Yeast lipid metabolism at a glance
Open accessAbstract
During the last decades, lipids have gained much attention due to their involvement in health and disease. Lipids are required for the formation of membranes and contribute to many different processes such as cell signaling, energy supply, and cell death. Various organelles such as the endoplasmic reticulum, mitochondria, peroxisomes, and lipid droplets are involved in lipid metabolism. The yeast Saccharomyces cerevisiae has become a reliable model organism to study biochemistry, molecular biology, and cell biology of lipids. The availability of mutants bearing defects in lipid metabolic pathways and the ease of manipulation by culture conditions facilitated these investigations. Here, we summarize the current knowledge about lipid metabolism in yeast. We grouped this large topic into three sections dealing with (1) fatty acids; (2) membrane lipids; and (3) storage lipids. Fatty acids serve as building blocks for the synthesis of membrane lipids (phospholipids, sphingolipids) and storage lipids (triacylglycerols, steryl esters). Phospholipids, sterols, and sphingolipids are essential components of cellular membranes. Recent investigations addressing lipid synthesis, degradation, and storage as well as regulatory aspects are presented. The role of enzymes governing important steps of the different lipid metabolic pathways is described. Finally, the link between lipid metabolic and dynamic processes is discussed.
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Lipid droplets play an important role in overcoming the potential toxic effect of abnormal sterols and free fatty acids, and affect cellular energy homeostasis and lipid metabolism.
“Lipid droplets not only play an important role in overcoming the potential toxic effect of abnormal sterols and free fatty acids (FA), but also affect cellular energy homeostasis and lipid metabolism.”
From The synthesis, regulation, and functions of sterols in<i>Candida albicans</i>: Well-known but still lots to learn (2016) · cites this paper as [51]
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Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae
Hu, Z., He, B., Ma, L., Sun, Y., Niu, Y., & Zeng, B. (2017) · Indian Journal of Microbiology · doi:10.1007/s12088-017-0657-1 · Cited by 225 · see citing works
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Joshua, I., & Höfken, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040772 · Cited by 40 · see citing works
Geltinger, F., Tevini, J., Briza, P., Geiser, A., Bischof, J., Richter, K., Felder, T., & Rinnerthaler, M. (2020) · GeroScience · doi:10.1007/s11357-019-00103-0 · Cited by 26 · see citing works
- Authors
- Klug, L., & Daum, G.
- Affiliations
- Graz University of Technology (AT)
- Venue
- FEMS Yeast Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-03-05
- Volume
- 14
- Issue
- 3
- Pages
- 369-388
- ISSN
- 1567-1356 (ISSN-L)
- OpenAlex
- W2004399350
- Cited by
- 349
- References
- 225
- Citations by year
- 2026: 24 · 2025: 26 · 2024: 26 · 2023: 28 · 2022: 40 · 2021: 52 · 2020: 33 · 2019: 45 · 2018: 26 · 2017: 23 · 2016: 11 · 2015: 12 · 2014: 3
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Yeast Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- lipid metabolism, Saccharomyces cerevisiae, fatty acids, membrane lipids, storage lipids, phospholipids, sphingolipids, triglycerides, sterol esters, lipogenesis, lipid degradation, lipid metabolism enzymes, lipid metabolism regulation, lipid droplets, peroxisomes, endoplasmic reticulum, mitochondria
- MeSH terms
- Saccharomyces cerevisiae, Lipid Metabolism, Metabolic Networks and Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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