Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

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Items 101–200 of 546

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2. Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease
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3. Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease
   Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru et al. · 2020 · Acta Neuropathologica Communications
4. Acetylation: a new key to unlock tau’s role in neurodegeneration
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5. Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies
   Valera, Elvira, Masliah, Eliezer · 2013 · Pharmacology & Therapeutics
6. Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain
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7. Functional Connectivity in Autosomal Dominant and Late-Onset Alzheimer Disease
   Thomas, Jewell B., Brier, Matthew R., Bateman, Randall J., Snyder, Abraham Z., Benzinger, Tammie L., Xiong, Chengjie, Raichle, Marcus, Holtzman, David M., Sperling, Reisa A., Mayeux, Richard et al. · 2014 · JAMA Neurology
8. Therapeutic strategies for tau mediated neurodegeneration
   Yasumasa Yoshiyama, Virginia M.‐Y. Lee, John Q. Trojanowski · 2012 · Journal of Neurology Neurosurgery & Psychiatry
9. “Prion‐Like” Templated Misfolding in Tauopathies
   Florence Clavaguera, Isabelle Lavenir, Ben Falcon, Stephan Frank, Michel Goedert, Markus Tolnay · 2013 · Brain Pathology
10. Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders
    Elvira Valera, Brian J. Spencer, Eliezer Masliah · 2015 · Neurotherapeutics
11. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement
    Lee, Seung-Hye, Le Pichon, Claire E., Adolfsson, Oskar, Gafner, Valérie, Pihlgren, Maria, Lin, Han, Solanoy, Hilda, Brendza, Robert, Ngu, Hai, Foreman, Oded et al. · 2016 · Cell Reports
12. The prion model for progression and diversity of neurodegenerative diseases
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13. Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets
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14. Cell Death and Neurodegeneration
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15. Structure-based inhibitors of amyloid beta core suggest a common interface with tau
    Griner, Sarah L, Seidler, Paul, Bowler, Jeannette, Murray, Kevin A, Yang, Tianxiao Peter, Sahay, Shruti, Sawaya, Michael R, Cascio, Duilio, Rodriguez, Jose A, Philipp, Stephan et al. · 2019 · eLife
16. Insights into T‐cell dysfunction in Alzheimer's disease
    Linbin Dai, Yong Shen · 2021 · Aging Cell
17. Propagation of Tau via Extracellular Vesicles
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18. Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved
    Eftychia Vasili, Antonio Dominguez‐Meijide, Tiago F. Outeiro · 2019 · Frontiers in Molecular Neuroscience
19. Synaptic tau: A pathological or physiological phenomenon?
    Miranda Robbins, Emma L. Clayton, Gabriele S. Kaminski Schierle · 2021 · Acta Neuropathologica Communications
20. Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
    Yuxing Xia, Stefan Prokop, Kimberly-Marie M. Gorion, Justin D. Kim, Zachary A. Sorrentino, Brach M. Bell, Alyssa N. Manaois, Paramita Chakrabarty, Peter Davies, Benoit I. Giasson · 2020 · Acta Neuropathologica Communications
21. Prion-Like Propagation of Post-Translationally Modified Tau in Alzheimer’s Disease: A Hypothesis
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22. Progressive supranuclear palsy: Advances in diagnosis and management
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23. Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases
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24. Spreading of tau pathology in A lzheimer's disease by cell‐to‐cell transmission
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25. The aggregation of mutant p53 produces prion-like properties in cancer
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26. Role of Microglial Cells in Alzheimer’s Disease Tau Propagation
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27. Tau deposition is associated with functional isolation of the hippocampus in aging
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28. Tau-Based Therapeutics for Alzheimer’s Disease: Active and Passive Immunotherapy
    Francesco Panza, Vincenzo Solfrizzi, Davide Seripa, Bruno Pietro Imbimbo, Madia Lozupone, Andrea Santamato, Rosanna Tortelli, Ilaria Galizia, Camilla Prete, Antonio Daniele et al. · 2016 · Immunotherapy
29. Possible Mechanisms of Tau Spread and Toxicity in Alzheimer’s Disease
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30. Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis
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31. Human iPSC-derived neuronal model of Tau-A152T frontotemporal dementia reveals tau-mediated mechanisms of neuronal vulnerability
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32. Pathological Changes of Tau Related to Alzheimer’s Disease
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33. The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease
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34. Frontotemporal Lobar Degeneration: A Clinical Approach
    Elissaios Karageorgiou, Bruce L. Miller · 2014 · Seminars in Neurology
35. Current Status of Clinical Trials on Tau Immunotherapies
    Ji, Changyi, Sigurdsson, Einar M. · 2021 · Drugs
36. Extracellular low‐n oligomers of tau cause selective synaptotoxicity without affecting cell viability
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37. Review: Prion‐like mechanisms of transactive response DNA binding protein of 43 kDa ( TDP ‐43) in amyotrophic lateral sclerosis ( ALS )
    Phillip Smethurst, Katie C. L. Sidle, John Hardy · 2014 · Neuropathology and Applied Neurobiology
38. Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions
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39. Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo Studies
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40. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo
    Marianna Karina Gorsky, Sylvie Burnouf, Jacqueline Dols, Eckhard Mandelkow�, Linda Partridge · 2016 · Scientific Reports
41. Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway
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42. New Features about Tau Function and Dysfunction
    Miguel Medina, Félix Hernández, Jesús Ávila · 2016 · Biomolecules
43. Tau immunotherapies: Lessons learned, current status and future considerations
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44. Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau
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45. An N-terminal Nuclear Export Signal Regulates Trafficking and Aggregation of Huntingtin (Htt) Protein Exon 1*
    Zhiqiang Zheng, Aimin Li, Brandon B. Holmes, Jayne C. Marasa, Marc I. Diamond · 2013 · Journal of Biological Chemistry
46. Emerging Therapeutics for Alzheimer's Disease
    Karen Chiang, Edward H. Koo · 2014 · The Annual Review of Pharmacology and Toxicology
47. Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies
    M. Catarina Silva, Stephen J. Haggarty · 2020 · International Journal of Molecular Sciences
48. Using Human iPSC-Derived Neurons to Model TAU Aggregation
    Verheyen, An, Diels, Annick, Dijkmans, Joyce, Oyelami, Tutu, Meneghello, Giulia, Mertens, Liesbeth, Versweyveld, Sofie, Borgers, Marianne, Buist, Arjan, Peeters, Pieter et al. · 2015 · PLOS ONE
49. Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity
    Satish Kumar, Katharina Tepper, Senthilvelrajan Kaniyappan, Jacek Biernat, Susanne Wegmann, Eva‐Maria Mandelkow, Daniel J. Müller, Eckhard Mandelkow� · 2014 · Journal of Biological Chemistry
50. Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons
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51. Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy
    Nadia Mazzaro, Erica Barini, Maria Grazia Spillantini, Michel Goedert, Paolo Medini, Laura Gasparini · 2016 · Journal of Neuroscience
52. O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease
    Philip Ryan, Mingming Xu, Andrew Keith Davey, Jonathan J. Danon, George D. Mellick, Michael Kassiou, Santosh Rudrawar · 2019 · ACS Chemical Neuroscience
53. RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth
    Paul D. Dinkel, Michael R. Holden, Nadira Matin, Martin Margittai · 2015 · Biochemistry
54. Cell-based Models To Investigate Tau Aggregation
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55. Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology
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56. Tau prion-like propagation: state of the art and current challenges
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57. Natural Compounds May Open New Routes to Treatment of Amyloid Diseases
    Jan Bieschke · 2013 · Neurotherapeutics
58. Signature of an aggregation-prone conformation of tau
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59. Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau
    Anett Hudák, Erzsébet Kúsz, Ildikó Domonkos, Katalin Jósvay, Alpha Tom Kodamullil, László Szilák, Martin Hofmann‐Apitius, Tamás Letoha · 2019 · Scientific Reports
60. Cellular mechanisms of protein aggregate propagation
    Brandon B. Holmes, Marc I. Diamond · 2012 · Current Opinion in Neurology
61. Presenilin Deficiency or Lysosomal Inhibition Enhances Wnt Signaling through Relocalization of GSK3 to the Late-Endosomal Compartment
    Radek Dobrowolski, Philipp Vick, Diego Ploper, Iwona Gumper, Harriet Snitkin, David D. Sabatini, Edward M. De Robertis · 2012 · Cell Reports
62. Nuclear Translocation Uncovers the Amyloid Peptide Aβ42 as a Regulator of Gene Transcription*
    Christian Barucker, Anja Harmeier, Joerg Weiske, Beatrix Fauler, Kai Frederik Albring, Stefan Prokop, Peter Werner Hildebrand, Rudi Lurz, Frank L. Heppner, Otmar Huber et al. · 2014 · Journal of Biological Chemistry
63. Copper and iron ions accelerate the prion-like propagation of α-synuclein: A vicious cycle in Parkinson's disease
    Yang Li, Chen Yang, Shilin Wang, Dong Liang Yang, Yu Zhang, Li Xu, Liang Ma, Jiaojiao Zheng, Robert B. Petersen, Ling Zheng et al. · 2020 · International Journal of Biological Macromolecules
