The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Up-regulation of miR-21 by HER2/neu Signaling Promotes Cell Invasion
Open accessAbstract
The cell surface receptor tyrosine kinase HER2/neu enhances tumor metastasis. Recent studies suggest that deregulated microRNA (miRNA) expression promotes invasion and metastasis of cancer cells; we therefore explored the possibility that HER2/neu signaling induces the expression of specific miRNAs involved in this process. We identified a putative oncogenic miRNA, miR-21, whose expression is correlated with HER2/neu up-regulation and is functionally involved in HER2/neu-induced cell invasion. We show that miR-21 is up-regulated via the MAPK (ERK1/2) pathway upon stimulation of HER2/neu signaling in breast cancer cells, and overexpression of other ERK1/2 activators such as RASV12 or ID-1 is sufficient to induce miR-21 up-regulation in HER2/neu-negative breast cancer cells. Furthermore, the metastasis suppressor protein PDCD4 (programmed cell death 4) is down-regulated by miR-21 in breast cancer cells expressing HER2/neu. Our data reveal a mechanism for HER2/neu-induced cancer cell invasion via miRNA deregulation. In addition, our results identify miR-21 as a potential therapeutic target for the prevention of breast cancer invasion and metastasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“As well, epidermal growth factor receptor (EGFR) and HER2/neu signaling positively regulates miR-21 expression in human lung and breast carcinoma cell lines, respectively (Huang et al., 2009; Seike et al., 2009).”
From Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21 (2010) · cites this paper as Huang et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038
Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer
Slamon, D. J., Godolphin, W. J., Jones, L. A., Holt, J. A., Wong, S., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J. A., Ullrich, A., et al. (1989) · Science · doi:10.1126/science.2470152 · Cited by 6,817
Real-time quantification of microRNAs by stem-loop RT-PCR
Chen, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni178 · Cited by 4,989
Exploring the metabolic and genetic control of gene expression on a genomic scale.
Derisi, J., Iyer, V., & Brown, P. (1997) · Science · doi:10.1126/science.278.5338.680 · Cited by 4,832
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317
miRBase: microRNA sequences, targets and gene nomenclature
Griffiths-Jones, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj112 · Cited by 3,950
A microRNA polycistron as a potential human oncogene
He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642
MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
Meng, F., Henson, R., Wehbe–Janek, H., Ghoshal, K., Jacob, S. T., & Patel, T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.022 · Cited by 2,773
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605
MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells
Chan, J. A., Krichevsky, A. M., & Kosik, K. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0137 · Cited by 2,557
Flagged first, then by citations
Research works printed but not linked: 2
- Tan, 1997, Cancer Res., 57, 1199
- Hellawell, 2002, Cancer Res., 62, 2942
Cited by
Sorted by citations
MicroRNAs in Development and Disease
Sayed, D. H., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,101
Farazi, T. A., Spitzer, J., Morozov, P. S., & Tuschl, T. (2010) · The Journal of Pathology · doi:10.1002/path.2806 · Cited by 900
Farazi, T. A., Hoell, J. I., Morozov, P. S., & Tuschl, T. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-5590-1_1 · Cited by 709
Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21
Hatley, M. E., Patrick, D. M., Garcia, M. R., Richardson, J. A., Bassel-Duby, R., van Rooij, E., & Olson, E. N. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.013 · Cited by 626
“In addition, epidermal growth factor receptor (EGFR) and HER2/neu signaling positively regulates miR-21 expression in human lung and breast carcinoma cell lines, respectively (Huang et al., 2009; Seike et al., 2009).”
