The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

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Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species

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Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

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Dysregulation of mitochondrial α-ketoglutarate dehydrogenase leads to elevated lipid peroxidation in CHCHD2-linked Parkinson’s disease models

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Nitrite Confers Preconditioning and Cytoprotection After Ischemia/Reperfusion Injury Through the Modulation of Mitochondrial Function

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Reverse and Forward Electron Flow-Induced H2O2 Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote Knock Out Animals

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Fatty acid oxidation drives mitochondrial hydrogen peroxide production by α-ketoglutarate dehydrogenase

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Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria

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Proteomics Research on the Protective Effect of Mangiferin on H9C2 Cell Injury Induced by H2O2

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Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice

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Stoichiometry and architecture of the human pyruvate dehydrogenase complex

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Oxidative Stress and Mitochondria Are Involved in Anaphylaxis and Mast Cell Degranulation: A Systematic Review

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S-nitroso-glutathione (GSNO) inhibits hydrogen peroxide production by alpha-ketoglutarate dehydrogenase: An investigation into sex and diet effects

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Superoxide produced in the matrix of mitochondria enhances methylmercury toxicity in human neuroblastoma cells

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An Updated View on the Molecular Pathomechanisms of Human Dihydrolipoamide Dehydrogenase Deficiency in Light of Novel Crystallographic Evidence

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Effects of sugars, fatty acids and amino acids on cytosolic and mitochondrial hydrogen peroxide release from liver cells

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Functional and evolutionary characterization of Ohr proteins in eukaryotes reveals many active homologs among pathogenic fungi

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The dose-dependent dual effects of alpha-ketoglutarate (AKG) on cumulus oocyte complexes during in vitro maturation

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The Concept of Oxidative Stress After 30 Years

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Brain bioenergetics in rats with acute hyperphenylalaninemia

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Sexual Preferences in Nutrient Utilization Regulate Oxygen Consumption and Reactive Oxygen Species Generation in Schistosoma mansoni: Potential Implications for Parasite Redox Biology

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Directed regulation of multienzyme complexes of 2-oxo acid dehydrogenases using phosphonate and phosphinate analogs of 2-oxo acids

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Mitochondrial Physiology of Cellular Redox Regulations

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Facts, Dogmas, and Unknowns About Mitochondrial Reactive Oxygen Species in Cancer

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NADPH supply and the contribution of NAD(P)+ transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria

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Ischemia/reperfusion-associated oxidative stress is an aggravating factor for pressure ulcers

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Hypoxia decreases mitochondrial ROS production in cells

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Identification of 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine as a novel, highly potent and specific inhibitor of mitochondrial complex I

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Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase

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Mitochondrial Alpha-Keto Acid Dehydrogenase Complexes: Recent Developments on Structure and Function in Health and Disease

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The glutathionylation agent disulfiram augments superoxide/hydrogen peroxide production when liver mitochondria are oxidizing ubiquinone pool-linked and branched chain amino acid substrates

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NMR-Based Metabonomic Analysis of Physiological Responses to Starvation and Refeeding in the Rat

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Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria

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Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration

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Assessment of Tissue Oxidative Stress, Antioxidant Parameters, and Zinc and Copper Levels in Patients with Breast Cancer

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Structural alterations by five disease-causing mutations in the low-pH conformation of human dihydrolipoamide dehydrogenase (hLADH) analyzed by molecular dynamics – Implications in functional loss and modulation of reactive oxygen species generation by pathogenic hLADH forms

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Catalysis of transthiolacylation in the active centers of dihydrolipoamide acyltransacetylase components of 2‐oxo acid dehydrogenase complexes

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Mimicking caloric restriction for anti-aging effects: The pro-oxidant role of alpha-ketoglutarate

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Metformin suppresses the mitochondrial and transcriptional response to exercise, revealing a conserved BCL6B-associated angiogenic program

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Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA

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Effect of alternative oxidase (AOX) expression on mouse cerebral mitochondria bioenergetics

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Canonical transient receptor potential channel 1 aggravates myocardial ischemia-and-reperfusion injury by upregulating reactive oxygen species

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Complex II phosphorylation is triggered by unbalanced redox homeostasis in cells lacking complex III

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Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases

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A rational foundation for micheliolide-based combination strategy by targeting redox and metabolic circuit in cancer cells

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Interaction and regulation of the mitochondrial proteome – in health and disease

