Inactivation of the Hepatic Cytochrome P450 System by Conditional Deletion of Hepatic Cytochrome P450 Reductase

Henderson, Colin J.; Otto, Diana M.E.; Carrie, Dianne; Magnuson, Mark A.; McLaren, Aileen W.; Rosewell, Ian; Wolf, C. Roland

doi:10.1074/jbc.m212087200

Inactivation of the Hepatic Cytochrome P450 System by Conditional Deletion of Hepatic Cytochrome P450 Reductase

Cytochrome P450 (CYP) monooxygenases catalyze the oxidation of a large number of endogenous compounds and the majority of ingested environmental chemicals, leading to their elimination and often to their metabolic activation to toxic products. This enzyme system therefore provides our primary def…