Plasma exosome microRNAs are indicative of breast cancer
Hannafon, B. N., Trigoso, Y. D., Calloway, C. L., Zhao, Y. D., Lum, D. H., Welm, A. L., Zhao, Z. J., Blick, K. E., Dooley, W. C., & Ding, W. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0753-x · Cited by 603
The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics
Bautista-Sánchez, D., Arriaga-Canon, C., Pedroza-Torres, A., De La Rosa-Velázquez, I. A., González-Barrios, R., Contreras-Espinosa, L., Montiel-Manríquez, R., Castro-Hernández, C., Fragoso-Ontiveros, V., Álvarez-Gómez, R. M., et al. (2020) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2020.03.003 · Cited by 549
Negative regulation of lncRNA GAS5 by miR-21
Zhang, Z., Zhu, Z., Watabe, K., Zhang, X., Bai, C., Xu, M., Wu, F., & Mo, Y.-Y. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.110 · Cited by 419
Self-citationApoptosis and the target genes of microRNA-21
Buscaglia, L. E. B., & Li, Y. (2011) · 癌症:英文版 · doi:10.5732/cjc.011.10132 · Cited by 383
MicroRNAs in idiopathic pulmonary fibrosis
Pandit, K. V., Milošević, J., & Kaminski, N. (2011) · Translational research · doi:10.1016/j.trsl.2011.01.012 · Cited by 316
Up-regulation of miR-21 Mediates Resistance to Trastuzumab Therapy for Breast Cancer
Gong, C., Yao, Y., Wang, Y., Liu, B., Wu, W. G., Chen, J., Su, F., Yao, H., & Song, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.216887 · Cited by 313
The role of microRNAs in endometriosis and associated reproductive conditions
Ohlsson Teague, E. M. C., Print, C. G., & Hull, M. L. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp034 · Cited by 309
van Schooneveld, E., Wildiers, H. P. M. W., Vergote, I. B., Vermeulen, P. B., Dirix, L. Y., & Laere, S. V. (2015) · Breast Cancer Research · doi:10.1186/s13058-015-0526-y · Cited by 297
Mittal, S., Kaur, H., Gautam, N., & Mantha, A. K. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.08.028 · Cited by 295
MicroRNA control of epithelial–mesenchymal transition and metastasis
Zhang, J., & Ma, L. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9368-6 · Cited by 273
MicroRNAs in cancer — from research to therapy
Cho, W. C. S. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.11.003 · Cited by 234
Intracellular and Extracellular MicroRNAs in Breast Cancer
Corcoran, C., Friel, A. M., Duffy, M. J., Crown, J. P., & O’Driscoll, L. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.150730 · Cited by 231
MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer
Andorfer, C. A., Necela, B. M., Thompson, E. A., & Perez, E. A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.01.006 · Cited by 213
Micro RNA s play a central role in molecular dysfunctions linking inflammation with cancer
Tili, E., Michaille, J., & Croce, C. M. (2013) · Immunological Reviews · doi:10.1111/imr.12050 · Cited by 211
Aitken, S. J., Thomas, J. S. J., Langdon, S. P., Harrison, D. J., & Faratian, D. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp427 · Cited by 187
MicroRNAs in regulation of triple-negative breast cancer progression
Piasecka, D., Braun, M., Kordek, R., Sądej, R., & Romańska, H. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2689-2 · Cited by 193
Metastamirs: a stepping stone towards improved cancer management
White, N. M. A., Fatoohi, E., Metias, M., Jung, K., Stephan, C., & Yousef, G. M. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.173 · Cited by 184
Martínez, A. R., de Miguel‐Pérez, D., Ortega, F. G., García-Puche, J. L., Robles‐Fernandez, I., Expósito, J., Martorell‐Marugán, J., Carmona‐Sáez, P., Garrido-Navas, M. C., Rolfo, C. D., et al. (2019) · Breast Cancer Research · doi:10.1186/s13058-019-1109-0 · Cited by 180
MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation
