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Cited by 759

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The Role of Orphan Nuclear Receptors in the Regulation of Cholesterol Homeostasis

Repa, Joyce J., Mangelsdorf, David J.·2000·Annual Review of Cell and Developmental Biology
DOI 10.1146/annurev.cellbio.16.1.459
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Abstract

▪ Abstract Cholesterol balance is maintained by a series of regulatory pathways that control the acquisition of cholesterol from endogenous and exogenous sources and the elimination of cholesterol, facilitated by its conversion to bile acids. Over the past decade, investigators have discovered that a family of membrane-bound transcription factors, sterol regulatory element-binding proteins (SREBPs), mediate the end-product repression of key enzymes of cholesterol biosynthesis. Recently orphan members of another family of transcription factors, the nuclear hormone receptors, have been found to regulate key pathways in bile acid metabolism, thereby controlling cholesterol elimination. The study of these orphan nuclear receptors suggests their potential as targets for new drug therapies.

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Show all 10 references

Research works printed but not linked: 120

  1. 10.1139/bcb-75-3-255 · DOI
  2. 10.1016/0009-8981(83)90397-2 · DOI
  3. Andersson S, 1989, J. Biol. Chem., 264, 8222, 10.1016/S0021-9258(18)83172-6 · DOI · Paper page
  4. Arias IM, 1994, The Liver: Biology and Pathobiology.
  5. 10.1016/0022-4731(90)90182-R · DOI · Paper page
  6. 10.1016/S0889-8553(05)70042-X · DOI
  7. 10.1006/bbrc.1993.1976 · DOI · Paper page
  8. Bertolotti M, 1995, J. Gastroenterol., 27, 446
  9. Bosner MS, 1999, J. Lipid Res., 40, 302, 10.1016/S0022-2275(20)33370-8 · DOI · Paper page
  10. 10.1016/S0092-8674(00)80213-5 · DOI · Paper page
  11. 10.1073/pnas.96.20.11041 · DOI · Paper page
  12. Cali JJ, 1991, J. Biol. Chem., 266, 7779, 10.1016/S0021-9258(20)89518-0 · DOI · Paper page
  13. Cali JJ, 1991, J. Biol. Chem., 266, 7774, 10.1016/S0021-9258(20)89517-9 · DOI · Paper page
  14. 10.1093/jn/127.7.1344 · DOI
  15. 10.1006/bbrc.1999.0980 · DOI
  16. 10.2741/A273 · DOI · Paper page
  17. Chiang JYL, 1994, J. Biol. Chem., 269, 17502, 10.1016/S0021-9258(17)32469-9 · DOI
  18. 10.1016/S0076-6879(97)82092-7 · doi:10.1016/s0076-6879(97)82092-7
  19. Cohen BI, 1977, J. Lipid Res., 18, 223, 10.1016/S0022-2275(20)41701-8 · doi:10.1016/s0022-2275(20)41701-8
  20. 10.1016/S0888-7543(05)80298-8 · DOI
  21. 10.1006/abbi.1993.1537 · doi:10.1006/abbi.1993.1537
  22. 10.1083/jcb.126.6.1547 · DOI
  23. 10.1097/00041433-199504000-00009 · DOI
  24. 10.1097/00041433-199908000-00005 · DOI
  25. 10.1111/j.1471-4159.1973.tb04224.x · DOI
  26. 10.1016/0006-291X(70)91060-0 · DOI
  27. 10.1074/jbc.271.50.32269 · DOI
  28. 10.1128/MCB.14.4.2786 · DOI
  29. 10.1016/0092-8674(95)90530-8 · DOI · Paper page
  30. 10.1006/geno.1998.5606 · DOI
