The Role of Multicellular Aggregation in the Survival of ErbB2-positive Breast Cancer Cells during Extracellular Matrix Detachment
Open accessAbstract
The metastasis of cancer cells from the site of the primary tumor to distant sites in the body represents the most deadly manifestation of cancer. In order for metastasis to occur, cancer cells need to evade anoikis, which is defined as apoptosis caused by loss of attachment to extracellular matrix (ECM). Signaling from ErbB2 has previously been linked to the evasion of anoikis in breast cancer cells but the precise molecular mechanisms by which ErbB2 blocks anoikis have yet to be unveiled. In this study, we have identified a novel mechanism by which anoikis is inhibited in ErbB2-expressing cells: multicellular aggregation during ECM-detachment. Our data demonstrate that disruption of aggregation in ErbB2-positive cells is sufficient to induce anoikis and that this anoikis inhibition is a result of aggregation-induced stabilization of EGFR and consequent ERK/MAPK survival signaling. Furthermore, these data suggest that ECM-detached ErbB2-expressing cells may be uniquely susceptible to targeted therapy against EGFR and that this sensitivity could be exploited for specific elimination of ECM-detached cancer cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cancer cells need to acquire at least some degree of resistance to anoikis to initiate and progress through the metastatic cascade.
“Accordingly, cancer cells need to acquire at least some degree of resistance to anoikis to initiate and progress though the so-called “metastatic cascade” [237–239].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [237]
Neoplastic cells can evade anoikis upon activation of ERK2 caused by cellular aggregation and consequent EGFR stabilization mediated by ERBB2, or degradation of the negative ERK2 regulator BRAP, which is favored by CCDC178.
“Neoplastic cells can evade anoikis upon activation of mitogen-activated protein kinase 1 (MAPK1; best known as ERK2) caused by cellular aggregation and consequent epidermal growth factor receptor (EGFR) stabilization mediated by erb-b2 receptor tyrosine kinase 2 (ERBB2) [237, 240], or degradation of the negative ERK2 regulator BRCA1-associated protein (BRAP), which is favored by coiled-coil domain”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [237]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091 · see citing works
Disruption of epithelial cell-matrix interactions induces apoptosis
Frisch, S., & Francis, H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.4.619 · Cited by 3,272 · see citing works
Metastasis: a question of life or death
Mehlen, P., & Puisieux, A. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1886 · Cited by 1,854 · see citing works
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
Stott, S. L., Hsu, C., Tsukrov, D. I., Yu, M., Miyamoto, D. T., Waltman, B. A., Rothenberg, S. M., Shah, A. M., Smas, M. E., Korir, G. K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012539107 · Cited by 1,637 · see citing works
Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways
Önder, T. T., Gupta, P. B., Mani, S. A., Yang, J., Lander, E. S., & Weinberg, R. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2938 · Cited by 1,527 · see citing works
A causal role for E-cadherin in the transition from adenoma to carcinoma
Perl, A. T., Wilgenbus, P., Dahl, U., Semb, H., & Christofori, G. (1998) · Nature · doi:10.1038/32433 · Cited by 1,419 · see citing works
Frisch, S. M., & Screaton, R. A. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00251-9 · Cited by 1,249 · see citing works
Ca 2+ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD
Wang, H., Pathan, N., Ethell, I. M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Bobo, T., Franke, T. F., & Reed, J. C. (1999) · Science · doi:10.1126/science.284.5412.339 · Cited by 1,132 · see citing works
Circulating tumor cells: approaches to isolation and characterization
Yu, M., Stott, S. L., Toner, M., Maheswaran, S., & Haber, D. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010021 · Cited by 1,085 · see citing works
Tsai, J. H., Donaher, J. L., Murphy, D. A., Chau, S., & Yang, J. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.022 · Cited by 1,073 · see citing works
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics
Arteaga, C. L., & Engelman, J. A. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.02.025 · Cited by 1,048 · see citing works
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Z., Irie, H. Y., Gao, S., Puigserver, P., & Brugge, J. S. (2009) · Nature · doi:10.1038/nature08268 · Cited by 1,031 · see citing works
Self-citationOcaña, O. H., Córcoles, R. C., Fabra, À., Moreno‐Bueno, G., Acloque, H., Vega, S., Barrallo‐Gimeno, A., Cano, A., & Nieto, M. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.012 · Cited by 973 · see citing works
Genetic determinants of cancer metastasis
