Natural Nrf2 Modulators for Skin Protection

Boo, Yong Chool

doi:10.3390/antiox9090812

Cited by 69Genomics, phytochemicals, and oxidative stressSkin Protection and AgingPhytochemicals and Antioxidant Activities

Natural Nrf2 Modulators for Skin Protection

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Boo, Yong Chool·2020·Antioxidants

DOI 10.3390/antiox9090812PMC PMC7556038

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Abstract

Since the discovery of antioxidant responsive elements (ARE), which are commonly found in the promoter of the Phase II metabolism/antioxidant enzymes, and nuclear factor erythroid 2-related factor 2 (Nrf2), the transcription factor that binds to ARE, the study conducted in this field has expanded remarkably over the decades, and the Nrf2-mediated pathway is now recognized to occupy a central position in cell defense mechanisms. Induction of the Phase II metabolism/antioxidant enzymes through direct activation of Nrf2 can be a promising strategy for preventing degenerative diseases in general, but a dark side of this strategy should be considered, as Nrf2 activation can enhance the survival of cancer cells. In this review, we discuss the historical discovery of Nrf2 and the regulatory mechanism of the Nrf2-mediated pathway, focusing on the interacting proteins and post-translational modifications. In addition, we discuss the latest studies that examined various natural Nrf2 modulators for the protective roles in the skin, in consideration of their dermatological and cosmetic applications. Studies are reviewed in the order of time of research as much as possible, to help understand how and why such studies were conducted under the circumstances of that time. We hope that this review can serve as a steppingstone in conducting more advanced research by providing a scientific basis for researchers newly entering this field.

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The NRF2/HO-1 signaling axis is well recognized as a critical mediator of cutaneous oxidative stress responses.
“Moreover, the NRF2/HO-1 signaling axis is well recognized as a critical mediator of cutaneous oxidative stress responses [140,141,142].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [142]

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Ding (2009) · International Journal of Oncology · doi:10.3892/ijo_00000475 · Cited by 27 · see citing works
Salidroside's Protection Against UVB-Mediated Oxidative Damage and Apoptosis Is Associated with the Upregulation of Nrf2 Expression
Yuan, X., Pang, X.-W., Zhang, G., & Guo, J. (2016) · Photomedicine and Laser Surgery · doi:10.1089/pho.2016.4151 · Cited by 26 · see citing works
The C-Terminal Domain of Nrf1 Negatively Regulates the Full-Length CNC-bZIP Factor and Its Shorter Isoform LCR-F1/Nrf1β; Both Are Also Inhibited by the Small Dominant-Negative Nrf1γ/δ Isoforms that Down-Regulate ARE-Battery Gene Expression
Zhang, Y., Qiu, L., Li, S., Xiang, Y., Chen, J., & Ren, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109159 · Cited by 25 · see citing works
3-Bromo-4,5-dihydroxybenzaldehyde Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes
Kim, K., Hyun, Y., Hewage, S. R. K. M., Piao, M. J., Kang, K. A., Kang, H. K., Koh, Y. S., Ahn, M. J., & Hyun, J. W. (2017) · Marine Drugs · doi:10.3390/md15090291 · Cited by 25 · see citing works
Ginsenoside C‐Mx Isolated from Notoginseng Stem‐leaf Ginsenosides Attenuates Ultraviolet B‐mediated Photoaging in Human Dermal Fibroblasts
Liu, X., Hwang, E., Park, B., Ngo, H. T. T., Xiao, Y., & Yi, T. (2018) · Photochemistry and Photobiology · doi:10.1111/php.12940 · Cited by 25 · see citing works
Dual Protective Effects of Flavonoids from Petasites japonicus against UVB-Induced Apoptosis Mediated via HSF-1 Activated Heat Shock Proteins and Nrf2-Activated Heme Oxygenase-1 Pathways
Kim, K. M., Im, A., Lee, S., & Chae, S. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00691 · Cited by 24 · see citing works
Photoprotective effects of 2S,3R-6-methoxycarbonylgallocatechin isolated from Anhua dark tea on UVB-induced inflammatory responses in human keratinocytes.
