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Cited by 617Lipid metabolism and biosynthesisCancer, Lipids, and MetabolismLipid metabolism and disorders

Lipid droplet biogenesis and functions in health and disease

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Zadoorian, Armella, Du, Ximing, Yang, Hongyuan·2023·Nature Reviews Endocrinology
DOI 10.1038/s41574-023-00845-0PMC PMC10204695
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Abstract

Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being recognized for their versatility beyond energy storage. Advances uncovering the intricacies of their biogenesis and the diversity of their physiological and pathological roles have yielded new insights into lipid droplet biology. Despite these insights, the mechanisms governing the biogenesis and functions of lipid droplets remain incompletely understood. Moreover, the causal relationship between the biogenesis and function of lipid droplets and human diseases is poorly resolved. Here, we provide an update on the current understanding of the biogenesis and functions of lipid droplets in health and disease, highlighting a key role for lipid droplet biogenesis in alleviating cellular stresses. We also discuss therapeutic strategies of targeting lipid droplet biogenesis, growth or degradation that could be applied in the future to common diseases, such as cancer, hepatic steatosis and viral infection.

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Cited by

Sorted by citations

Authors
Zadoorian, A., Du, X., & Yang, H.
Affiliations
UNSW Sydney (AU)
Corresponding author
Yang, Hongyuan
ORCID
Venue
Nature Reviews Endocrinology
Publisher
Springer Science and Business Media LLC
Published
2023-05-23
Volume
19
Issue
8
Pages
443-459
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
DOI
10.1038/s41574-023-00845-0
PMC
PMC10204695
OpenAlex
W4377819991
Cited by
617
References
20
Citations by year
2026: 182 · 2025: 261 · 2024: 145 · 2023: 29
FWCI
13.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Reviews Endocrinology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Commons-TMC (Texas Medical Center) (submittedVersion)
Funders
  • Medical Research Council
  • Australian Research Council (DP210102576)
  • National Health and Medical Research Council (1141938, 1141939, 1144726, 2009852)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
lipid droplets, lipid droplet formation, lipid droplet degradation, cellular stress, energy storage, lipid metabolism, cancer, hepatic steatosis, viral infection
MeSH terms
Humans, Lipogenesis, Lipid Metabolism, Lipid Droplets

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