Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

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ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110

Peroxynitrite oxidation of sulfhydryls.

Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492

Regulation of biosynthesis of nitric oxide.

Nathan, C., & Xie, Q. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36703-0 · Cited by 1,669

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652

Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors

Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484

Nitric oxide synthase structure and mechanism

Marletta, M. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31375-9 · Cited by 1,338

Mammalian nitric oxide synthases

Stuehr, D. J. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00016-x · Cited by 996

Simulation of Multiple Isotropic Spin-Trap EPR Spectra

Duling, D. (1994) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1994.1062 · Cited by 940

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

Ting, H. H., Timimi, F. K., Boles, K., Creager, S. J., Ganz, P., & Creager, M. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118394 · Cited by 869

Molecular mechanisms and modulation of endothelial progenitor cell function in South Asian men

Baliga, V. (2012) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York) · Cited by 1

Activity of endothelial nitric oxide synthase: substrates, modulators and products

Bevers, L. M. (2006) · Utrecht University Repository (Utrecht University) · Cited by 1

The Effects of E-Cigarette Exposure on the Peripheral Vasculature

Pitzer, C. R. (2018) · doi:10.33915/etd.7229 · Cited by 1

BIOMARKERS OF OXIDATIVE STRESS IN NEURODEGENERATIVE DISEASES

Rukhsana Sultana, A., Cenini, G., & Butterfield, D. A. (2025) · Wiley eBooks · doi:10.1002/9781119790419.ch18 · Cited by 1

Lesions and lipids and radicals--O my!

Wilson, J. M., & Walton, B. L. (2004) · Europe PMC (PubMed Central) · Cited by 1

Tetrahydrobiopterin and Endothelial Nitric Oxide Synthase: Implications for Radiation-Induced Endothelial Dysfunction and Normal Tissue Radiation Injury

Berbée, M., Fu, Q., Kumar, K. S., & Hauer‐Jensen, M. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-397-4_7 · Cited by 1

Optical Cryoimaging of Tissue Metabolism in Renal Injuries: Rodent Model

Chadgani, F. S. (2015) · UWM Digital Commons (University of Wisconsin–Milwaukee)

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Giraldo, A. (2019) · Acta Médica Colombiana · doi:10.36104/amc.2010.1570

Manipulation of the insulin-like growth factor 1 receptor on the vascular endothelium : the effect on whole body and endothelial specific insulin sensitivity

Gatenby, V. K. (2014) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)

Uncoupling of Endothelial Nitric Oxide Synthase in Atherosclerosis

Cunnington, C., & Channon, K. M. (2010) · Atherosclerosis · doi:10.1002/9783527629589.ch14

Novel pharmacological strategies to reduce acute radiation injury

Berbée, M. (2011) · Research Publications (Maastricht University) · doi:10.26481/dis.20111021mb

Targeted delivery of biological agents.

Greig, J. A. (2009) · Enlighten: Theses (The University of Glasgow)

Oxidative and Nitrosative Stress in Critical Illness and Injury

Mason, K. E. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6362-6_23

Utilidad de la medición de óxido nítrico en aire espirado en la patología respiratoria

Gutierrez, F. P., & Ma, A. (2014) · TDX (Tesis Doctorals en Xarxa)

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Shinozaki, K., Kashiwagi, A., Masada, M., & Okamura, T. (2006) · Pteridines · doi:10.1515/pteridines.2006.17.1.11

Regulation of ATF3 expression in cardiomyocytes

Giraldo Ramirez, D. A. (2008) · Spiral (Imperial College London) · doi:10.25560/1300

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Boulden, B. M. (2005) · SMARTech Repository (Georgia Institute of Technology)

The relationship between glucose metabolism byproduct, D-lactate, and vascular endothelial cell dysfunction and possible role in diabetes

Tomić, J. (2013) · University Library - University of Saskatchewan (University of Saskatchewan)

Comparison between Carotid Artery Doppler Ultrasound and Coronary Calcium Score as Predictors of Significant Coronary Artery Disease in Patients Undergoing Computed Tomography Coronary Angiography

Tresoldi, S. (2014) · Cardiovascular Pharmacology Open Access · doi:10.4172/2329-6607.1000116 · Cited by 1

