The Shank Family of Postsynaptic Density Proteins Interacts with and Promotes Synaptic Accumulation of the βPIX Guanine Nucleotide Exchange Factor for Rac1 and Cdc42

Park, Eunhye; Na, Moonseok; Choi, Jeonghoon; Kim, Seho; Lee, Jae-Ran; Yoon, Jiyoung; Park, Dongeun; Sheng, Morgan; Kim, Eunjoon

doi:10.1074/jbc.m301052200

The Shank Family of Postsynaptic Density Proteins Interacts with and Promotes Synaptic Accumulation of the βPIX Guanine Nucleotide Exchange Factor for Rac1 and Cdc42

The Shank/ProSAP family of multidomain proteins is known to play an important role in organizing synaptic multiprotein complexes. Here we report a novel interaction between Shank and βPIX, a guanine nucleotide exchange factor for the Rac1 and Cdc42 small GTPases. This interaction is mediated by t…