An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

Shevach, E. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.010 · Cited by 1,754 · see citing works

Oligodendroglia metabolically support axons and contribute to neurodegeneration

Lee, Y., Morrison, B. M., Li, Y., Lengacher, S., Farah, M. H., Hoffman, P. N., Liu, Y., Tsingalia, A., Jin, L., Zhang, P.-W., et al. (2012) · Nature · doi:10.1038/nature11314 · Cited by 1,664 · cited 1× · see citing works

Plasma phospholipids identify antecedent memory impairment in older adults

Mapstone, M. E., Cheema, A. K., Fiandaca, M. S., Zhong, X., Mhyre, T. R., MacArthur, L. H., Hall, W. J., Fisher, S. G., Peterson, D. R., Haley, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3466 · Cited by 1,031 · see citing works

Cellular function and molecular structure of ecto-nucleotidases

Zimmermann, H., Zebisch, M., & Sträter, N. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9309-4 · Cited by 985 · see citing works

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

Kugiyama, K., Kerns, S. A., Morrisett, J. D., Roberts, R., & Henry, P. D. (1990) · Nature · doi:10.1038/344160a0 · Cited by 858 · see citing works

LPA Receptors: Subtypes and Biological Actions

Choi, J. W., Herr, D. R., Noguchi, K., Yung, Y. C., Lee, C., Mutoh, T., Lin, M., Teo, S. T., Park, K. E., Austin, A. M., et al. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105753 · Cited by 840 · see citing works

Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis

Lu, H., Forbes, R. A., & Verma, A. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202487200 · Cited by 839 · see citing works

Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.

Kume, N., Cybulsky, M. I., & Gimbrone, M. A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115932 · Cited by 824 · see citing works

Lipoprotein-Associated Phospholipase A 2 as an Independent Predictor of Coronary Heart Disease

Packard, C. J., O’Reilly, D. S. J., CASLAKE, M. J., McMahon, A. D., Ford, I., Cooney, J., Macphee, C. H., Suckling, K. E., Krishna, M., Wilkinson, F. E., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010193431603 · Cited by 822 · see citing works

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

Kamphorst, J. J., Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., & Rabinowitz, J. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307237110 · Cited by 726 · see citing works

Novel biomarkers for pre-diabetes identified by metabolomics

Wang‐Sattler, R., Yu, Z., Herder, C., Messias, A. C., Floegel, A., He, Y., Heim, K., Campillos, M., Holzapfel, C., Thorand, B., et al. (2012) · Molecular Systems Biology · doi:10.1038/msb.2012.43 · Cited by 701 · see citing works

The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes.

Yao, Z. M., & Vance, D. E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69166-5 · Cited by 618 · see citing works

Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies

‡ (2010) · The Lancet · doi:10.1016/s0140-6736(10)60319-4 · Cited by 595 · see citing works

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.

Stracke, M. L., Krutzsch, H. C., Unsworth, E. J., Arestad, A. A., Cioce, V., Schiffmann, E., & Liotta, L. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45911-x · Cited by 592 · see citing works

Lipidomics Profiling and Risk of Cardiovascular Disease in the Prospective Population-Based Bruneck Study

Stegemann, C., Pechlaner, R., Willeit, P., Langley, S. R., Mangino, M., Mayr, U., Menni, C., Moayyeri, A., Santer, P., Rungger, G., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.002500 · Cited by 563 · see citing works

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

Fourcade, O. A., Simon, M., Viodé, C., Rugani, N., Balle, F. L., Ragab, A., Fournié, B., Sarda, L., & Chap, H. (1995) · Cell · doi:10.1016/0092-8674(95)90295-3 · Cited by 536 · see citing works

Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

van Meeteren, L. A., Ruurs, P., Stortelers, C., Bouwman, P., van Rooijen, M. A., Pradère, J., Pettitt, T. R., Wakelam, M. J. O., Saulnier‐Blache, J. S., Mummery, C. L., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02419-05 · Cited by 531 · see citing works

Effects of the Direct Lipoprotein-Associated Phospholipase A 2 Inhibitor Darapladib on Human Coronary Atherosclerotic Plaque

Serruys, P. W. J. C., García‐García, H. M., Buszman, P. E., Erné, P., Verheye, S., Aschermann, M., Duckers, H., Bleie, Ø., Dudek, D., Bøtker, H. E., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.771899 · Cited by 503 · see citing works

Acyl-CoA:Lysophospholipid Acyltransferases

Shindou, H., & Shimizu, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800046200 · Cited by 478 · see citing works

Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid

Tanaka, M., Okudaira, S., Kishi, Y., Ohkawa, R., Iseki, S., Ota, M. S., Noji, S., Yatomi, Y., Aoki, J., & Arai, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605142200 · Cited by 454 · see citing works

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

Rinella, M. E., Elias, M. S., Smolak, R. R., Fu, T., Borensztajn, J., & Green, R. M. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800042-jlr200 · Cited by 451 · see citing works

Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways

Aoki, J., Taira, A., Takanezawa, Y., Kishi, Y., Hama, K., Kishimoto, T., Mizuno, K., Saku, K., Taguchi, R., & Arai, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206812200 · Cited by 427 · see citing works

Small-molecule inhibition of APT1 affects Ras localization and signaling.

Dekker, F., Rocks, O., Vartak, N., Menninger, S., Hedberg, C., Balamurugan, R., Wetzel, S., Renner, S., Gerauer, M., Schölermann, B., et al. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.362 · Cited by 401 · see citing works

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

Wilensky, R. L., Shi, Y., Mohler, E. R., Hamamdzic, D., Burgert, M. E., Li, J., Postle, A. D., Fenning, R. S., Bollinger, J. G., Hoffman, B. E., et al. (2008) · Nature Medicine · doi:10.1038/nm.1870 · Cited by 387 · see citing works

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

Liu, S., Umezu‐Goto, M., Murph, M. M., Lu, Y., Liu, W., Zhang, F., Yu, S., Stephens, L. C., Cui, X., Murrow, G., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.027 · Cited by 385 · see citing works

Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

Barber, M., Risis, S., Yang, C., Meikle, P. J., Staples, M., Febbraio, M. A., & Bruce, C. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041456 · Cited by 370 · see citing works

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

Cotte, A. K., Aires, V., Fredon, M., Limagne, E., Dérangère, V., Thibaudin, M., Humblin, É., Scagliarini, A., de Barros, J.-P. P., Hillon, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02732-5 · Cited by 365 · see citing works

Metabolism and atherogenic disease association of lysophosphatidylcholine

Schmitz, G., & Ruebsaamen, K. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.05.029 · Cited by 358 · see citing works

Intermittent hypoxia induces hyperlipidemia in lean mice

Li, J., Thorne, L. N., Punjabi, N. M., Sun, C.-K., Schwartz, A. R., Smith, P. L., Marino, R. L., Rodriguez, A., Hubbard, W. C., O’Donnell, C. P., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000183879.60089.a9 · Cited by 335 · see citing works

Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells.

