The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Human Lysophosphatidylcholine Acyltransferases 1 and 2 Are Located in Lipid Droplets Where They Catalyze the Formation of Phosphatidylcholine
Open accessAbstract
Phosphatidylcholine (PC) is synthesized by two different pathways, the Lands cycle and the Kennedy pathway. The recently identified key enzymes of the Lands cycle, lysophosphatidylcholine acyltransferase 1 and 2 (LPCAT1 and -2), were reported to localize to the endoplasmic reticulum and to function in lung surfactant production and in inflammation response. Here, we show in various mammalian cell lines that both enzymes additionally localize to lipid droplets (LDs), which consist of a core of neutral lipids surrounded by a monolayer of phospholipid, mainly PC. This dual localization is enabled by the monotopic topology of these enzymes demonstrated in this study. Furthermore, we show that LDs have the ability to locally synthesize PC and that this activity correlates with the LPCAT1 and -2 expression level. This suggests that LPCAT1 and -2 have, in addition to their known function in specialized cells, a ubiquitous role in LD-associated lipid metabolism.
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Cites
A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling
Hofmann, K. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01539-x · Cited by 495
Stone, S. J., Levin, M. C., Zhou, P., Han, J., Walther, T. C., & Farese, R. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805768200 · Cited by 390
Catherine C. Y., C., Chen, J., Thomas, M. A., Cheng, D., Veronica A., D. P., Newton, R. S., Pape, M. E., & Chang, T.-Y. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29532 · Cited by 158
Cited by
An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases
Law, S.-H., Chan, M.-L., Marathe, G. K., Parveen, F., Chen, C.-H., & Ke, L.-Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051149 · Cited by 817
Phospholipid Remodeling in Physiology and Disease
Wang, B., & Tontonoz, P. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114444 · Cited by 527
Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites
Pol, A., Gross, S. P., & Parton, R. G. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201311051 · Cited by 466
Cotte, A. K., Aires, V., Fredon, M., Limagne, E., Derangère, V., Thibaudin, M., Humblin, E., Scagliarini, A., de Barros, J.-P. P., Hillon, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02732-5 · Cited by 359
Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains
Kassan, A., Herms, A., Fernández-Vidal, A., Bosch, M., Schieber, N. L., Reddy, B. J. N., Fajardo, A., Gelabert-Baldrich, M., Tebar, F., Enrich, C., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201305142 · Cited by 339
Metadata
- Authors
- Moessinger, C., Kuerschner, L., Spandl, J., Shevchenko, A., & Thiele, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 286
- Issue
- 24
- Pages
- 21330-21339
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2040567024
- Cited by
- 176
- References
- 3
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Moessinger, C., Kuerschner, L., Spandl, J., Shevchenko, A., & Thiele, C. (2011). Human Lysophosphatidylcholine Acyltransferases 1 and 2 Are Located in Lipid Droplets Where They Catalyze the Formation of Phosphatidylcholine. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m110.202424
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