The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Phospholipid Remodeling in Physiology and Disease
Open accessAbstract
Phospholipids are major constituents of biological membranes. The fatty acyl chain composition of phospholipids determines the biophysical properties of membranes and thereby affects their impact on biological processes. The composition of fatty acyl chains is also actively regulated through a deacylation and reacylation pathway called Lands’ cycle. Recent studies of mouse genetic models have demonstrated that lysophosphatidylcholine acyltransferases (LPCATs), which catalyze the incorporation of fatty acyl chains into the sn-2 site of phosphatidylcholine, play important roles in pathophysiology. Two LPCAT family members, LPCAT1 and LPCAT3, have been particularly well studied. LPCAT1 is crucial for proper lung function due to its role in pulmonary surfactant biosynthesis. LPCAT3 maintains systemic lipid homeostasis by regulating lipid absorption in intestine, lipoprotein secretion, and de novo lipogenesis in liver. Mounting evidence also suggests that changes in LPCAT activity may be potentially involved in pathological conditions, including nonalcoholic fatty liver disease, atherosclerosis, viral infections, and cancer. Pharmacological manipulation of LPCAT activity and membrane phospholipid composition may provide new therapeutic options for these conditions.
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Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism
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Polyunsaturated Fatty Acids Drive Lipid Peroxidation during Ferroptosis
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XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
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Metadata
- Authors
- Wang, B., & Tontonoz, P.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2019-02-10
- Volume
- 81
- Issue
- 1
- Pages
- 165-188
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2899384460
- Cited by
- 527
- References
- 155
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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