Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake
Abstract
The hypothalamus and other regions within the central nervous system (CNS) link the sensing of nutrients to the control of metabolism and feeding behavior. Here, we report that intracerebroventricular (ICV) administration of the long-chain fatty acid oleic acid markedly inhibits glucose production and food intake. The anorectic effect of oleic acid was independent of leptin and was accompanied by a decrease in the hypothalamic expression of neuropeptide Y. The short-chain fatty acid octanoic acid failed to reproduce the metabolic effects of oleic acid, and ICV coadministration of inhibitors of ATP-sensitive K+ channels blunted the effect of oleic acid on glucose production. This is the first demonstration that fatty acids can signal nutrient availability to the CNS, which in turn limits further delivery of nutrients to the circulation.
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Blocking LCFA oxidation by increasing malonyl CoA levels in the CNS reduces food intake and hepatic glucose production.
“pharmacological interventions designed to block LCFA oxidation by increasing malonyl CoA levels (e.g. oleic acid, fatty acid synthase (FAS) inhibitor) in the CNS reduce food intake and HGP (99, 107, 133, 147)”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [133]
Accumulating evidence suggests that leptin, insulin, and nutrient-related signals in the CNS improve hepatic insulin sensitivity.
“Although accumulating evidence suggests that leptin (10 -13), insulin (14,15), and nutrient-related signals (16 -18) in the CNS improve hepatic insulin sensitivity”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [16]
Cites
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works
Environmental Contributions to the Obesity Epidemic
Hill, J. O., & Peters, J. C. (1998) · Science · doi:10.1126/science.280.5368.1371 · Cited by 2,206 · see citing works
Signals That Regulate Food Intake and Energy Homeostasis
Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,169 · see citing works
Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors
Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., Ronnett, G. V., Lane, M. D., & Kuhajda, F. P. (2000) · Science · doi:10.1126/science.288.5475.2379 · Cited by 1,004 · see citing works
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
Wang, J., Liu, R., Hawkins, M. A., Barzilai, N., & Rossetti, L. (1998) · Nature · doi:10.1038/31474 · Cited by 823 · see citing works
Self-citationRossetti, L., Smith, D. J., Shulman, G. I., Papachristou, D. N., & DeFronzo, R. A. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112981 · Cited by 808 · see citing works
Self-citationA possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736 · see citing works
Friedman, J. M. (2000) · Nature · doi:10.1038/35007504 · Cited by 701 · see citing works
Malonyl-CoA, fuel sensing, and insulin resistance
Ruderman, N. B., Saha, A. K., Vavvas, D. G., & Witters, L. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e1 · Cited by 644 · see citing works
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D., & Ashford, M. L. J. (1997) · Nature · doi:10.1038/37379 · Cited by 628 · see citing works
Miki, T., Liss, B., Minami, K., Shiuchi, T., Saraya, A., Kashima, Y., Horiuchi, M., Ashcroft, F., Minokoshi, Y., Roeper, J., et al. (2001) · Nature Neuroscience · doi:10.1038/87455 · Cited by 547 · see citing works
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J. (2000) · Nature Neuroscience · doi:10.1038/77660 · Cited by 495 · see citing works
Central melanocortin receptors regulate insulin action
Obici, S., Feng, Z., Tan, J., Liu, L., Karkanias, G. B., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12954 · Cited by 370 · see citing works
Self-citationCentral melanocortin receptors regulate insulin action
Obici, S., Feng, Z., Tan, J., Liu, L., Karkanias, G., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112954 · Cited by 370 · see citing works
Self-citationBrain glucose sensing and body energy homeostasis: role in obesity and diabetes
Levin, B. E., Dunn-Meynell, A. A., & Routh, V. H. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.5.r1223 · Cited by 270 · see citing works
Rossetti, L., & Giaccari, A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114636 · Cited by 249 · see citing works
