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Glucose Regulates Hypothalamic Long-chain Fatty Acid Metabolism via AMP-activated Kinase (AMPK) in Neurons and Astrocytes
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Limited availability of glucose enforces a switch in neurons to alternative metabolic fuels, including ketone bodies and fatty acids.
“Limited availability of glucose enforces a switch in neurons to alternative metabolic fuels, including ketone bodies45 and fatty acids46.”
From Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel (2025) · cites this paper as [46]
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Cites
Central nervous system control of food intake and body weight
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Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
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Minireview: Malonyl CoA, AMP-Activated Protein Kinase, and Adiposity
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“In addition, they suggest that the previously described effect of MCD overexpression in the MBH, the malonyl-CoA-degrading enzyme, leading to increased food intake and adiposity (17, 18) may involve modulation ofmalonyl-CoA andLCFA-CoAoxidation in astrocytes and/or neurons.”
BackgroundLeptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake
Gao, S., Kinzig, K. P., Aja, S., Scott, K. A., Keung, W., Kelly, S., Strynadka, K., Chohnan, S., Smith, W. W., Tamashiro, K. L. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708385104 · Cited by 215
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
Pocai, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26640 · Cited by 211
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“In agreement with this idea, etomoxir had a minor effect on oleateinduced calciummobilization in ventromedial nucleus neurons (67).”
BackgroundHypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
Yang, C. S., Lam, C. K. L., Chari, M., Cheung, G. W. C., Kokorovic, A., Gao, S., Leclerc, I., Rutter, G. A., & Lam, T. K. T. (2010) · Diabetes · doi:10.2337/db10-0221 · Cited by 86
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Metadata
- Authors
- Taïb, B., Bouyakdan, K., Hryhorczuk, C., Rodaros, D., Fulton, S., & Alquier, T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 288
- Issue
- 52
- Pages
- 37216-37229
- ISSN
- 0021-9258
- Cited by
- 65
- References
- 12
- Language
- en
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