Cooperation of adenosine with macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works

Signaling to NF-κB

Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842 · see citing works

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works

HIF-1α is essential for myeloid cell-mediated inflammation

Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00154-5 · Cited by 2,046 · see citing works

Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation

Vats, D., Mukundan, L., Odegaard, J. I., Zhang, L., Smith, K. L., Morel, C. R., Greaves, D. R., Murray, P. J., & Chawla, A. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.011 · Cited by 1,369 · see citing works

Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage

Ohta, A., & Sitkovsky, M. V. (2001) · Nature · doi:10.1038/414916a · Cited by 1,336 · see citing works

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

Haskó, G., Linden, J. M., Cronstein, B. N., & Pacher, P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2638 · Cited by 1,224 · see citing works

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

Rodríguez-Prados, J.-C., Través, P. G., Cuenca, J., Rico, D., Aragonés, J., Martín-Sanz, P., Cascante, M., & Boscá, L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901698 · Cited by 1,022 · see citing works

Adenosine: an endogenous regulator of innate immunity

Haskó, G. (2003) · Trends in Immunology · doi:10.1016/j.it.2003.11.003 · Cited by 900 · see citing works

Inflammatory Resolution: new opportunities for drug discovery

Gilroy, D. W., Lawrence, T., Perretti, M., & Rossi, A. G. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1383 · Cited by 772 · see citing works

P hysiological C ontrol of I mmune R esponse and I nflammatory T issue D amage by H ypoxia -I nducible F actors and A denosine A 2A R eceptors

Sitkovsky, M. V., Lukashev, D. E., Apasov, S. G., Kojima, H., Koshiba, M., Caldwell, C. C., Ohta, A., & Thiel, M. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104731 · Cited by 697 · see citing works

IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis

Jung, Y., Isaacs, J. S., Lee, S., Trepel, J. B., & Neckers, L. (2003) · The FASEB Journal · doi:10.1096/fj.03-0329fje · Cited by 680 · see citing works

A Kinetic Study of Pyrophosphate: Fructose‐6‐Phosphate Phosphotransferase from Potato Tubers

SCHAFTINGEN, E. V., Lederer, B., Bartrons, R., & Hers, H. G. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb07039.x · Cited by 652 · see citing works

Adenosine, an endogenous anti-inflammatory agent

Cronstein, B. N. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.76.1.5 · Cited by 633 · see citing works

Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors

Sitkovsky, M., & Lukashev, D. (2005) · Nature Reviews Immunology · doi:10.1038/nri1685 · Cited by 518 · see citing works

Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism

Castrillo, A., Joseph, S. B., Vaidya, S. A., Haberland, M. E., Fogelman, A. M., Cheng, G., & Tontonoz, P. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00384-8 · Cited by 488 · see citing works

Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway

Almeida, Á., Moncada, S., & Bolaños, J. P. (2003) · Nature Cell Biology · doi:10.1038/ncb1080 · Cited by 481 · see citing works

Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1α

Blouin, C. C., Pagé, E. L., Soucy, G. M., & Richard, D. E. (2003) · Blood · doi:10.1182/blood-2003-07-2427 · Cited by 459 · see citing works

Hypoxia Regulates Macrophage Functions in Inflammation

Murdoch, C., Muthana, M., & Lewis, C. E. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6257 · Cited by 455 · see citing works

Induction of Hypoxia-inducible Factor-1α by Transcriptional and Translational Mechanisms

Pagé, E. L., Robitaille, G., Pouysségur, J., & Richard, D. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209114200 · Cited by 385 · see citing works

The Stimulation of Glycolysis by Hypoxia in Activated Monocytes Is Mediated by AMP-activated Protein Kinase and Inducible 6-Phosphofructo-2-kinase

Marsin, A.-S., Bouzin, C., Bertrand, L., & Hue, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205213200 · Cited by 380 · see citing works

Hypoxia-inducible Factor-1-mediated Expression of the 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) Gene

Minchenko, О. H., Leshchinsky, I., Opentanova, I., Sang, N., Srinivas, V., Armstead, V. E., & Caro, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110978200 · Cited by 370 · see citing works

PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate

Okar, D. A., Lange, A. J., Manzano, À., Navarro‐Sabaté, À., Riera, L., & Bartrons, R. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01699-6 · Cited by 356 · see citing works

Revving the Engine: Signal Transduction Fuels T Cell Activation

Jones, R. G., & Thompson, C. B. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.008 · Cited by 349 · see citing works

Sp1 Phosphorylation and Its Regulation of Gene Transcription

Tan, N. Y., & Khachigian, L. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01828-08 · Cited by 344 · see citing works

High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers.

Atsumi, T., Chesney, J. A., Metz, C. N., Leng, L., Donnelly, S. C., Makita, Z., Mitchell, R., & Bucala, R. (2002) · PubMed · Cited by 322 · see citing works

The Pasteur effect and the relations between respiration and fermentation.

