The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Storage Lipid Synthesis Is Non-essential in Yeast
Open accessAbstract
Steryl esters and triacylglycerol (TAG) are the main storage lipids in eukaryotic cells. In the yeast Saccharomyces cerevisiae, these storage lipids accumulate during stationary growth phase within organelles known as lipid bodies. We have used single and multiple gene disruptions to study storage lipid synthesis in yeast. Four genes, ARE1, ARE2, DGA1, and LRO1, were found to contribute to TAG synthesis. The most significant contribution is made by DGA1, which encodes a novel acyl-CoA:diacylglycerol acyltransferase. Two of the genes, ARE1 and ARE2, are also involved in steryl ester synthesis. A yeast strain that lacks all four genes is viable and has no apparent growth defects under standard conditions. The strain is devoid of both TAG and steryl esters, and fluorescence microscopy revealed that it also lacks lipid bodies. We conclude that neither storage lipids nor lipid bodies are essential for growth in yeast.
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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members
Cases, S., Stone, S. J., Zhou, P., Yen, E., Tow, B., Lardizabal, K. D., Voelker, T., & Farese, R. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106219200 · Cited by 818
DGAT2 Is a New Diacylglycerol Acyltransferase Gene Family
Lardizabal, K. D., Mai, J. T., Wagner, N. W., Wyrick, A., Voelker, T., & Hawkins, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106168200 · Cited by 371
Cited by
Dynamics and functions of lipid droplets
Olzmann, J. A., & Carvalho, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0085-z · Cited by 2,740
Lipid droplet biogenesis and functions in health and disease
Zadoorian, A., Du, X., & Yang, H. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00845-0 · Cited by 617
Lipid Production from Nannochloropsis
Ma, X.-N., Chen, T.-P., Yang, B., Liu, J., & Chen, F. (2016) · Marine Drugs · doi:10.3390/md14040061 · Cited by 394
Stone, S. J., Levin, M. C., Zhou, P., Han, J., Walther, T. C., & Farese, R. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805768200 · Cited by 390
Yeast lipid metabolism at a glance
Klug, L., & Daum, G. (2014) · FEMS Yeast Research · doi:10.1111/1567-1364.12141 · Cited by 349
Metadata
- Authors
- Sandager, L., Gustavsson, M. H., Ståhl, U., Dahlqvist, A., Wiberg, E., Banas, A., Lenman, M., Ronne, H., & Stymne, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 277
- Issue
- 8
- Pages
- 6478-6482
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2094758309
- Cited by
- 536
- References
- 3
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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