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Sterol Regulatory Element-binding Proteins Are Negatively Regulated through SUMO-1 Modification Independent of the Ubiquitin/26 S Proteasome Pathway
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Nuclear SREBP2 can be SUMOylated at K464 for decreased transcriptional activity.
“The nuclear form of sterol regulatory element-binding protein (SREBP) 2, the master transcriptional regulator of cholesterol biosynthesis and uptake, can be SUMOylated at the K464 residue for decreased transcriptional activity (24).”
From SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1 (2021) · cites this paper as [24]
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Mechanisms and regulation of cholesterol homeostasis
Luo, J., Yang, H., & Song, B.-L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0190-7 · Cited by 1,980
Walker, A. K., Yang, F., Jiang, K., Ji, J.-Y., Watts, J. L., Purushotham, A., Boss, O., Hirsch, M. L., Ribich, S., Smith, J. J., et al. (2010) · Genes & Development · doi:10.1101/gad.1901210 · Cited by 357
Cholesterol: From Feeding to Gene Regulation
Martini, C., & Pallottini, V. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0049-y · Cited by 53
SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1
Wang, J.-Q., Lin, Z.-C., Li, L.-L., Zhang, S.-F., Li, W.-H., Liu, W., Song, B.-L., & Luo, J. (2021) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015420 · Cited by 24
Metadata
- Authors
- Hirano, Y., Murata, S., Tanaka, K., Shimizu, M., & Sato, R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 278
- Issue
- 19
- Pages
- 16809-16819
- ISSN
- 0021-9258
- Cited by
- 110
- References
- 1
- Language
- en
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