Ha, K. (1972) · PubMed · Cited by 309 · see citing works

Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals

Litvak, V., Ramsey, S. A., Rust, A. G., Zak, D. E., Kennedy, K. A., Lampano, A. E., Nykter, M., Shmulevich, I., & Aderem, A. (2009) · Nature Immunology · doi:10.1038/ni.1721 · Cited by 295 · see citing works

Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6

Natsuka, S., Akira, S., Nishio, Y., Hashimoto, S., Sugita, T., Isshiki, H., & Kishimoto, T. (1992) · Blood · doi:10.1182/blood.v79.2.460.460 · Cited by 289 · see citing works

An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: Role in tumor cell glycolysis and the Warburg effect

Chesney, J. A., Mitchell, R., Benigni, F., Bacher, M., Spiegel, L. A., Al‐Abed, Y., Han, J. H., Metz, C. N., & Bucala, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3047 · Cited by 284 · see citing works

6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE: A METABOLIC SIGNALING ENZYME

Pilkis, S. J., Claus, T. H., Kurland, I. J., & Lange, A. J. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.004055 · Cited by 278 · see citing works

An Angiogenic Switch in Macrophages Involving Synergy between Toll-Like Receptors 2, 4, 7, and 9 and Adenosine A2A Receptors

Pinhal-Enfield, G., Ramanathan, M., Hasko, G., Vogel, S. N., Salzman, A. L., Boons, G.-J., & Leibovich, S. J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63698-x · Cited by 278 · see citing works

6-Phosphofructo-2-kinase (pfkfb3) Gene Promoter Contains Hypoxia-inducible Factor-1 Binding Sites Necessary for Transactivation in Response to Hypoxia

Obach, M., Navarro‐Sabaté, À., Caro, J., Kong, X., Duran, J., Gómez, M., Perales, J. C., Ventura, F., Rosa, J. L., & Bartrons, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406096200 · Cited by 274 · see citing works

The ‘danger’ sensors that STOP the immune response: the A2 adenosine receptors?

Sitkovsky, M. V., & Ohta, A. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.04.004 · Cited by 265 · see citing works

A2A receptors in inflammation and injury: lessons learned from transgenic animals

Haskó, G., & Pacher, P. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0607359 · Cited by 240 · see citing works

Inflammatory Cytokines Regulate Function and Expression of Adenosine A2A Receptors in Human Monocytic THP-1 Cells

Khoa, N. D., Montesinos, M. C., Reiss, A. B., Delano, D. L., Awadallah, N. W., & Cronstein, B. N. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.4026 · Cited by 234 · see citing works

NF-IL6 and NF-kappa B in cytokine gene regulation.

Akira, S., & Kishimoto, T. (1997) · PubMed · Cited by 231 · see citing works

Regulation of the Hypoxia-inducible Factor 1α by the Inflammatory Mediators Nitric Oxide and Tumor Necrosis Factor-α in Contrast to Desferroxamine and Phenylarsine Oxide

Sandau, K. B., Zhou, J., Kietzmann, T., & Brüne, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107689200 · Cited by 214 · see citing works

Phosphorylation of the 6-Phosphofructo-2-Kinase/Fructose 2,6-Bisphosphatase/PFKFB3 Family of Glycolytic Regulators in Human Cancer

Bando, H., Atsumi, T., Nishio, T., Niwa, H., Mishima, S., Shimizu, C., Yoshioka, N., Bucala, R., & Koike, T. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0149 · Cited by 208 · see citing works

A2A adenosine receptors and C/EBPβ are crucially required for IL-10 production by macrophages exposed to Escherichia coli

Csóka, B., Nemeth, Z. H., Virág, L., Gergely, P., Leibovich, S. J., Pacher, P., Sun, C.-X., Blackburn, M. R., Vizi, E. S., Deitch, E. A., et al. (2007) · Blood · doi:10.1182/blood-2007-01-065870 · Cited by 205 · see citing works

NF-IL6 and NF-κB in Cytokine Gene Regulation

Akira, S., & Kishimoto, T. (1997) · Advances in immunology · doi:10.1016/s0065-2776(08)60740-3 · Cited by 201 · see citing works

Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients

Escoll, P., del Fresno, C., Garcia, L. G., Vallés, G., Lendinez, M. J., Arnalich, F., & López‐Collazo, E. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.10.019 · Cited by 199 · see citing works

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappaB activation

Jung, Y., Isaacs, J. S., Lee, S., Trepel, J. B., Liu, Z.-G., & Neckers, L. (2003) · Biochemical Journal · doi:10.1042/bj20021279 · Cited by 190 · see citing works

Activation of Hypoxia-Inducible Factor-1 in Bacillary Angiomatosis

Kempf, V. A. J., Lebiedziejewski, M., Alitalo, K. K., Wälzlein, J.-H., Ehehalt, U., Fiebig, J., Huber, S. M., Schüett, B. S., Sander, C. A., Müller, S., et al. (2005) · Circulation · doi:10.1161/01.cir.0000155608.07691.b7 · Cited by 162 · see citing works

Cutting Edge: Physiologic Attenuation of Proinflammatory Transcription by the Gs Protein-Coupled A2A Adenosine Receptor In Vivo

Lukashev, D. E., Ohta, A., Apasov, S. G., Chen, J., & Sitkovsky, M. V. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.21 · Cited by 153 · see citing works

Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-κB in A2A adenosine receptor induction