  31. 10.1128/MCB.16.7.3853 · DOI · Paper page
  32. 10.1111/j.1432-1033.1975.tb02136.x · DOI
  33. 10.1210/er.20.5.689 · DOI
  34. 10.1074/jbc.274.42.29749 · DOI · Paper page
  35. Gylling H, 1992, J. Lipid Res., 33, 1361, 10.1016/S0022-2275(20)40550-4 · DOI
  36. 10.1161/01.ATV.14.5.694 · DOI
  37. Heuman DM, 1989, J. Lipid Res., 30, 1161, 10.1016/S0022-2275(20)38276-6 · DOI · Paper page
  38. Hofmann AF. 1994. Bile acids. See Arias et al, pp. 677–718
  39. Homan R, 1997, Curr. Pharmaceut. Des., 3, 29, 10.2174/138161280301221005124721 · DOI
  40. 10.1074/jbc.270.10.5381 · DOI
  41. 10.1097/00041433-199904000-00008 · DOI · Paper page
  42. 10.1073/pnas.96.1.266 · DOI · Paper page
  43. 10.1038/383728a0 · DOI · Paper page
  44. Jelinek DF, 1990, J. Biol. Chem., 265, 8190, 10.1016/S0021-9258(19)39056-8 · DOI · Paper page
  45. 10.1042/bj3300261 · DOI
  46. 10.1016/0014-5793(96)00291-8 · DOI
  47. 10.1111/j.1365-2362.1987.tb01132.x · DOI · Paper page
  48. Kirk EA, 1995, J. Lipid Res., 36, 1522, 10.1016/S0022-2275(20)39739-X · DOI
  49. 10.1126/science.284.5415.757 · DOI · Paper page
  50. 10.1016/S0092-8674(00)80900-9 · DOI · Paper page
  51. 10.1210/me.11.6.779 · doi:10.1210/me.11.6.779 · Paper page
  52. 10.1016/S0378-1119(97)00270-9 · DOI
  53. 10.1101/gad.7.10.1871 · DOI · Paper page
  54. Lavy U, 1977, J. Lipid Res., 18, 232, 10.1016/S0022-2275(20)41702-X · doi:10.1016/s0022-2275(20)41702-x
  55. Li YC, 1990, J. Biol. Chem., 265, 12012, 10.1016/S0021-9258(19)38501-1 · DOI · Paper page
  56. 10.1016/0005-2760(74)90230-6 · DOI
  57. 10.1073/pnas.93.18.9799 · DOI · Paper page
  58. 10.1126/science.284.5418.1362 · DOI · Paper page
  59. 10.1016/S0016-5085(73)80088-5 · DOI
  60. 10.1101/gad.6.3.329 · DOI · Paper page
  61. 10.1016/0092-8674(95)90200-7 · DOI · Paper page
  62. 10.1016/S0168-8278(98)80358-9 · DOI
  63. 10.1210/er.20.3.321 · DOI
  64. 10.1093/ajcn/49.4.629 · DOI · Paper page
  65. 10.1021/bi00124a014 · doi:10.1021/bi00124a014
  66. 10.1016/S0026-0495(99)90243-3 · DOI
  67. 10.1006/abio.1997.2557 · DOI
  68. 10.1073/pnas.96.12.6660 · DOI · Paper page
  69. 10.1016/0014-5793(89)81795-8 · DOI
  70. 10.1016/S0092-8674(00)80726-6 · DOI · Paper page
  71. 10.1210/er.18.3.361 · DOI
  72. 10.1126/science.284.5418.1365 · DOI · Paper page
  73. 10.1016/S0092-8674(00)81432-4 · DOI · Paper page
  74. 10.1016/0076-6879(90)89297-U · DOI
  75. Poorman JA, 1993, J. Lipid Res., 34, 1675, 10.1016/S0022-2275(20)35730-8 · DOI
  76. Princen HMG, 1997, Curr. Pharmaceut. Des., 3, 59, 10.2174/138161280301221006092642 · DOI
  77. 10.1016/S0958-1669(99)00031-2 · DOI · Paper page
  78. 10.1074/jbc.273.24.14805 · DOI · Paper page
  79. 10.1172/JCI117255 · DOI
  80. 10.1152/physrev.2000.80.1.361 · DOI · Paper page
  81. 10.1074/jbc.272.38.23995 · DOI
  82. 10.1097/00041433-199804000-00006 · DOI
  83. 10.1074/jbc.271.30.18024 · DOI · Paper page
  84. Schwarz M, 1998, J. Lipid Res., 39, 1833, 10.1016/S0022-2275(20)32171-4 · DOI · Paper page
