The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Lipid II Is an Intrinsic Component of the Pore Induced by Nisin in Bacterial Membranes
Open accessAbstract
The peptidoglycan layers surrounding bacterial membranes are essential for bacterial cell survival and provide an important target for antibiotics. Many antibiotics have mechanisms of action that involve binding to Lipid II, the prenyl chain-linked donor of the peptidoglycan building blocks. One of these antibiotics, the pore-forming peptide nisin uses Lipid II as a receptor molecule to increase its antimicrobial efficacy dramatically. Nisin is the first example of a targeted membrane-permeabilizing peptide antibiotic. However, it was not known whether Lipid II functions only as a receptor to recruit nisin to bacterial membranes, thus increasing its specificity for bacterial cells, or whether it also plays a role in pore formation. We have developed a new method to produce large amounts of Lipid II and variants thereof so that we can address the role of the lipid-linked disaccharide in the activity of nisin. We show here that Lipid II is not only the receptor for nisin but an intrinsic component of the pore formed by nisin, and we present a new model for the pore complex that includes Lipid II.
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Cites
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Use of the Cell Wall Precursor Lipid II by a Pore-Forming Peptide Antibiotic
Breukink, E., Wiedemann, I., Kraaij, C. V., Kuipers, O. P., Sahl, H.-G., & de Kruijff, B. (1999) · Science · doi:10.1126/science.286.5448.2361 · Cited by 814
Self-citationWiedemann, I., Breukink, E., van Kraaij, C., Kuipers, O. P., Bierbaum, G., de Kruijff, B., & Sahl, H.-G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006770200 · Cited by 790
Self-citationFormation of the glycan chains in the synthesis of bacterial peptidoglycan
Heijenoort, J. V. (2001) · Glycobiology · doi:10.1093/glycob/11.3.25r · Cited by 526
Brötz, H., Josten, M., Wiedemann, I., Schneider, U., Götz, F., Bierbaum, G., & Sahl, H. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01065.x · Cited by 421
Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine
Sheldrick, G. M., Jones, P. G., Kennard, O., Williams, D. H., & Smith, G. A. (1978) · Nature · doi:10.1038/271223a0 · Cited by 297
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Self-citationEngineering dehydrated amino acid residues in the antimicrobial peptide nisin.
Kuipers, O. P., Rollema, H. S., Yap, W. M., Boot, H. J., Siezen, R. J., & de Vos, W. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35771-5 · Cited by 196
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Cited by
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis
Sauvage, E., Kerff, F., Terrak, M., Ayala, J. A., & Charlier, P. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00105.x · Cited by 1,317
Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli
Vollmer, W., & Bertsche, U. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.06.007 · Cited by 451
Nisin biotechnological production and application: a review
de Arauz, L. J., Jozala, A. F., Mazzola, P. G., & Vessoni Penna, T. C. (2009) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2009.01.056 · Cited by 451
Antimicrobial Peptides Targeting Gram-Positive Bacteria
Malanovic, N., & Lohner, K. (2016) · Pharmaceuticals · doi:10.3390/ph9030059 · Cited by 420
Effects of Bacteriocins on Methicillin-Resistant Staphylococcus aureus Biofilm
Okuda, K.-I., Zendo, T., Sugimoto, S., Iwase, T., Tajima, A., Yamada, S., Sonomoto, K., & Mizunoe, Y. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00888-13 · Cited by 305
Metadata
- Authors
- Breukink, E., van Heusden, H. E., Vollmerhaus, P. J., Swiezewska, E., Brunner, L., Walker, S., Heck, A. J. R., & de Kruijff, B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 278
- Issue
- 22
- Pages
- 19898-19903
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2155398486
- Cited by
- 339
- References
- 20
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Breukink, E., van Heusden, H. E., Vollmerhaus, P. J., Swiezewska, E., Brunner, L., Walker, S., Heck, A. J. R., & de Kruijff, B. (2003). Lipid II Is an Intrinsic Component of the Pore Induced by Nisin in Bacterial Membranes. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m301463200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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