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Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis

Baeza-Raja, B., Goodyear, A., Liu, X., Lam, K., Yamamoto, L., Li, Y., Dodson, G. S., Takeuchi, T., Kisseleva, T., Brenner, D. A., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234038 · Cited by 51 · see citing works

Participation of satellite glial cells of the dorsal root ganglia in acute nociception

Lemes, J. B. P., Lima, T. D. C., Santos, D. C. D. S., Neves, A. F., de Oliveira, F. S., Parada, C. A., & Lotufo, C. M. D. C. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.04.003 · Cited by 49 · see citing works

P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats

Gourine, A. V., Poputnikov, D. M., Zhernosek, N., Melenchuk, E. V., Gerstberger, R., Spyer, K. M., & Gourine, V. N. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706287 · Cited by 48 · see citing works

P2X7 inhibition in stellate ganglia prevents the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischemic injury

Tu, G., Li, G., Peng, H., Hu, J., Liu, J., Kong, F., Liu, S., Gao, Y., Xu, C., Xu, X., et al. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.05.004 · Cited by 45 · see citing works

Pattern recognition receptors in chronic pain: Mechanisms and therapeutic implications

Kato, J., Agalave, N. M., & Svensson, C. I. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.06.039 · Cited by 44 · see citing works

Docosahexaenoic acid ameliorates palmitate-induced lipid accumulation and inflammation through repressing NLRC4 inflammasome activation in HepG2 cells

Luo, X., Yang, Y., Shen, T., Tang, X., Xiao, Y., Zou, T., Xia, M., & Ling, W. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-34 · Cited by 42 · see citing works

Sensory–sympathetic coupling in superior cervical ganglia after myocardial ischemic injury facilitates sympathoexcitatory action via P2X7 receptor

Liu, J., Li, G., Peng, H., Tu, G., Kong, F., Liu, S., Gao, Y., Xu, H., Qiu, S., Fan, B., et al. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9367-2 · Cited by 42 · see citing works

Peripheral Inflammatory Hyperalgesia Depends on P2X7 Receptors in Satellite Glial Cells

Neves, A. F., Farias, F. H., de Magalhães, S. F., Araldi, D., Pagliusi, M., Tambeli, C. H., Sartori, C. R., Lotufo, C. M. D. C., & Parada, C. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00473 · Cited by 42 · see citing works

P2X 7 Receptor Activation in Rat Brain Cultured Astrocytes Increases the Biosynthetic Release of Cysteinyl Leukotrienes

Ballerini, P., Ciccarellf, R., Caciagli, F., Rathbone, M. P., Werstiuk, E. S., Traversa, U., Buccella, S., Giuliani, P., Jiang, S. J. Y. G., Nargi, E., et al. (2005) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200501800303 · Cited by 42 · see citing works

IL-27 enhances LPS-induced IL-1β in human monocytes and murine macrophages

Petes, C., Wynick, C., Guzzo, C., Mehta, D., Logan, S., Banfield, B. W., Basta, S., Cooper, A. M., & Gee, K. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0316-098r · Cited by 41 · see citing works

ATP binding cassette transporter ABC1 is required for the release of interleukin‐1β by P2X₇‐stimulated and lipopolysaccharide‐primed mouse Schwann cells

Marty, V., Médina, C., Combe, C., Parnet, P., & Amédée, T. (2005) · Glia · doi:10.1002/glia.20138 · Cited by 41 · see citing works

Ezrin/Radixin/Moesin Are Required for the Purinergic P2X7 Receptor (P2X7R)-dependent Processing of the Amyloid Precursor Protein

Darmellah, A., Rayah, A., Auger, R., Cuif, M.-H., Prigent, M., Arpin, M., Alcover, A., Delarasse, C., & Kanellopoulos, J. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400010 · Cited by 38 · see citing works

Review on the immunology of European sea bass Dicentrarchus labrax

Chistiakov, D. A., Hellemans, B., & VOLCKAERT, F. A. M. (2007) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2007.02.005 · Cited by 38 · see citing works

Puerarin blocks the signaling transmission mediated by P2X3 in SG and DRG to relieve myocardial ischemic damage

Liu, S., Zhang, C., Shi, Q., Li, G., Song, M., Gao, Y., Xu, C., Xu, H., Fan, B., Yu, S., et al. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.01.001 · Cited by 36 · see citing works

Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis

Cambien, B., Rezzonico, R., Vitale, S., Rouzaire-Dubois, B., Dubois, J., Barthel, R., Karimdjee-Soilihi, B., Mograbi, B., Schmid‐Alliana, A., & Schmid‐Antomarchi, H. (2008) · International Journal of Cancer · doi:10.1002/ijc.23511 · Cited by 35 · see citing works