  85. 10.1210/me.9.1.72 · DOI · Paper page
  86. 10.1016/S0016-5085(97)70239-7 · DOI · Paper page
  87. 10.1016/0378-1119(94)90080-9 · DOI
  88. 10.1073/pnas.91.23.10809 · DOI · Paper page
  89. 10.1172/JCI118113 · DOI
  90. 10.1074/jbc.273.1.126 · DOI
  91. Spady DK, 1983, J. Lipid Res., 24, 303, 10.1016/S0022-2275(20)37999-2 · DOI · Paper page
  92. 10.1021/ar00039a004 · DOI
  93. 10.1007/BF02536046 · DOI
  94. 10.1074/jbc.270.50.29739 · DOI
  95. Stolz A, 1993, J. Biol. Chem., 268, 10448, 10.1016/S0021-9258(18)82220-7 · DOI
  96. Stroup D, 2000, J. Lipid Res., 41, 1, 10.1016/S0022-2275(20)32068-X · DOI
  97. 10.1089/dna.1990.9.657 · DOI
  98. 10.1101/gad.13.7.755 · DOI · Paper page
  99. Taniguchi T, 1994, J. Biol. Chem., 269, 10071, 10.1016/S0021-9258(17)36991-0 · DOI
  100. 10.1073/pnas.92.6.2096 · DOI · Paper page
  101. Turley SD, 1981, J. Lipid Res., 22, 551, 10.1016/S0022-2275(20)37366-1 · DOI · Paper page
  102. Turley SD, Dietschy JM. 1982.Cholesterol metabolism and excretion.InThe Liver: Biology and Pathobiology. ed. I Arias, H Popper, D Schachter, DA Shafritz, pp. 467–92. New York: Raven
  103. 10.1006/geno.1994.1250 · DOI
  104. 10.1093/oxfordjournals.jbchem.a132724 · DOI
  105. 10.1074/jbc.275.19.14700 · DOI · Paper page
  106. 10.1016/S0016-5085(00)70267-8 · DOI
  107. Vlahcevic ZR, Hylemon PB, Chiang JYL. 1994. Hepatic cholesterol metabolism. See Arias et al, pp. 379–89
  108. 10.1097/00004836-199901000-00001 · doi:10.1097/00004836-199901000-00001
  109. 10.1016/S0016-5085(85)80145-1 · DOI
  110. 10.1093/ajcn/59.6.1325 · DOI
  111. 10.1152/ajpgi.1999.276.3.G751 · DOI
  112. Watt SM, 1984, J. Lipid Res., 25, 448, 10.1016/S0022-2275(20)37796-8 · DOI
  113. 10.1146/annurev.biochem.68.1.559 · DOI · Paper page
  114. 10.1101/gad.11.3.289 · DOI · Paper page
  115. 10.1016/B978-012312411-1/50011-1 · DOI
  116. 10.1101/gad.9.9.1033 · DOI · Paper page
  117. Wu Z, 1999, J. Lipid Res., 40, 2195, 10.1016/S0022-2275(20)32094-0 · DOI
  118. Xu G, 2000, J. Lipid Res., 41, 298, 10.1016/S0022-2275(20)32064-2 · DOI
  119. 10.1073/pnas.94.15.7909 · DOI
  120. 10.1210/me.12.10.1594 · DOI · Paper page

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Metadata

Authors
Repa, J. J., & Mangelsdorf, D. J.
Venue
Annual Review of Cell and Developmental Biology
Publisher
Annual Reviews
Published
2000-11
Volume
16
Issue
1
Pages
459-481
ISSN
  • 1081-0706 (ISSN-L)
  • 1530-8995
DOI
10.1146/annurev.cellbio.16.1.459
OpenAlex
W2157038552
Cited by
759
References
10
FWCI
5.93
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Role of Orphan Nuclear Receptors in the Regulation of Cholesterol Homeostasis. https://app.cochat.ai/papers/10.1146/annurev.cellbio.16.1.459
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Repa, J. J., & Mangelsdorf, D. J. (2000). The Role of Orphan Nuclear Receptors in the Regulation of Cholesterol Homeostasis. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.16.1.459

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