Dampened mesolimbic dopamine function and signaling by saturated but not monounsaturated dietary lipids
Open accessAbstract
Overconsumption of dietary fat is increasingly linked with motivational and emotional impairments. Human and animal studies demonstrate associations between obesity and blunted reward function at the behavioral and neural level, but it is unclear to what degree such changes are a consequence of an obese state and whether they are contingent on dietary lipid class. We sought to determine the impact of prolonged ad libitum intake of diets rich in saturated or monounsaturated fat, separate from metabolic signals associated with increased adiposity, on dopamine (DA)-dependent behaviors and to identify pertinent signaling changes in the nucleus accumbens (NAc). Male rats fed a saturated (palm oil), but not an isocaloric monounsaturated (olive oil), high-fat diet exhibited decreased sensitivity to the rewarding (place preference) and locomotor-sensitizing effects of amphetamine as compared with low-fat diet controls. Blunted amphetamine action by saturated high-fat feeding was entirely independent of caloric intake, weight gain, and plasma levels of leptin, insulin, and glucose and was accompanied by biochemical and behavioral evidence of reduced D1R signaling in the NAc. Saturated high-fat feeding was also tied to protein markers of increased AMPA receptor-mediated plasticity and decreased DA transporter expression in the NAc but not to alterations in DA turnover and biosynthesis. Collectively, the results suggest that intake of saturated lipids can suppress DA signaling apart from increases in body weight and adiposity-related signals known to affect mesolimbic DA function, in part by diminishing D1 receptor signaling, and that equivalent intake of monounsaturated dietary fat protects against such changes.
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Prolonged high-fat diet triggers neurobehavioral deficits associated with blunted mesolimbic dopamine function in rodents.
“To this end, rodent research has revealed that prolonged high-fat diet (HFD) elicits metabolic dysfunction and increases anxiety-and depressive-like behaviors [28][29][30][31][32][33][34][35][36], heightens stress and hypothalamic-pituitary-adrenal (HPA) responses [37,38], and triggers neurobehavioral deficits associated with blunted mesolimbic dopamine function [39][40][41].”
From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [41]
In the absence of obesity development, saturated high-fat diets can still potentiate HPA reactivity and feedback and suppress behavioral responses to rewards in rodents.
“However, in the absence of obesity development, these diets can still potentiate HPA reactivity [37] and feedback [38] and suppress behavioral responses to rewards [41].”
From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [41]
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- Authors
- Hryhorczuk, C., Florea, M., Rodaros, D., Poirier, I., Daneault, C., Des Rosiers, C., Arvanitogiannis, A., Alquier, T., & Fulton, S.
- Affiliations
- Concordia University (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Université de Montréal (CA)
- Montreal Heart Institute (CA)
- Corresponding author
- Fulton, Stephanie
- Venue
- Neuropsychopharmacology
- Published
- 2015-07-14
- Volume
- 41
- Issue
- 3
- Pages
- 811-821
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC4707827
- OpenAlex
- W959791702
- Cited by
- 119
- References
- 76
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 11 · 2022: 15 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 14 · 2017: 15 · 2016: 12 · 2015: 4
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP9575, MOP123280, MOP115042)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- high-fat diet, mesolimbic dopamine system, nucleus accumbens, locomotor sensitization, dopamine transporter, obesity, palm oil, olive oil
- MeSH terms
- Olive Oil, Palm Oil, Amphetamine, Central Nervous System Stimulants, Animals, Benzazepines, Conditioning, Psychological, Dopamine, Male, Motor Activity, Nucleus Accumbens, Plant Oils, Random Allocation, Reward, Spatial Behavior, Signal Transduction, Rats, Wistar, Receptors, Dopamine D1, Receptors, AMPA, Dopamine Agonists, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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