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Functional Characterization of a Novel Mammalian Zinc Transporter, ZnT6
Open accessAbstract
We describe ZnT6, a new member of the CDF (cation diffusion facilitator) family of heavy metal transporters. The human ZNT6 gene was mapped at 2p21-22, while the mouse Znt6 was localized to chromosome 17. Overexpression of ZnT6 in both wild-type yeast and mutants that are deficient in cytoplasmic zinc causes growth inhibition, but this inhibition is abolished in mutant cells with high cytoplasmic zinc. ZnT6 may function in transporting the cytoplasmic zinc into the Golgi apparatus as well as the vesicular compartment, as evidenced by its overlapping intracellular localization with TGN38 and transferrin receptor in the normal rat kidney cells. We also demonstrate that the intracellular distributions of ZnT6 as well as ZnT4 are regulated by zinc in the normal rat kidney cells. The results from this report, combined with those from other studies, suggest that the intracellular zinc homeostasis is mediated by many ZnT proteins, which act in tissue-, cell-, and organelle-specific manners.
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Cited by
Kambe, T., Tsuji, T., Hashimoto, A., & Itsumura, N. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2014 · Cited by 1,158
Zinc transporters and the cellular trafficking of zinc
Eide, D. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.03.005 · Cited by 874
Montanini, B., Blaudez, D., Jeandroz, S., Sanders, D., & Chalot, M. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-107 · Cited by 420
A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models
Maares, M., & Haase, H. (2020) · Nutrients · doi:10.3390/nu12030762 · Cited by 367
Role of zinc in health and disease
Stiles, L. I., Ferrao, K., & Mehta, K. J. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01302-6 · Cited by 275
Metadata
- Authors
- Huang, L., Kirschke, C. P., & Gitschier, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 277
- Issue
- 29
- Pages
- 26389-26395
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2092686460
- Cited by
- 212
- References
- 0
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Huang, L., Kirschke, C. P., & Gitschier, J. (2002). Functional Characterization of a Novel Mammalian Zinc Transporter, ZnT6. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m200462200
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