Kume, N., & Gimbrone, M. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117047 · Cited by 329 · see citing works

P4-ATPases as Phospholipid Flippases—Structure, Function, and Enigmas

Andersen, J. P., Vestergaard, A. L., Mikkelsen, S. A., Mogensen, L. S., Chalat, M., & Molday, R. S. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00275 · Cited by 318 · see citing works

Lipid composition of human serum lipoproteins

Skipski, V. P., Barclay, M., Barclay, R. K., Fetzer, V., Good, J., & Archibald, F. M. (1967) · Biochemical Journal · doi:10.1042/bj1040340 · Cited by 303 · see citing works

Biological membranes

Watson, H. (2015) · Essays in Biochemistry · doi:10.1042/bse0590043 · Cited by 303 · see citing works

Large-scale Metabolomic Profiling Identifies Novel Biomarkers for Incident Coronary Heart Disease

Ganna, A., Salihović, S., Sundström, J., Broeckling, C. D., Hedman, Å. K., Magnusson, P. K. E., Pedersen, N. L., Larsson, A. O., Siegbahn, A. G., Zilmer, M., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004801 · Cited by 283 · see citing works

Inflammatory risk factors, biomarkers and associated therapy in ischaemic stroke

Esenwa, C. C., & Elkind, M. S. V. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.125 · Cited by 282 · see citing works

Migration to Apoptotic “Find-me” Signals Is Mediated via the Phagocyte Receptor G2A

Peter, C., Waibel, M., Radu, C. G., Yang, L. V., Witte, O. N., Schulze-Osthoff, K., Wesselborg, S., & Lauber, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706586200 · Cited by 258 · see citing works

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

Kanda, H., Newton, R. A., Klein, R., Morita, Y., Gunn, M. D., & Rosen, S. D. (2008) · Nature Immunology · doi:10.1038/ni1573 · Cited by 255 · see citing works

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

Tanaka, N., Matsubara, T., Krausz, K. W., Patterson, A. D., & Gonzalez, F. J. (2012) · Hepatology · doi:10.1002/hep.25630 · Cited by 250 · see citing works

Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer

Brindley, D. N. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20126 · Cited by 244 · see citing works

Lipoprotein-Associated Phospholipase A 2 , Platelet-Activating Factor Acetylhydrolase, Is Expressed by Macrophages in Human and Rabbit Atherosclerotic Lesions

Häkkinen, T., Luoma, J. S., Hiltunen, M., Macphee, C. H., Milliner, K. J., Patel, L., Rice, S. Q. J., Tew, D. G., Karkola, K. O., & Ylä‐Herttuala, S. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.12.2909 · Cited by 239 · see citing works

Local Production of Lipoprotein-Associated Phospholipase A 2 and Lysophosphatidylcholine in the Coronary Circulation

Lavi, S., McConnell, J. P., Rihal, C. S., Prasad, A., Mathew, V., Lerman, L. O., & Lerman, A. (2007) · Circulation · doi:10.1161/circulationaha.106.671420 · Cited by 229 · see citing works

Using Peripheral Blood Mononuclear Cells to Determine a Gene Expression Profile of Acute Ischemic Stroke

Moore, D. F., Li, H., Jeffries, N. O., Wright, V., Cooper, R. A., ELKAHLOUN, A. G., Gelderman, M. P., Zudaire, E., Blevins, G., Yu, H., et al. (2005) · Circulation · doi:10.1161/01.cir.0000152105.79665.c6 · Cited by 220 · see citing works

Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation

Li, X., Fang, P., Li, Y., Kuo, Y., Andrews, A. J., Nanayakkara, G., Johnson, C., Fu, H., Shan, H., Du, F., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306964 · Cited by 220 · see citing works

Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy

Plemel, J. R., Michaels, N. J., Weishaupt, N., Caprariello, A. V., Keough, M. B., Rogers, J. A., Yukseloglu, A., Lim, J., Patel, V. V., Rawji, K. S., et al. (2018) · Glia · doi:10.1002/glia.23245 · Cited by 220 · see citing works

T cell chemotaxis to lysophosphatidylcholine through the G2A receptor

Radu, C. G., Yang, L. V., Riedinger, M., Au, M., & Witte, O. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536801100 · Cited by 210 · see citing works

A Gender-specific Role For Phosphatidylethanolamine N-Methyltransferase-derived Phosphatidylcholine in the Regulation of Plasma High Density and Very Low Density Lipoproteins in Mice

Noga, A. A., & Vance, D. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301982200 · Cited by 200 · see citing works

Identification and Characterization of a Major Liver Lysophosphatidylcholine Acyltransferase

Zhao, Y., Chen, Y., Bonacci, T. M., Bredt, D. S., Li, S., Bensch, W. R., Moller, D. E., Kowala, M. C., Konrad, R. J., & Cao, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710422200 · Cited by 196 · see citing works

Targeted Deletion of Hepatic CTP:phosphocholine Cytidylyltransferase α in Mice Decreases Plasma High Density and Very Low Density Lipoproteins

Jacobs, R. L., Devlin, C. M., Tabas, I. A., & Vance, D. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404027200 · Cited by 195 · see citing works

Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells

Chen, X., Hyatt, B. A., Mucenski, M. L., Mason, R. J., & Shannon, J. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604946103 · Cited by 193 · see citing works

Hepatocyte autotaxin expression promotes liver fibrosis and cancer

Kaffe, E., Katsifa, A., Xylourgidis, N., Ninou, I., Ζαννίκου, Μ., Harokopos, V., Foka, P., Dimitriadis, A., Evangelou, K., Moulas, A. N., et al. (2016) · Hepatology · doi:10.1002/hep.28973 · Cited by 192 · see citing works

Human ABCA7 Supports Apolipoprotein-mediated Release of Cellular Cholesterol and Phospholipid to Generate High Density Lipoprotein

Abe-Dohmae, S., Ikeda, Y., Matsuo, M., Hayashi, M., Okuhira, K., Ueda, K., & Yokoyama, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309888200 · Cited by 190 · see citing works

Evidence Supporting a Key Role of Lp-PLA2-Generated Lysophosphatidylcholine in Human Atherosclerotic Plaque Inflammation

Gonçalves, I., Edsfeldt, A., Ko, N. Y., Grufman, H., Berg, K. E., Björkbacka, H., Nitulescu, M., Persson, A. F., Nilsson, M., Prehn, C. P., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.249854 · Cited by 188 · see citing works