Endothelial dysfunction in cardiac microvascular endothelial cells : an investigation into cellular mechanisms and putative role of oleanolic acid in reversing endothelial dysfunction

Mudau, M. (2010) · SUNScholar (Stellenbosch University)

Modeling of the in vivo kinetics of antioxidants delineates suitable parameters for selecting potential antioxidant adjuvants for cancer therapy

Yang, M.-H., Chuang, C.-M., Hsieh, C.-L., Wang, H.-E., Chen, K., Chiu, W., Shih, C., & Peng, R. Y. (2010) · Pharmaceutical Biology · doi:10.3109/13880200903127375

Molecular and cellular characterization of cardiac overload-induced hypertrophy and failure

Umar, S. (2009) · Leiden Repository (Leiden University)

Rational Design and Therapeutic Potential of a Novel Nox1 Inhibitor for the Treatment of Pulmonary Hypertension: In Vitro and In Vivo Effects of Nox1 Inhibition

Ranayhossaini, D. (2014) · D-Scholarship@Pitt (University of Pittsburgh)

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Welch, W. J., Patel, K., Modlinger, P., Mendonca, M., Kawada, N., Dennehy, K., Aslam, S., Wilcox, C. S., Welch, W. J., Patel, K. B., et al. (2007)

ISOPROSTAGLANDIN F2 AND OXIDIZED LDL IN HYPERCHOLESTEROLEMIC RABBITS

Hosseini, M., Javanmard, S. H., & Nematbakhsh, M. (2010)

The Effects of Two Modes of Exercise Training on Plasma Biomarkers of Inflammation and Oxidative Stress in Patients with Symptomatic Peripheral Artery Disease

Salisbury, D. L. (2014) · University of Minnesota Digital Conservancy (University of Minnesota)

NADPH Oxidase as a Mechanistic Link Between Erectile Dysfunction Peripheral and Coronary Endothelial Dysfunction in Obesity

La, F. J. D. (2012)

The Reciprocal Regulation of Nitric Oxide Synthase and Alpha-subunit of Eukaryotic Initiation Factor 2 Post Ultraviolet B Irradiation

Lü, W. (2010) · OhioLink ETD Center (Ohio Library and Information Network)

The responses of endothelium to insult : does endothelial heterogeneity play a role in in vitro cell models

Mthethwa, M. (2015) · SUNScholar (Stellenbosch University)

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Giraldo, A. (2010)

Conséquences d’une restriction de croissance intra-utérine sur la réactivité aortique chez le rat en fonction de l’âge et du sexe biologique

Ennehas, Y. (2013) · doi:10.71781/30096

intact coronary endothelium · production in the - 2 bradykinin through enhanced O response to 2+ Endostatin uncouples NO and Ca

Li, P., Zhang, A. Y., Teggatz, E. G., Zou, A.-P., Campbell, W. B., Xia, M., Zhang, C., Boini, K. M., & Thacker, A. M. (2007)

Antioxidants and Modulation of Cardiovascular Disease

Heller, R. (2008) · CRC Press eBooks · doi:10.3109/9781420044348-3

Effects of p67phox on the mitochondrial oxidative state in the kidney of Dahl

Salehpour, F., Ghanian, Z., Yang, C., Zheleznova, N. N., Kurth, T., Rk, D., Aw, C., & Ranji, M. (2015)

La función endotelial es afectada por la lipemia posprandial: presentación de dos casos

Ramírez‐Vélez, R., Ortega, J. G., Hurtado, C., & Zúñiga, R. A. A. (2011) · Revista Médicas UIS

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Gillis, K. A. (2016) · Enlighten: Theses (The University of Glasgow)

Review Article Evidence of endothelial dysfunction in the development of Alzheimer's disease: Is Alzheimer's a vascular disorder?

Kelleher, R. J., & Soiza, R. L. (2013)

Induced by Angiotensin II Uncoupling and Nitro-oxidative Stress Endothelial Nitric-oxide Synthase Inflammatory Monocytes Determine

Daiber, A., Wenzel, P., Bauersachs, J. K., Widder, J. D., Becker, C., Oelze, M. W., Knorr, M., Brandt, M., Schönfelder, T., & Hu, H. (2014)

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Teixeira, B. C., Lopes, A. L., Macedo, R. C. O., Correa, C. S., Ramis, T. R., Ribeiro, J. L., & Reischak-Oliveira, Á. (2014)

Investigate the relationship between serum levels of homocysteine ,oxidative strees and lipid profiles in women with pre-eclampsia.

