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Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.
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Cleavage of I2PP2A generates two fragments, I2NTF and I2CTF.
“This cleavage generates two fragments, I2NTF and I2CTF”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Basurto-Islas et al., 2013
In the cytoplasm, legumain cleaves I2PP2A (also known as SET).
“where it cleaves I2PP2A (also known as SET).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Basurto-Islas et al., 2013
PP2A is a key phosphatase that limits Tau hyperphosphorylation in vitro and in vivo.
“a key phosphatase that limits Tau hyperphosphorylation both in vitro (Basurto-Islas et al., 2013) and in vivo (Basurto-Islas et al., 2018).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Basurto-Islas et al., 2013
Under acidic conditions such as brain ischemia, hypoxia, or AD, legumain can translocate from neuronal lysosomes into the cytoplasm.
“Under acidic conditions (e.g., brain ischemia, hypoxia, or AD), legumain can translocate from neuronal lysosomes into the cytoplasm”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Basurto-Islas et al., 2013
Legumain modulates Tau phosphorylation in AD.
“Legumain has been described in relation with AD as a modulator of Tau phosphorylation (Basurto-Islas et al., 2013)”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Basurto-Islas et al., 2013
I2NTF and I2CTF inhibit protein phosphatase 2A (PP2A).
“that inhibit protein phosphatase 2A (PP2A)”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Basurto-Islas et al., 2013
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Stat3 controls lysosomal-mediated cell death in vivo
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Compagnone, N. A., Zhang, P., Vigne, J.-L., & Mellon, S. H. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.6.0469 · Cited by 81
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Metadata
- Authors
- Basurto-Islas, G., Grundke-Iqbal, I., Tung, Y. C., Liu, F., & Iqbal, K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 288
- Issue
- 24
- Pages
- 17495-17507
- ISSN
- 0021-9258
- Cited by
- 144
- References
- 2
- Language
- en
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