Autotaxin: structure-function and signaling

Perrakis, A., & Moolenaar, W. H. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046391 · Cited by 188 · see citing works

Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism

Huang, Y., Elinder, L. S., Wu, R., CLAESSON, H.-E., & Frostegård, J. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00871.x · Cited by 185 · see citing works

Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression

Morita, Y., Sakaguchi, T., Ikegami, K., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.02.030 · Cited by 181 · see citing works

Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A

Yang, L. V., Radu, C. G., Wang, L., Riedinger, M., & Witte, O. N. (2004) · Blood · doi:10.1182/blood-2004-05-1916 · Cited by 180 · see citing works

Enhanced Expression of Lp-PLA 2 and Lysophosphatidylcholine in Symptomatic Carotid Atherosclerotic Plaques

Mannheim, D., Herrmann, J., Versari, D., Gössl, M., Meyer, F. B., McConnell, J. P., Lerman, L. O., & Lerman, A. (2008) · Stroke · doi:10.1161/strokeaha.107.503193 · Cited by 180 · see citing works

The Autotaxin–LPA Axis Emerges as a Novel Regulator of Lymphocyte Homing and Inflammation

Knowlden, S. A., & Georas, S. N. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302831 · Cited by 178 · see citing works

Lecithin:cholesterol acyltransferase: old friend or foe in atherosclerosis?

Kunnen, S., & Eck, M. V. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r024513 · Cited by 177 · see citing works

Human Lysophosphatidylcholine Acyltransferases 1 and 2 Are Located in Lipid Droplets Where They Catalyze the Formation of Phosphatidylcholine

Moessinger, C., Kuerschner, L., Spandl, J., Shevchenko, A., & Thiele, C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202424 · Cited by 176 · see citing works

Risk of adenocarcinoma of the stomach and esophagus with meat cooking method and doneness preference

Ward, M. H., Sinha, R. R., Heineman, E. F., Rothman, N., Markin, R. S., Weisenburger, D. D., Correa, P., & Zahm, S. H. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970328)71:1 · Cited by 176 · see citing works

Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer?s disease

Mulder, C., Wahlund, L., Teerlink, T., Blomberg, M. I., Veerhuis, R., van Kamp, G. J., Scheltens, P., & Scheffer, P. G. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0007-9 · Cited by 174 · see citing works

Role of LCAT in HDL remodeling: investigation of LCAT deficiency states

Asztalos, B. F., Schaefer, E. J., Horvath, K. V., Yamashita, S., Miller, M. J., Franceschini, G., & Calabresi, L. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600403-jlr200 · Cited by 172 · see citing works

Metabolic Interactions between the Lands Cycle and the Kennedy Pathway of Glycerolipid Synthesis in Arabidopsis Developing Seeds

Wang, L., Shen, W., Kazachkov, M., et al. (2012) · The Plant Cell · doi:10.1105/tpc.112.104604 · Cited by 168 · see citing works

Transport of lysolecithin by albumin in human and rat plasma

Switzer, S., & Eder, H. A. (1965) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39614-0 · Cited by 157 · see citing works

Dynamic Palmitoylation Links Cytosol-Membrane Shuttling of Acyl-protein Thioesterase-1 and Acyl-protein Thioesterase-2 with That of Proto-oncogene H-Ras Product and Growth-associated Protein-43

Kong, E., Peng, S., Chandra, G., Sarkar, C., Zhang, Z., Bagh, M. B., & Mukherjee, A. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.421073 · Cited by 153 · see citing works

Novel biomarkers of cardiovascular disease: Applications in clinical practice

Lyngbakken, M. N., Myhre, P. L., Røsjø, H. R., & Omland, T. (2018) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2018.1525335 · Cited by 143 · see citing works

Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses

Shi, Y., Zhang, P., Zhang, L., Osman, H. E., Mohler, E. R., Macphee, C. H., Zalewski, A. A., Postle, A. D., & Wilensky, R. L. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.05.001 · Cited by 136 · see citing works

P4-ATPases: lipid flippases in cell membranes

López‐Marqués, R. L., Theorin, L., Palmgren, M. B., et al. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1363-4 · Cited by 136 · see citing works

Independent Association Between Nocturnal Intermittent Hypoxemia and Metabolic Dyslipidemia

Trzépizur, W., Vaillant, M. L., Meslier, N., Pigeanne, T., Masson, P., Humeau, M. P., Bizieux‐Thaminy, A., Goupil, F., Chollet, S., Ducluzeau, P., et al. (2012) · CHEST Journal · doi:10.1378/chest.12-1652 · Cited by 135 · see citing works

Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance

Han, M. S., Lim, Y.-M., Quan, W., Kim, J. R., Chung, K. W., Kang, M., Kim, S., Park, S. Y., Han, J., Park, S., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m014787 · Cited by 135 · see citing works

Transferable lipids in oxidized low-density lipoprotein stimulate plasminogen activator inhibitor-1 and inhibit tissue-type plasminogen activator release from endothelial cells.

Kugiyama, K., Sakamoto, T., Misumi, I., et al. (1993) · Circulation Research · doi:10.1161/01.res.73.2.335 · Cited by 134 · see citing works

Lysophosphatidylcholine Triggers TLR2- and TLR4-Mediated Signaling Pathways but Counteracts LPS-Induced NO Synthesis in Peritoneal Macrophages by Inhibiting NF-κB Translocation and MAPK/ERK Phosphorylation

Carneiro, A. B., Iaciura, B. M. F., Nohara, L. L., Lopes, C. D., Cordero, E. M., Mariano, V. S., Bozza, P. T., Lopes, U. G., Atella, G. C., de Almeida, I. C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076233 · Cited by 133 · see citing works

Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines

Murugesan, G. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2003.08.004 · Cited by 131 · see citing works

Distinct Acyl Protein Transferases and Thioesterases Control Surface Expression of Calcium-activated Potassium Channels

Tian, L., McClafferty, H., Knaus, H., Ruth, P., & Shipston, M. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.335547 · Cited by 128 · see citing works

Imaging mass spectrometry revealed the production of lyso-phosphatidylcholine in the injured ischemic rat brain

Koizumi, S., Yamamoto, S., Hayasaka, T., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.056 · Cited by 128 · see citing works

Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer

Mansilla, F., da Costa, K.-A., Wang, S., et al. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0409-0 · Cited by 127 · see citing works

Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT 4

Kurabe, N., Hayasaka, T., Ogawa, M., Masaki, N., Ide, Y., Waki, M., Nakamura, T., Kurachi, K., Kahyo, T., Shinmura, K., et al. (2013) · Cancer Science · doi:10.1111/cas.12221 · Cited by 126 · see citing works

Endothelial lipase releases saturated and unsaturated fatty acids of high density lipoprotein phosphatidylcholine