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MitoSNO inhibits mitochondrial hydrogen peroxide generation by α-ketoglutarate dehydrogenase

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Superoxide signals for the mitophagy of dysfunctional mitochondria to maintain quality control

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Copper modulates heart mitochondrial H2O2 emission differently during fatty acid and pyruvate oxidation

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Mitochondrial Reactive Oxygen Species in Cellular Senescence

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Prospect of thioredoxin as a possibly effective tool to combat OSAHS

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The molecular determinants regulating redox signaling in diabetic endothelial cells

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Targeted Redox Regulation α-Ketoglutarate Dehydrogenase Complex for the Treatment of Human Diseases

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The Interplay Between Reactive Oxygen Species, Glucose Metabolism and NF-kB in the Pathogenesis of Type 2 Diabetes

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Potential Antioxidant Enzymes from Fungi and Their Clinical Significance

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Substrate Selection and Its Impact on Mitochondrial Respiration and Redox

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Inactivation of mitochondrial pyruvate dehydrogenase by singlet oxygen involves lipoic acid oxidation, side-chain modification and structural changes

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Modes of Mitochondrial Reactive Oxygen Species Production in Inflammation

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HIF1 and DROSHA are involved in MMACHC repression in hypoxia

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Lipoamide dehydrogenase (LADH) deficiency: medical perspectives of the structural and functional characterization of LADH and its pathogenic variants

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Alpha-ketoglutarate dehydrogenase: more than just a TCA cycle enzyme

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The NADase CD38 may not dictate NAD levels in brain mitochondria of aged mice but regulates hydrogen peroxide generation

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Anoxia-reoxygenation alters H2O2 efflux and sensitivity of redox centers to copper in heart mitochondria

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Identifying Site-specific Superoxide and Hydrogen Peroxide Production Rates from the Mitochondrial Electron Transport System Using a Computational StrategyPreprint

Duong, Q. V., Levitsky, Y., Dessinger, M. J., & Bazil, J. N. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.01.450791 · Cited by 5

The polyphenols phloretin and quercetin are potent horseradish peroxidase (HRP) inhibitors

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Attenuation of Mycoplasma hyopneumoniae Strain ES-2 and Comparative Genomic Analysis of ES-2 and Its Attenuated Form ES-2L

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Overexpression of Renin-B Induces Warburg-like Effects That Are Associated with Increased AKT/mTOR Signaling

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Status of prooxidative-antioxidative balance and activity of Krebs cycle enzymes in liver, heart and kidney tissues for action of various cumulative doses of doxorubicin

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Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesityPreprint

Gonçalves, R. L. S., Wang, Z. B., Inouye, K., Lee, G. Y., Fu, X., Saksi, J., Rosique, C., Parlakgül, G., Arruda, A. P., Hui, S. T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.21.528863 · Cited by 3

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Melittin-induced modulation of mitochondrial physiology: Beyond the antitumoral actions

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Mitochondrial Ca 2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

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Mitochondrial ROS and T Cell Activation

Mallilankaraman, K. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805417-8.00005-6 · Cited by 2

Murburn precepts for redox dynamics in glycolysis, Cori cycle and Warburg effect: Is lactate dehydrogenase a murzyme?Preprint

Manoj, K. M., Nirusimhan, V., Parashar, A., Jesu Castin, E., & Gideon, D. A. (2021) · doi:10.31219/osf.io/abf6n · Cited by 2

Enzymatic Sources of Free Radicals

Volodyaev, I., & Vladimirov, Y. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-39078-4_14 · Cited by 2

Suppressing Mitochondrial ROS Production is Beneficial in Multiple Preclinical Models of Human Disease

Brand, M. D. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297925602527 · Cited by 2

Mammalian 2-Oxo Acid Dehydrogenase Complexes in Metabolic Regulation and Signaling

Bunik, V. I. (2026) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061824-065013 · Cited by 1

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

Deepak, K., Roy, P., Shee, M., Mukherjee, B., Ward, A., & Mandal, M. (2026) · MedComm – Oncology · doi:10.1002/mog2.70083 · Cited by 1

Influence of vicasol on oxidative reducing processes of myocardium geese

Yakoviichuk, O. V., Данченко, О., Danchenko, M., Fedorko, A. S., & Haponenko, T. (2019) · Problems of bioindications and ecology · doi:10.26661/2312-2056/2019-24/1-11 · Cited by 1

