The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Up-regulation of miR-21 Mediates Resistance to Trastuzumab Therapy for Breast Cancer
Open accessAbstract
Trastuzumab resistance emerges to be a major issue in anti-human epidermal growth factor receptor 2 (HER2) therapy for breast cancers. Here, we demonstrated that miR-21 expression was up-regulated and its function was elevated in HER2(+) BT474, SKBR3, and MDA-MB-453 breast cancer cells that are induced to acquire trastuzumab resistance by long-term exposure to the antibody, whereas protein expression of the PTEN gene, a miR-21 target, was reduced. Blocking the action of miR-21 with antisense oligonucleotides re-sensitized the resistant cells to the therapeutic activities of trastuzumab by inducing growth arrest, proliferation inhibition, and G(1)-S cell cycle checking in the presence of the antibody. Ectopic expression of miR-21 in HER2(+) breast cancer cells confers resistance to trastuzumab. Rescuing PTEN expression with a p3XFLAG-PTEN-mut construct with deleted miR-21 targeting sequence at its 3' UTR restored the growth inhibition of trastuzumab in the resistant cells by inducing PTEN activation and AKT inhibition. In vivo, administering miR-21 antisense oligonucleotides restored trastuzumab sensitivity in the resistant breast cancer xenografts by inducing PTEN expression, whereas injection of miR-21 mimics conferred trastuzumab resistant in the sensitive breast tumors via PTEN silence. Up-regulatin of miR-21 in tumor biopsies obtained from patients receiving pre-operative trastuzumab therapy was associated with poor trastuzumab response. Therefore, miR-21 overexpression contributes to trastuzumab resistance in HER2(+) breast cancers and antagonizing miR-21 demonstrates therapeutic potential by sensitizing the malignancy to anti-HER2 treatment.
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OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
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MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
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MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers
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Self-citationAn autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation
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Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion
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The role and mechanisms of action of microRNAs in cancer drug resistance
Si, W., Shen, J., Zheng, H., & Fan, W. (2019) · Clinical Epigenetics · doi:10.1186/s13148-018-0587-8 · Cited by 668
Emerging role of microRNA-21 in cancer
Feng, Y.-H., & Tsao, C.-J. (2016) · Biomedical Reports · doi:10.3892/br.2016.747 · Cited by 454
Jung, E., Santarpia, L., Kim, J., Esteva, F. J., Moretti, E., Buzdar, A. U., Di Leo, A., Le, X., Bast, R. C., Park, S., et al. (2012) · Cancer · doi:10.1002/cncr.26565 · Cited by 292
Upregulation of miR-21 in Cisplatin Resistant Ovarian Cancer via JNK-1/c-Jun Pathway
Echevarría-Vargas, I. M., Valiyeva, F., & Vivas-Mejía, P. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097094 · Cited by 118
MicroRNAs as therapeutic targets and their potential applications in cancer therapy
Cho, W. C. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.696102 · Cited by 70
Metadata
- Authors
- Gong, C., Yao, Y., Wang, Y., Liu, B., Wu, W., Chen, J., Su, F., Yao, H., & Song, E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 286
- Issue
- 21
- Pages
- 19127-19137
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2145848169
- Cited by
- 311
- References
- 10
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gong, C., Yao, Y., Wang, Y., Liu, B., Wu, W., Chen, J., Su, F., Yao, H., & Song, E. (2011). Up-regulation of miR-21 Mediates Resistance to Trastuzumab Therapy for Breast Cancer. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m110.216887
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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