Kim, D., Hu, R., Fan, Y.-H., Xu, Y.-N., Park, H., & Lee, S. (2019) · Journal of Photochemistry and Photobiology. B: Biology · doi:10.1016/j.jphotobiol.2019.111704 · Cited by 23 · see citing works
Long-Term Intake of Glucoraphanin-Enriched Kale Suppresses Skin Aging via Activating Nrf2 and the TβRII/Smad Pathway in SAMP1 Mice
Chawalitpong, S., Ichikawa, S., Uchibori, Y., Nakamura, S., & Katayama, S. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02725 · Cited by 19 · see citing works
Phloroglucinol Attenuates Ultraviolet B-Induced 8-Oxoguanine Formation in Human HaCaT Keratinocytes through Akt and ErkMediated Nrf2/Ogg1 Signaling Pathways
Piao, M. J., Kim, K. C., Kang, K. A., Fernando, P. D. S. M., Herath, H. M. U. L., & Hyun, J. W. (2020) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2020.059 · Cited by 16 · see citing works
E-p-Methoxycinnamoyl-α-l-rhamnopyranosyl Ester, a Phenylpropanoid Isolated from Scrophularia buergeriana, Increases Nuclear Factor Erythroid-Derived 2-Related Factor 2 Stability by Inhibiting Ubiquitination in Human Keratinocytes
Jeong, J., Wahyudi, L. D., Keum, Y., Yang, H., & Kim, J. H. (2018) · Molecules · doi:10.3390/molecules23040768 · Cited by 10 · see citing works
Protective Effects of 2′,3′-Dihydroxy-4′,6′-dimethoxychalcone Derived from Green Perilla Leaves against UV Radiation-Induced Cell Injury in Human Cultured Keratinocytes
Takada‐Takatori, Y., Tomii, Y., Takemasa, S., Takeda, Y., Izumi, Y., Akaike, A., Tsuchida, K., & Kume, T. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00618 · Cited by 3 · see citing works
The bright and the dark sides of Nrf2 in wound repair and skin tumorigenesis
Werner, S. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.06.1139 · Cited by 1 · see citing works

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Focus on the Contribution of Oxidative Stress in Skin Aging
Papaccio, F., D’Arino, A., Caputo, S., & Bellei, B. (2022) · Antioxidants · doi:10.3390/antiox11061121 · Cited by 431 · see citing works
Arbutin as a Skin Depigmenting Agent with Antimelanogenic and Antioxidant Properties
Boo, Y. C. (2021) · Antioxidants · doi:10.3390/antiox10071129 · Cited by 241 · see citing works
Self-citation
Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation
Boo, Y. C. (2021) · Antioxidants · doi:10.3390/antiox10081315 · Cited by 215 · see citing works
Self-citation
Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2
Chaiprasongsuk, A., & Panich, U. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.823881 · Cited by 128 · see citing works
GSK-3β, FYN, and DYRK1A: Master Regulators in Neurodegenerative Pathways
Demuro, S., Martino, R. M. C. D., Ortega, J. A., & Cavalli, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169098 · Cited by 85 · see citing works
Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors
Darvin, M. E., Lademann, J. M., von Hagen, J., Lohan, S. B., Kolmar, H., Meinke, M. C., & Jung, S. (2022) · Antioxidants · doi:10.3390/antiox11081451 · Cited by 89 · see citing works
Potential Role of Natural Antioxidant Products in Oncological Diseases
Marino, P., Pepe, G., Basilicata, M. G., Vestuto, V., Marzocco, S., Autore, G., Procino, A., Gomez-Monterrey, I. M., Manfra, M., & Campiglia, P. (2023) · Antioxidants · doi:10.3390/antiox12030704 · Cited by 82 · see citing works
Normal and Pathological NRF2 Signalling in the Central Nervous System
Heurtaux, T., Bouvier, D. S., Bénani, A., Helgueta, S., Frauenknecht, K. B. M., Mittelbronn, M. G. A., & Sinkkonen, L. (2022) · Antioxidants · doi:10.3390/antiox11081426 · Cited by 76 · see citing works