Murphree, L. J., Sullivan, G. W., Marshall, M. A., & Linden, J. M. (2005) · Biochemical Journal · doi:10.1042/bj20050888 · Cited by 138 · see citing works

Synergistic Up-Regulation of Vascular Endothelial Growth Factor (VEGF) Expression in Macrophages by Adenosine A2AReceptor Agonists and Endotoxin Involves Transcriptional Regulation via the Hypoxia Response Element in the VEGF Promoter

Ramanathan, M., Pinhal‐Enfield, G., Hao, I., & Leibovich, S. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0596 · Cited by 124 · see citing works

C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment

Yeamans, C., Wang, D., Paz-Priel, I., Torbett, B. E., Tenen, D. G., & Friedman, A. D. (2007) · Blood · doi:10.1182/blood-2007-03-080291 · Cited by 118 · see citing works

Hypoxia inhibits macrophage migration

Turner, L., Scotton, C. J., Negus, R. P. M., & Balkwill, F. R. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199907)29:07 · Cited by 117 · see citing works

Lipopolysaccharide-induced transcriptional activation of interleukin-10 is mediated by MAPK- and NF-κB-induced CCAAT/enhancer-binding protein δ in mouse macrophages

Liu, Y., Chen, C.-C., Tseng, H.-P., & Chang, W. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.12.001 · Cited by 103 · see citing works

Adenosine A2a receptor-mediated, normoxic induction of HIF-1 through PKC and PI-3K-dependent pathways in macrophages

Ponti, C. D., Carini, R., Alchera, E., Nitti, M. P., Locati, M., Albano, E., Cairo, G., & Tacchini, L. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0107060 · Cited by 76 · see citing works

Adenosine stimulates CREB activation in macrophages via a p38 MAPK-mediated mechanism

Németh, Z. H., Leibovich, S. J., Deitch, E. A., Sperlágh, B., Virág, L., Vizi, E. S., Szabó, C., & Haskó, G. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.006 · Cited by 75 · see citing works

Epidermal Growth Factor Induction of Apolipoprotein A-I Is Mediated by the Ras-MAP Kinase Cascade and Sp1

Zheng, X., Matsubara, S., Diao, C. T. M., Hollenberg, M. D., & Wong, N. C. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011031200 · Cited by 67 · see citing works

Regulation of Energy Metabolism in Macrophages during Hypoxia

Kawaguchi, T., Veech, R. L., & Uyeda, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101396200 · Cited by 65 · see citing works

THE NATURE OF LEUKEMIC BLOOD CELLS AS DETERMINED BY THEIR METABOLISM

Kempner, W. (1939) · Journal of Clinical Investigation · doi:10.1172/jci101045 · Cited by 64 · see citing works

The C/EBPβ Isoform 34-kDa LAP Is Responsible for NF-IL-6-Mediated Gene Induction in Activated Macrophages, but Is Not Essential for Intracellular Bacteria Killing

Uematsu, S., Kaisho, T., Tanaka, T., Matsumoto, M., Yamakami, M., Omori, H., Yamamoto, M., Yoshimori, T., & Akira, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5378 · Cited by 61 · see citing works

Activation of Apolipoprotein AI Gene Expression by Protein Kinase A and Kinase C through Transcription Factor, Sp1

Zheng, X., Matsubara, S., Diao, C. T. M., Hollenberg, M. D., & Wong, N. C. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000621200 · Cited by 56 · see citing works

L(+) LACTIC ACID AND THE STEADY STATE OF CELLULAR RED/OX‐SYSTEMS

Hohorst, H. J., Arese, P., Bartels, H., Stratmann, D., & Talke, H. (1965) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1965.tb47456.x · Cited by 52 · see citing works

Interleukin-21 Receptor Gene Induction in Human T Cells Is Mediated by T-Cell Receptor-Induced Sp1 Activity

Wu, Z., Kim, H., Xue, H., Liu, H., Zhao, K., & Leonard, W. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.9741-9752.2005 · Cited by 49 · see citing works

Insulin induces PFKFB3 gene expression in HT29 human colon adenocarcinoma cells

Riera, L., Manzano, À., Navarro‐Sabaté, À., Perales, J. C., & Bartrons, R. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00169-6 · Cited by 48 · see citing works

The human ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3): promoter characterization and genomic structure

Navarro‐Sabaté, À., Manzano, À., Riera, L., Rosa, J. L., Ventura, F., & Bartrons, R. (2001) · Gene · doi:10.1016/s0378-1119(00)00591-6 · Cited by 42 · see citing works

Pfkfb3is transcriptionally upregulated in diabetic mouse liver through proliferative signals

Duran, J., Obach, M., Navarro‐Sabaté, À., Manzano, À., Gómez, M., Rosa, J. L., Ventura, F., Perales, J. C., & Bartrons, R. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07161.x · Cited by 37 · see citing works

Regulation of ubiquitous 6‐phosphofructo‐2‐kinase by the ubiquitin‐proteasome proteolytic pathway during myogenic C2C12 cell differentiation

Riera, L., Obach, M., Navarro‐Sabaté, À., Duran, J., Perales, J. C., Viñals, F., Rosa, J. L., Ventura, F., & Bartrons, R. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00808-1 · Cited by 35 · see citing works

Role of transcriptional factors Sp1, c-Rel, and c-Jun in LPS-induced C/EBPδ gene expression of mouse macrophages

Liu, Y.-W., Chen, C.-C., Wang, J.-M., Chang, W., Huang, Y.-C., Chung, S.-Y., Chen, B.-K., & Hung, J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7375-5 · Cited by 33 · see citing works

Effects of 2-deoxy-D-glucose on human monocyte metabolism and function.

