AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

Basic local alignment search tool

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AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

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The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

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Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

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AMPK as a Therapeutic Target for Treating Metabolic Diseases

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Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

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AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

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Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

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Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

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Hypothalamic AMPK: a canonical regulator of whole-body energy balance

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Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

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AMPK and Exercise: Glucose Uptake and Insulin Sensitivity

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Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation

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Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

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Adipose tissue: between the extremes

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Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)

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Quercetin activates AMP‐activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol‐induced neurotoxicity

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Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity

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Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

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Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

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Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

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Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

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AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

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Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

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Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

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CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis

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Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance

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A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

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Involvement of AMP‐activated protein kinase in neuroinflammation and neurodegeneration in the adult and developing brain

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Creatine maintains intestinal homeostasis and protects against colitis

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Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

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A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies

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Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetic mice via the Sirt1/AMPK signaling pathway

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The metabolic sensor AMPK: Twelve enzymes in one

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AMPK activation regulates neuronal structure in developing hippocampal neurons

Ramamurthy, S., Chang, E., Cao, Y., Zhu, J., & Ronnett, G. V. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.048 · Cited by 65

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release

Scott, J. W., Galić, S., Graham, K. L., Foitzik, R. C., Ling, N. X. Y., Dite, T. A., Issa, S. M. A., Langendorf, C. G., Weng, Q. P., Thomas, H. E., et al. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.05.011 · Cited by 61

AMPK-dependent modulation of hepatic lipid metabolism by nesfatin-1

Yin, Y., Li, Z., Gao, L., Li, Y., Zhao, J., & Zhang, W. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.006 · Cited by 62

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain

Ramamurthy, S., & Ronnett, G. V. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.2.52 · Cited by 62

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice

Hughey, C. C., James, F. D., Bracy, D. P., Donahue, E. P., Young, J. D., Viollet, B., Foretz, M., & Wasserman, D. H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.811547 · Cited by 56

Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway

Yu, L., Gong, L., Wang, C., Hu, N., Tang, Y.-Q., Li, Z., Dai, X., & Li, Y. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s243893 · Cited by 57

Increased 4-Hydroxynonenal Formation Contributes to Obesity-Related Lipolytic Activation in Adipocytes

Zhang, X., Wang, Z., Li, J., Gu, D., Li, S., Shen, C., & Song, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070663 · Cited by 58

Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK.

Banskota, S., Wang, H.-Q., Kwon, Y. H., Gautam, J., Gurung, P., Haq, S., Hassan, F. M. N., Bowdish, D., Kim, J.-A., Carling, D., et al. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa305 · Cited by 41

AMPK beta subunits: more than just a scaffold in the formation of AMPK complex

Sanz, P., Rubio, T., & García-Gimeno, M. A. (2013) · FEBS Journal · doi:10.1111/febs.12364 · Cited by 57

Homocysteine suppresses lipolysis in adipocytes by activating the AMPK pathway

Wang, Z., Pini, M., Yao, T., Zhou, Z., Sun, C., Fantuzzi, G., & Song, Z. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00050.2011 · Cited by 52

Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance

Palanivel, R., Fullerton, M. D., Galić, S., Honeyman, J. E., Hewitt, K., Jørgensen, S. B., & Steinberg, G. R. (2012) · Diabetologia · doi:10.1007/s00125-012-2665-3 · Cited by 53

Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes

Rao, Y., Liu, H., Gao, L., Yu, H., Tan, J., Ou, T., Huang, S., Gu, L., Ye, J., & Huang, Z. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.05.057 · Cited by 50

AMPK mediates energetic stress‐induced liver GDF15

Townsend, L. K., Weber, A. J., Day, E. A., Shamshoum, H., Shaw, S. J., Perry, C. G. R., Kemp, B. E., Steinberg, G. R., & Wright, D. C. (2020) · The FASEB Journal · doi:10.1096/fj.202000954r · Cited by 48

ESR1, FTO, and UCP2 Genes Interact with Bariatric Surgery Affecting Weight Loss and Glycemic Control in Severely Obese Patients

Liou, T., Chen, H., Wang, W., Wu, S., Lee, Y.-C., Yang, W., & Lee, W. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0457-3 · Cited by 45

The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

Desjardins, E. M., Smith, B. K., Day, E. A., Ducommun, S., Sanders, M. J., Nederveen, J. P., Ford, R. J., Pinkosky, S. L., Townsend, L. K., Gutgesell, R. M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119824119 · Cited by 47

AMPK regulates macrophage polarization in adipose tissue inflammation and NASH

Weng, S., & Schuppan, D. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.09.031 · Cited by 45