Nguyen, D. X., & Massagué, J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2101 · Cited by 796 · see citing works
Tumor metastasis: moving new biological insights into the clinic
Wan, L., Pantel, K., & Kang, Y. (2013) · Nature Medicine · doi:10.1038/nm.3391 · Cited by 746 · see citing works
Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
Yonesaka, K., Zejnullahu, K., Okamoto, I., Satoh, T., Cappuzzo, F., Souglakos, J., Ercan, D., Rogers, A., Roncalli, M., Takeda, M., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002442 · Cited by 663 · see citing works
Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
Douma, S., van Laar, T., Zevenhoven, J., Meuwissen, R. L. J., van Garderen, E., & Peeper, D. S. (2004) · Nature · doi:10.1038/nature02765 · Cited by 608 · see citing works
Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival
Fung, C., Lock, R., Gao, S., Salas, E., & Debnath, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1092 · Cited by 558 · see citing works
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
Reginato, M. J., Mills, K. R., Paulus, J. K., Lynch, D. K., Sgroi, D. C., Debnath, J., Muthuswamy, S. K., & Brugge, J. S. (2003) · Nature Cell Biology · doi:10.1038/ncb1026 · Cited by 545 · see citing works
Witta, S. E., Gemmill, R. M., Hirsch, F. R., Coldren, C. D., Hedman, K., Ravdel, L., Helfrich, B. A., Dziadziuszko, R., Chan, D. C. F., Sugita, M., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1988 · Cited by 515 · see citing works
Wang, S. E., Narasanna, A., Pérez-Torres, M., Xiang, B., Wu, F. Y., Yang, S., Carpenter, G. F., Gazdar, A. F., Muthuswamy, S. K., & Arteaga, C. L. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.05.023 · Cited by 474 · see citing works
Beyond E-cadherin: roles of other cadherin superfamily members in cancer
Roy, F. M. V. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3647 · Cited by 471 · see citing works
Endocytosis of Receptor Tyrosine KinasesPreprint
Goh, L. K., & Sorkin, A. D. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017459 · Cited by 462 · see citing works
She, Q., Solit, D. B., Ye, Q., O'Reilly, K. E., Lobo, J. M., & Rosen, N. X. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.09.006 · Cited by 416 · see citing works
E-cadherin expression in primary carcinomas of the breast and its distant metastases
Kowalski, P. J., Rubin, M. A., & Kleer, C. G. (2003) · Breast Cancer Research · doi:10.1186/bcr651 · Cited by 414 · see citing works
Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition
Chao, Y. L., Shepard, C. R., & Wells, A. H. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-179 · Cited by 414 · see citing works
Fidler, I. J. (1973) · European Journal of Cancer (1965) · doi:10.1016/s0014-2964(73)80022-2 · Cited by 411 · see citing works
Targeted therapies for breast cancer
Higgins, M. J., & Baselga, J. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57152 · Cited by 368 · see citing works
Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression
Buchheit, C. L., Weigel, K. J., & Schafer, Z. T. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3789 · Cited by 367 · see citing works
Self-citationInflammatory Breast Cancer: The Disease, the Biology, the Treatment
Robertson, F. M., Bondy, M. L., Yang, W. T., Yamauchi, H., Wiggins, S., Kamrudin, S. A., Krishnamurthy, S., Le‐Petross, H. T., Bidaut, L. M., Player, A. N., et al. (2010) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20082 · Cited by 365 · see citing works
Avivar‐Valderas, A., Salas, E., Bobrovnikova-Marjon, E. V., Diehl, J. A., Nagi, C. S., Debnath, J., & Aguirre‐Ghiso, J. A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05164-11 · Cited by 280 · see citing works
Activation of the Protein Kinase Akt/PKB by the Formation of E-cadherin-mediated Cell-Cell Junctions
Pece, S., Chiariello, M., Murga, C., & Gutkind, J. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19347 · Cited by 265 · see citing works
Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK
Avivar‐Valderas, A., Bobrovnikova-Marjon, E. V., Diehl, J. A., Bardeesy, N. M., Debnath, J., & Aguirre‐Ghiso, J. A. (2012) · Oncogene · doi:10.1038/onc.2012.512 · Cited by 163 · see citing works
Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini Is Targeted by Oncogenes
Reginato, M. J., Mills, K. R., Becker, E. B. E., Lynch, D. K., Bonni, A., Muthuswamy, S. K., & Brugge, J. S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.11.4591-4601.2005 · Cited by 147 · see citing works
Schmelzle, T., Mailleux, A., Overholtzer, M., Carroll, J. S., Solimini, N. L., Lightcap, E. S., Veiby, O. P., & Brugge, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700115104 · Cited by 145 · see citing works
Pierceall, W. E., Woodard, A. S., Morrow, J. S., Rimm, D. L., & Fearon, E. R. (1995) · PubMed · Cited by 139 · see citing works
Kumar, S., Park, S. H., Cieply, B. W., Schupp, J. E., Killiam, E. J., Zhang, F., Rimm, D. L., & Frisch, S. M. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01342-10 · Cited by 132 · see citing works