Self-citationIntracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes
Liu, L., Karkanias, G. B., Morales, J. C., Hawkins, M., Barzilai, N., Wang, J., & Rossetti, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31160 · Cited by 222 · see citing works
Self-citationActivation of the ATP-sensitive K+ Channel by Long Chain Acyl-CoA
Larsson, O., Deeney, J. T., Bränström, R., Berggren, P., & Corkey, B. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10623 · Cited by 166 · see citing works
Harvey, J., McKay, N. G., Walker, K. S., KAAY, J. V. D., Downes, C. P., & Ashford, M. L. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4660 · Cited by 136 · see citing works
Mechanism of Cloned ATP-sensitive Potassium Channel Activation by Oleoyl-CoA
Gribble, F. M., Proks, P., Corkey, B. E., & Ashcroft, F. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26383 · Cited by 133 · see citing works
Miller, J. C., Gnaedinger, J. M., & Rapoport, S. I. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb01021.x · Cited by 111 · see citing works
Makimura, H., Mizuno, T. M., Yang, X.-J., Silverstein, J. H., Beasley, J., & Mobbs, C. V. (2001) · Diabetes · doi:10.2337/diabetes.50.4.733 · Cited by 80 · see citing works
Yaksh, T. L., Jang, J., Nishiuchi, Y., Braun, K. P., Ro, S., & Goodman, M. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90537-l · Cited by 70 · see citing works
Kopelman, P. G., & Hitman, G. A. (1998) · The Lancet · doi:10.1016/s0140-6736(98)90267-7 · Cited by 63 · see citing works
Parenteral Hydroxypropyl Cyclodextrins: Intravenous and Intracerebral Administration of Lipophiles
Pitha, J., Gerloczy, A., & Olivi, A. (1994) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600830615 · Cited by 44 · see citing works
In vivo labeling of brain phospholipids by long‐chain fatty acids: Relation to turnover and function
Rapoport, S. I. (1996) · Lipids · doi:10.1007/bf02637059 · Cited by 43 · see citing works
Fatty Acid Profiles of Various Lipids in the Cerebrospinal Fluid
Goto, M., & Spitzer, J. J. (1971) · Experimental Biology and Medicine · doi:10.3181/00379727-136-35478 · Cited by 11 · see citing works
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Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works
Energy Metabolism in the Liver
Rui, L. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130024 · Cited by 2,258 · see citing works
Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,633 · see citing works
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Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works
Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583 · see citing works
High‐fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents
Buettner, R., Schölmerich, J., & Bollheimer, L. C. (2007) · Obesity · doi:10.1038/oby.2007.608 · Cited by 1,241 · see citing works
Flier, J. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01081-x · Cited by 1,105 · see citing works
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904 · see citing works
Self-citationDiabetes, Obesity, and the Brain
Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841 · see citing works
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Qatanani, M., & Lazar, M. A. (2007) · Genes & Development · doi:10.1101/gad.1550907 · Cited by 780 · see citing works
Biochemical and physiological function of stearoyl-CoA desaturase
Paton, C. M., & Ntambi, J. M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90897.2008 · Cited by 742 · see citing works
Hypothalamic KATP channels control hepatic glucose production
Pocai, A., Lam, T. K. T., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., & Rossetti, L. (2005) · Nature · doi:10.1038/nature03439 · Cited by 645 · see citing works
Self-citationValdearcos, M., Robblee, M. M., Benjamin, D. I., Nomura, D. K., Xu, A. W., & Koliwad, S. K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.018 · Cited by 629 · see citing works
Flanagan, J. L., Simmons, P. A., Vehige, J., Willcox, M. D., & Garrett, Q. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-30 · Cited by 611 · see citing works
“There is some debate in the literature regarding whether satiety depends on the cytosolic concentration of long-chain fatty acids, with the suggestion that an increased concentration correlates with satiety and decreased feeding and body weight [77-80].”