Role of Voltage Gated Ca2+Channels in Rat Visceral Hypersensitivity Change Induced by 2, 4, 6-Trinitrobenzene Sulfonic Acid

Qian, A., Song, D., Li, Y., Liu, X., Tang, D., Yao, W., & Yuan, Y. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-15 · Cited by 34 · see citing works

Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists

Gleave, R. J., Walter, D. S., Beswick, P., Fonfría, E., Michel, A. D., Roman, S. A., & Tang, S.-P. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.05.018 · Cited by 33 · see citing works

Peripheral mechanisms underlying the essential role of P2X7 receptors in the development of inflammatory hyperalgesia

Teixeira, J. M., Oliveira, M. C. G., Parada, C. A., & Tambeli, C. H. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.06.061 · Cited by 33 · see citing works

Double‐stranded RNA induces iNOS gene expression in Schwann cells, sensory neuronal death, and peripheral nerve demyelination

Lee, H., Park, C., Cho, I., Kim, H. Y., Jo, E., Lee, S., Kho, H., Choi, S., Oh, S. B., Park, K., et al. (2007) · Glia · doi:10.1002/glia.20493 · Cited by 32 · see citing works

NLRP3 inflammasome as therapeutic targets in inflammatory diseases

Prakash, A. V., Park, I.-H., Park, J. W., Bae, J. P., Lee, G. S., & Kang, T. J. (2023) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2023.099 · Cited by 31 · see citing works

Implication of the LRR Domain in the Regulation and Activation of the NLRP3 Inflammasome

Cescato, M., Zhu, Y. Y. J., Corre, L. L., Py, B. F., Georgin‐Lavialle, S., & Rodero, M. P. (2024) · Cells · doi:10.3390/cells13161365 · Cited by 30 · see citing works

Dengue virus envelope protein domain III induces pro-inflammatory signature and triggers activation of inflammasome

Khan, R. A., Afroz, S., Minhas, G., Battu, S., & Khan, N. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154780 · Cited by 30 · see citing works

LncRNA NONRATT021972 involved the pathophysiologic processes mediated by P2X7 receptors in stellate ganglia after myocardial ischemic injury

Zou, L., Tu, G., Xie, W., Wen, S., Xie, Q., Liu, S., Li, G., Gao, Y., Xu, H., Wang, S., et al. (2015) · Purinergic Signalling · doi:10.1007/s11302-015-9486-z · Cited by 28 · see citing works

Purinergic signaling in peripheral nervous system glial cells

Cram, J. P., Coover, R. A., Jankowski, M. P., & Ratner, N. (2021) · Glia · doi:10.1002/glia.23969 · Cited by 28 · see citing works

Spotlight on P2X7 Receptor PET Imaging: A Bright Target or a Failing Star?

Schmidt, S., Isaak, A., & Junker, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021374 · Cited by 28 · see citing works

Single‐cell RNA ‐seq uncovers novel metabolic functions of Schwann cells beyond myelination

Eid, S., Noureldein, M. H., Kim, B., Hinder, L. M., Mendelson, F. E., Hayes, J. M., Hur, J., & Feldman, E. L. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15877 · Cited by 28 · see citing works

The impact of the P2X7 receptor antagonist A-804598 on neuroimmune and behavioral consequences of stress

Catanzaro, J. M., Hueston, C. M., Deak, M. M., & Deak, T. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000072 · Cited by 27 · see citing works

Peripheral P2X7 receptor-induced mechanical hyperalgesia is mediated by bradykinin

Teixeira, J. M., Oliveira, M. C. G., Parada, C. A., & Tambeli, C. H. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.057 · Cited by 26 · see citing works

p38 MAPK Mediates Glial P2X7R-Neuronal P2Y1R Inhibitory Control of P2X3R Expression in Dorsal Root Ganglion Neurons

Chen, Y., Li, G., & Huang, L.-Y. M. (2015) · Molecular Pain · doi:10.1186/s12990-015-0073-7 · Cited by 26 · see citing works

The role of chemical transmitters in neuron-glia interaction and pain in sensory ganglion

Matsuka, Y., Afroz, S., Dalanon, J., Iwasa, T., Waskitho, A., & Oshima, M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.019 · Cited by 25 · see citing works

Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia

Yang, X., Wang, G., Cao, T., Zhang, L., Ma, Y., Jiang, S., Teng, X., & Sun, X. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006425 · Cited by 24 · see citing works

P2X7 Receptor: an Emerging Target in Alzheimer’s Disease

Huang, Q., Ying, J., Yu, W., Dong, Y., Xiong, H., Zhang, Y., Liu, J., Wang, X., & Hua, F. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03699-9 · Cited by 22 · see citing works