Shen, X., & Kramer, R. H. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63390-1 · Cited by 124 · see citing works
Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix
Davison, C. A., Durbin, S., Thau, M. R., Zellmer, V. R., Chapman, S. E., Diener, J. M., Wathen, C. A., Leevy, W. M., & Schafer, Z. T. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2482 · Cited by 124 · see citing works
Self-citationThe regulation of cancer cell death and metabolism by extracellular matrix attachment
Buchheit, C. L., Rayavarapu, R. R., & Schafer, Z. T. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.04.007 · Cited by 115 · see citing works
Self-citationMoss, N. M., Barbolina, M. V., Liu, Y., Sun, L., Munshi, H. G., & Stack, M. S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4151 · Cited by 105 · see citing works
Haenssen, K. K., Caldwell, S. A., Shahriari, K. S., Jackson, S. R., Whelan, K. A., Klein–Szanto, A. J., & Reginato, M. J. (2010) · Journal of Cell Science · doi:10.1242/jcs.050906 · Cited by 101 · see citing works
Critical Role for TrkB Kinase Function in Anoikis Suppression, Tumorigenesis, and Metastasis
Geiger, T. R., & Peeper, D. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0121 · Cited by 100 · see citing works
Whelan, K. A., Schwab, L. P., Karakashev, S. V., Franchetti, L. D., Johannes, G. J., Seagroves, T. N., & Reginato, M. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426999 · Cited by 93 · see citing works
Inflammatory breast cancer (IBC): clues for targeted therapies
Fernandez, S. V., Robertson, F. M., Pei, J., Aburto-Chumpitaz, L., Mu, Z., Chu, K., Alpaugh, R. K., Huang, Y., Cao, Y., Ye, Z., et al. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2600-4 · Cited by 80 · see citing works
Enhanced Activation of Epidermal Growth Factor Receptor Caused by Tumor-Derived E-Cadherin Mutations
Bremm, A., Walch, A. K., Fuchs, M., Mages, J., Duyster, J., Keller, G., Hermannstädter, C., Becker, K., Rauser, S., Langer, R., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-1588 · Cited by 80 · see citing works
Hypoxia Suppression of Bim and Bmf Blocks Anoikis and Luminal Clearing during Mammary Morphogenesis
Whelan, K. A., Caldwell, S. A., Shahriari, K. S., Jackson, S. R., Franchetti, L. D., Johannes, G. J., & Reginato, M. J. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-04-0353 · Cited by 70 · see citing works
Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration
Buchheit, C. L., Angarola, B. L., Steiner, A., Weigel, K. J., & Schafer, Z. T. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.209 · Cited by 63 · see citing works
Self-citationAssays for Cytochrome c Release from Mitochondria during Apoptosis
Bossy‐Wetzel, E., & Green, D. R. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)22024-7 · Cited by 59 · see citing works
Grassian, A. R., Schafer, Z. T., & Brugge, J. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169821 · Cited by 51 · see citing works
Self-citationCAF-Secreted IGFBPs Regulate Breast Cancer Cell Anoikis
Weigel, K. J., Jakimenko, A., Conti, B. A., Chapman, S. E., Kaliney, W. J., Leevy, W. M., Champion, M. M., & Schafer, Z. T. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0090 · Cited by 49 · see citing works
Self-citationXeroderma pigmentosum.Showing common skin cancers plus melanocarcinoma controlled by surgery
Moore, C., & Iverson, P. C. (1954) · Cancer · doi:10.1002/1097-0142(195403)7:2 · Cited by 47 · see citing works
Mutation of BAD within the BH3 domain impairs its phosphorylation‐mediated regulation
Adachi, M., Zhang, Y.-B., & Imai, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00915-3 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Fibronectin regulates anoikis resistance via cell aggregate formation
Han, H., Sung, J. Y., Kim, S.-H., Yun, U.-J., Kim, H., Jang, E.-J., Yoo, H.-E., Hong, E. K., Goh, S., Moon, A., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.03.011 · Cited by 126 · see citing works
Role of extracellular matrix in breast cancer development: a brief update
Jena, M. K., & Janjanam, J. (2018) · F1000Research · doi:10.12688/f1000research.14133.1 · Cited by 114 · see citing works
Hawk, M. A., Gorsuch, C. L., Fagan, P., Lee, C., Kim, S. E., Hamann, J. C., Mason, J. A., Weigel, K. J., Tsegaye, M. A., Shen, L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0034-2 · Cited by 94 · see citing works
Self-citationUnderstanding and targeting anoikis in metastasis for cancer therapies
Fard, F. S., Jalilzadeh, N., Mehdizadeh, A., Sajjadian, F., & Velaei, K. (2022) · Cell Biology International · doi:10.1002/cbin.11970 · Cited by 85 · see citing works
Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment
Hawk, M. A., & Schafer, Z. T. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm117.000260 · Cited by 80 · see citing works
Self-citationMetabolism during ECM Detachment: Achilles Heel of Cancer Cells?