BackgroundPosey, K. A., Clegg, D. J., Printz, R. L., Byun, J., Morton, G. J., Vivekanandan-Giri, A., Pennathur, S., Baskin, D. G., Heinecke, J. W., Woods, S. C., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90377.2008 · Cited by 586 · see citing works
Obici, S., Feng, Z., Arduini, A., Conti, R., & Rossetti, L. (2003) · Nature Medicine · doi:10.1038/nm873 · Cited by 548 · see citing works
Self-citationThe role of fatty acids in insulin resistance
Sears, B., & Perry, M. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0123-1 · Cited by 557 · see citing works
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Palomer, X., Pizarro‐Delgado, J., Barroso, E., & Vázquez‐Carrera, M. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.11.009 · Cited by 551 · see citing works
Kim, M., Park, J., NamKoong, C., Jang, P., Ryu, J., Song, H.-S., Yun, J.-Y., Nam‐Goong, I. S., Ha, J., Park, I.-S., et al. (2004) · Nature Medicine · doi:10.1038/nm1061 · Cited by 522 · see citing works
Merkel, M., Eckel, R. H., & Goldberg, I. J. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200015-jlr200 · Cited by 520 · see citing works
Hindbrain Neurons as an Essential Hub in the Neuroanatomically Distributed Control of Energy Balance
Grill, H. J., & Hayes, M. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.015 · Cited by 483 · see citing works
Hypothalamic sensing of fatty acids
Lam, T. K. T., Schwartz, G. J., & Rossetti, L. (2005) · Nature Neuroscience · doi:10.1038/nn1456 · Cited by 478 · see citing works
Self-citationCentral Control of Body Weight and Appetite
Woods, S. C., & D’Alessio, D. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1630 · Cited by 460 · see citing works
Biology's response to dieting: the impetus for weight regain
MacLean, P. S., Bergouignan, A., Cornier, M., & Jackman, M. R. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00755.2010 · Cited by 449 · see citing works
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine · doi:10.1038/nm1201 · Cited by 432 · see citing works
Self-citationEmerging role of the brain in the homeostatic regulation of energy and glucose metabolism
Roh, E., Song, D. K., & Kim, M.-S. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.4 · Cited by 391 · see citing works
A brain-liver circuit regulates glucose homeostasis
Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.001 · Cited by 392 · see citing works
Self-citationIdentifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
Elmquist, J. K., Coppari, R., Balthasar, N., Ichinose, M., & Lowell, B. B. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20786 · Cited by 388 · see citing works
Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity
Cintra, D. E., Ropelle, E. R., Moraes, J. C., Pauli, J. R., Morari, J., de Souza, C. T., Grimaldi, R., Stahl, M., Carvalheira, J. B., Saad, M. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030571 · Cited by 381 · see citing works
Energy Metabolism in the Liver
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Leptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works
“In addition to effects on HGP, at pharmacological doses, central administration of leptin in normal animals increases whole body glucose turnover and glucose uptake in peripheral tissues including skeletal muscle, heart, and BAT, but not WAT, without changes in plasma insulin or glucose levels (91).”
BackgroundInfluentialMammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling
Coleman, R., & Mashek, D. G. (2011) · Chemical Reviews · doi:10.1021/cr100404w · Cited by 332 · see citing works
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Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake
Sandoval, D. A., Bagnol, D., Woods, S. C., D’Alessio, D. A., & Seeley, R. J. (2008) · Diabetes · doi:10.2337/db07-1824 · Cited by 316 · see citing works
Woods, S. C. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00448.2003 · Cited by 311 · see citing works
Morton, G. J., Gelling, R. W., Niswender, K. D., Morrison, C. D., Rhodes, C. J., & Schwartz, M. W. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.009 · Cited by 292 · see citing works
Sarruf, D. A., Thaler, J. P., Morton, G. J., German, J. P., Fischer, J. D., Ogimoto, K., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db09-1878 · Cited by 287 · see citing works
Miyazaki, M., Dobrzyń, A., Man, W. C., Chu, K., Sampath, H., Kim, H.-J., & Ntambi, J. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402781200 · Cited by 283 · see citing works
Pancreatic signals controlling food intake; insulin, glucagon and amylin
Woods, S. C., Lutz, T. A., Geary, N., & Langhans, W. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1858 · Cited by 286 · see citing works
Recent insights into stearoyl-CoA desaturase-1
Ntambi, J. M., & Miyazaki, M. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200306000-00005 · Cited by 267 · see citing works
Ketosis and appetite-mediating nutrients and hormones after weight loss
Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A. D., & Proietto, J. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.90 · Cited by 261 · see citing works
Gut hormones in the control of appetite
Murphy, K. G., & Bloom, S. R. (2004) · Experimental Physiology · doi:10.1113/expphysiol.2004.027789 · Cited by 251 · see citing works
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis
Wolfgang, M. J., Kurama, T., Dai, Y., Suwa, A., Asaumi, M., Matsumoto, S.-I., Cha, S. H., Shimokawa, T., & Lane, M. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602205103 · Cited by 250 · see citing works
Mitochondrial fatty acid oxidation in obesity
Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246 · see citing works
Kalsbeek, A., La Fleur, S., Van Heijningen, C., & Buijs, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5328-03.2004 · Cited by 244 · see citing works
Blouet, C., Jo, Y., Li, X., & Schwartz, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1668-09.2009 · Cited by 240 · see citing works
Brain Insulin: Regulation, Mechanisms of Action and Functions
Gerozissis, K. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1022598900246 · Cited by 235 · see citing works
Molecular disruption of hypothalamic nutrient sensing induces obesity
He, W., Lam, T. K. T., Obici, S., & Rossetti, L. (2006) · Nature Neuroscience · doi:10.1038/nn1626 · Cited by 233 · see citing works
Self-citationCritical role of STAT3 in leptin's metabolic actions
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Self-citationMonitoring of stored and available fuel by the CNS: implications for obesity
Seeley, R. J., & Woods, S. C. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1245 · Cited by 228 · see citing works
Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance
Obici, S., & Rossetti, L. (2003) · Endocrinology · doi:10.1210/en.2003-0999 · Cited by 218 · see citing works
Self-citationFGF19 action in the brain induces insulin-independent glucose lowering
Morton, G. J., Matsen, M. E., Bracy, D. P., Meek, T. H., Hồng, N. T., Stefanovski, D., Bergman, R. N., Wasserman, D. H., & Schwartz, M. W. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70710 · Cited by 216 · see citing works
Leptin signaling in brain: A link between nutrition and cognition?
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Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake
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Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
Pocai, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26640 · Cited by 211 · see citing works
The role for adipose tissue in weight regain after weight loss
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Energy balance, body composition, sedentariness and appetite regulation: pathways to obesity
Hopkins, M., & Blundell, J. E. (2016) · Clinical Science · doi:10.1042/cs20160006 · Cited by 212 · see citing works
Brain fatty acid synthase activates PPARα to maintain energy homeostasis
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Obesity: Genes, brain, gut, and environment
Das, U. N. (2009) · Nutrition · doi:10.1016/j.nut.2009.09.020 · Cited by 207 · see citing works
Increased Brain Fatty Acid Uptake in Metabolic Syndrome