Li, Q., Zhang, D., Wang, Y., Sun, P., Hou, X., Larner, J., Xiong, W., & Mi, J. (2013) · Scientific Reports · doi:10.1038/srep02038 · Cited by 179
Regulation of microRNAs in cancer metastasis
Bouyssou, J., Manier, S., Huynh, D., Issa, S., Roccaro, A. M., & Ghobrial, I. M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.02.002 · Cited by 176
Jin, L., Wessely, O., Marcusson, E. G., Ivan, C., Călin, G. A., & Alahari, S. K. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2162 · Cited by 176
Aigner, A. M. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0716-0 · Cited by 147
Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease
Wancket, L. M., Frazier, W. J., & Liu, Y. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.11.017 · Cited by 137
Han, M., Wang, Y., Liu, M., Bi, X., Bao, J., Zeng, N., Zhu, Z.-K., Mo, Z., Wu, C., & Chen, X. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02281.x · Cited by 131
Park, Y. M., Hwang, S. J., Masuda, K., Choi, K.-M., Jeong, M., Nam, D., Gorospe, M., & Kim, H. H. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00443-12 · Cited by 126
Aktas, B., Müller, V., Tewes, M., Zeitz, J., Kasimir‐Bauer, S., Loehberg, C. R., Rack, B. K., Schneeweiß, A., & Fehm, T. N. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.04.039 · Cited by 124
Magnetobiosensors Based on Viral Protein p19 for MicroRNA Determination in Cancer Cells and Tissues
Campuzano, S., Torrente-Rodríguez, R. M., López‐Hernández, E., Conzuelo, F., Granados, R., Sánchez-Puelles, J.-M., & Pingarrón, J. M. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403270 · Cited by 119
Ming-li, H., Liu, M., Wang, Y., Mo, Z., Bi, X., Liu, Z., Fan, Y., Chen, X., & Wu, C. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1195-5 · Cited by 115
The roles of oncogenic miRNAs and their therapeutic importance in breast cancer
O’Bryan, S. M., Dong, S., Mathis, J. M., & Alahari, S. K. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.11.004 · Cited by 117
MicroRNA regulation of innate immune responses in epithelial cells
Zhou, R., O’Hara, S. P., & Chen, X. (2011) · Cellular and Molecular Immunology · doi:10.1038/cmi.2011.19 · Cited by 111
MicroRNA expression in ovarian carcinoma and its correlation with clinicopathological features
Lee, H.-J., Park, C. S., Deftereos, G., Morihara, J. K., Stern, J., Hawes, S. E., Swisher, E. M., Kiviat, N. B., & Feng, Q. (2012) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-10-174 · Cited by 109
Metastasis-related miRNAs, active players in breast cancer invasion, and metastasis
Shi, M., Liu, D., Duan, H., Shen, B., & Guo, N. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9265-9 · Cited by 108
Zhao, J., Tang, N., Wu, K., Dai, W., Ye, C., Shi, J. G., Zhang, J., Ning, B., Zeng, X. Y., & Lin, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108005 · Cited by 106
Rivas, M. A., Venturutti, L., Huang, Y., Schillaci, R., Huang, T. H. ‐., & Elizalde, P. V. (2012) · Breast Cancer Research · doi:10.1186/bcr3187 · Cited by 106
Self-citationMa, Y., Li, C., Huang, Y., Wang, Y., Xia, X., & Zheng, J. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0418-3 · Cited by 105
Wang, X., Li, C., Ju, S., Wang, Y., Wang, H., & Zhong, R. (2011) · Leukemia & Lymphoma · doi:10.3109/10428194.2011.591004 · Cited by 103
miR-21 promotes EGF-induced pancreatic cancer cell proliferation by targeting Spry2
Zhao, Q., Chen, S., Zhu, Z., Yu, L., Ren, Y., Jiang, M., Weng, J., & Li, B. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1182-9 · Cited by 109
MicroRNA-mediated breast cancer metastasis: from primary site to distant organs
Wang, L., & Wang, J. (2011) · Oncogene · doi:10.1038/onc.2011.444 · Cited by 102
Huang, Y., Yang, Y. B., Zhang, X. H., Yu, X. L., Wang, Z. B., & Cheng, X. C. (2012) · Medical Oncology · doi:10.1007/s12032-012-0376-8 · Cited by 102