AMPK β1 reduces tumor progression and improves survival in p53 null mice

Houde, V. P., Donzelli, S., Sacconi, A., Galić, S., Hammill, J. A., Bramson, J. L., Foster, R. A., Tsakiridis, T. K., Kemp, B. E., Grasso, G., et al. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12079 · Cited by 41

The Outcome of Renal Ischemia-Reperfusion Injury Is Unchanged in AMPK-β1 Deficient Mice

Mount, P. F., Gleich, K., Tam, S., Fraser, S. A., Choy, S., Dwyer, K. M., Lü, B., van Denderen, B., Fingerle‐Rowson, G., Bucala, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029887 · Cited by 41

Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis

Basseri, S., Lhoták, Š., Fullerton, M. D., Palanivel, R., Jiang, H. L., Lynn, E. G., Ford, R. J., Maclean, K. N., Steinberg, G. R., & Austin, R. C. (2012) · Diabetes · doi:10.2337/db12-0256 · Cited by 40

The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

Day, E. A., Ford, R. J., Lu, J. H., Lu, R., Lundenberg, L., Desjardins, E. M., Green, A. E., Lally, J., Schertzer, J. D., & Steinberg, G. R. (2020) · Biochemical Journal · doi:10.1042/bcj20200278 · Cited by 41

Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK

Xu, H., Liu, M., Liu, H., Zhao, B., Zheng, M., & Liu, J. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104582 · Cited by 43

Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

Lee, M. K. S., Cooney, O. D., Lin, X., Nadarajah, S., Dragoljevic, D., Huynh, K., Onda, D.-A., Galić, S., Meikle, P. J., Edlund, H., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101514 · Cited by 38

AMPK inhibits liver gluconeogenesis: fact or fiction?

Johanns, M., Hue, L., & Rider, M. H. (2023) · Biochemical Journal · doi:10.1042/bcj20220582 · Cited by 46

Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney

Christensen, M. S., Jensen, J., Jakobsen, S., Jessen, N., Frøkiær, J., Kemp, B. E., Marciszyn, A. L., Li, H., Pastor‐Soler, N. M., Hallows, K. R., et al. (2016) · Scientific Reports · doi:10.1038/srep35952 · Cited by 37

Meroterpenoid-rich fraction of an ethanolic extract from Sargassum serratifolium alleviates obesity and non-alcoholic fatty liver disease in high fat-fed C57BL/6J mice

Kwon, M., Lim, S.-J., Joung, E., Lee, B., Oh, C., & Kim, H. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.05.063 · Cited by 37

CB1 receptor mediates the effects of glucocorticoids on AMPK activity in the hypothalamus

Scerif, M., Füzesi, T., Thomas, J., Kola, B., Grossman, A. B., Fekete, C., & Korbonits, M. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0192 · Cited by 36

AMP ‐activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events

Jiang, S., Wang, Y., Luo, L., Shi, F., Zou, J., Lin, H., Ying, Y., Luo, Y., Zhan, Z., Liu, P., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14279 · Cited by 36

Effect of 24 h Fasting on Gene Expression of AMPK, Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks

Liu, L., & LiXian, Z. (2012) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2012.12153 · Cited by 33

Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus

Liu, Y., Wang, D., & Yang, L. (2022) · Current Drug Targets · doi:10.2174/1389450123666220429082702 · Cited by 35

Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis

Kuwako, K.-I., & Okano, H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00354 · Cited by 29

AMP-Activated Protein Kinase a1 Protects Against Diet-Induced Insulin Resistance and Obesity

(2016)

Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity

Steinberg, G. R., O'Neill, H. M., Dzamko, N. L., Galic, S., Naim, T., Koopman, R., Jørgensen, S. B., Honeyman, J., Hewitt, K., Chen, Z.-P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.102434 · Cited by 164

Early prediction of outcome in acute pancreatitis: A retrospective study on single parameters and scores

Kemnitz, V., Beitz, A., Roos, A.-B., Schaerdl, D., Spaeth, R., Schmid, R. M., & Huber, W. (2016) · Pancreatology · doi:10.1016/j.pan.2016.05.060

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

Mottillo, E. P., Desjardins, E. M., Crane, J. D., Smith, B. K., Green, A. E., Ducommun, S., Henriksen, T. I., Rebalka, I. A., Razi, A., Sakamoto, K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.006 · Cited by 338

Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

Sun, G., Tarasov, A. I., McGinty, J., McDonald, A., Xavier, G. D. S., Gorman, T., Marley, A. E., French, P. M. W., Parker, H., Gribble, F. M., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1692-1 · Cited by 99