Kay, N. E., Bumol, T. F., & Douglas, S. D. (1980) · PubMed · Cited by 9 · see citing works

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

Kelly, B., & O'Neill, L. A. (2015) · Cell Research · doi:10.1038/cr.2015.68 · Cited by 1,876 · see citing works

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

Hoque, R., Farooq, A., Ghani, A., Gorelick, F. S., & Mehal, W. Z. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.03.014 · Cited by 576 · see citing works

Macrophages and the Recovery from Acute and Chronic Inflammation

Hamidzadeh, K., Christensen, S. M., Dalby, E., Chandrasekaran, P., & Mosser, D. M. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034348 · Cited by 439 · see citing works

Roles of PFKFB3 in cancer

Shi, L., Pan, H., Liu, Z., Xie, J., & Han, W. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.44 · Cited by 293 · see citing works

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

Penny, H. L., Sieow, J. L., Adriani, G., Yeap, W. H., See, P., Luis, B. S., Lee, B. T. K., Lee, T. K., Mak, S. Y., Ho, Y. S., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1191731 · Cited by 255 · see citing works

Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis

Tabas, I. A., & Bornfeldt, K. (2020) · Circulation Research · doi:10.1161/circresaha.119.315939 · Cited by 249 · see citing works

Regulation of Macrophage Function by Adenosine

Haskó, G., & Pacher, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.226852 · Cited by 223 · see citing works

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

Holland, R., McIntosh, A. L., Finucane, O. M., Mela, V., Rubio‐Araiz, A., Timmons, G. A., McCarthy, S. A., Gun’ko, Y. K., & Lynch, M. A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.017 · Cited by 218 · see citing works

Macrophage function in obesity-induced inflammation and insulin resistance

Lauterbach, M., & Wunderlich, F. T. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1955-5 · Cited by 209 · see citing works

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

McIntosh, A. L., Mela, V., Harty, C., Minogue, A. M., Costello, D. A., Kerskens, C., & Lynch, M. A. (2019) · Brain Pathology · doi:10.1111/bpa.12704 · Cited by 190 · see citing works

Specific and Complex Reprogramming of Cellular Metabolism in Myeloid Cells during Innate Immune Responses

Stienstra, R., Netea-Maier, R. T., Riksen, N. P., Joosten, L. A. B., & Netea, M. G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.001 · Cited by 194 · see citing works

TGF ‐β1 targets Smad, p38 MAPK , and PI 3K/Akt signaling pathways to induce PFKFB 3 gene expression and glycolysis in glioblastoma cells

Rodríguez‐García, A., Samsó, P., Fontova, P., Simon‐Molas, H., Manzano, À., Castaño, E., Rosa, J. L., Martinez-Outshoorn, U. E., Ventura, F., Navarro‐Sabaté, À., et al. (2017) · FEBS Journal · doi:10.1111/febs.14201 · Cited by 174 · see citing works

Neuroglial Transmission

Gundersen, V., Storm‐Mathisen, J., & Bergersen, L. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00024.2014 · Cited by 172 · see citing works

Time and Demand are Two Critical Dimensions of Immunometabolism: The Process of Macrophage Activation and the Pentose Phosphate Pathway

Nagy, C., & Haschemi, A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00164 · Cited by 164 · see citing works

Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation

Woods, P. S., Kimmig, L. M., Meliton, A. Y., Sun, K. A., Tian, Y., O’Leary, E. M., Gökalp, G. A., Hamanaka, R. B., & Mutlu, G. M. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0244oc · Cited by 145 · see citing works

Fructose 2,6-Bisphosphate in Cancer Cell Metabolism

Bartrons, R., Simon‐Molas, H., Rodríguez‐García, A., Castaño, E., Navarro‐Sabaté, À., Manzano, À., & Martinez‐Outschoorn, U. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00331 · Cited by 134 · see citing works

PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense

Jiang, H., Shi, H., Sun, M., Wang, Y., Meng, Q., Guo, P., Cao, Y., Chen, J., Gao, X., Li, E., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600474 · Cited by 117 · see citing works

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid

Rubio‐Araiz, A., Finucane, O. M., Keogh, S., & Lynch, M. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1281-7 · Cited by 114 · see citing works

HIF1α-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection

Li, C., Wang, Y., Li, Y., Yu, Q., Jin, X., Wang, X., Jia, A., Hu, Y., Han, L., Wang, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22039-9 · Cited by 101 · see citing works

TET2 Regulates the Neuroinflammatory Response in Microglia

Carrillo-Jimenez, A., Deniz, Ö., Niklison-Chirou, M. V., Ruiz, R., Bezerra-Salomão, K., Stratoulias, V., Amouroux, R., Yip, P. K., Vilalta, A., Cheray, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.013 · Cited by 104 · see citing works