Antioxidant and Cytoprotective Potential of the Essential Oil Pistacia lentiscus var. chia and Its Major Components Myrcene and α-Pinene
Xanthis, V., Fitsiou, E., Voulgaridou, G.-P., Bogadakis, A., Chlichlia, K., Galanis, Α., & Pappa, A. (2021) · Antioxidants · doi:10.3390/antiox10010127 · Cited by 73 · see citing works
Effect of ultraviolet radiation on the Nrf2 signaling pathway in skin cells
Ryšavá, A., Vostálová, J., & Svobodová, A. R. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1962566 · Cited by 65 · see citing works
Combined Effects of Carotenoids and Polyphenols in Balancing the Response of Skin Cells to UV Irradiation
Calniquer, G., Khanin, M., Ovadia, H., Linnewiel‐Hermoni, K., Stepensky, D., Trachtenberg, A., Sedlov, T., Braverman, O., Levy, J., & Sharoni, Y. (2021) · Molecules · doi:10.3390/molecules26071931 · Cited by 59 · see citing works
Poly-D,L-Lactic Acid Filler Increases Extracellular Matrix by Modulating Macrophages and Adipose-Derived Stem Cells in Aged Animal Skin
Oh, S., Seo, S. B., Kim, G., Batsukh, S., Park, C., Son, K. H., & Byun, K. (2023) · Antioxidants · doi:10.3390/antiox12061204 · Cited by 58 · see citing works
Cold atmospheric plasma (CAP): a revolutionary approach in dermatology and skincare
Khalaf, A. T., Abdalla, A. N., Ren, K., & Liu, X. (2024) · European journal of medical research · doi:10.1186/s40001-024-02088-9 · Cited by 56 · see citing works
On the Potential Role of the Antioxidant Couple Vitamin E/Selenium Taken by the Oral Route in Skin and Hair Health
Pincemail, J., & Meziane, S. (2022) · Antioxidants · doi:10.3390/antiox11112270 · Cited by 58 · see citing works
NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis
Kahremany, S., Hofmann, L., Gruzman, A., Dinkova‐Kostova, A. T., & Cohen, G. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.06.238 · Cited by 51 · see citing works
Advances in the modulation of ROS and transdermal administration for anti-psoriatic nanotherapies
Xu, J., Chen, H., Qian, H., Wang, F., & Xu, Y. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01651-y · Cited by 40 · see citing works
Siegesbeckiae Herba Extract and Chlorogenic Acid Ameliorate the Death of HaCaT Keratinocytes Exposed to Airborne Particulate Matter by Mitigating Oxidative Stress
Ha, J. W., & Boo, Y. C. (2021) · Antioxidants · doi:10.3390/antiox10111762 · Cited by 38 · see citing works
Self-citation
High Resolution Mass Spectroscopy-Based Secondary Metabolite Profiling of Nymphaea nouchali (Burm. f) Stem Attenuates Oxidative Stress via Regulation of MAPK/Nrf2/HO-1/ROS Pathway
Alam, M. B., Naznin, M., Islam, S., Alshammari, F. H., Choi, H.-J., Song, B., Kim, S., & Lee, S. (2021) · Antioxidants · doi:10.3390/antiox10050719 · Cited by 36 · see citing works
NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products
Frantz, M., Rozot, R., & Marrot, L. (2022) · BioFactors · doi:10.1002/biof.1907 · Cited by 26 · see citing works
NRF2 , a crucial modulator of skin cells protection against vitiligo, psoriasis, and cancer
Panieri, E., Telkoparan‐Akillilar, P., & Saso, L. (2022) · BioFactors · doi:10.1002/biof.1912 · Cited by 27 · see citing works
Therapeutic Potential and Mechanisms of Rosmarinic Acid and the Extracts of Lamiaceae Plants for the Treatment of Fibrosis of Various Organs
Boo, Y. C. (2024) · Antioxidants · doi:10.3390/antiox13020146 · Cited by 25 · see citing works
Self-citation
Comprehensive characterization of naturally occurring antioxidants from the twigs of mulberry ( Morus alba ) using on‐line high‐performance liquid chromatography coupled with chemical detection and high‐resolution mass spectrometry