Taklifi, E., Nourazarian, A., Sayyah-Melli, M., Vatankhah, A. M., & Safaiyan, A. (2014) · Advances in Environmental Biology

Bilirubin Induced Cardioprotection: From Endogenous Protection to Therapeutic Potential

Bakrania, B. A. (2015) · Griffith Research Online · doi:10.25904/1912/441

Regulation of Induced Nitric Oxide Synthase in Vascular Smooth Muscle Cells by Glucocorticoids

Alsugoor, M. H. (2018) · University of Hertfordshire Research Archive (University of Hertfordshire) · doi:10.18745/th.19617

Sleep Disorders and Endothelial Dysfunction

Borges, F. F., Lorenzi‐Filho, G., & Drager, L. F. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812348-5.00035-0

The Role of Matrix Metalloproteinase-2 in the Pathophysiology of a Reduced Utero-Placental Perfusion Pressure Model of Preeclampsia

Abdalvand, A. (2012) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3pt57

Regulation of the Inducible L-Arginine-Nitric Oxide Pathway by Oxidative Stress and Statins

Costa, M. A. B. D. V. N. (2010) · University of Hertfordshire Research Archive (University of Hertfordshire)

Omega-3 Polyunsaturated Fatty Acids: Impact on Oxidative Stress, Antioxidant Responses and Vascular Function

Zehr, K. R. (2017) · UNM’s Digital Repository (University of New Mexico)

An investigation into the cerebral autoregulatory upper limit: Normal control mechanisms and changes associated with ageing

Thompson, E. (2018) · University of Birmingham Institutional Research Archive (University of Birmingham)

IDENTIFICATION OF CORONARY ATHEROSCLEROTIC LESIONS IN RAT INDUCED BY INTRAVENOUS CANDIDA ALBICANS

Prasetya, R. C., Fatimatuzzahro, N., Susilawati, I. D. A., & Yonenda, A. P. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i12.28062

Use of nanoparticles (HPPS) to carry Curcumin to induce Heme Oxygenase-1 (HO-1) as a cytoprotective agent in human endothelial cells

Rasul, A. (2019) · DalSpace (Dalhousie University)

An Exercise Mimetic That Targets Nitroso-Redox Balance as a Therapeutic for Heart Disease

Shettigar, V., & Ziolo, M. T. (2019) · Springer eBooks · doi:10.1007/978-981-13-8946-7_22

Mitochondrial Permeability Regulates Cardiac Graft Ischemia-Reperfusion Injury and Allograft Rejection

Qamar, A. (2020) · Scholarship@Western (Western University)

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Bruchelt, G., Kuçi, Z., & Schmidt, K. (2020) · Ernährung & Medizin · doi:10.1055/a-1115-9676

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Guo, E., Yoon, J.-H., Jo, W., Jin, J., & Lee, S. K. (2021) · Exercise Science · doi:10.15857/ksep.2021.30.2.205

Solution Tetrahydrobiopterin Radical vs. the Enzyme-Bound Radical: A Paramagnetic Reconciliation

NejatyJahromy, Y. (2021) · Current Chemical Biology · doi:10.2174/2212796816666211221095934

New Therapeutic Targets in Neonatal Pulmonary Hypertension

Dillard, J., Murray, C., & Mathur, A. A. (2022) · Newborn · doi:10.5005/jp-journals-11002-0015

Tyrosin plus Vitamin C – ein mögliches nutritiv-präventives Konzept beim Morbus Parkinson im Frühstadium

Bruchelt, G., Kuçi, Z., & Schmidt, K. (2021) · Erfahrungsheilkunde · doi:10.1055/a-1695-9958

Editorial: Oxidative Stress in Cardiovascular Diseases and Pulmonary Hypertension

Parajuli, N., & Kosanovic, D. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.868988

Ist eine Therapie mit organischen Nitraten heute noch sinnvoll?

