Cited by 190Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamicsCancer-related molecular mechanisms research

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KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases

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Xiao, Ling, Chen, Yuanhong, Ji, Ming, Dong, Jixin·2011·Journal of Biological Chemistry

DOI 10.1074/jbc.m110.173468PMC PMC3048666

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Abstract

The Hippo pathway controls tissue growth and tumorigenesis by inhibiting cell proliferation and promoting apoptosis. Recent genetic studies in Drosophila identified Kibra as a novel regulator of Hippo signaling. Human KIBRA has been associated with memory performance and cell migration. However, it is unclear whether or how KIBRA is connected to the Hippo pathway in mammalian cells. Here, we show that KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif. KIBRA overexpression stimulates the phosphorylation of Yes-associated protein (YAP), the Hippo pathway effector. Conversely, depletion of KIBRA by RNA interference reduces YAP phosphorylation. Furthermore, KIBRA stabilizes Lats2 by inhibiting its ubiquitination. We also found that KIBRA mRNA is induced by YAP overexpression in both murine and human cells, suggesting the evolutionary conservation of KIBRA as a transcriptional target of the Hippo signaling pathway. Thus, our study revealed a new connection between KIBRA and mammalian Hippo signaling.

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Authors: Xiao, L., Chen, Y., Ji, M., & Dong, J.
Affiliations: University of Nebraska Medical Center (US)
Corresponding author: Ji, Ming
Dong, Jixin
ORCID: Xiao, Ling
Chen, Yuanhong
Ji, Ming
Dong, Jixin
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2011-03
Volume: 286
Issue: 10
Pages: 7788-7796
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m110.173468
PMC: PMC3048666
OpenAlex: W2000662094
Cited by: 190
References: 47
Citations by year: 2026: 4 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 13 · 2021: 14 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 17 · 2016: 11 · 2015: 14 · 2014: 13 · 2013: 19 · 2012: 11
FWCI: 7.98
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 3482 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Health and Human Services
University of Nebraska Medical Center
Johns Hopkins University
Nebraska Department of Health and Human Services
National Institutes of Health
National Center for Research Resources (5P20-RR018759-07, P20RR018759)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: KIBRA, Hippo signaling pathway, LATS1, LATS2, YAP, YAP phosphorylation, hydrophobic motif, kinase activation, ubiquitination, protein stability, transcriptional regulation, cell proliferation, apoptosis, tissue growth, carcinogenesis
MeSH terms: YAP-Signaling Proteins, Animals, Carrier Proteins, Drosophila melanogaster, Humans, Phosphoproteins, Phosphorylation, Proteins, Transcription Factors, Signal Transduction, Protein Serine-Threonine Kinases, Amino Acid Motifs, Tumor Suppressor Proteins, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Mice, Ubiquitination, HEK293 Cells

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KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases

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