Pannakal, S. T., Eilstein, J., Prasad, A., Ekhar, P., Shetty, S., Peng, Z., Bordier, E., Boudah, S., Paillat, L., Marrot, L., et al. (2021) · Phytochemical Analysis · doi:10.1002/pca.3072 · Cited by 25 · see citing works
Activation of Nrf2 by Lithospermic Acid Ameliorates Myocardial Ischemia and Reperfusion Injury by Promoting Phosphorylation of AMP-Activated Protein Kinase α (AMPKα)
Zhang, M., Li, W., Xie, S., Xing, Y., Shi, W., Zeng, X., Chen, S., Wang, S., Deng, W., & Tang, Q. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.794982 · Cited by 22 · see citing works
Synthetic and Natural Agents Targeting Advanced Glycation End-Products for Skin Anti-Aging: A Comprehensive Review of Experimental and Clinical Studies
Choi, J. Y., Ha, N. G., Lee, W. J., & Boo, Y. C. (2025) · Antioxidants · doi:10.3390/antiox14040498 · Cited by 24 · see citing works
Self-citation
An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver
Fernández-Ginés, R., Encinar, J. A., Hayes, J. D., Oliva, B., Rodrı́guez-Franco, M. I., Rojo, A. I., & Cuadrado, A. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102396 · Cited by 20 · see citing works
Antioxidant Effects of Korean Propolis in HaCaT Keratinocytes Exposed to Particulate Matter 10
Bae, I. A., Ha, J. W., Choi, J. Y., & Boo, Y. C. (2022) · Antioxidants · doi:10.3390/antiox11040781 · Cited by 19 · see citing works
Self-citation
Attenuation of Pancreatic Cancer In Vitro and In Vivo via Modulation of Nrf2 and NF-κB Signaling Pathways by Natural Compounds
Cykowiak, M., Kleszcz, R., Kucińska, M., Paluszczak, J., Szaefer, H., Plewiński, A., Piotrowska‐Kempisty, H., Murias, M., & Krajka‐Kuźniak, V. (2021) · Cells · doi:10.3390/cells10123556 · Cited by 20 · see citing works
Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives
Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
Mesenchymal Stem Cells Early Response to Low-Dose Ionizing Radiation
Konkova, M. S., Abramova, M. S., Кальянов, А. А., Ershova, E. S., Dolgikh, O. А., Umriukhin, P. E., Izhevskaya, V. L., Kutsev, S. I., Veiko, N. N., & Kostyuk, S. V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.584497 · Cited by 18 · see citing works
Design, synthesis and evaluation of antioxidant and anti-inflammatory activities of novel resveratrol derivatives as potential multifunctional drugs
Lu, J., Wang, W., Zhang, Q., Guo, Z., Jin, Z. H., & Tang, Y. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116148 · Cited by 17 · see citing works
Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes
Steinhoff, M. S., Alam, M. A., Ahmad, A., Shahab Uddin, M. S., & Buddenkotte, J. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.11.009 · Cited by 15 · see citing works
Retracing from Outcomes to Causes: NRF2-Driven GSTA4 Transcriptional Regulation Controls Chronic Inflammation and Oxidative Stress in Atopic Dermatitis Recurrence
Ma, X., Zhao, H., Song, J., Zhang, Z., Gao, C.-J., Luo, Y., Ding, X., Xue, T.-T., Zhang, Y., Zhang, M.-J., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.05.018 · Cited by 14 · see citing works
Nrf2 Activation in Keratinocytes: A Central Role in Diabetes‐Associated Wound Healing
Kaussikaa, S., Prasad, M. K., & Ramkumar, K. M. (2024) · Experimental Dermatology · doi:10.1111/exd.15189 · Cited by 14 · see citing works
Antioxidant, Anti-Inflammation, and Melanogenesis Inhibition of Sang 5 CMU Rice (Oryza sativa) Byproduct for Cosmetic Applications
Linsaenkart, P., Ruksiriwanich, W., Muangsanguan, A., Sommano, S. R., Sringarm, K., Arjin, C., Rachtanapun, P., Jantanasakulwong, K., Castagnini, J. M., Chutoprapat, R., et al. (2024) · Plants · doi:10.3390/plants13131795 · Cited by 12 · see citing works