Münzel, T. F., & Daiber, A. (2006) · Steinkopff eBooks · doi:10.1007/3-7985-1560-3_2

Dynamic increase of intrahepatic vascular resistance in cirrhosis

Rodrı́guez-Vilarrupla, A., & García‐Pagán, J. C. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8656-4_17

Sodium nitrite induces tolerance in the mouse aorta: Involvement of the renin-angiotensin system, nitric oxide synthase, and reactive oxygen species

de Araújo, N. F., Nóbrega, N. R. C., Costa, D. E. F. D. R., Simplicio, J. A., Ribeiro, N. D. A. R., Tirapelli, C. R., & Bonaventura, D. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177056

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Cale, J. A., Farr, T. D., Serres, S., & Steinert, J. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22354-9.00005-x

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Aboolian, A., Younes, J., Romero, A., Jha, J. C., Jandeleit-Dahm, K. A. M., & Meister, A. J. (2025) · Wiley eBooks · doi:10.1002/9781119790419.ch17

Rudraksha attenuates right ventricular dysfunction in pulmonary hypertension induced Wistar rats

Das, P., Kumar, B., Yellurkar, M. L., Prasanna, V. S., Sarkar, S., Taraphdar, A. K., Dhaked, D. K., Nanjappan, S. K., Sreedhar, R., Sahu, A., et al. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100180

Molecular mechanisms of reactive oxygen species and regulation of gene expression in cardiometabolic syndrome

Fronczek, M., Banach, M., Goławski, M., & Osadnik, T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27333-9.00013-0

The nitric oxide and glutathione response in tissues of trained mice during hyperbaric oxygenation preconditioning and after physical stressPreprint

Duclosel, D., Kormanovski, A., Castro, C. C. P., Guevara‐Balcázar, G., Franco‐Vadillo, A., Toledo‐Blass, M., & Lara‐Padilla, E. (2025) · Research Square · doi:10.21203/rs.3.rs-7801806/v1

Biology of Nitric Oxide Synthases

Fleming, I. (1984) · Comprehensive physiology · doi:10.1002/j.2040-4603.1984.tb01012.x

Ocena działania antyoksydantów u pacjentów z zaburzeniami erekcji leczonych preparatem hamującym aktywność fosfodiesterazy typu 5

Tomasz, P. (2014)

Mechanisms of over-active endothelium-derived contracting factor signaling causing common carotid artery endothelial vasomotor dysfunction in hypertension and aging

Denniss, S. G. (2011) · UWSpace (University of Waterloo)

Oxidative Stress and Endothelial Dysfunction in Obstructive Sleep Apnea

Haddad, D. N. (2010) · The Knowledge Bank (The Ohio State University)

Research Progress on Preventing and Treating Atrial Fibrillation through Modulating Oxidative Stress in Traditional Chinese Medicine

谢, 蕾. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.161086

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Meyer, G. (2010) · doi:10.70675/a05b0553zc00fz4945za3dbz939308c5e9d5

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Yzydorczyk, C. (2011) · theses.fr (ABES) · doi:10.70675/79493b0fz49ecz4151zad3ezc0d9f2e5d333

Rôle de la Thrombospondine-1 dans le remodelage vasculaire

Grenier, C. (2016) · theses.fr (ABES) · doi:10.70675/32ae12b8z1945z4c94z8696z4bfe4e8cc8ee

Endothélium, inflammation et cognition : focus sur le BDNF

Pédard, M. (2018) · theses.fr (ABES) · doi:10.70675/f92d159ez738fz46b0zb7dcze8003d3a0886

Effets de l’administration de tétrahydrobioptérine en condition physiologique et pathologique : De la neurobiologie au comportement

Fanet, H. (2018) · theses.fr (ABES) · doi:10.70675/b46d2065zecc9z4e97zae20zf9e2e4fe0c69

Effets de la pollution atmosphérique particulaire sur la circulation pulmonaire : rôles du stress oxydant et de la signalisation calcique.

Deweirdt, J. (2018) · theses.fr (ABES) · doi:10.70675/965ae416zb6eaz4dd2z9f06zbdc887f2a0f1

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Arcambal, A. (2019) · theses.fr (ABES) · doi:10.70675/db97d791zc861z4773zb985zebf7a06ffd32

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Ribon‐Demars, A. (2019) · doi:10.70675/23c609b8zf57cz4ac6z92cazbee25a75ff12

Return to an extreme environment exposure after pulmonary infection: SCUBA diving as a model?

