Cited by 654Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

Obici, Silvana, Feng, Zhaohui, Morgan, Kimyata, Stein, Daniel, Karkanias, George, Rossetti, Luciano·2002·Diabetes

Abstract

The hypothalamus and other regions within the central nervous system (CNS) link the sensing of nutrients to the control of metabolism and feeding behavior. Here, we report that intracerebroventricular (ICV) administration of the long-chain fatty acid oleic acid markedly inhibits glucose production and food intake. The anorectic effect of oleic acid was independent of leptin and was accompanied by a decrease in the hypothalamic expression of neuropeptide Y. The short-chain fatty acid octanoic acid failed to reproduce the metabolic effects of oleic acid, and ICV coadministration of inhibitors of ATP-sensitive K+ channels blunted the effect of oleic acid on glucose production. This is the first demonstration that fatty acids can signal nutrient availability to the CNS, which in turn limits further delivery of nutrients to the circulation.

Integrity signals

Registry

Crossref · 10.2337/diabetes.51.2.271

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Blocking LCFA oxidation by increasing malonyl CoA levels in the CNS reduces food intake and hepatic glucose production.

    “pharmacological interventions designed to block LCFA oxidation by increasing malonyl CoA levels (e.g. oleic acid, fatty acid synthase (FAS) inhibitor) in the CNS reduce food intake and HGP (99, 107, 133, 147)”
  • Accumulating evidence suggests that leptin, insulin, and nutrient-related signals in the CNS improve hepatic insulin sensitivity.

    “Although accumulating evidence suggests that leptin (10 -13), insulin (14,15), and nutrient-related signals (16 -18) in the CNS improve hepatic insulin sensitivity”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L.
Affiliations
Albert Einstein College of Medicine (US)
Venue
Diabetes
Published
2002-02-01
Volume
51
Issue
2
Pages
271-275
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
OpenAlex
W2148366635
Cited by
654
References
27
Citations by year
2026: 7 · 2025: 9 · 2024: 12 · 2023: 19 · 2022: 14 · 2021: 19 · 2020: 22 · 2019: 19 · 2018: 20 · 2017: 34 · 2016: 28 · 2015: 41 · 2014: 36 · 2013: 36 · 2012: 30
FWCI
8.75
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK-48321, DK20541, DK-45024)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
oleic acid, long-chain fatty acids, glucose production, dietary intake, anorectic effect, hypothalamus, neuropeptide Y, octanoic acid, short-chain fatty acids, ATP-sensitive potassium channels, nutrient sensing, intracerebroventricular administration
MeSH terms
Adenosine Triphosphate, Animals, Eating, Glucose, Hypothalamus, Injections, Intraventricular, Insulin, Male, Neuropeptide Y, Sulfonylurea Compounds, Potassium Channels, Rats, Sprague-Dawley, Oleic Acid, Third Ventricle, Potassium Channel Blockers, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review