, Q., & Ren, T. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.01.029 · Cited by 45 · see citing works
MicroRNA-gene signaling pathways in pancreatic cancer
Iliopoulos, D., & Drakaki, A. (2013) · Biomedical Journal · doi:10.4103/2319-4170.119690 · Cited by 44 · see citing works
Menju, T., Hashimoto, S., Hashimoto, A., Otsuka, Y., Handa, H., Ogawa, E., Toda, Y., Wada, H., Date, H., & Sabe, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025301 · Cited by 44 · see citing works
Potentially predictive microRNAs of gastric cancer with metastasis to lymph node
Wu, W. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i31.3645 · Cited by 44 · see citing works
Insights into the Regulatory Role of Non-coding RNAs in Cancer Metabolism
Beltrán‐Anaya, F. O., Cedro‐Tanda, A., Hidalgo‐Miranda, A., & Romero-Cordoba, S. L. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00342 · Cited by 44 · see citing works
Urtica dioica extract suppresses miR-21 and metastasis-related genes in breast cancer
Mansoori, B., Mohammadi, A., Hashemzadeh, S., Shirjang, S., Baradaran, A., Asadi, M., Doustvandi, M. A., & Baradaran, B. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.021 · Cited by 43 · see citing works
Small molecule with big role: MicroRNAs in cancer metastatic microenvironments
Su, Y., Li, X., Ji, W., Sun, B., Xu, C., Li, Z., Qian, G., & Su, C. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.10.024 · Cited by 42 · see citing works
McAnena, P. F., McGuire, A., Ramli, A., Curran, C. E., Malone, C., McLaughlin, R. A., Barry, K., Brown, J. A. L., & Kerin, M. J. (2018) · BMC Cancer · doi:10.1186/s12885-018-4101-7 · Cited by 42 · see citing works
Wilmott, J. S., Zhang, X. D., Hersey, P., & Scolyer, R. A. (2011) · Pathology · doi:10.1097/pat.0b013e32834a7358 · Cited by 41 · see citing works
Medimegh, I., Omrane, I., Privat, M., Uhrhummer, N., Ayari, H., Belaiba, F., Benayed, F., Benromdhan, K., Mader, S., Bignon, I.-J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111877 · Cited by 41 · see citing works
- Authors
- Huang, T.-H., Wu, F., Loeb, G. B., Hsu, R., Heidersbach, A., Brincat, A., Horiuchi, D., Lebbink, R. J., Mo, Y.-Y., Goga, A., & McManus, M. T.
- Affiliations
- University of California, San Francisco (US)
- SIU Medicine (US)
- Corresponding author
- McManus, Michael T.
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 284
- Issue
- 27
- Pages
- 18515-18524
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2709372
- OpenAlex
- W1998000044
- Cited by
- 191
- References
- 48
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 11 · 2019: 11 · 2018: 7 · 2017: 6 · 2016: 17 · 2015: 15 · 2014: 21 · 2013: 23 · 2012: 15
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Susan G. Komen for the Cure
- National Institutes of Health (5k08ca104032-05)
- Directorate for Biological Sciences
- University of California, San Francisco
- National Cancer Institute (K08-CA104032, P50CA058207, P50-CA 58207)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- miR-21, HER2/neu, cell invasion, breast cancer, MAPK/ERK1/2 signaling, RasV12, Id1, PDCD4, metastasis suppressor, microRNA regulation, therapeutic target
- MeSH terms
- Breast Neoplasms, Female, HeLa Cells, Humans, Neoplasm Invasiveness, Up-Regulation, Gene Expression Regulation, Neoplastic, RNA-Binding Proteins, Receptor, ErbB-2, Erb-b2 Receptor Tyrosine Kinases, Mitogen-Activated Protein Kinase 1, MAP Kinase Signaling System, MicroRNAs, Mitogen-Activated Protein Kinase 3, MAP Kinase Kinase 1, Apoptosis Regulatory Proteins
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