Cialoni, D., Brizzolari, A., Mrakic‐Sposta, S., Vezzoli, A., Dellanoce, C., Pieri, M., Pelliccia, R., Petrassi, C., Bosco, G., Barassi, A., et al. (2026) · Physiological Reports · doi:10.14814/phy2.70862

Inflammatory biomarkers of atherosclerosis in SLE that may improve SLE-specific cardiovascular risk assessment tools

Santis, S. D., Prete, M., Leone, P., Liakouli, V., Vomero, M., Navarini, L., Ruscitti, P., Ciccia, F., Giacomelli, R., Favoino, E., et al. (2026) · Autoimmunity Reviews · doi:10.1016/j.autrev.2026.104073

Nicotine-Mediated Redox and Nitrosative Stress in Cardiorenal Health

Semenikhina, M., Jones, A., Pasham, V., Budisavljevic, M. N., Palygin, O., & Ilatovskaya, D. V. (2026) · Hypertension · doi:10.1161/hypertensionaha.126.26095

Computational modeling of tyrosine hydroxylase pathway for dopamine synthesis in nerve cells: effect of tetrahydrobiopterin deficiency and oxidative stress

Damdoum, M., Kar, S., & Kavdia, M. (2026) · Cognitive Neurodynamics · doi:10.1007/s11571-026-10486-4

Genistein Restores Nitric Oxide Bioavailability and Attenuates Oxidative Stress in Angiotensin II-Induced Hypertensive Mice

Ku, C., Feng, H., Wu, M., Xie, J., Jiang, K., Li, C., Qin, Z., Abdrakhmanov, A. S., & Zhang, Y. (2026) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2025.290

DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults

Zhong, R., Guo, Y., You, X., Fu, J., Liu, J., Wen, Y., Wen, J., & Zhao, C. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70569

Advances in nitric oxide donors for myocardial protection: From traditional molecules to smart responsive delivery systems

Pan, Y., Xu, G., & Gou, S.-H. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119268

e NOS Uncoupling, Shear‐Stress Tolerance, and the Two‐Threshold Model of Post‐Exertional Malaise in Long COVID : A Mechanistic Hypothesis With Implications for Physiotherapy and Recovery Protocols

Karipidis, Y. K., & Karipidis, K. Y. (2026) · Microcirculation · doi:10.1111/micc.70082

Therapeutic Modulation of Nitric Oxide Pathways to Address Insulin Resistance in Cardiovascular–Kidney–Metabolic Syndrome

Ceteraș, L.-M., Brata, V. D., Dobrotă, I. R., Borbei, R., Clim, M., Alexescu, T., Milaciu, M. V., Perné, M.-G., Gerdanovics, C.-A., Cozma, A., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177701

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Szabó, C. (2026) · Nitric Oxide · doi:10.1016/j.niox.2026.10.010

Mechanisms responsible for homocysteine mediated damage to human endothelial cells : the role of oxidative stress in atherogenesis

Alkhoury, K. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

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Menicucci, S. D. (2011) · UNM’s Digital Repository (University of New Mexico)

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Iames, E. S. (2011) · Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)

Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

Milstien, S., & Katušić, Z. S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1422 · Cited by 492

Computational analysis of interactions of oxidative stress and tetrahydrobiopterin reveals instability in eNOS coupling

Panday, S., Kar, S., & Kavdia, M. (2017) · Microvascular Research · doi:10.1016/j.mvr.2017.07.001 · Cited by 14

Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production

Kar, S., & Kavdia, M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.009 · Cited by 42

The Role of Tetrahydrobiopterin in Superoxide Generation from eNOS: Enzymology and Physiological Implications

Vasquez-Vivar, J. M., Kalyanaraman, B., & Martásek, P. (2003) · Free Radical Research · doi:10.1080/1071576021000040655 · Cited by 218

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

Crabtree, M. J., Tatham, A. L., Al-Wakeel, Y., Warrick, N., Hale, A. B., Cai, S., Channon, K. M., & Alp, N. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805403200 · Cited by 200