The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
hINADl/PATJ, a Homolog of Discs Lost, Interacts with Crumbs and Localizes to Tight Junctions in Human Epithelial Cells
Open accessAbstract
dCrumbs is an apical organizer crucial for the maintenance of epithelial polarity in Drosophila (1). It is known that dCrumbs interacts with Discs lost (Dlt), a protein with four PDZ (PSD95/Discs Large/ZO-1) domains (2), and Stardust (Sdt), a protein of the MAGUK (membrane-associated guanylate kinase) family (3, 4). We have searched for potential homologs of Dlt in human epithelial cells and characterized one of them in intestinal epithelial cells. Human INAD-like (hINADl) contains 8 PDZ domains, is concentrated in tight junctions, and is also found at the apical plasma membrane. Overexpression of hINADl disrupted the tight junctions localization of ZO-1 and 3. We also identified a partial cDNA coding the transmembrane and cytoplasmic domains of a new human crumbs (CRB3) expressed in Caco-2 cells. This CRB3 was able to interact through its C-terminal end with the N-terminal domain of hINADl. Taken together, the data indicate that hINADl is likely to represent a Dlt homolog in mammalian epithelial cells and might be involved in regulating the integrity of tight junctions. We thus propose to rename hINADl PATJ for protein associated to tight junctions.
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Cites
Occludin: a novel integral membrane protein localizing at tight junctions.
Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
Bilder, D., & Perrimon, N. (2000) · Nature · doi:10.1038/35001108 · Cited by 716
Tanentzapf, G., Smith, C., McGlade, J., & Tepass, U. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.4.891 · Cited by 199
Cited by
Assémat, E., Bazellières, E., Pallesi-Pocachard, E., Le Bivic, A., & Massey-Harroche, D. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.029 · Cited by 470
Self-citationComposition and Formation of Intercellular Junctions in Epithelial Cells
Knust, E., & Bossinger, O. (2002) · Science · doi:10.1126/science.1072161 · Cited by 423
Macara, I. G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1332 · Cited by 341
Setting up a selective barrier at the apical junction complex
Anderson, J. M., Van Itallie, C. M., & Fanning, A. S. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.01.005 · Cited by 215
The blood-retinal barrier: structure and functional significance
Runkle, E. A., & Antonetti, D. A. (2011) · Methods in Molecular Biology · doi:10.1007/978-1-60761-938-3_5 · Cited by 171
Metadata
- Authors
- Lemmers, C., Médina, E., Delgrossi, M.-H., Michel, D., Arsanto, J.-P., & Le Bivic, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 277
- Issue
- 28
- Pages
- 25408-25415
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1965064672
- Cited by
- 173
- References
- 3
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: hINADl/PATJ, a Homolog of Discs Lost, Interacts with Crumbs and Localizes to Tight Junctions in Human Epithelial Cells. https://app.cochat.ai/papers/10.1074/jbc.m202196200
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- Lemmers, C., Médina, E., Delgrossi, M.-H., Michel, D., Arsanto, J.-P., & Le Bivic, A. (2002). hINADl/PATJ, a Homolog of Discs Lost, Interacts with Crumbs and Localizes to Tight Junctions in Human Epithelial Cells. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m202196200
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