The DOI matches its Crossref record; 250 of the 250 references it cites were found in a registry or an index.
Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer
Abstract
Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits different biological properties than oligomers and low‐molecular weight HA. Depending on their molecular size, HA fragments can influence cellular behavior in a different mode of action. This phenomenon is attributed to the different manner of interaction with the HA receptors, especially CD 44 and RHAMM. Both receptors can trigger signaling cascades that regulate cell functional properties, such as proliferation migration, angiogenesis, and wound healing. HA fragments are able to enhance or attenuate the HA receptor‐mediated signaling pathways, as they compete with the endogenous HA for binding to the receptors. The modulation of these pathways could be crucial for the development of pathological conditions, such as inflammation and cancer. The primary goal of this review is to critically present the importance of HA molecular size on cellular signaling, functional cell properties, and morphology in normal and pathological conditions, including inflammation and cancer. A deeper understanding of these mechanisms could contribute to the development of novel therapeutic strategies.
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Cites
Extracellular matrix structure
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Self-citationHyaluronan: from extracellular glue to pericellular cue
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Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
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Self-citationRegulation of lung injury and repair by Toll-like receptors and hyaluronan
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Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
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The biology and role of CD44 in cancer progression: Therapeutic implications
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Angiogenesis Induced by Degradation Products of Hyaluronic Acid
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Hyaluronan fragments: An information-rich system
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Functions of hyaluronan in wound repair
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Cited by
Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977
Hyaluronic Acid: Redefining Its Role
Abatangelo, G., Vindigni, V., Avruscio, G., Pandis, L., & Brun, P. (2020) · Cells · doi:10.3390/cells9071743 · Cited by 533
Fernandes, A., Rodrigues, P. M., Pintado, M., & Tavaria, F. K. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154824 · Cited by 264
Foote, C. A., Soares, R. N., Ramirez‐Perez, F. I., Ghiarone, T., Aroor, A., Manrique‐Acevedo, C., Padilla, J., & Martinez‐Lemus, L. (2022) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2022.tb00232.x · Cited by 89
Sugitani, K., Egorova, D., Mizumoto, S., Nishio, S., Yamada, S., Kitagawa, H., Oshima, K., Nadano, D., Matsuda, T., & Miyata, S. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129804 · Cited by 28
Metadata
- Authors
- Tavianatou, A. G., Caon, I., Franchi, M., Piperigkou, Z., Galesso, D., & Karamanos, N. K.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2019-02-21
- Volume
- 286
- Issue
- 15
- Pages
- 2883-2908
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2913224919
- Cited by
- 462
- References
- 250
- FWCI
- 19.17
- Type
- journal article
- Language
- en
- Open access
- closed
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