Karmi, A., Iozzo, P., Viljanen, A. P. M., Hirvonen, J., Fielding, B. A., Virtanen, K. A., Oikonen, V., Kemppainen, J., Viljanen, T., Guiducci, L., et al. (2010) · Diabetes · doi:10.2337/db09-0138 · Cited by 205 · see citing works
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Miyazaki, M., Jacobson, M. J., Man, W. C., Cohen, P., Asilmaz, E., Friedman, J. M., & Ntambi, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304724200 · Cited by 204 · see citing works
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Blouet, C., Ono, H., & Schwartz, G. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.004 · Cited by 197 · see citing works
Hypothalamic Responses to Long-chain Fatty Acids Are Nutritionally Regulated
Morgan, K., Obici, S., & Rossetti, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400458200 · Cited by 187 · see citing works
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Clegg, D. J., Gotoh, K., Kemp, C., Wortman, M. D., Benoit, S. C., Brown, L. M., D’Alessio, D. A., Tso, P., Seeley, R. J., & Woods, S. C. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.01.010 · Cited by 187 · see citing works
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Vohra, M. S., Benchoula, K., Serpell, C. J., & Wong, E. H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174611 · Cited by 181 · see citing works
Kreier, F., Kap, Y. S., Mettenleiter, T. C., van Heijningen, C., van der Vliet, J., Kalsbeek, A., Sauerwein, H. P., Fliers, E., Romijn, J. A., & Buijs, R. M. (2006) · Endocrinology · doi:10.1210/en.2005-0667 · Cited by 183 · see citing works
Amino acids inhibit <i>Agrp</i> gene expression via an mTOR-dependent mechanism
Morrison, C. D., Xi, X., White, C. L., Ye, J., & Martin, R. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00675.2006 · Cited by 183 · see citing works
The Integrative Role of CNS Fuel-Sensing Mechanisms in Energy Balance and Glucose Regulation
Sandoval, D., Cota, D., & Seeley, R. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.120806.095256 · Cited by 178 · see citing works
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
Ono, H., Pocai, A., Wang, Y., Sakoda, H., Asano, T., Backer, J., Schwartz, G. J., & Rossetti, L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34277 · Cited by 176 · see citing works
Self-citationInsulin action in the brain contributes to glucose lowering during insulin treatment of diabetes
Gelling, R. W., Morton, G. J., Morrison, C. D., Niswender, K. D., Myers, M. G., Rhodes, C. J., & Schwartz, M. W. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.013 · Cited by 169 · see citing works
German, J. P., Thaler, J. P., Wisse, B. E., Oh-I, S., Sarruf, D. A., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2011) · Endocrinology · doi:10.1210/en.2010-0890 · Cited by 169 · see citing works
The role of stearoyl-CoA desaturase in the control of metabolism
Dobrzyń, A., & Ntambi, J. M. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.011 · Cited by 167 · see citing works
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis
Jordan, S. D., Könner, A. C., & Brüning, J. C. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0414-7 · Cited by 160 · see citing works
Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing
Le Foll, C., Irani, B. G., Magnan, C., Dunn-Meynell, A. A., & Levin, B. E. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00223.2009 · Cited by 159 · see citing works
Insulin Resistance and Mitochondrial Dysfunction
González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 154 · see citing works
Carnitine, mitochondrial function and therapy
Zammit, V. A., Ramsay, R. R., Bonomini, M., & Arduini, A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.04.024 · Cited by 149 · see citing works
López, M., Lelliott, C. J., Tovar, S. A., Kimber, W. L., Gallego, R., Virtue, S., Blount, M., Vazquez, M. J., Finer, N., Powles, T. J., et al. (2006) · Diabetes · doi:10.2337/db05-1356 · Cited by 151 · see citing works
Blood-Brain Barriers in Obesity
Rhea, E. M., Salameh, T. S., Logsdon, A. F., Hanson, A. J., Erickson, M. A., & Banks, W. A. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0079-3 · Cited by 152 · see citing works
Molecular Mechanisms of Appetite Regulation
Yu, J. H., & Kim, M. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.6.391 · Cited by 148 · see citing works
McCrimmon, R. J., Fan, X., Ding, Y., Zhu, W., Jacob, R. J., & Sherwin, R. S. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1953 · Cited by 148 · see citing works
Coccurello, R., & Moles, A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.008 · Cited by 146 · see citing works
Hypothalamic dysfunction in obesity
Williams, L. M. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s002966511200078x · Cited by 145 · see citing works
Yang, M., Zhang, Z., Wang, C., Li, K., Li, S., Boden, G. H., Li, L., & Yang, G. (2012) · Diabetes · doi:10.2337/db11-1755 · Cited by 146 · see citing works
Metabolic Sensing and the Brain: Who, What, Where, and How?
