The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron
Open accessAbstract
Increased brain metal levels have been associated with normal aging and a variety of diseases, including Alzheimer's disease (AD). Copper and iron levels both show marked increases with age and may adversely interact with the amyloid-beta (Abeta) peptide causing its aggregation and the production of neurotoxic hydrogen peroxide (H(2)O(2)), contributing to the pathogenesis of AD. Amyloid precursor protein (APP) possesses copper/zinc binding sites in its amino-terminal domain and in the Abeta domain. Here we demonstrate that overexpression of the carboxyl-terminal fragment of APP, containing Abeta, results in significantly reduced copper and iron levels in transgenic mouse brain, while overexpression of the APP in Tg2576 transgenic mice results in significantly reduced copper, but not iron, levels prior to the appearance of amyloid neuropathology and throughout the lifespan of the mouse. Concomitant increases in brain manganese levels were observed with both transgenic strains. These findings, complemented by our previous findings of elevated copper levels in APP knock-out mice, support roles for APP and Abeta in physiological metal regulation.
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Cites
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Cited by
Neurodegenerative diseases and oxidative stress
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Self-citationMetals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
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Amyloid Beta: Structure, Biology and Structure-Based Therapeutic Development
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The metallobiology of Alzheimer's disease
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Metadata
- Authors
- Maynard, C. J., Cappai, R., Volitakis, I., Cherny, R. A., White, A. R., Beyreuther, K., Masters, C. L., Bush, A. I., & Li, Q.-X.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 277
- Issue
- 47
- Pages
- 44670-44676
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2039517040
- Cited by
- 353
- References
- 13
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron. https://app.cochat.ai/papers/10.1074/jbc.m204379200
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- Maynard, C. J., Cappai, R., Volitakis, I., Cherny, R. A., White, A. R., Beyreuther, K., Masters, C. L., Bush, A. I., & Li, Q.-X. (2002). Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m204379200
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