Gauster, M., Rechberger, G. N., Sovic, A., et al. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500054-jlr200 · Cited by 126 · see citing works

Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4

Qiao, J., Huang, F., Naikawadi, R. P., Kim, K. S., Said, T., & Lum, H. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00508.2005 · Cited by 125 · see citing works

Autotaxin in the crosshairs: Taking aim at cancer and other inflammatory conditions

Benesch, M. G. K., Ko, Y. M., McMullen, T. P. W., & Brindley, D. N. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.02.009 · Cited by 125 · see citing works

Overexpression of Human Lecithin Cholesterol Acyltransferase Leads to Hyperalphalipoproteinemia in Transgenic Mice

Vaisman, B. L., Klein, H., Rouis, M., Bérard, A. M., Kindt, M. R., Talley, G. D., Meyn, S. M., Hoyt, R. F., Marcovina, S. M., Albers, J. J., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.12269 · Cited by 125 · see citing works

ABCA7 and Pathogenic Pathways of Alzheimer’s Disease

Aikawa, T., Holm, M., & Kanekiyo, T. (2018) · Brain Sciences · doi:10.3390/brainsci8020027 · Cited by 124 · see citing works

Lecithin:Cholesterol Acyltransferase, High-Density Lipoproteins, and Atheroprotection in Humans

Calabresi, L., & Franceschini, G. (2010) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2010.03.007 · Cited by 123 · see citing works

Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer

Uehara, T., Kikuchi, H., Miyazaki, S., et al. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4459-6 · Cited by 121 · see citing works

Charcot-Leyden Crystal Protein (Galectin-10) Is Not a Dual Function Galectin with Lysophospholipase Activity but Binds a Lysophospholipase Inhibitor in a Novel Structural Fashion

Ackerman, S. J., Liu, L., Kwatia, M. A., Savage, M. P., Leonidas, D. D., Swaminathan, G. J., & Acharya, K. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200221200 · Cited by 121 · see citing works

Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

Abrami, L., Dallavilla, T., Sandoz, P. A., Demir, M., Kunz, B., Savoglidis, G., Vassily Hatzimanikatis, A., & van der Goot, F. G. (2017) · eLife · doi:10.7554/elife.27826 · Cited by 121 · see citing works

Lysophosphatidylcholine Stimulates the Release of Arachidonic Acid in Human Endothelial Cells

Wong, J. T., Tran, K. T., Pierce, G. N., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.6830 · Cited by 120 · see citing works

Cancer Cell Expression of Autotaxin Controls Bone Metastasis Formation in Mouse through Lysophosphatidic Acid-Dependent Activation of Osteoclasts

David, M., Wannecq, E., Descôtes, F., Jansen, S., Deux, B., Ribeiro, J., Serre, C., Grès, S., Bendriss‐Vermare, N., Bollen, M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009741 · Cited by 120 · see citing works

Role of the autotaxin–lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy

Brindley, D. N., Lin, F., & Tigyi, G. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.08.015 · Cited by 120 · see citing works

Identification of human eosinophil lysophospholipase as the constituent of Charcot-Leyden crystals.

Weller, P. F., Goetzl, E. J., & Austen, K. F. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7440 · Cited by 120 · see citing works

Bioactive lysolipids in cancer and angiogenesis

Hisano, Y., & Hla, T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.07.006 · Cited by 120 · see citing works

Formation of Charcot-Leyden crystals by human basophils.

Ackerman, S. J., Weil, G. J., & Gleich, G. J. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.155.6.1597 · Cited by 118 · see citing works

Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes

Soupène, E., Fyrst, H., & Kuypers, F. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709737104 · Cited by 117 · see citing works

Novel Trimodal MALDI Imaging Mass Spectrometry (IMS3) at 10 μm Reveals Spatial Lipid and Peptide Correlates Implicated in Aβ Plaque Pathology in Alzheimer’s Disease

Kaya, I., Brinet, D., Michno, W., Başkurt, M., Zetterberg, H., Blenow, K., & Hanrieder, J. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00314 · Cited by 116 · see citing works

Alpha 1-acid glycoprotein and alpha 1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice

Molle, W. V., Libert, C., Fiers, W., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.7.3555 · Cited by 114 · see citing works

The ratio of phosphatidylcholines to lysophosphatidylcholines in plasma differentiates healthy controls from patients with Alzheimer's disease and mild cognitive impairment

Klavins, K., Koal, T., Dallmann, G., Marksteiner, J., Kemmler, G., & Humpel, C. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.05.003 · Cited by 110 · see citing works

A Brief History of Choline

Zeisel, S. H. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000343120 · Cited by 108 · see citing works

Expression, regulation and function of autotaxin in thyroid carcinomas

Kehlen, A., Englert, N., Seifert, A., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20022 · Cited by 107 · see citing works

Autotaxin as a novel serum marker of liver fibrosis

Nakagawa, H., Ikeda, H., Nakamura, K., et al. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.03.014 · Cited by 104 · see citing works

Micromolar changes in lysophosphatidylcholine concentration cause minor effects on mitochondrial permeability but major alterations in function

Hollie, N. I., Cash, J. G., Matlib, M. A., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.013 · Cited by 103 · see citing works

Genetic lecithin:cholesterol acyltransferase deficiency and cardiovascular disease

Calabresi, L., Simonelli, S., Gomaraschi, M., & Franceschini, G. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.11.034 · Cited by 102 · see citing works

Reduced Na(+)-K(+)-ATPase activity and plasma lysophosphatidylcholine concentrations in diabetic patients

Rabini, R. A., Galassi, R., Fumelli, P., Dousset, N., Solera, M. L., Valdiguié, P. M., CURATOLA, G., Ferretti, G., Taus, M., & Mazzanti, L. (1994) · Diabetes · doi:10.2337/diab.43.7.915 · Cited by 102 · see citing works

Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation

Li, X., Wang, L., Fang, P., Sun, Y., Jiang, X., Wang, H., & Yang, X. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002752 · Cited by 100 · see citing works

Regulation of lecithin cholesterol acyltransferase activity

Jonas, A. (1998) · Progress in Lipid Research · doi:10.1016/s0163-7827(98)00007-1 · Cited by 99 · see citing works

Autotaxin through Lysophosphatidic Acid Stimulates Polarization, Motility, and Transendothelial Migration of Naive T Cells

Zhang, Y., Chen, Y.-C. M., Krummel, M. F., & Rosen, S. D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201604 · Cited by 96 · see citing works

The Significance of Plasma Lysophospholipids in Patients with Renal Failure on Hemodialysis.