Antioxidant and skin anti-aging effects of the aqueous ethanol extract of Ginkgo biloba leaf: an in vitro study using HaCaT keratinocytes
Kim, D., Hwang, I., Ku, B., & Choi, E.-M. (2021) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-021-00088-4 · Cited by 10 · see citing works
Polydopamine-loaded prunetin nanomaterials activate DRD2 to reduce UV-induced inflammation by stabilizing and promoting Nrf2 nuclear translocation
Han, J., Zheng, S., Jin, J., Wu, T., Shi, Y., Yang, K., Zhang, H., Li, Y., Sun, Y., Lv, Y. H., et al. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.07.050 · Cited by 10 · see citing works
Deferasirox Causes Leukaemia Cell Death through Nrf2-Induced Ferroptosis
Hsu, W., Wang, L., Lin, P., Liao, Y., Hsu, S., & Chiou, S. (2024) · Antioxidants · doi:10.3390/antiox13040424 · Cited by 10 · see citing works
A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells
Tang, Y.-C., Chang, H.-H., Chen, H., Yao, J.-Y., Chen, Y.-T., Chuang, Y., Chang, J.-Y., & Kuo, C. (2021) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.3376 · Cited by 10 · see citing works
Tanshinone Alleviates UVA-induced Melanogenesis in Melanocytes via the Nrf2-regulated Antioxidant Defense Signaling Pathway
Chen, J., Yin, Z., Yu, N., Ou, S., Wang, X., Li, H., & Zhu, H. (2023) · Current Molecular Medicine · doi:10.2174/0115665240263196230920161019 · Cited by 10 · see citing works
Discovery and Anti-Inflammatory Activity of a Cyanobacterial Fatty Acid Targeting the Keap1/Nrf2 Pathway
Al‐Awadhi, F. H., Simon, E. F., Liu, N., Ratnayake, R., Paul, V. J., & Luesch, H. (2023) · Marine Drugs · doi:10.3390/md21110553 · Cited by 9 · see citing works
Protective mechanisms of intra- and extracellular polysaccharides from Schizophyllum commune on H 2 O 2 -induced oxidative damage of human skin fibroblasts
Cheng, W., Yang, Y., Zhang, J., Di, F. Q., Li, L., Wang, C., Li, M., Zhao, D., Shi, X., Huo, T., et al. (2023) · Food and Agricultural Immunology · doi:10.1080/09540105.2023.2203407 · Cited by 8 · see citing works
Structural identification and antioxidant potency evaluation of pomelo vinegar polyphenols
Zou, B., Li, T., Xu, Y., Yu, Y., & Wu, J. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101674 · Cited by 9 · see citing works
Phytoconstituents in photoaging: therapeutic potential in prevention and regeneration
Ilma, B., Kaushik, K., Shekhar, N., Tyagi, A., & Tyagi, S. (2025) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-025-00776-x · Cited by 7 · see citing works
StandardizedThunbergia laurifoliaExtract Inhibits PM2.5-Induced Oxidative Stress by Regulating p62–KEAP1–NRF2 Signaling Pathway
Jirabanjerdsiri, B., Sriratanasak, N., Towiwat, P., Prueksasit, T., Sukrong, S., & Pithi Chanvorachote, B. (2022) · In Vivo · doi:10.21873/invivo.13009 · Cited by 7 · see citing works
Medical Plaster Enhancement by Coating with Cistus L. Extracts within a Chitosan Matrix: From Natural Complexity to Health Care Simplicity
Hapońska, M., Modrakowska, P., Balik, K., Bajek, A., Coloigner, A., Tylkowski, B., & Giamberini, M. (2021) · Materials · doi:10.3390/ma14030582 · Cited by 6 · see citing works
Primary perspectives towards kimchi as a beauty food enhancing collagen, elastin, hyaluronic acid, and antioxidant enzymes in skin cells
Surya, R., Kim, J.-Y., Kamal, N., Tedjakusuma, F., Thinthasit, A., Petsong, K., & Nugroho, D. (2025) · Discover Food · doi:10.1007/s44187-025-00466-8 · Cited by 5 · see citing works
Live-cell imaging Unveils stimulus-specific dynamics of Nrf2 activation in UV-exposed melanoma cells: Implications for antioxidant compound screening