Dong, G., Liang, X., Wang, D., Gao, H., Wang, L., Wang, L., Liu, J., & Du, Z. (2014) · Medical Oncology · doi:10.1007/s12032-014-0057-x · Cited by 100
Zhao, Y., Zhao, L., Ischenko, I., Bao, Q., Schwarz, B., Nieß, H., Wang, Y., Renner, A., Mysliwietz, J., Jauch, K., et al. (2015) · Targeted Oncology · doi:10.1007/s11523-015-0360-2 · Cited by 101
Loayza‐Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., & Noda, M. (2010) · Oncogene · doi:10.1038/onc.2010.23 · Cited by 97
Markou, A. N., Yousef, G. M., Stathopoulos, E. N., Georgoulias, V., & Lianidou, E. S. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2013.210542 · Cited by 96
β2-AR signaling controls trastuzumab resistance-dependent pathway
Liu, D., Yang, Z., Wang, T., Yang, Z., Chen, H., Hu, Y., Hu, C., Guo, L., Deng, Q., Liu, Y., et al. (2015) · Oncogene · doi:10.1038/onc.2015.58 · Cited by 95
miRNAs and Other Epigenetic Changes as Biomarkers in Triple Negative Breast Cancer
Mathe, A., Scott, R. J., & Avery‐Kiejda, K. A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226090 · Cited by 97
Curcumin as tyrosine kinase inhibitor in cancer treatment
Golonko, A., Lewandowska, H., Świsłocka, R., Jasińska, U., Priebe, W., & Lewandowski, W. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.07.015 · Cited by 96
Anfossi, S., Giordano, A., Gao, H., Cohen, E. N., Tin, S., Wu, Q., Garza, R. J., Debeb, B. G., Álvarez, R. H., Valero, V., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083113 · Cited by 95
microRNAs in Cancer Cell Response to Ionizing Radiation
Czochor, J. R., & Glazer, P. M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5718 · Cited by 90
Therapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment
Esposito, S., Bianco, A., Russo, R., Maro, A. D., Isernia, C., & Pedone, P. V. (2019) · Molecules · doi:10.3390/molecules24152753 · Cited by 89
Venturutti, L., Russo, R. I. C., Rivas, M. A., Mercogliano, M. F., Izzo, F., Oakley, R. H., Pereyra, M. G., Martino, M. D., Proietti, C. J., Yankilevich, P., et al. (2016) · Oncogene · doi:10.1038/onc.2016.151 · Cited by 86
Self-citationJiang, Y., Chen, X., Tian, W., Yin, X., Wang, J., & Yang, H. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.368 · Cited by 85
miRNAs and regulation of cell signaling
Ichimura, A., Ruike, Y., Terasawa, K., & Tsujimoto, G. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08087.x · Cited by 86
The role of oncomirs in the pathogenesis and treatment of breast cancer
Hemmatzadeh, M., Mohammadi, H., Jadidi‐Niaragh, F., Asghari, F., & Yousefi, M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.01.026 · Cited by 85
Wang, D., Huang, J., & Hu, Z. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.011932 · Cited by 85
Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs
Velagapudi, S. P., Costales, M. G., Vummidi, B. R., Nakai, Y., Angelbello, A. J., Tran, T. A., Haniff, H. S., Matsumoto, Y., Wang, Z. F., Chatterjee, A. K., et al. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.05.015 · Cited by 81
microRNAs in Gliomas: Small Regulators of a Big Problem
Silber, J., James, C. D., & Hodgson, J. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8087-9 · Cited by 80
Ando, W., Kikuchi, K., Uematsu, T., Yokomori, H., Takaki, T., Sogabe, M., Kohgo, Y., Otori, K., Ishikawa, S., & Okazaki, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-50084-5 · Cited by 80
Ren, J., Zhu, D., Liu, M., Sun, Y., & Tian, L. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.07.047 · Cited by 79
MicroRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases
Li, S., Liang, Z., Liu, X., & Zou, F. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1052-6 · Cited by 78
MiR-21 Is Required for the Epithelial–Mesenchymal Transition in MDA-MB-231 Breast Cancer Cells