Sasagawa, T., Suzuki, K., Shiota, T., et al. (1998) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.44.809 · Cited by 93 · see citing works

Molecular Identification of a Novel Mammalian Brain Isoform of Acyl-CoA:Lysophospholipid Acyltransferase with Prominent Ethanolamine Lysophospholipid Acylating Activity, LPEAT2

Cao, J., Shan, D., Revett, T., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800364200 · Cited by 93 · see citing works

Mature Dendritic Cell Generation Promoted by Lysophosphatidylcholine

Coutant, F., Perrin‐Cocon, L., Agaugué, S., Delair, T., André, P., & Lotteau, V. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1688 · Cited by 92 · see citing works

Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination

Ou, Z., Sun, Y., Li, L., You, N., Liu, X., Li, H., Ma, Y., Cao, L., Han, Y., Liu, M., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0898-16.2016 · Cited by 91 · see citing works

Lysophosphatidylcholine stimulates the expression and production of MCP-1 by human vascular endothelial cells

Takahara, N., Kashiwagi, A., Maegawa, H., & Shigeta, Y. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90024-4 · Cited by 88 · see citing works

Role of LCAT in Atherosclerosis

Ossoli, A., Simonelli, S., Vitali, C., Franceschini, G., & Calabresi, L. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.32854 · Cited by 88 · see citing works

To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase

Marathe, G. K., Pandit, C., Lakshmikanth, C. L., Chaithra, V. H., Jacob, S. P., & D'Souza, C. J. M. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r045492 · Cited by 87 · see citing works

Lysophosphatidylcholine perpetuates macrophage polarization toward classically activated phenotype in inflammation

Qin, X., Qiu, C., & Zhao, L. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.04.010 · Cited by 87 · see citing works

Charcot-Leyden crystal protein and eosinophil granule major basic protein in sputum of patients with respiratory diseases.

Dor, P. J., Ackerman, S. J., & Gleich, G. J. (1984) · PubMed · doi:10.1164/arrd.1984.130.6.1072 · Cited by 85 · see citing works

Targeted profiling of atherogenic phospholipids in human plasma and lipoproteins of hyperlipidemic patients using MALDI-QIT-TOF-MS/MS

Stübiger, G., Aldover‐Macasaet, E., Bicker, W., Sobal, G., Willfort‐Ehringer, A., Pock, K., Bochkov, V. N., Widhalm, K., & Belgacem, O. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.06.010 · Cited by 85 · see citing works

Deficiency in Lysophosphatidylcholine Acyltransferase 3 Reduces Plasma Levels of Lipids by Reducing Lipid Absorption in Mice

Li, Z., Jiang, H., Ding, T., Lou, C., Bui, H. H., Kuo, M., & Jiang, X. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.012 · Cited by 84 · see citing works

Lysophosphatidylcholine acyltransferase 1 (LPCAT1) upregulation in breast carcinoma contributes to tumor progression and predicts early tumor recurrence

Abdelzaher, E., & Mostafa, M. F. (2015) · Tumor Biology · doi:10.1007/s13277-015-3214-8 · Cited by 82 · see citing works

Measurement of plasma lysophosphatidic acid concentration in healthy subjects: strong correlation with lysophospholipase D activity

Hosogaya, S., Yatomi, Y., Nakamura, K., Ohkawa, R., Okubo, S., Yokota, H., Ohta, M., Yamazaki, H., Koike, T., & Ozaki, Y. (2008) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2008.007242 · Cited by 81 · see citing works

Lysophosphatidylcholine contents in plasma LDL in patients with type 2 diabetes mellitus: Relation with lipoprotein-associated phospholipase A2 and effects of simvastatin treatment

Iwase, M., Sonoki, K., Sasaki, N., Ohdo, S., Higuchi, S., Hattori, H., & Iida, M. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.02.012 · Cited by 79 · see citing works

Identification of the serum factor required for in vitro activation of macrophages. Role of vitamin D3-binding protein (group specific component, Gc) in lysophospholipid activation of mouse peritoneal macrophages

Yamamoto, N., Homma, S., & Millman, I. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.1.273 · Cited by 79 · see citing works

Nascent VLDL phospholipid composition is altered when phosphatidylcholine biosynthesis is inhibited: evidence for a novel mechanism that regulates VLDL secretion

Fast, D. G., & Vance, D. E. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00116-t · Cited by 77 · see citing works

Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis

Oldoni, F., Baldassarre, D., Castelnuovo, S., Ossoli, A., Amato, M., van Capelleveen, J. C., Hovingh, G. K., de Groot, E., Bochem, A. E., Simonelli, S., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.034706 · Cited by 75 · see citing works

A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research

Su, J. (2018) · Molecules · doi:10.3390/molecules23112931 · Cited by 75 · see citing works

Potential role of ABCA7 in cellular lipid efflux to apoA-I

Linsel‐Nitschke, P., Jehle, A. W., Shan, J., Cao, G., Bacic, D., Lan, D., Wang, N., & Tall, A. R. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400247-jlr200 · Cited by 74 · see citing works

Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance

D’Souza, K., Paramel, G. V., & Kienesberger, P. C. (2018) · Nutrients · doi:10.3390/nu10040399 · Cited by 74 · see citing works

Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure

Chandra, M., Escalante‐Alcalde, D., Bhuiyan, M. S., Orr, A. W., Kevil, C. G., Morris, A. J., Nam, H. W., Dominic, P. S., McCarthy, K. J., Miriyala, S., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.09.015 · Cited by 73 · see citing works

Lysophosphatidylcholine induces cytotoxicity/apoptosis and IL-8 production of human endothelial cells: Related mechanisms

Chang, M., Lee, J., Chen, Y., Lin, S.-I., Lin, L., Liou, E. J., Huang, W., Chan, C., Huang, C.-C., & Jeng, J. (2017) · Oncotarget · doi:10.18632/oncotarget.22425 · Cited by 73 · see citing works

Increased lysophosphatidylcholine and non-esterified fatty acid content in LDL induces chemokine release in endothelial cells

Benı́tez, S., Camacho, M., Arcelús, R., Vila, L., Bancells, C., Ordóñez‐Llanos, J., & Sánchez‐Quesada, J. L. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.07.027 · Cited by 72 · see citing works

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins

Hirsch‐Reinshagen, V., Donkin, J. J., Stukas, S. K., Chan, J., Wilkinson, A., Fan, J., Parks, J. S., Kuivenhoven, J. A., ̈tjohann, D. L., Pritchard, H., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800584-jlr200 · Cited by 72 · see citing works

Quantitative lipidomic analysis of plasma and plasma lipoproteins using MALDI-TOF mass spectrometry

Serna, J., García‐Seisdedos, D., Alcázar, A., et al. (2015) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2015.05.005 · Cited by 71 · see citing works