The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent

Zhang, X., Meng, L., Baoling, H., Chen, J., Liu, P., Zhao, J., Zhang, Y., Li, M., & An, D. (2009) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmp016 · Cited by 22 · see citing works

On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory, and Neuropathic Pain

Toulmé, E., Tsuda, M., Khakh, B. S., & Inoue, K. (2009) · Frontiers in neuroscience · doi:10.1201/9781439812105-c10 · Cited by 21 · see citing works

Extracellular ATP Induces Calcium Signaling in Odontoblasts

Lee, B. M., Jo, H. J., Park, G., Kim, Y. H., Park, C. K., Jung, S. J., Chung, G., & Oh, S. B. (2016) · Journal of Dental Research · doi:10.1177/0022034516671308 · Cited by 21 · see citing works

Kinetics of ATP release following compression injury of a peripheral nerve trunk

Grafe, P., Schaffer, V., & Rücker, F. (2006) · Purinergic Signalling · doi:10.1007/s11302-006-9018-y · Cited by 21 · see citing works

Antiallergic effects of peiminine through the regulation of inflammatory mediators in HMC-1 cells

Lee, B., Kim, E., Kim, J., Min, J.-H., Jeong, D.-W., Jun, J.-Y., Cho, C.-Y., Sohn, Y., & Jung, H. (2015) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2015.1059441 · Cited by 20 · see citing works

Loss of P2X7 Receptor Plasma Membrane Expression and Function in Pathogenic B220+ Double-Negative T Lymphocytes of Autoimmune MRL/lpr Mice

Le Gall, S. M., Legrand, J., Benbijja, M., Safya, H., Benihoud, K., Kanellopoulos, J. M., & Bobé, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052161 · Cited by 19 · see citing works

Role of ATP in Trauma‐Associated Cytokine Release and Apoptosis by P2X7 Ion Channel Stimulation

Schneider, E. M., VORLAENDER, K., Ma, X., Du, W., & WEISS, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1378.027 · Cited by 18 · see citing works

Variations in Cellular Responses of Mouse T Cells to Adenosine-5′-Triphosphate Stimulation Do Not Depend on P2X7 Receptor Expression Levels but on Their Activation and Differentiation Stage

Safya, H., Mellouk, A., Legrand, J., Gall, S. M. L., Benbijja, M., Kanellopoulos‐Langevin, C., Kanellopoulos, J., & Bobé, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00360 · Cited by 18 · see citing works

Adenosine 5′-Triphosphate (ATP) Inhibits Schwann Cell Demyelination During Wallerian Degeneration

Shin, Y. H., Chung, H.-J., Park, C., Jung, J., & Jeong, N. Y. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-0020-y · Cited by 17 · see citing works

Lipopolysaccharide-induced inflammatory cytokine production by Schwann's cells dependent upon TLR4 expression

Hao, H., Peduzzi-Nelson, J. D., VandeVord, P. J., Barami, K., DeSilva, S. P., Pelinkovic, D., & Morawa, L. G. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.04.020 · Cited by 16 · see citing works

Tetrachlorobenzoquinone Stimulates NLRP3 Inflammasome-Mediated Post-Translational Activation and Secretion of IL-1β in the HUVEC Endothelial Cell Line

Xia, X., Shi, Q., Song, X., Fu, J., Liu, Z., Wang, Y., Wang, Y., Su, C., Song, E., & Song, Y. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00021 · Cited by 16 · see citing works

Caspase-1-mediated cytokine release from gestational tissues, placental, and cord blood

Maneta, E., Warren, A. Y., Hay, D. P., & Khan, R. N. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00186 · Cited by 14 · see citing works

CD8 + , but not CD4 + effector/memory T cells, express the CD44 high CD45RB high phenotype with aging, which displays reduced expression levels of P2X 7 receptor and ATP‐induced cellular responses

Mellouk, A., & Bobé, P. (2018) · The FASEB Journal · doi:10.1096/fj.201800867r · Cited by 13 · see citing works

Allyl isothiocyanate regulates caspase-1/receptor interacting protein-2 expression

Han, N., Park, W., Um, J., Kim, H., & Jeong, H. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2010.12.021 · Cited by 10 · see citing works

P2X7 receptor as a novel drug delivery system to increase the entrance of hydrophilic drugs into cells during photodynamic therapy

Pacheco, P. A. F., Ferreira, L. B. G., Mendonça, L. M., Ferreira, D. N. M., Salles, J. P., Faria, R. X., Teixeira, P. C. N., & Alves, L. A. (2016) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-016-9668-6 · Cited by 10 · see citing works