Immuohistochemical expression and significance of NADPH oxidase 1 and CXCR4 in hepatitis C virus-induced hepatocellular carcinoma

Allah, M. S. A., & Elosaily, G. M. (2018) · Egyptian Journal of Pathology · doi:10.1097/01.xej.0000542234.06636.ab · Cited by 1

Mitochondrial Regulation of Inflammation in Cancer

Inigo, J. R., Woytash, J., Kumar, R., & Chandra, D. (2021) · Physiology in health and disease · doi:10.1007/978-3-030-67951-4_13 · Cited by 1

Role of Mitochondrial Oxidative Stress in Pathophysiology of Lung Cancer

Sharma, A. K., Zaki, A., Tabassum, G., Khan, S. F., Mohsin, M., & Ali, S. M. (2021) · Molecular and integrative toxicology · doi:10.1007/978-3-030-83446-3_8 · Cited by 1

Atrial mitochondrial calcium handling in patients with atrial fibrillation

Pronto, J. R. D. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9901 · Cited by 1

Co-treatment with conjugated linoleic acid and nitrite modulates mitochondrial respiration and electron transport chain activity in vivo and attenuates mitochondrial dysfunction during cardiac injury.

Hoose, P. M. V. (2015) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2293

REDOX PROCESSES AND OXIDATIVE STRESS IN CELL AND TISSUE DAMAGE

Selenius, L. A. (2015) · Figshare

Biomarkers and progress of antioxidant therapy for rare mitochondrial disorders

Chico, L., Orsucci, D., Gerfo, A. L., Marconi, L., Mancuso, M., & Siciliano, G. (2016) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2016.1178570

Metabolism of Superoxide Radicals and Hydrogen Peroxide in Mitochondria

Marinho, H. S., & Antunes, F. (2015) · Oxidative stress and disease · doi:10.1201/b19420-3

The role of glutaredoxin-2 in regulating superoxide/hydrogen peroxide formation from liver and cardiac tissue

Chalker, J. (2017) · Memorial University Research Repository (Memorial University)

Conserved structural and dynamic aspects behind Ohr enzymatic catalysis: Ohr as potential drug targets

Domingos, R. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2019.tde-07032019-090053

An unexpected lack of difference in superoxide/H 2 O 2 production rates in isolated heart and skeletal muscle mitochondria from a mouse model of Barth SyndromePreprint

Gonçalves, R. L. S., Schlame, M., Bartelt, A., Brand, M. D., & Hotamışlıgil, G. S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.07.083105

Combretum dolichopentalum extract normalized biochemical and haematological parameters in carbon tetrachloride (CCL4) intoxicated rats

Ujowundu, F. N., Oparaeche, N. N., Onuoha, C. H., Haruna, M. A., Chukwudoruo, C. S., & Ujowundu, C. O. (2021) · AROC in Natural Products Research · doi:10.53858/arocnpr01021728

Participação da transidrogenase de nucleotídeos de nicotinamida (NNT) na manutenção do estado redox de NADP mitocondrial

Ronchi, J. A. (2016) · doi:10.47749/t/unicamp.2016.976866

Metabolic mapping of high-fit and low-fit individuals for human physiological health

Janssen, J. J. E. (2022) · doi:10.18174/573397

Generation of superoxide and hydrogen peroxide by side reactions of mitochondrial 2-oxoacid dehydrogenase complexes in isolation and in cells

Bunik, V. I., & Brand, M. D. (2018) · Biological Chemistry · doi:10.1515/hsz-2017-0284 · Cited by 30

Production of superoxide/hydrogen peroxide by the mitochondrial 2-oxoadipate dehydrogenase complex

Goncalves, R. L. S., Bunik, V. I., & Brand, M. D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.020 · Cited by 72

Characterization and suppression of mitochondrial production of superoxide and hydrogen peroxide under near-physiological conditions

Brand, M. D., Quinlan, C. L., Goncalves, R. L. S., Perevoshchikova, I. V., Treberg, J. R., Hey‐Mogensen, M., Gerencser, A. A., & Orr, A. L. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.05.224

Dissociation of superoxide production by mitochondrial complex I from NAD(P)H redox state

Lambert, A. J., Buckingham, J. A., & Brand, M. D. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.04.030 · Cited by 40

Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters

Quinlan, C. L., Treberg, J. R., Perevoshchikova, I. V., Orr, A. L., & Brand, M. D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.015 · Cited by 156