Lysophosphatidylcholine Inhibits Endothelial Cell Migration by Increasing Intracellular Calcium and Activating Calpain

Chaudhuri, P., Colles, S. M., Damron, D. S., & Graham, L. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000052673.77316.01 · Cited by 71 · see citing works

Lysophosphatidylcholine Inhibits Endothelial Cell Migration and Proliferation via Inhibition of the Extracellular Signal–Regulated Kinase Pathway

Rikitake, Y., Kawashima, S., Yamashita, T., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.4.1006 · Cited by 70 · see citing works

Lysophosphatidic acid plasma concentrations in healthy subjects: circadian rhythm and associations with demographic, anthropometric and biochemical parameters

Michalczyk, A., Budkowska, M., Dołęgowska, B., et al. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0536-0 · Cited by 68 · see citing works

Role of elevated lecithin: Cholesterol acyltransferase and cholesteryl ester transfer protein activities in abnormal lipoproteins from proteinuric patients

Dullaart, R. P. F., Gansevoort, R. T., Dikkeschei, B. D., de Zeeuw, D., de Jong, P. E., & van Tol, A. (1993) · Kidney International · doi:10.1038/ki.1993.217 · Cited by 66 · see citing works

Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment

Xu, Y. (2018) · Cancers · doi:10.3390/cancers10070227 · Cited by 66 · see citing works

Lysophosphatidylcholine Enhances Superoxide Anions Production via Endothelial NADH/NADPH Oxidase

Takeshita, S., Inoue, N., Gao, D., Rikitake, Y., Kawashima, S., Tawa, R., Sakurai, H., & Yokoyama, M. (2000) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.7.238 · Cited by 65 · see citing works

Lysophosphatidylcholine induces endothelial cell injury by nitric oxide production through oxidative stress

Kim, E. A., Kim, J. A., Park, M. H., Jung, S., Suh, S. H., Pang, M., & Kim, Y. J. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050802556075 · Cited by 64 · see citing works

Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1

Hirano, T., Kishi, M., Sugimoto, H., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.05.001 · Cited by 64 · see citing works

Regulation of tumor cell – Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis

Tigyi, G., Yue, J., Norman, D. D., et al. (2018) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.09.008 · Cited by 64 · see citing works

Serum lysophosphatidic acid concentrations measured by dot immunogold filtration assay in patients with acute myocardial infarction

Chen, X., Yang, X., Wang, N., Ding, C., Yang, Y., You, Z. J., Su, Q., & Chen, J. (2003) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510310003265 · Cited by 63 · see citing works

Identification of Alpha-1 Acid Glycoprotein as a Lysophospholipid Binding Protein: A Complementary Role to Albumin in the Scavenging of Lysophosphatidylcholine

Ojala, P. J., Hermansson, M., Tolvanen, M. E. E., Polvinen, K., Hirvonen, T., Impola, U., Jauhiainen, M., Somerharju, P. J., & Parkkinen, J. (2006) · Biochemistry · doi:10.1021/bi061657l · Cited by 60 · see citing works

Prostacyclin Prevents Pericyte Loss and Demyelination Induced by Lysophosphatidylcholine in the Central Nervous System

Muramatsu, R., Kuroda, M., Matoba, K., Lin, H., Takahashi, C., Koyama, Y., & Yamashita, T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.587253 · Cited by 60 · see citing works

Platelets, autotaxin and lysophosphatidic acid signalling: win‐win factors for cancer metastasis

Leblanc, R., Houssin, A., & Peyruchaud, O. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14362 · Cited by 60 · see citing works

Autotaxin–Lysophosphatidic Acid Signaling in Alzheimer’s Disease

Ramesh, S., Govindarajulu, M., Suppiramaniam, V. D., Moore, T., & Dhanasekaran, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071827 · Cited by 60 · see citing works

Studies on diagnostic biomarkers and therapeutic mechanism of Alzheimer's disease through metabolomics and hippocampal proteomics

Lin, W., Zhang, J., Liu, Y., Wu, R., Yang, H., Hu, X., & Ling, X. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.05.003 · Cited by 59 · see citing works

Determination of nonpolar and polar lipid classes in human plasma, erythrocytes and plasma lipoprotein fractions using ultrahigh-performance liquid chromatography-mass spectrometry

Holčapek, M., Cífková, E., Červená, B., et al. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.12.023 · Cited by 57 · see citing works

Platelet-activating factor acetylhydrolase: is it good or bad for you?

Chen, C. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200406000-00015 · Cited by 57 · see citing works

G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Differentiation in Response to Lysolecithin-Induced Demyelination

Lu, C., Dong, L., Zhou, H., Li, Q., Huang, G., Bai, S. J., & Liao, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-22452-0 · Cited by 57 · see citing works

Lysophosphatidylcholine Acyltransferase 3 Knockdown-mediated Liver Lysophosphatidylcholine Accumulation Promotes Very Low Density Lipoprotein Production by Enhancing Microsomal Triglyceride Transfer Protein Expression

Li, Z., Ding, T., Pan, X., Li, Y., Li, R., Sanders, P. E., Kuo, M., Hussain, M. M., Cao, G., & Jiang, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.334664 · Cited by 56 · see citing works

Suppression of lysophosphatidic acid and lysophosphatidylcholine formation in the plasma in vitro: Proposal of a plasma sample preparation method for laboratory testing of these lipids

Nakamura, K., Kishimoto, T., Ohkawa, R., et al. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2007.05.004 · Cited by 56 · see citing works

Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkers

Ward-Caviness, C. K., Xu, T., Aspelund, T., Thorand, B., Montrone, C., Meisinger, C., Dunger-Kaltenbach, I., Zierer, A., Yu, Z., Helgadottir, I. R., et al. (2017) · Heart · doi:10.1136/heartjnl-2016-310789 · Cited by 56 · see citing works

Lysophosphatidylcholine Activates a Novel PKD2-Mediated Signaling Pathway That Controls Monocyte Migration

Tan, M., Feng, H., Xu, X., Chisolm, G. M., & Cui, M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.191585 · Cited by 54 · see citing works

Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers

Agarwal, A. K., & Garg, A. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m004762 · Cited by 54 · see citing works

Lysophosphatidylcholine Acyltransferase1 Overexpression Promotes Oral Squamous Cell Carcinoma Progression via Enhanced Biosynthesis of Platelet-Activating Factor

Shida-Sakazume, T., Endo‐Sakamoto, Y., Unozawa, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120143 · Cited by 53 · see citing works

Lysophosphatidylcholine increases the neurotoxicity of Alzheimer’s amyloid β1-42 peptide: Role of oligomer formation

Sheikh, A. M., Michikawa, M., Kim, S. U., & Nagai, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.034 · Cited by 53 · see citing works