Htut, N. W., Onkoksoong, T., Saelim, M., Kueanjinda, P., Sampattavanich, S., & Panich, U. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.12.007 · Cited by 5 · see citing works
Ultraviolet Protection From a Patented Amino Acid Complex Technology
Wu, J. X., Namkoong, J., Goswami, S., Cohen, J. L., & Soliman, N. (2024) · Journal of Drugs in Dermatology · doi:10.36849/jdd.7916 · Cited by 4 · see citing works
Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage
Ivarsson, J., Bennett, A. E., Ferrara, F., Strauch, R. C., Vallese, A., Iorizzo, M., Pecorelli, A., Lila, M. A., & Valacchi, G. (2024) · Food & Function · doi:10.1039/d4fo01874e · Cited by 4 · see citing works
Intrinsic and Extrinsic Factors Associated with Hair Graying (Canities) and Therapeutic Potential of Plant Extracts and Phytochemicals
Boo, Y. C. (2024) · Applied Sciences · doi:10.3390/app14177450 · Cited by 4 · see citing works
Self-citation
Evaluation of Cannabis sativa L. Callus Extract as a Novel Cosmetic Ingredient with Dual Anti-Inflammatory and Antioxidant Effects
Yu, G., Kim, D.-H., Kim, H., & Lim, D. (2025) · Plants · doi:10.3390/plants14071148 · Cited by 4 · see citing works
Identifying a Role of Polysaccharides from Agaricus Blazei Murill in Combating Skin Photoaging: The Effect of Antioxidants on Fibroblast Behavior
Di, F., Cheng, W., Li, L., Pu, C., Sun, R., Zhang, J., Wang, C., & Li, M. (2024) · Fermentation · doi:10.3390/fermentation10060292 · Cited by 4 · see citing works
Biomimetic liposomal co-delivery of quercetin and carnosine for enhanced transdermal penetration and NRF2/HES1-mediated antioxidant photoprotection
Xia, X., Zhang, Z., Wang, Y., Chen, C., Wang, Y., Luo, Y., Gao, Y., Hong, W., & Ren, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-28957-9 · Cited by 3 · see citing works
Chlorogenic Acid, a Component of Oenanthe javanica (Blume) DC., Attenuates Oxidative Damage and Prostaglandin E2 Production Due to Particulate Matter 10 in HaCaT Keratinocytes
Bae, I. A., Ha, J. W., & Boo, Y. C. (2023) · Cosmetics · doi:10.3390/cosmetics10020060 · Cited by 3 · see citing works
Self-citation
NRF2 as a Therapeutic Target in Dermatological Disorders: Mechanisms and Molecules
Khiar-Fernández, I., Khiar‐Fernández, N., Pereyra-Rodríguez, J.-J., & Fernández, I. (2026) · Pharmaceuticals · doi:10.3390/ph19030497 · Cited by 2 · see citing works
Supplementation with nicotinamide limits accelerated aging in affected individuals with cockayne syndrome and restores antioxidant defenses
Chikhaoui, A., Zayoud, K., Kraoua, I., Bouchoucha, S., Tebourbi, A., Turki, I., & Yacoub‐Youssef, H. (2024) · Aging · doi:10.18632/aging.206160 · Cited by 2 · see citing works
Insights into the role of Nrf2 in vitiligo pathogenesis: a target for herbal medicine
Qawasmeh, A., Qaisiya, M., Ishnaiwer, A., Khdour, D., Shawar, S., Fallah, S., Haslamon, D., Sinokrot, H., & Kharaiwesh, A. (2025) · Frontiers in Natural Products · doi:10.3389/fntpr.2025.1593684 · Cited by 2 · see citing works
Alteration of reactive oxygen species master transcription factor Nrf2 in keratinocytes exposed to monoclonal pathogenic antibody AK23 against desmoglein-3 in pemphigus vulgaris
Alabeedi, F. M. (2024) · Autoimmunity · doi:10.1080/08916934.2024.2377138 · Cited by 1 · see citing works
Modulation of the KEAP1-NRF2 pathway by Erianin: A novel approach to reduce psoriasiform inflammation and inflammatory signaling
Yan, H., & Wang, G. (2025) · Open Life Sciences · doi:10.1515/biol-2025-1139 · Cited by 1 · see citing works
Pycnogenol® Mitigates Oxidative Stress and Improves Skin Defenses Against Environmental Pollutants: An Ex-Vivo Human Skin Explant Study