Mason, J. A., Hagel, K. R., Hawk, M. A., & Schafer, Z. T. (2017) · Trends in Cancer · doi:10.1016/j.trecan.2017.04.009 · Cited by 78 · see citing works
Self-citationLiu, X., Adorno-Cruz, V., Chang, Y.-F., Jia, Y., Kawaguchi, M., Dashzeveg, N. K., Taftaf, R., Ramos, E. K., Schuster, E. J., El-Shennawy, L., et al. (2021) · Theranostics · doi:10.7150/thno.57706 · Cited by 76 · see citing works
Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells
Mason, J. A., Davison-Versagli, C. A., Leliaert, A. K., Pape, D. J., McCallister, C. M., Zuo, J.-L., Durbin, S., Buchheit, C. L., Zhang, S., & Schafer, Z. T. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.15 · Cited by 72 · see citing works
Self-citationQiao, Y., Xu, Z., Yu, Y., Hou, S., Geng, J., Xiao, T., Liang, Y., Dong, Q., Mei, Y., Wang, B., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119573 · Cited by 68 · see citing works
Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment
Endo, H., Owada, S., Inagaki, Y., Shida, Y., & Tatemichi, M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101643 · Cited by 63 · see citing works
Brown, C. W., Amante, J. J., & Mercurio, A. M. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003017 · Cited by 62 · see citing works
Collective metastasis: coordinating the multicellular voyage
Wrenn, E. D., Huang, Y. C., & Cheung, K. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10111-0 · Cited by 43 · see citing works
Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis
Gravel, S. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00075 · Cited by 40 · see citing works
Saleh, A., Marhuenda, E., Fabre, C., Hassani, Z., de Weille, J. R., Boukhaddaoui, H., Guelfi, S., Maldonado, I. L., Hugnot, J., Duffau, H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51108-w · Cited by 34 · see citing works
Shaw, P., Bhowmik, A. D., Pillai, M. S. G., Robbins, N., Dwivedi, S. K. D., & Rao, G. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217750 · Cited by 33 · see citing works
Zhou, Y., Xu, Z., Quan, D. L., Zhang, F., Zhang, H., Xiao, T., Hou, S., Qiao, H., Harismendy, O., Wang, J. Y. J., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0349-2 · Cited by 31 · see citing works
Mitochondrial Kinases and the Role of Mitochondrial Protein Phosphorylation in Health and Disease
Kotrasová, V., Keresztesová, B., Ondrovičová, G., Bauer, J., Havalová, H., Pevala, V., Kutějová, E., & Kunová, N. (2021) · Life · doi:10.3390/life11020082 · Cited by 33 · see citing works
The HDAC6 Inhibitor Tubacin Induces Release of CD133+ Extracellular Vesicles From Cancer Cells
Chao, O. S., Chang, T. C., Bella, M. A. D., Alessandro, R., Anzanello, F., Rappa, G., Goodman, O. B., & Lorico, A. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26095 · Cited by 29 · see citing works
Baqai, U., Purwin, T. J., Bechtel, N., Chua, V. Y. L., Han, A., Hartsough, E. J., Kuznetsoff, J. N., Harbour, J. W., & Aplin, A. E. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0657 · Cited by 27 · see citing works
Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells
He, J., Abikoye, A. M., McLaughlin, B. P., Middleton, R. S., Sheldon, R. D., Jones, R. G., & Schafer, Z. T. (2023) · iScience · doi:10.1016/j.isci.2023.106827 · Cited by 25 · see citing works
Self-citationZhong, Z., Pannu, V., Rosenow, M. A., Stark, A., & Spetzler, D. B. (2018) · Cancers · doi:10.3390/cancers10060180 · Cited by 23 · see citing works
Xiao, T., Xu, Z., Zhou, Y., Zhang, H., Geng, J., Liang, Y., Qiao, H., & Suo, G. (2018) · IUBMB Life · doi:10.1002/iub.1949 · Cited by 19 · see citing works
Peerapen, P., Sueksakit, K., Boonmark, W., Yoodee, S., & Thongboonkerd, V. (2021) · Journal of Cancer · doi:10.7150/jca.65511 · Cited by 18 · see citing works
Protein Kinase-Mediated Decision Between the Life and Death