Levin, B. E., Magnan, C., Dunn-Meynell, A. A., & Foll, C. L. (2011) · Endocrinology · doi:10.1210/en.2011-0194 · Cited by 146 · see citing works
Brainstem Nutrient Sensing in the Nucleus of the Solitary Tract Inhibits Feeding
Blouet, C., & Schwartz, G. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.003 · Cited by 145 · see citing works
Hypothalamic fatty acid metabolism: A housekeeping pathway that regulates food intake
López, M., Lelliott, C. J., & Vidal‐Puig, A. (2007) · BioEssays · doi:10.1002/bies.20539 · Cited by 144 · see citing works
Central Nervous System Regulation of Food Intake
Schwartz, M. W. (2006) · Obesity · doi:10.1038/oby.2006.275 · Cited by 146 · see citing works
Gillum, M. P., Zhang, D., Zhang, X., Erion, D. M., Jamison, R. A., Choi, C., Dong, J., Shanabrough, M., Duenas, H. R., Frederick, D. W., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.043 · Cited by 142 · see citing works
Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis
Conde‐Sieira, M., & Soengas, J. L. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00603 · Cited by 142 · see citing works
MacLean, D. B., & Luo, L. (2004) · Brain Research · doi:10.1016/j.brainres.2004.04.041 · Cited by 140 · see citing works
Wang, H., Astarita, G., Taussig, M. D., Bharadwaj, K. G., DiPatrizio, N. V., Nave, K.-A., Piomelli, D., Goldberg, I. J., & Eckel, R. H. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.006 · Cited by 139 · see citing works
Getting the message across: mechanisms of physiological cross talk by adipose tissue
Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 137 · see citing works
Regulation of stearoyl‐CoA desaturase expression
Ntambi, J. M., Miyazaki, M., & Dobrzyń, A. (2004) · Lipids · doi:10.1007/s11745-004-1331-2 · Cited by 136 · see citing works
Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system
Nakamoto, K., Nishinaka, T., Matsumoto, K., Kasuya, F., Mankura, M., Kōyama, Y., & Tokuyama, S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.012 · Cited by 134 · see citing works
Hedonic Eating and the “Delicious Circle”: From Lipid-Derived Mediators to Brain Dopamine and Back
Coccurello, R., & Maccarrone, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00271 · Cited by 133 · see citing works
Signals that influence food intake and body weight
WOODS, S. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.060 · Cited by 131 · see citing works
Evidence From Glut2-Null Mice That Glucose Is a Critical Physiological Regulator of Feeding
Bady, I., Marty, N., Dallaporta, M., Emery, M., Gyger, J., Tarussio, D., Foretz, M., & Thorens, B. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1386 · Cited by 130 · see citing works
- Authors
- Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2002-02-01
- Volume
- 51
- Issue
- 2
- Pages
- 271-275
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2148366635
- Cited by
- 654
- References
- 27
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 12 · 2023: 19 · 2022: 14 · 2021: 19 · 2020: 22 · 2019: 19 · 2018: 20 · 2017: 34 · 2016: 28 · 2015: 41 · 2014: 36 · 2013: 36 · 2012: 30
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-48321, DK20541, DK-45024)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- oleic acid, long-chain fatty acids, glucose production, dietary intake, anorectic effect, hypothalamus, neuropeptide Y, octanoic acid, short-chain fatty acids, ATP-sensitive potassium channels, nutrient sensing, intracerebroventricular administration
- MeSH terms
- Adenosine Triphosphate, Animals, Eating, Glucose, Hypothalamus, Injections, Intraventricular, Insulin, Male, Neuropeptide Y, Sulfonylurea Compounds, Potassium Channels, Rats, Sprague-Dawley, Oleic Acid, Third Ventricle, Potassium Channel Blockers, Rats
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