Cited by 349Lipid metabolism and biosynthesisCancer, Lipids, and MetabolismFungal and yeast genetics research

Yeast lipid metabolism at a glance

Open access
Klug, Lisa, Daum, Günther·2014·FEMS Yeast Research

Abstract

During the last decades, lipids have gained much attention due to their involvement in health and disease. Lipids are required for the formation of membranes and contribute to many different processes such as cell signaling, energy supply, and cell death. Various organelles such as the endoplasmic reticulum, mitochondria, peroxisomes, and lipid droplets are involved in lipid metabolism. The yeast Saccharomyces cerevisiae has become a reliable model organism to study biochemistry, molecular biology, and cell biology of lipids. The availability of mutants bearing defects in lipid metabolic pathways and the ease of manipulation by culture conditions facilitated these investigations. Here, we summarize the current knowledge about lipid metabolism in yeast. We grouped this large topic into three sections dealing with (1) fatty acids; (2) membrane lipids; and (3) storage lipids. Fatty acids serve as building blocks for the synthesis of membrane lipids (phospholipids, sphingolipids) and storage lipids (triacylglycerols, steryl esters). Phospholipids, sterols, and sphingolipids are essential components of cellular membranes. Recent investigations addressing lipid synthesis, degradation, and storage as well as regulatory aspects are presented. The role of enzymes governing important steps of the different lipid metabolic pathways is described. Finally, the link between lipid metabolic and dynamic processes is discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/1567-1364.12141

Cites

225 of 225 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Klug, L., & Daum, G.
Affiliations
Graz University of Technology (AT)
Venue
FEMS Yeast Research
Published
2014-03-05
Volume
14
Issue
3
Pages
369-388
ISSN
1567-1356 (ISSN-L)
OpenAlex
W2004399350
Cited by
349
References
225
Citations by year
2026: 24 · 2025: 26 · 2024: 26 · 2023: 28 · 2022: 40 · 2021: 52 · 2020: 33 · 2019: 45 · 2018: 26 · 2017: 23 · 2016: 11 · 2015: 12 · 2014: 3
FWCI
1.40
Type
journal article
Language
en
Open access
Locations
  • FEMS Yeast Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
lipid metabolism, Saccharomyces cerevisiae, fatty acids, membrane lipids, storage lipids, phospholipids, sphingolipids, triglycerides, sterol esters, lipogenesis, lipid degradation, lipid metabolism enzymes, lipid metabolism regulation, lipid droplets, peroxisomes, endoplasmic reticulum, mitochondria
MeSH terms
Saccharomyces cerevisiae, Lipid Metabolism, Metabolic Networks and Pathways

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review