Engin, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-49844-3_1 · Cited by 17 · see citing works
Orai1 is an Entotic Ca 2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development
Lee, A. R., & Park, C. Y. (2023) · Advanced Science · doi:10.1002/advs.202205913 · Cited by 16 · see citing works
Sharma, A., & Elble, R. C. (2020) · Biomedicines · doi:10.3390/biomedicines8060169 · Cited by 15 · see citing works
Stankevičius, V., Vasauskas, G., NOREIKIENE, R., Kuodyte, K., Valius, M., & Sužiedėlis, K. (2016) · Anticancer Research · doi:10.21873/anticanres.11004 · Cited by 15 · see citing works
Li, D., Park, Y.-H., Hemati, H., & Liu, X. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105377 · Cited by 14 · see citing works
Compton, S. L. E., Pyne, E. S., Liu, L., Guinan, J., Shea, A. A., Grieco, J. P., Frisard, M. I., & Schmelz, E. M. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112397 · Cited by 13 · see citing works
Silva, D., Quintas, C., Gonçalves, J., & Fresco, P. (2024) · Cells · doi:10.3390/cells13030262 · Cited by 10 · see citing works
Komemi, O., Shochet, G. E., Pomeranz, M., Fishman, A., Pasmanik‐Chor, M., Drucker, L., Matalon, S. T., & Lishner, M. (2018) · International Journal of Cancer · doi:10.1002/ijc.31861 · Cited by 7 · see citing works
Wang, H., Li, M., Liu, W., Yao, G., Xia, M., Hayashi, T., Fujisaki, H., Hattori, S., Tashiro, S., Onodera, S., et al. (2016) · Connective Tissue Research · doi:10.3109/03008207.2016.1146713 · Cited by 5 · see citing works
Tsai, M.-Y., Aratsu, F., Sekida, S., Kobayashi, S., & Tanaka, M. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00885 · Cited by 5 · see citing works
Ras-ling with new therapeutic targets for metastasis
Mason, J. A., & Schafer, Z. T. (2017) · Small GTPases · doi:10.1080/21541248.2017.1310650 · Cited by 4 · see citing works
Self-citationLi, D., Park, Y.-H., Hemati, H., & Liu, X. (2023) · Research Square · doi:10.21203/rs.3.rs-2535728/v1 · Cited by 4 · see citing works
Unveiling an anoikis-related risk model and the role of RAD9A in colon cancer
Yang, T., Liu, Y.-L., Guo, H.-L., Peng, X., Zhang, B., Wang, D., Yao, H., Zhang, J., Wang, X., Chen, P.-C., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112874 · Cited by 3 · see citing works
SGK-1 and PHLPP1: Ras-mediated effectors during ECM-detachment
Mason, J. A., & Schafer, Z. T. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1194136 · Cited by 3 · see citing works
Self-citationXiao, T., Zhang, H., Zhou, Y., Geng, J., Xu, Z., Liang, Y., Qiao, H., & Suo, G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/301499
Bano, N., Browning, J. L., Lewis, I., Amin, M., Zimmerman, P., Lee, L., & Schmelz, E. M. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1744403
Lu, X., Li, M., Yu, Y., Pan, M., Wang, Y. L., He, J., Tan, J., Yin, H., Lin, H., & Li, M. (2026) · Translational Oncology · doi:10.1016/j.tranon.2026.102917
- Authors
- Rayavarapu, R. R., Heiden, B., Pagani, N., Shaw, M. M., Shuff, S., Zhang, S., & Schafer, Z. T.
- Affiliations
- University of Notre Dame (US)
- Corresponding author
- Schafer, Zachary T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 290
- Issue
- 14
- Pages
- 8722-8733
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC4423663
- OpenAlex
- W1965349285
- Cited by
- 42
- References
- 54
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 12 · 2017: 3 · 2016: 4
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5R00CA158066)
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- ERBB2, HER2-positive breast cancer, anoikis, extracellular matrix detachment, ERK signaling, tumor cell survival, metastasis, anti-EGFR therapy
- MeSH terms
- Breast Neoplasms, Extracellular Matrix, Female, Humans, Signal Transduction, Erb-b2 Receptor Tyrosine Kinases, Cell Line, Tumor, Extracellular Signal-Regulated MAP Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