Plasma Lecithin: Cholesterol Acyltransferase Activity Is Elevated in Metabolic Syndrome and Is an Independent Marker of Increased Carotid Artery Intima Media Thickness

Dullaart, R. P. F., Perton, F. G., Sluiter, W. J., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1213 · Cited by 53 · see citing works

Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids

Marathe, G. K., Silva, A. R., Neto, H. C. D. C. F., et al. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30275-3 · Cited by 53 · see citing works

The identification of a phospholipase B precursor in human neutrophils

Xu, S., Zhao, L., Larsson, A. O., et al. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06771.x · Cited by 52 · see citing works

Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury

Tzekov, R. T., Dawson, C., Orlando, M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153608 · Cited by 52 · see citing works

Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-β production

Hasegawa, H., Jin, L., Matsumoto, T., Onishi, S., Suemori, K., & Yasukawa, M. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.119 · Cited by 51 · see citing works

Autotaxin in embryonic development

Moolenaar, W. H., Houben, A. J. S., Lee, S., & van Meeteren, L. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.09.013 · Cited by 51 · see citing works

Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis

Navab, M., Chattopadhyay, A., Hough, G., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m056614 · Cited by 51 · see citing works

Plasma lecithin:cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk

Calabresi, L., Baldassarre, D., Simonelli, S., Gomaraschi, M., Amato, M., Castelnuovo, S., Frigerio, B., Ravani, A. L., Sansaro, D., Kauhanen, J., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.p014977 · Cited by 51 · see citing works

Lysophosphatidylcholine export by human ABCA7

Tomioka, M., Toda, Y., Manucat-Tan, N. B., Akatsu, H., Fukumoto, M., Kono, N., Arai, H., Kioka, N., & Ueda, K. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.03.012 · Cited by 51 · see citing works

Oxidized lipoproteins found in patients with NIDDM stimulate radical-induced monocyte chemoattractant protein-1 mRNA expression in cultured human endothelial cells

Takahara, N., Kashiwagi, A., Nishio, Y., et al. (1997) · Diabetologia · doi:10.1007/s001250050731 · Cited by 50 · see citing works

Deciphering the Causal Role of sPLA2s and Lp-PLA2 in Coronary Heart Disease

Talmud, P. J., & Holmes, M. V. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305234 · Cited by 48 · see citing works

Changes in the hippocampal and peripheral phospholipid profiles are associated with neurodegeneration hallmarks in a long-term global cerebral ischemia model: Attenuation by Linalool

Sabogal-Guáqueta, A. M., Posada‐Duque, R., Cortés, N., Arias-Londoño, J. D., & Cardona‐Gómez, G. P. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.015 · Cited by 48 · see citing works

Lipoprotein-associated phospholipase A2 and risks of coronary heart disease and ischemic stroke in the general population: A systematic review and meta-analysis

Li, D., Wei, W., Ran, X., Yu, J., Li, H., Zhao, L., Zeng, H., Cao, Y., Zeng, Z., & Wan, Z. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.05.017 · Cited by 47 · see citing works

A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization

Wang, A., Yang, H., Friedman, P., et al. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00012-8 · Cited by 46 · see citing works

Impaired endothelial function in patients with nephritic range proteinuria

Stroes, E. S. G., Joles, J. A., Chang, P. C., et al. (1995) · Kidney International · doi:10.1038/ki.1995.325 · Cited by 45 · see citing works

Lysophosphatidylcholine, Oxidized Low-Density Lipoprotein and Cardiovascular Disease in Korean Hemodialysis Patients: Analysis at 5 Years of Follow-up

Lee, Y., Lee, D. H., Kim, J. K., et al. (2013) · Journal of Korean Medical Science · doi:10.3346/jkms.2013.28.2.268 · Cited by 44 · see citing works

Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression through reactive oxygen species generation and ERK1/2 activation in 3T3-L1 adipocytes

Kuniyasu, A., Tokunaga, M., Yamamoto, T., Inoue, S., Obama, K., Kawahara, K., & Nakayama, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.11.011 · Cited by 44 · see citing works

Lipid composition of circulating multiple-modified low density lipoprotein

Zakiev, E., Sukhorukov, V. N., Melnichenko, A. А., Sobenin, I. A., Ivanova, E. A., & Orekhov, A. N. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0308-2 · Cited by 44 · see citing works

Isolation of very low density lipoprotein phospholipids enriched in ethanolamine phospholipids from rats injected with Triton WR 1339

Ågren, J. J., Kurvinen, J., & Kuksis, A. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.02.001 · Cited by 43 · see citing works

Loss of LCAT activity in the golden Syrian hamster elicits pro-atherogenic dyslipidemia and enhanced atherosclerosis

Zhao, D., Shi, H., Zhao, M., Zhang, X., Huang, W. Y., Wang, Y., Zheng, L., Xian, X., & Liu, C. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.003 · Cited by 43 · see citing works

Lp-PLA 2 as a risk factor of early neurological deterioration in acute ischemic stroke with TOAST type of large arterial atherosclerosis

Wang, Y., Hu, S., Ren, L., et al. (2018) · Neurological Research · doi:10.1080/01616412.2018.1493850 · Cited by 43 · see citing works

Presence in human eosinophils of a lysophospholipase similar to that found in the pancreas

Holtsberg, F. W., Ozgur, L., Garsetti, D. E., et al. (1995) · Biochemical Journal · doi:10.1042/bj3090141 · Cited by 42 · see citing works

Lysophosphatidic acid induces increased BACE1 expression and Aβ formation

Shi, J., Dong, Y., Cui, M., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.09.010 · Cited by 42 · see citing works

A lipidomics investigation of the induced hypoxia stress on HeLa cells by using MS and NMR techniques

Yang, Y., Vidalino, L., Anesi, A., Macchi, P., & Guella, G. (2014) · Molecular BioSystems · doi:10.1039/c3mb70540d · Cited by 39 · see citing works

Role of autotaxin in cancer stem cells

Lee, D., Suh, D., Lee, S. Ç., et al. (2018) · Cancer and Metastasis Reviews · doi:10.1007/s10555-018-9745-x · Cited by 39 · see citing works

Increased lysophosphatidylcholine and non-esterified fatty acid content in LDL induces chemokine release in endothelial cellsRelationship with electronegative LDL

Benı́tez, S., CAMACHO, M., Arcelús, R., et al. (2004) · Atherosclerosis · doi:10.1016/s0021-9150(04)00399-5 · Cited by 39 · see citing works

Expression profile based gene clusters for ischemic stroke detection

Adamski, M. G., Li, Y., Wagner, E., et al. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.004 · Cited by 38 · see citing works

Oxidative stress mediates apoptosis induced by oxidized low-density lipoprotein and oxidized lipoprotein(a)

