The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
miR-331-3p Regulates ERBB-2 Expression and Androgen Receptor Signaling in Prostate Cancer
Open accessAbstract
MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression and are aberrantly expressed in human cancer. The ERBB-2 tyrosine kinase receptor is frequently overexpressed in prostate cancer and is associated with disease progression and poor survival. We have identified two specific miR-331-3p target sites within the ERBB-2 mRNA 3'-untranslated region and show that miR-331-3p expression is decreased in prostate cancer tissue relative to normal adjacent prostate tissue. Transfection of multiple prostate cancer cell lines with miR-331-3p reduced ERBB-2 mRNA and protein expression and blocked downstream phosphatidylinositol 3-kinase/AKT signaling. Furthermore, miR-331-3p transfection blocked the androgen receptor signaling pathway in prostate cancer cells, reducing activity of an androgen-stimulated prostate-specific antigen promoter and blocking prostate-specific antigen expression. Our findings provide insight into the regulation of ERBB-2 expression in cancer and suggest that miR-331-3p has the capacity to regulate signaling pathways critical to the development and progression of prostate cancer cells.
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Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., & Thun, M. J. (2007) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.57.1.43 · Cited by 7,439
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
A microRNA component of the p53 tumour suppressor network
He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692
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Mellinghoff, I. K., Vivanco, I., Kwon, A., Tran, C., Wongvipat, J., & Sawyers, C. L. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.031 · Cited by 344
Cited by
miR-323a regulates ERBB4 and is involved in depression
Fiori, L. M., Kos, A., Lin, R., Théroux, J.-F., Lopez, J. P., Kühne, C., Eggert, C., Holzapfel, M., Huettl, R.-E., Mechawar, N., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00953-7 · Cited by 88
Interplay between steroid signalling and microRNAs: implications for hormone-dependent cancers
Fletcher, C. E., Dart, D. A., & Bevan, C. L. (2014) · Endocrine Related Cancer · doi:10.1530/erc-14-0208 · Cited by 37
Metadata
- Authors
- Epis, M. R., Giles, K. M., Barker, A., Kendrick, T. S., & Leedman, P. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 284
- Issue
- 37
- Pages
- 24696-24704
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1992459095
- Cited by
- 163
- References
- 6
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Epis, M. R., Giles, K. M., Barker, A., Kendrick, T. S., & Leedman, P. J. (2009). miR-331-3p Regulates ERBB-2 Expression and Androgen Receptor Signaling in Prostate Cancer. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m109.030098
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