Arısan, E. D., Rencüzoğulları, Ö., Cieza-Borrella, C., Miralles, F., Dwek, M. V., Lange, S., & Onganer, P. U. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041557 · Cited by 74
Sun, S.-S., Zhou, X., Huang, Y.-Y., Kong, L.-P., Mei, M., Guo, W.-Y., Zhao, M.-H., Ren, Y., Shen, Q., & Zhang, L. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0487-x · Cited by 72
Sareyeldin, R. M., Gupta, I., Al‐Hashimi, I., Al-Thawadi, H., Farsi, H. F. A., Vranić, S., & Moustafa, A. A. (2019) · Cancers · doi:10.3390/cancers11050646 · Cited by 76
Toraih, E. A., Mohammed, E. A.-M., Farrag, S. H., Ramsis, N., & Hosny, S. (2015) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-015-0143-6 · Cited by 69
Ismail, A., El‐Mahdy, H. A., Abulsoud, A. I., Sallam, A.-A. M., Eldeib, M. G., Elsakka, E. G. E., Zaki, M. B., & Doghish, A. S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.10.241 · Cited by 67
Venturutti, L., Romero, L., Urtreger, A., Chervo, M., Russo, R., Mercogliano, M., Inurrigarro, G., Pereyra, M., Proietti, C., Izzo, F., et al. (2016) · Oncogene · doi:10.1038/onc.2015.281 · Cited by 65
Petrović, N. (2016) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-016-0186-3 · Cited by 66
MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival
Mima, K., Nishihara, R., Yang, J., Dou, R., Masugi, Y., Shi, Y. X., da Silva, A., Cao, Y., Song, M., Nowak, J. A., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2173 · Cited by 65
MicroRNAs: Promising New Antiangiogenic Targets in Cancer
Gallach, S., Fariñas, S. C., Lewintre, E. J., & Camps, C. (2014) · BioMed Research International · doi:10.1155/2014/878450 · Cited by 64
ErbB-2 nuclear function in breast cancer growth, metastasis and resistance to therapy
Elizalde, P. V., Russo, R. I. C., Chervo, M. F., & Schillaci, R. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0360 · Cited by 68
Wang, T., Zhang, L., Shi, C., Sun, H., Wang, J., Li, R., Zou, Z., Ran, X., & Su, Y. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.11.012 · Cited by 62
MicroRNAs: a complex regulatory network drives the acquisition of malignant cell phenotype
Santarpia, L., Nicoloso, M. S., & Calin, G. A. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0222 · Cited by 63
The Role of MicroRNAs in Lung Cancer: Implications for Diagnosis and Therapy
Naeli, P., Yousefi, F., Ghasemi, Y., Savardashtaki, A., & Mirzaei, H. (2019) · Current Molecular Medicine · doi:10.2174/1566524019666191001113511 · Cited by 60
Chen, Z., Yuan, Y.-C., Wang, Y., Liu, Z., Chan, H. J., & Chen, S. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3446-8 · Cited by 59
Ho, C., Bar, E. E., Giannini, C., Marchionni, L., Karajannis, M. A., Zagzag, D., Gutmann, D. H., Eberhart, C. G., & Rodriguez, F. J. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos269 · Cited by 59
Weidle, U. H., Dickopf, S., Hintermair, C., Kollmorgen, G., Birzele, F., & Brinkmann, U. (2018) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20062 · Cited by 57
Luo, F., Ji, J., Liu, Y., Xu, Y., Zheng, G., Jing, J., Wang, B., Xu, W., Shi, L., Lü, X., et al. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.11.001 · Cited by 56
Han, M., Wang, F., Gu, Y., Pei, X., Guo, G., Yu, C., Li, L., Zhu, M., Xiong, Y., & Wang, Y. (2015) · Oncology Reports · doi:10.3892/or.2015.4360 · Cited by 54
TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion
Chevalier, C., Collin, G., Descamps, S., Touaitahuata, H., Simon, V., Reymond, N., Fernandez, L., Milhiet, P., Georget, V., Urbach, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms10765 · Cited by 53
MicroRNAs and lung cancers: from pathogenesis to clinical implications
Qi, J., & Mu, D. (2012) · Frontiers of Medicine · doi:10.1007/s11684-012-0188-4 · Cited by 52
Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks.