Perception of self: distinguishing autoimmunity from autoinflammation

van Kempen, T. S., Wenink, M. H., Leijten, E. F. A., Radstake, T. R. D. J., & Boes, M. L. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.60 · Cited by 105 · see citing works

Origins and diversity of macrophages in health and disease

Sreejit, G., Fleetwood, A. J., Murphy, A. J., & Nagareddy, P. R. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1222 · Cited by 102 · see citing works

Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells

Minchenko, О. H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i38.13705 · Cited by 94 · see citing works

The potential utility of PFKFB3 as a therapeutic target

Bartrons, R., Rodríguez‐García, A., Simon‐Molas, H., Castaño, E., Manzano, À., & Navarro‐Sabaté, À. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1498082 · Cited by 90 · see citing works

Can the emerging field of immunometabolism provide insights into neuroinflammation?

Lynch, M. A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101719 · Cited by 87 · see citing works

Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis

Nishizawa, T., Kanter, J. E., Kramer, F., Barnhart, S., Shen, X., Vivekanandan-Giri, A., Wall, V. Z., Kowitz, J., Devaraj, S., O’Brien, K. D., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.028 · Cited by 87 · see citing works

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

Novellasdemunt, L., Bultot, L., Manzano, À., Ventura, F., Rosa, J. L., Vertommen, D., Rider, M. H., Navarro‐Sabaté, À., & Bartrons, R. (2013) · Biochemical Journal · doi:10.1042/bj20121886 · Cited by 87 · see citing works

Neuroinflammatory inhibition of synaptic long‐term potentiation requires immunometabolic reprogramming of microglia

York, E. M., Zhang, J., Choi, H. B., & MacVicar, B. A. (2020) · Glia · doi:10.1002/glia.23913 · Cited by 78 · see citing works

Role of purines in regulation of metabolic reprogramming

Tang, Z., Ye, W., Chen, H., Kuang, X., Guo, J., Xiang, M., Peng, C., Chen, X., & Liu, H. (2019) · Purinergic Signalling · doi:10.1007/s11302-019-09676-z · Cited by 72 · see citing works

Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities

Stroope, C., Nettersheim, F. S., Coon, B. G., Finney, A. C., Schwartz, M. A., Ley, K. F., Rom, O., & Yurdagul, A. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01015-w · Cited by 72 · see citing works

Acyl-CoA Synthetase 1 Is Induced by Gram-negative Bacteria and Lipopolysaccharide and Is Required for Phospholipid Turnover in Stimulated Macrophages

Rubinow, K. B., Wall, V., Nelson, J. D., Mar, D., Bomsztyk, K., Askari, B., Lai, M. A., Smith, K. D., Han, M. S., Vivekanandan‐Giri, A., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.458372 · Cited by 67 · see citing works

Role of PFKFB3-driven glycolysis in sepsis

Xiao, M., Liu, D., Xu, Y., Mao, W., & Li, W. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2191217 · Cited by 64 · see citing works

Metabolic reprogramming and interventions in angiogenesis

Liu, Y., Wu, Z., Li, Y., Chen, Y., Zhao, X., Wu, M., & Xia, Y. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.001 · Cited by 68 · see citing works

Augmented PFKFB3-mediated glycolysis by interferon-γ promotes inflammatory M1 polarization through the JAK2/STAT1 pathway in local vascular inflammation in Takayasu arteritis

Chen, R., Wang, J., Dai, X., Wu, S., Huang, Q., Jiang, L., & Kong, X. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02960-1 · Cited by 53 · see citing works

Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells

Crean, D., Cummins, E. P., Bahar, B., Mohan, H. M., McMorrow, J. P., & Murphy, E. P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402039 · Cited by 52 · see citing works

ZIF-8-based Nanoparticles for Inflammation Treatment and Oxidative Stress Reduction in Periodontitis

Li, Y., Xu, C., Mao, J., Mao, L., Li, W., Liu, Z., Shin, A., Wu, J., Hou, L., Li, D., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c05722 · Cited by 52 · see citing works

Peripheral Blood Monocyte Gene Expression Profile Clinically Stratifies Patients With Recent-Onset Type 1 Diabetes

Irvine, K. M., Gallego, P., An, X., Best, S. E., Thomas, G. P., Wells, C. A., Harris, M. A., Cotterill, A. M., & Thomas, R. (2012) · Diabetes · doi:10.2337/db11-1549 · Cited by 49 · see citing works

Age-associated metabolic dysregulation in bone marrow-derived macrophages stimulated with lipopolysaccharide

Fei, F., Lee, K. M., McCarry, B. E., & Bowdish, D. M. E. (2016) · Scientific Reports · doi:10.1038/srep22637 · Cited by 49 · see citing works

A2a and a2b adenosine receptors affect HIF‐1α signaling in activated primary microglial cells

Merighi, S., Borea, P. A., Stefanelli, A., Bencivenni, S., Castillo, C. A., Varani, K., & Gessi, S. (2015) · Glia · doi:10.1002/glia.22861 · Cited by 44 · see citing works

PFKFB3/HIF-1α feedback loop modulates sorafenib resistance in hepatocellular carcinoma cells