Avaltroni, F., Bürki, C., Weichmann, F., Percoco, G., Peno‐Mazzarino, L., & Lati, E. (2026) · Cosmetics · doi:10.3390/cosmetics13010026 · Cited by 1 · see citing works
Evaluating the Antioxidant, Cytoprotective and Wound-Healing-Associated Effects of Haberlea rhodopensis Ethanolic Extract in Human Skin Keratinocytes
Ermogenous, A., Sarigiannidou, E., Psomiadou, M., Panagiotidou, A., Voulgaridou, G.-P., Kiousi, D. E., Moyankova, D., Djilianov, D. L., Galanis, Α., & Pappa, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104262 · Cited by 1 · see citing works
Cutaneous Nrf2‐Keap1 pathway modulation by environmental factors: The Dead Sea area as a test case
Cohen, D., Portugal‐Cohen, M., Oron, M., Frušić‐Zlotkin, M., Soroka, Y., Ma’or, Z., Amar, D., & Kohen, R. (2022) · BioFactors · doi:10.1002/biof.1926 · Cited by 1 · see citing works
Antioxidant activity of thunbergia laurifolia lindl. Ethanolic extract in keratinocytes
Jirabanjerdsiri, B. (2021) · doi:10.58837/chula.the.2021.302
Advancements in Cold Atmospheric Plasma for Skin Disease Treatment and Skincare: A Brief UpdatePreprint
Khalaf, A. T., Oglah, Z., & Liu, X. (2023) · Preprints.org · doi:10.20944/preprints202312.0934.v1
The effect of cooper, zinc and selenium on skin condition
Kulik, A. (2023) · Polish Hyperbaric Research · doi:10.2478/phr-2023-0009
Serum Formulation Containing Salmon DNA and Various Plant Extracts as Antioxidant and Anti-aging on UV-Induced Human Skin Fibroblast Cells
Widowati, W., Tjokropranoto, R., Onggowidjaja, P., Na, M. K., Triharsiwi, D. N., Hadiprasetyo, D. S., Alexandro, G., Azis, R., Askar, K. A., & Utomo, H. S. (2026) · Natural Resources for Human Health · doi:10.53365/nrfhh/213305
The Antioxidant Activity of a Prepared Cream Containing Saffron Extract and Grape Seed Extract
Zam, W., Alkhaddour, A., & Housheh, S. (2026) · BioMed Research International · doi:10.1155/bmri/4463017
Protective Effects of Violaxanthin on Cellular Oxidative Stress via NRF2 Activation in H2O2-Stimulated Human Keratinocytes
Kim, J.-S., Kim, H. S., Shin, H.-J., Park, S., Kim, J. W., Park, S., Kim, H.-S., Lee, Y. J., & Bae, S. (2026) · Applied Sciences · doi:10.3390/app16105132
NRF2 in hypertrophic scarring: A stage-dependent redox hub poised between resolution and persistence
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The role of transcription factor Nrf2 in skin cells metabolism
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REVIEW The role of transcription factor Nrf2 in skin cells metabolism
Skrzydlewska, E. (2016)
The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders
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Authors: Boo, Y. C.
Affiliations: Kyungpook National University (KR)
Corresponding author: Boo, Yong Chool
ORCID: Boo, Yong Chool
Venue: Antioxidants
Publisher: MDPI AG
Published: 2020-09-01
Volume: 9
Issue: 9
Pages: 812
ISSN: 2076-3921 (ISSN-L)
DOI: 10.3390/antiox9090812
PMC: PMC7556038
OpenAlex: W3081980397
Cited by: 69
References: 166
Citations by year: 2026: 7 · 2025: 8 · 2024: 13 · 2023: 10 · 2022: 15 · 2021: 15 · 2020: 1
FWCI: 0.98
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Antioxidants (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Korea Health Industry Development Institute (HP20C0004)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: Nrf2, antioxidant response element, phase II metabolism, antioxidant enzymes, skin protection, post-translational modification, tumor cell survival, dermatological applications, cosmetic applications

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