Heermeier, K., Schneider, R., Heinloth, A. N., Wanner, C., Dimmeler, S., & Galle, J. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00685.x · Cited by 37 · see citing works

Increased autotaxin activity in multiple sclerosis

Zahednasab, H., Balood, M., Harirchian, M. H., et al. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.06.006 · Cited by 36 · see citing works

Transgenic overexpression of human lecithin: cholesterol acyltransferase (LCAT) in mice does not increase aortic cholesterol deposition

Furbee, J. W., & Parks, J. S. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00201-0 · Cited by 35 · see citing works

Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction

Filho, A. F. D. S., de Sena, W. L. B., de Lima, L. R. A., Carvalho, L. V. D. N., Pereira, M. C., Santos, L. G. S., Santos, R. V. C., Tavares, L. B., Pitta, M. G. D. R., & Rêgo, M. J. B. D. M. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471912 · Cited by 35 · see citing works

Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice

Kritikou, E., van Puijvelde, G. H. M., van der Heijden, T., van Santbrink, P. J., Swart, M., Schaftenaar, F. H., Kröner, M. J., Kuiper, J., & Bot, I. (2016) · Scientific Reports · doi:10.1038/srep37585 · Cited by 34 · see citing works

TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury

Matsubara, T., Tanaka, N., Sato, M., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m031773 · Cited by 33 · see citing works

Detection of Independent Associations of Plasma Lipidomic Parameters with Insulin Sensitivity Indices Using Data Mining Methodology

Kopprasch, S., Dheban, S., Schuhmann, K., Xu, A., Schulte, K., Simeonovic, C. J., Schwarz, P. E. H., Bornstein, S. R., Shevchenko, A., & Graessler, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164173 · Cited by 32 · see citing works

Modified lipoproteins provide lipids that modulate dendritic cell immune function

Perrin‐Cocon, L., Diaz, O., André, P., et al. (2012) · Biochimie · doi:10.1016/j.biochi.2012.08.006 · Cited by 31 · see citing works

Distinct disruptions in Land's cycle remodeling of glycerophosphocholines in murine cortex mark symptomatic onset and progression in two Alzheimer's disease mouse models

Granger, M. W., Liu, H., Fowler, C., Blanchard, A. P., Taylor, M. W., Sherman, S., Xu, H., Le, W., & Bennett, S. A. L. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14560 · Cited by 31 · see citing works

ADSCs and adipocytes are the main producers in the autotaxin–lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro

Schmid, R., Wolf, K., Robering, J. W., et al. (2018) · BMC Cancer · doi:10.1186/s12885-018-5166-z · Cited by 31 · see citing works

Albumin restores lysophosphatidylcholine-induced inhibition of vasodilation in rat aorta

Vuong, T. D., de Kimpe, S. J., de Roos, R., et al. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0600031088.x · Cited by 30 · see citing works

Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients

Nakamura, K., Takeuchi, T., Ohkawa, R., et al. (2007) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/000456307782268147 · Cited by 30 · see citing works

Role of lysophosphatidic acid in ion channel function and disease

Hernández‐Araiza, I., Morales‐Lázaro, S. L., Canul-Sánchez, J. A., Islas, L. D., & Rosenbaum, T. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00226.2018 · Cited by 30 · see citing works

TSG attenuates LPC ‐induced endothelial cells inflammatory damage through notch signaling inhibition

Zhao, J., Liang, Y., Song, F., Xu, S., Nian, L., Zhou, X., & Wang, S. (2015) · IUBMB Life · doi:10.1002/iub.1458 · Cited by 29 · see citing works

Hypoalbuminemia increases lysophosphatidylcholine in low-density lipoprotein of normocholesterolemic subjects

Vuong, T. D., Stroes, E. S. G., Willekes-Koolschijn, N., et al. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.0550031005.x · Cited by 28 · see citing works

Plasma lecithin:cholesterol acyltransferase and phospholipid transfer protein activity independently associate with nonalcoholic fatty liver disease

Nass, K. J., van den Berg, E. H., Gruppen, E. G., & Dullaart, R. P. F. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12988 · Cited by 28 · see citing works

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

Blanchard, J. W., Akay, L. A., Davila-Velderrain, J., von Maydell, D., Mathys, H., Davidson, S. M., Effenberger, A., Chen, C.-Y., Maner-Smith, K., Hajjar, I., et al. (2022) · Nature · doi:10.1038/s41586-022-05439-w · Cited by 493 · see citing works

Phospholipases and Reactive Oxygen Species Derived Lipid Biomarkers in Healthy and Diseased Humans and Animals – A Focus on Lysophosphatidylcholine

Engel, K. M., Schiller, J., Galuska, C. E., & Fuchs, B. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.732319 · Cited by 64 · see citing works

Pathways to Severe COVID‐19 for People with Obesity

O’Rourke, R. W., & Lumeng, C. N. (2021) · Obesity · doi:10.1002/oby.23099 · Cited by 42 · see citing works

Alterations in Plasma Lipidomic Profiles in Adult Patients with Schizophrenia and Major Depressive Disorder

Wang, F., Guo, L., Zhang, T., Cui, Z., Wang, J., Zhang, C., Xue, F., Zhou, C., Li, B., Tan, Q., et al. (2022) · Medicina · doi:10.3390/medicina58111509 · Cited by 18 · see citing works

The lipid paradox in neuroprogressive disorders: Causes and consequences

Morris, G., Berk, M., Walder, K., O’Neil, A., Maes, M., & Puri, B. K. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.017 · Cited by 17 · see citing works

Evidence for two distinct lysophospholipase activities that degrade lysophosphatidylcholine and lysophosphatidic acid in neuronal nuclei of cerebral cortex

Baker, R. R., & Chang, H.-Y. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00057-8 · Cited by 18 · see citing works

Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency

Salgado-Polo, F., Fish, A., Matsoukas, M., Heidebrecht, T., Keune, W., & Anastassis Perrakis, A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004450 · Cited by 48 · see citing works

Measurement of lysophospholipase D/autotaxin activity in human serum samples

Nakamura, K., Ohkawa, R., Okubo, S., et al. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.10.009 · Cited by 62 · see citing works

Crystal Structure of Autotaxin, a Lysophospholipase D that Produces Lipid Mediator Lysophosphatidic Acids

Nishimasu, H., Takagi, J., Aoki, J., et al. (2011) · Nihon Kessho Gakkaishi · doi:10.5940/jcrsj.53.207

Distinct contributions of two choline-producing enzymatic activities to lysophosphatidic acid production in human amniotic fluid from pregnant women in the second trimester and after parturition

Fukui, M., Tsutsumi, T., Yamamoto-Mikami, A., et al. (2020) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2020.106471 · Cited by 4 · see citing works