Qian, L., Zou, X., Song, Y., Duan, Z., & Liu, L. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.109 · Cited by 40 · see citing works

Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation

Wang, M., Flaswinkel, H., Joshi, A., Napoli, M., Masgrau‐Alsina, S., Kamper, J. M., Henne, A., Heinz, A., Bérouti, M., Schmacke, N. A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50104-7 · Cited by 37 · see citing works

Inflammaging and fatty acid oxidation in monocytes and macrophages

Kruglov, V., Jang, I. H., & Camell, C. D. (2024) · Immunometabolism · doi:10.1097/in9.0000000000000038 · Cited by 38 · see citing works

Adenosine stimulates angiogenesis by up-regulating production of thrombospondin-1 by macrophages

Ernens, I., Bousquenaud, M., Lenoir, B., Devaux, Y., & Wagner, D. R. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3hi0514-249rr · Cited by 35 · see citing works

BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes

Kühtreiber, W. M., Takahashi, H., Keefe, R. C., Song, Y., Tran, L., Luck, T. G., Shpilsky, G. F., Moore, L., Sinton, S. M., Graham, J. C., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101085 · Cited by 35 · see citing works

The flux of energy in critical illness and the obesity paradox

Jaitovich, A., & Hall, J. B. (2025) · Physiological Reviews · doi:10.1152/physrev.00029.2024 · Cited by 33 · see citing works

Effects of glycolysis on the polarization and function of tumor‑associated macrophages (Review)

Cao, J., Zeng, F., Liao, S., Cao, L., & Zhou, Y. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5518 · Cited by 31 · see citing works

PI3K–Akt signaling controls PFKFB3 expression during human T-lymphocyte activation

Simon‐Molas, H., Arnedo-Pac, C., Fontova, P., Vidal‐Alabró, A., Castaño, E., Rodríguez‐García, A., Navarro‐Sabaté, À., Lloberas, N., Manzano, À., & Bartrons, R. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3325-9 · Cited by 29 · see citing works

Disuse-induced insulin resistance susceptibility coincides with a dysregulated skeletal muscle metabolic transcriptome

Mahmassani, Z. S., Reidy, P. T., McKenzie, A. I., Stubben, C., Howard, M. T., & Drummond, M. J. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01093.2018 · Cited by 29 · see citing works

Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease

Decano, J. L., & Aikawa, M. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00097 · Cited by 28 · see citing works

Macrophage NOS2 in Tumor Leukocytes

Brüne, B., Courtial, N., Dehne, N., Syed, S. N., & Weigert, A. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6811 · Cited by 28 · see citing works

Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells

Zhu, B., Guo, X., Xu, H., Jiang, B., Li, H., Wang, Y., Yin, Q., Zhou, T., Cai, J. J., Glaser, S. S., et al. (2021) · Laboratory Investigation · doi:10.1038/s41374-020-00523-z · Cited by 26 · see citing works

Anti-inflammatory effect of the medicinal herbal mixture infusion, Horchata, from southern Ecuador against LPS-induced cytotoxic damage in RAW 264.7 macrophages

Guevara, M., Tejera, E., Iturralde, G. A., Jaramillo-Vivanco, T., Granda-Albuja, M. G., Granda-Albuja, S., Santos‐Buelga, C., Paramás, A. M. G., & Álvarez-Suárez, J. M. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110594 · Cited by 25 · see citing works

Glycolytic reprogramming in microglia: A potential therapeutic target for ischemic stroke

Zhang, G., Zhao, A., Zhang, X., Zeng, M., Wei, H., Xu, Y., Wang, J., Jiang, X., & Dai, Y. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111466 · Cited by 23 · see citing works

Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors

Alvarez, R., Mandal, D., & Chittiboina, P. (2021) · Cells · doi:10.3390/cells10112913 · Cited by 23 · see citing works

HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation

Radford‐Smith, D. E., Yates, A. G., Rizvi, L., Anthony, D. C., & Probert, F. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01817-z · Cited by 23 · see citing works

PFKFB3 promotes endotoxemia-induced myocardial dysfunction through inflammatory signaling and apoptotic induction

Tian, W., Guo, H.-S., Li, C., Cao, W., Wang, X., Mo, D., Hao, X.-W., Feng, Y.-D., Sun, Y., Fan, L., et al. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.02.007 · Cited by 22 · see citing works

WIN55212-2 alleviates acute lung injury by inhibiting macrophage glycolysis through the miR-29b-3p/FOXO3/PFKFB3 axis

He, Q., Yin, J., Zou, B., & Guo, H. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.06.005 · Cited by 22 · see citing works

The Contact Allergen NiSO4 Triggers a Distinct Molecular Response in Primary Human Dendritic Cells Compared to Bacterial LPS

Höper, T., Siewert, K., Dumit, V. I., von Bergen�, M., Schubert, K. A., & Haase, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.644700 · Cited by 21 · see citing works

Uncomplicating the Macrovascular Complications of Diabetes: The 2014 Edwin Bierman Award Lecture

Bornfeldt, K. (2015) · Diabetes · doi:10.2337/db14-1963 · Cited by 18 · see citing works

The crucial role of metabolic reprogramming in driving macrophage conversion in kidney disease