Gomez, G. G., Wykosky, J., Zanca, C., Furnari, F. B., & Cavenee, W. K. (2013) · Europe PMC (PubMed Central) · doi:10.7497/j.issn.2095-3941.2013.04.003 · Cited by 53
Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival
Young, J. S., Kawaguchi, T., Yan, L., Qi, Q., Liu, S., & Takabe, K. (2017) · Oncotarget · doi:10.18632/oncotarget.21577 · Cited by 51
A comprehensive review on oncogenic miRNAs in breast cancer
Nurzadeh, M., Naemi, M., & Hasani, S. S. (2021) · Journal of Genetics · doi:10.1007/s12041-021-01265-7 · Cited by 51
Liu, F., Zheng, S., Liu, T., Liu, Q., Liang, M., Li, X., Sheyhidin, I., Lu, X., & Liu, W. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1693-8 · Cited by 46
Mehrgou, A., & Akouchekian, M. (2017) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_967_16 · Cited by 46
Huber, R. M., Rajski, M., Sivasankaran, B., Moncayo, G. E., Hemmings, B. A., & Merlo, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057793 · Cited by 44
Schmitz, U., Wolkenhauer, O., & Vera, J. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-5590-1 · Cited by 56
Zhu, D., Gu, L., Li, Z., Jin, W., Lu, Q., & Ren, T. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.01.029 · Cited by 45
MicroRNA-gene signaling pathways in pancreatic cancer
Iliopoulos, D., & Drakaki, A. (2013) · Biomedical Journal · doi:10.4103/2319-4170.119690 · Cited by 44
Menju, T., Hashimoto, S., Hashimoto, A., Otsuka, Y., Handa, H., Ogawa, E., Toda, Y., Wada, H., Date, H., & Sabe, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025301 · Cited by 44
Potentially predictive microRNAs of gastric cancer with metastasis to lymph node
Wu, W. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i31.3645 · Cited by 44
Insights into the Regulatory Role of Non-coding RNAs in Cancer Metabolism
Beltrán‐Anaya, F. O., Cedro‐Tanda, A., Hidalgo‐Miranda, A., & Romero-Cordoba, S. L. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00342 · Cited by 44
Urtica dioica extract suppresses miR-21 and metastasis-related genes in breast cancer
Mansoori, B., Mohammadi, A., Hashemzadeh, S., Shirjang, S., Baradaran, A., Asadi, M., Doustvandi, M. A., & Baradaran, B. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.021 · Cited by 43
Small molecule with big role: MicroRNAs in cancer metastatic microenvironments
Su, Y., Li, X., Ji, W., Sun, B., Xu, C., Li, Z., Qian, G., & Su, C. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.10.024 · Cited by 42
McAnena, P. F., McGuire, A., Ramli, A., Curran, C. E., Malone, C., McLaughlin, R. A., Barry, K., Brown, J. A. L., & Kerin, M. J. (2018) · BMC Cancer · doi:10.1186/s12885-018-4101-7 · Cited by 42
Wilmott, J. S., Zhang, X. D., Hersey, P., & Scolyer, R. A. (2011) · Pathology · doi:10.1097/pat.0b013e32834a7358 · Cited by 41
Medimegh, I., Omrane, I., Privat, M., Uhrhummer, N., Ayari, H., Belaiba, F., Benayed, F., Benromdhan, K., Mader, S., Bignon, I.-J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111877 · Cited by 41
Metadata
- Authors
- Huang, T.-H., Wu, F., Loeb, G. B., Hsu, R., Heidersbach, A., Brincat, A., Horiuchi, D., Lebbink, R. J., Mo, Y.-Y., Goga, A., & McManus, M. T.
- Affiliations
- University of California, San Francisco (US)
- SIU Medicine (US)
- Corresponding author
- McManus, Michael T.
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 284
- Issue
- 27
- Pages
- 18515-18524
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2709372
- OpenAlex
- W1998000044
- Cited by
- 191
- References
- 48
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 11 · 2019: 11 · 2018: 7 · 2017: 6 · 2016: 17 · 2015: 15 · 2014: 21 · 2013: 23 · 2012: 15
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Susan G. Komen for the Cure
- National Institutes of Health (5k08ca104032-05)
- Directorate for Biological Sciences
- University of California, San Francisco
- National Cancer Institute (K08-CA104032, P50CA058207, P50-CA 58207)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- miR-21, HER2/neu, cell invasion, breast cancer, MAPK/ERK1/2 signaling, RasV12, Id1, PDCD4, metastasis suppressor, microRNA regulation, therapeutic target
- MeSH terms
- Breast Neoplasms, Female, HeLa Cells, Humans, Neoplasm Invasiveness, Up-Regulation, Gene Expression Regulation, Neoplastic, RNA-Binding Proteins, Receptor, ErbB-2, Erb-b2 Receptor Tyrosine Kinases, Mitogen-Activated Protein Kinase 1, MAP Kinase Signaling System, MicroRNAs, Mitogen-Activated Protein Kinase 3, MAP Kinase Kinase 1, Apoptosis Regulatory Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review