The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
The High and Low Molecular Weight Forms of Hyaluronan Have Distinct Effects on CD44 Clustering
Open accessAbstract
CD44 is a major cell surface receptor for the glycosaminoglycan hyaluronan (HA). Native high molecular weight hyaluronan (nHA) and oligosaccharides of hyaluronan (oHA) provoke distinct biological effects upon binding to CD44. Despite the importance of such interactions, however, the feature of binding with CD44 at the cell surface and the molecular basis for functional distinction between different sizes of HA is still unclear. In this study we investigated the effects of high and low molecular weight hyaluronan on CD44 clustering. For the first time, we provided direct evidence for a strong relationship between HA size and CD44 clustering in vivo. In CD44-transfected COS-7 cells, we showed that exogenous nHA stimulated CD44 clustering, which was disrupted by oHA. Moreover, naturally expressed CD44 was distributed into clusters due to abundantly expressed nHA in HK-2 cells (human renal proximal tubule cells) and BT549 cells (human breast cancer cell line) without exogenous stimulation. Our results suggest that native HA binding to CD44 selectively induces CD44 clustering, which could be inhibited by oHA. Finally, we demonstrated that HA regulates cell adhesion in a manner specifically dependent on its size. oHA promoted cell adhesion while nHA showed no effects. Our results might elucidate a molecular- and/or cellular-based mechanism for the diverse biological activities of nHA and oHA.
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Cites
Hyaluronan fragments: An information-rich system
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CD44 and Its Interaction with Extracellular Matrix
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Signaling Properties of Hyaluronan Receptors
Turley, E. A., Noble, P. W., & Bourguignon, L. Y. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100038200 · Cited by 1,041
CD44: Structure, Function and Association with the Malignant Process
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Hyaluronan in Tissue Injury and Repair
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Hyaluronan-Cell Interactions in Cancer and Vascular Disease
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Hyaluronan and Homeostasis: A Balancing Act
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Hyaluronan Binding by Cell Surface CD44
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Hyaluronic Acid: Redefining Its Role
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The extracellular matrix and the immune system: A mutually dependent relationship
Sutherland, T. E., Dyer, D. P., & Allen, J. E. (2023) · Science · doi:10.1126/science.abp8964 · Cited by 519
Nicolas, J., Magli, S., Rabbachin, L., Sampaolesi, S., Nicotra, F., & Russo, L. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00045 · Cited by 509
Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer
Tavianatou, A. G., Caon, I., Franchi, M., Piperigkou, Z., Galesso, D., & Karamanos, N. K. (2019) · The FEBS Journal · doi:10.1111/febs.14777 · Cited by 462
3D bioprinting of methacrylated hyaluronic acid (MeHA) hydrogel with intrinsic osteogenicity
Poldervaart, M. T., Goversen, B., de Ruijter, M., Abbadessa, A., Melchels, F. P. W., Öner, F. C., Dhert, W. J. A., Vermonden, T., & Alblas, J. (2017) · PLOS ONE · doi:10.1371/journal.pone.0177628 · Cited by 357
Metadata
- Authors
- Yang, C., Cao, M., Liu, H., He, Y., Xu, J., Du, Y., Liu, Y., Wang, W., Cui, L., Hu, J., & Gao, F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 287
- Issue
- 51
- Pages
- 43094-43107
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2127053176
- Cited by
- 309
- References
- 55
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yang, C., Cao, M., Liu, H., He, Y., Xu, J., Du, Y., Liu, Y., Wang, W., Cui, L., Hu, J., & Gao, F. (2012). The High and Low Molecular Weight Forms of Hyaluronan Have Distinct Effects on CD44 Clustering. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m112.349209
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