Gong, N., Wang, W., Fu, Y., Zheng, X., Guo, X., Chen, Y., Chen, Y., Zheng, S., & Cai, G. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00746-2 · Cited by 20 · see citing works

Effect of different early weaning regimens for calves on adipogenic gene expression in Hanwoo loin at the fattening stage

Reddy, K. E., Jeong, J. Y., Lee, S. D., Baek, Y.-C., Oh, Y., Kim, M., So, K.-M., Kim, D. W., Kim, J. H., Park, S., et al. (2016) · Livestock Science · doi:10.1016/j.livsci.2016.11.014 · Cited by 17 · see citing works

Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis

Gai, X., Liu, F., Wu, Y., Zhang, B., Tang, B., Shang, K., Wang, L., Zhang, H., Chen, Y., Yang, S., et al. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12266 · Cited by 16 · see citing works

Pathogenic role of PFKFB3 in endothelial inflammatory diseases

Zhou, L., Li, J., Wang, J., Niu, X., Li, J., & Zhang, K. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1454456 · Cited by 15 · see citing works

MiR-106a-5p targets PFKFB3 and improves sepsis through regulating macrophage pyroptosis and inflammatory response

Chen, Y., Zhang, P., Han, F., Zhou, Y., Wei, J.-X., Wang, C., Song, M., Lin, S.-P., Xu, Y., & Chen, X. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107334 · Cited by 14 · see citing works

PFKFB3 knockdown attenuates Amyloid β-Induced microglial activation and retinal pigment epithelium disorders in mice

Wang, Y., Han, S., Chen, J., Sun, J., & Sun, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109691 · Cited by 15 · see citing works

Hyperglycemia induces PFKFB3 overexpression and promotes malignant phenotype of breast cancer through RAS/MAPK activation

Cheng, X., Jia, X., Wang, C., Zhou, S., Chen, J., Chen, L., & Chen, J. (2023) · World Journal of Surgical Oncology · doi:10.1186/s12957-023-02990-2 · Cited by 14 · see citing works

Protective Effect of Mesenchymal Stem Cells on Isolated Islets Survival and Against Hypoxia Associated With the HIF-1α/PFKFB3 Pathway

Wei, L., Zhang, L.-J., Yang, L.-Y., Wang, X., Zhao, C.-H., & Zhao, D. (2022) · Cell Transplantation · doi:10.1177/09636897211073127 · Cited by 13 · see citing works

HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages

Woods, P. S., Çetin-Atalay, R., Meliton, A. Y., Sun, K. A., Shamaa, O. R., Shin, K. W. D., Tian, Y., Haugen, B., Hamanaka, R. B., & Mutlu, G. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-95962-3 · Cited by 13 · see citing works

Hypoxia regulates GR function through multiple mechanisms involving microRNAs 103 and 107

Yang, N., Berry, A. A., Sauer, C. M., Baxter, M. D., Donaldson, I. J., Forbes, K. A., Donn, R. P., Matthews, L. C., & Ray, D. W. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111007 · Cited by 12 · see citing works

The role of glycolysis in immune response

Budikhina, A. S., & Pashenkov, M. V. (2021) · Immunologiya · doi:10.33029/0206-4952-2021-42-1-5-20 · Cited by 9 · see citing works

Costly immunometabolic remodelling in disused muscle buildup through physical exercise

Padilha, C. S., Figueiredo, C., Deminice, R., Krüger, K., Seelaender, M. C. L., Neto, J. C. R., & Lira, F. S. (2022) · Acta Physiologica · doi:10.1111/apha.13782 · Cited by 7 · see citing works

Genomic Deletion of PFKFB3 Decreases In Vivo Tumorigenesis

Imbert-Fernandez, Y., Chang, S., Lanceta, L., Sanders, N. M., Chesney, J. A., Clem, B. F., & Telang, S. (2024) · Cancers · doi:10.3390/cancers16132330 · Cited by 6 · see citing works

PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3)

Novellasdemunt, L., Navarro‐Sabaté, À., Manzano, À., Rodríguez‐García, A., & Bartrons, R. (2013) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/51425 · Cited by 5 · see citing works

Metabolic Reprogramming of Fibroblastic Reticular Cells in Immunity and Tolerance

Kong, D., WillsonShirkey, M., Piao, W., Wu, L., Luo, S., Kensiski, A., Zhao, J., Lee, Y., Abdi, R., Zheng, H., et al. (2024) · European Journal of Immunology · doi:10.1002/eji.202451321 · Cited by 3 · see citing works

Glucose Metabolism and Innate Immune Responses in Influenza Virus Infection: Mechanistic Insights and Clinical Perspectives

Awad, K., Shahin, N. N., Motawi, T. K., Abdelhadi, M., Barghash, R., Awad, A. M., Kakkola, L., & Julkunen, I. (2025) · Cells · doi:10.3390/cells15010047 · Cited by 3 · see citing works

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3: A potential target in the development of diabetes and its complications.