64. Extracellular vesicles and amyotrophic lateral sclerosis: from misfolded protein vehicles to promising clinical biomarkers
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65. Tau Immunotherapies for Alzheimer’s Disease and Related Tauopathies: Progress and Potential Pitfalls1
    Sigurdsson, Einar M. · 2018 · Journal of Alzheimer s Disease
66. Conformational basis for asymmetric seeding barrier in filaments of three- and four-repeat tau
    Siddiqua, Ayisha, Luo, Yin, Meyer, Virginia, Swanson, Michael A., Yu, Xiang, Wei, Guanghong, Zheng, Jie, Eaton, Gareth R., Ma, Buyong, Nussinov, Ruth et al. · 2012 · Journal of the American Chemical Society
67. Neuroimaging insights into network-based neurodegeneration
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68. Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology
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69. Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
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70. Proteomics of neurodegenerative diseases: analysis of human post‐mortem brain
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71. Corruption and Spread of Pathogenic Proteins in Neurodegenerative Diseases
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72. Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF
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73. Astrocyte senescence and SASP in neurodegeneration: tau joins the loop
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74. Amplification of Tau Fibrils from Minute Quantities of Seeds
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75. Proteins Recruited to Exosomes by Tau Overexpression Implicate Novel Cellular Mechanisms Linking Tau Secretion with Alzheimer's Disease
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76. Chronic traumatic encephalopathy-integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology
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77. Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus–pericoerulear complex by three-dimensional imaging
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78. Tau immunotherapies for Alzheimer’s disease
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79. Tau Immunotherapies for Alzheimer’s Disease and Related Tauopathies: Progress and Potential Pitfalls
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80. Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta
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81. The “Jekyll and Hyde” Actions of Nucleic Acids on the Prion-like Aggregation of Proteins
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82. Impact of Tau on Neurovascular Pathology in Alzheimer's Disease
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83. A fresh perspective from immunologists and vaccine researchers: Active vaccination strategies to prevent and reverse Alzheimer's disease
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84. Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies
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85. The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis
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86. Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early A lzheimer's disease
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87. Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A2A receptor inactivation
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88. Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin
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89. Cellular Aspects of Prion Replication In Vitro
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90. Antibody-DerivedIn VivoImaging of Tau Pathology
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91. Membrane-mediated fibrillation and toxicity of the tau hexapeptide PHF6
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92. FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
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93. Tau-targeting therapy in Alzheimer’s disease: Critical advances and future opportunities
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94. Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation
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95. Tangles, Toxicity, and Tau Secretion in AD – New Approaches to a Vexing Problem
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96. Intercellular transfer of tau aggregates and spreading of tau pathology: Implications for therapeutic strategies
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97. Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors
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98. Tau misfolding efficiently propagates between individual intact hippocampal neurons
    Hallinan, Grace I., Vargas-Caballero, Mariana, West, Jonathan, Deinhardt, Katrin · 2019 · The Journal of Neuroscience
99. Alzheimer’s disease brain contains tau fractions with differential prion-like activities
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100. Tau-Targeted Multifunctional Nanoinhibitor for Alzheimer’s Disease
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