McManus, Michael T.

Integrative analysis of 111 reference human epigenomes

Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 6,368

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Hangauer, M. J., Viswanathan, V. S., Ryan, M. J., Bole, D., Eaton, J. K., Matov, A., Galeas, J., Dhruv, H. D., Berens, M. E., Schreiber, S. L., et al. (2017) · Nature

Ferroptosis and cancer prognosisCancer Cells and Metastasis

Cited by 1,799

TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

Hong, J.-H., Hwang, E. S., McManus, M. T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B. M., Sharp, P. A., et al. (2005) · Science

Mesenchymal stem cell researchHippo pathway signaling and YAP/TAZ

Cited by 1,009

Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs

Hangauer, M. J., Vaughn, I. W., & McManus, M. T. (2013) · PLoS Genetics

Cancer-related molecular mechanisms researchRNA Research and Splicing

Cited by 738

Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination

Dugas, J. C., Cuellar, T. L., Scholze, A., Ason, B., Ibrahim, A., Emery, B., Zamanian, J. L., Foo, L. C., McManus, M. T., & Barres, B. A. (2010) · Neuron

Neurogenesis and neuroplasticity mechanismsMicroRNA in disease regulation

Cited by 577

Conditional Loss of Dicer Disrupts Cellular and Tissue Morphogenesis in the Cortex and Hippocampus

Davis, T. H., Cuellar, T. L., Koch, S. M., Barker, A. J., Harfe, B. D., McManus, M. T., & Ullian, E. M. (2008) · The Journal of Neuroscience

MicroRNA in disease regulationNeurogenesis and neuroplasticity mechanisms

Cited by 447

Unexplored therapeutic opportunities in the human genome

Oprea, T. I., Bologa, C. G., Brunak, S., Campbell, A., Gan, G. N., Gaulton, A., Gomez, S. M., Guha, R., Hersey, A., Holmes, J., et al. (2018) · Nature Reviews Drug Discovery

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 378

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

Bassik, M. C., Kampmann, M., Lebbink, R. J., Wang, S., Hein, M. Y., Poser, I., Weibezahn, J., Horlbeck, M. A., Chen, S., Mann, M., et al. (2013) · Cell

Toxin Mechanisms and ImmunotoxinsRNA Interference and Gene Delivery

Cited by 365

MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse

Lynn, F. C., Skewes-Cox, P., Kosaka, Y., McManus, M. T., Harfe, B. D., & German, M. S. (2007) · Diabetes

Pancreatic function and diabetesMicroRNA in disease regulation

Cited by 351

A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity

Inoue, F., Kircher, M., Martin, B., Cooper, G. M., Witten, D. M., McManus, M. T., Ahituv, N., & Shendure, J. (2017) · Genome Research

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 331

Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes

McManus, M. T., Haines, B. B., Dillon, C. P., Whitehurst, C. E., van Parijs, L., Chen, J., & Sharp, P. A. (2002) · The Journal of Immunology

RNA Interference and Gene DeliveryRNA Research and Splicing

Cited by 215

An expanded universe of cancer targets

Hahn, W. C., Bader, J. S., Braun, T. P., Califano, A., Clemons, P. A., Druker, B. J., Ewald, A. J., Fu, H., Jagu, S., Kemp, C. J., et al. (2021) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 213

Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion

Huang, T.-H., Wu, F., Loeb, G. B., Hsu, R., Heidersbach, A., Brincat, A., Horiuchi, D., Lebbink, R. J., Mo, Y.-Y., Goga, A., et al. (2009) · Journal of Biological Chemistry

MicroRNA in disease regulationHER2/EGFR in Cancer Research

Cited by 191

Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice

Soukup, G. A., Fritzsch, B., Pierce, M. L., Weston, M. D., Jahan, I., McManus, M. T., & Harfe, B. D. (2009) · Developmental Biology

Hearing, Cochlea, Tinnitus, GeneticsCongenital Ear and Nasal Anomalies

Cited by 125

Massively parallel functional annotation of 3′ untranslated regions

Zhao, W., Pollack, J. L., Blagev, D. P., Zaitlen, N., McManus, M. T., & Erle, D. J. (2014) · Nature Biotechnology

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 125

The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output

Bulut-Karslioglu, A., Macrae, T. A., Oses-Prieto, J. A., Covarrubias, S., Percharde, M., Ku, G., Diaz, A., McManus, M. T., Burlingame, A. L., & Ramalho-Santos, M. (2018) · Cell Stem Cell

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 97

The transcriptionally permissive chromatin state of ES cells is acutely tuned to translational output

Bulut-Karslioglu, A., Macrae, T. A., Oses-Prieto, J. A., Covarrubias, S., Percharde, M., Ku, G., Diaz, A., McManus, M. T., Burlingame, A. L., & Ramalho-Santos, M. (2017) · Cell stem cell

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 97