Anti-apoptotic Effects of Bone Marrow on Human Islets: A Preliminary Report

Luo, L. (2015) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000274 · Cited by 9 · see citing works

Effects of ATRA, acitretin and tazarotene on growth and apoptosis of Tca8113 cells

Liwei, R., Weiming, T., Sheng-shun, T., Zhang, R., Wanjuan, W., & Weihui, Z. (2005) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/bf02828205 · Cited by 9 · see citing works

P2X7‐induced nociception in the temporomandibular joint of rats depends on inflammatory mechanisms and C‐fibres sensitization

Teixeira, J. M., Pimentel, R. M., Abdalla, H. B., de Sousa, H. M. X., de Macedo, C. G., Napimoga, M. H., Tambeli, C. H., Oliveira, M. C. G., & Clemente‐Napimoga, J. T. (2021) · European Journal of Pain · doi:10.1002/ejp.1732 · Cited by 8 · see citing works

Intestinal alkaline phosphatase decreases intraperitoneal adhesion formation

Hyoju, S. K., Morrison, S. A., Gul, S. S., Gharedaghi, M. H., Mussa, M., Najibi, M., Economopoulos, K. P., Hamarneh, S. R., & Hodin, R. A. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.09.006 · Cited by 6 · see citing works

Methallyl isothiocyanate inhibits the caspase-1 activity through the inhibition of intracellular calcium levels

Han, N., Kim, I.-K., Kim, H., & Jeong, H. (2011) · Biochimie · doi:10.1016/j.biochi.2011.11.013 · Cited by 5 · see citing works

A cyclic pathway of P2 × 7, bradykinin, and dopamine receptor activation induces a sustained articular hyperalgesia in the knee joint of rats

Teixeira, J. M., Parada, C. A., & Tambeli, C. H. (2017) · Inflammation Research · doi:10.1007/s00011-017-1122-7 · Cited by 4 · see citing works

Localization of P2X7 receptor immunoreactivity in the dorsal root ganglia of guinea pig

Xuegong, B., Jiang, L., & Xiang, Z. (2005) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/bf02828199 · Cited by 2 · see citing works

P2X7 receptor mediated growth-inhibitory effect in KG1a cell line

Zhang, X., & Meng, L. (2008) · Chinese Journal of Clinical Oncology · doi:10.1007/s11805-008-0400-0 · Cited by 1 · see citing works

Toll-Like Receptors and Neuroinflammation

Lee, S. J. (2013) · Advances in neurobiology · doi:10.1007/978-1-4614-8313-7_9

Activation of Caspase-1 Signaling Complexes by the P2X7 Receptor Requires Intracellular K + Efflux and Protein Synthesis Induced by Priming with Toll-Like Receptor Ligands

Kahlenberg, J. M. (2004)

Characterization of NLRP3 in the Maintenance of Cardiac Tissue Homeostasis

Bracey, N. A. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/25279

Dexamethasone regulates gene expression induced by the mechanosensitive P2X7 receptor in osteoblasts

Na, M. (2015) · Scholarship@Western (Western University)

Environmental and Occupational agents and Cancer Drug-Induced Oxidative Stress in Pulmonary Fibrosis

Chakraborti, T., Sarkar, J., Pramanik, P. K., & Chakraborti, S. (2019) · Springer eBooks · doi:10.1007/978-981-32-9366-3_12

Purine Receptor Targets in the Treatment of Neuropathic Pain

Vulchanova, L. (2006) · Springer eBooks · doi:10.1007/978-3-540-29805-2_3685

Maturation and release of interleukin-1beta by lypopolysaccharide-primed mouse Schwann cells require the stimulation of P2X7 receptors

Colomar, A., Marty, V., Medina, C., Combe, C., Parnet, P., & Amédée, T. (2003) · HAL

Altered Cytokine Production in Mice Lacking P2X7Receptors

Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924 · see citing works

ATP binding cassette transporter ABC1 is required for the release of interleukin‐1β by P2X₇‐stimulated and lipopolysaccharide‐primed mouse Schwann cells

Marty, V., Médina, C., Combe, C., Parnet, P., & Amédée, T. (2005) · Glia · doi:10.1002/glia.20138 · Cited by 41 · see citing works

Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1β

López‐Castejón, G., Young, M. T., Meseguer, J., Surprenant, A., & Mulero, V. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.05.015 · Cited by 38 · see citing works

P2X4 and P2X7 receptors in the expression and release of interleukin-1β

Dippel, M. S., & Justus Liebig University Giessen (2024) · Universitätsbibliothek Gießen · doi:10.22029/jlupub-19590