Jiang, M., & An, X.-F. (2026) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2026.156621 · Cited by 2 · see citing works

Adenosine and Multiple Sclerosis

Sánchez‐Gómez, M. V., González‐Fernández, E., Arellano, R. O., & Matute, C. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3903-5_21 · Cited by 2 · see citing works

Type 2 Immunity and Metabolism

Prahalad, P., Odegaard, J. I., & Chawla, A. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2911-5_9 · Cited by 2 · see citing works

GPR81 LACTATE RECEPTORS IN THE REGULATION OF CELL FUNCTIONAL ACTIVITY

Boytsova, E. B., Morgun, A., Martynova, G. P., Tohidpour, A., Писарева, Н. В., Ruzaeva, V. A., & Salmina, A. B. (2016) · Siberian medical review · doi:10.20333/25000136-2016-5-15-23 · Cited by 2 · see citing works

Macrophage Metabolic Reprogramming After Myocardial Infarction

Zeng, L., Song, S., Zhang, X., Huang, Z., Sun, A., & Ge, J. (2023) · CardioMetabolic Syndrome Journal · doi:10.51789/cmsj.2023.3.e16 · Cited by 1 · see citing works

Mecanismos de regulación de la glucolisis en neuronas y su función en supervivencia celular

Rodríguez, P. R. (2013) · doi:10.14201/gredos.123044

Evaluación de la actividad biológica de leches fermentadas artesanales: función de la fracción no microbiana

Iraporda, C. (2016) · doi:10.35537/10915/51913

BASIC & TRANSLATIONAL—LIVER & PANCREAS Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor- and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

Hoque, R., Farooq, A., Ghani, A., Gorelick, F. S., & Mehal, W. Z. (2014)

Adenosine A2B receptor effects on post-MI remodeling and cardiac fibroblast function

Zhan, E. (2014) · Human Biology

Expression of DNA Repair and Response to Oxidative Stress Genes in Diabetes Mellitus

Takahashi, P., Xavier, D. J., & Sakamoto‐Hojo, E. T. (2014) · Springer eBooks · doi:10.1007/978-3-319-11985-4_9

Perfis de Expressão Gênica e Possíveis Interações entre microRNAs e mRNAs em Diabetes Mellitus Tipo 1 com Enfoque em Resposta ao Estresse Oxidativo e Reparo do DNA

Takahashi, P. (2015) · doi:10.11606/t.17.2015.tde-01072015-092915

Metabolic reprogramming of tumor-infiltrating myeloid cells conveys protection against pancreatic ductal adenocarcinoma

Sieow, J. L. (2018) · doi:10.32657/10220/47516

Tackling the Achilles heel of spondyloarthritis

van Kempen, T. S. (2020) · doi:10.33540/246

PFKFB3 Knockdown Attenuates Amyloid β-Induced Microglial Activation and Retinal Pigment Epithelium SenescencePreprint

Wang, Y., Han, S., Chen, J., Sun, J., & Sun, X. (2022) · Research Square · doi:10.21203/rs.3.rs-2123289/v1

Additional file 1 of Augmented PFKFB3-mediated glycolysis by interferon-γ promotes inflammatory M1 polarization through the JAK2/STAT1 pathway in local vascular inflammation in Takayasu arteritis

Chen, R., Wang, J., Dai, X., Wu, S., Huang, Q., Jiang, L., & Kong, X. (2023) · Figshare · doi:10.6084/m9.figshare.22603135

Additional file 1 of HDL and LDL have distinct, opposing effects on LPS-induced brain inflammation

Radford‐Smith, D. E., Yates, A. G., Rizvi, L., Anthony, D. C., & Probert, F. (2024) · Figshare · doi:10.6084/m9.figshare.26584428

The A2b adenosine receptor negatively regulates proinflammatory responses in Japanese flounder (Paralichthys olivaceus) head kidney macrophages

Li, S., Wang, S., Zhang, Y., Wang, J., & Sun, J. (2026) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2026.111679

Mechanistic insights into lactate-driven pathogenesis in diabetic kidney disease

He, S., Yang, L., & Yin, R. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1950569

La adenosina incrementa la expresión del gen pfkfb3 mediante los receptores de adenosina a2 y potencia el flujo glucolítico y el aporte energético en macrófagos activados

García, A. R. (2012) · Dialnet (Universidad de la Rioja)

A2A adenosine receptor stimulation enhances arginase I expression in macrophages resulting in a phenotypically unique macrophage

Black, S. G., Wilson, J. M., Ernst, P. B., & Smith, M. F. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.1065.25 · Cited by 1 · see citing works

Adenosine promotes alternative macrophage activation by triggering an A2B receptor-initiated p38-C/EBPβ signaling cascade (116.2)

Csóka, B., Koscsó, B., Németh, Z. H., Selmeczy, Z., Deitch, E. A., & Haskó, G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.186.supp.116.2

Alteration of the Expression of A 2 a Adenosine Receptor and Toll-like Receptor 4 in Macrophage Cell Lines.

Watanabe, K., Azuma, Y., Shirasu, S., Daito, M., & Ohura, K. (2003) · Japanese Journal of Oral Biology · doi:10.2330/joralbiosci1965.45.437

Importance of glycolytic metabolism in regulating the production od adenosine and IL-10 in macrophages: role of the metabolite fructose-1,6-bisphosphate and the enzyme PKM2

Viacava, P. R. (2021) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)