Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216

Oncogenic kinase signalling.

Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K. X., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,616

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,860

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D. J., Lefer, D. J., Sessa, W. C., & Walsh, K. X. (2000) · Nature Medicine · doi:10.1038/79510 · Cited by 1,438

Placental development: Lessons from mouse mutants

Rossant, J., & Cross, J. C. (2001) · Nature Reviews Genetics · doi:10.1038/35080570 · Cited by 1,299

Akt regulates growth by directly phosphorylating Tsc2

Potter, C. J., Pedraza, L. G., & Xu, T. (2002) · Nature Cell Biology · doi:10.1038/ncb840 · Cited by 959

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., & Birnbaum, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100462200 · Cited by 959

mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif

Wu, Y., Ouyang, W., Lazorchak, A. S., Liu, D., Shen, H., & Su, B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.219923 · Cited by 84

Specific Roles of Akt iso Forms in Apoptosis and Axon Growth Regulation in Neurons

Díez, H., Garrido, J. J., & Wandosell, F. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032715 · Cited by 82

AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines

Koseoglu, S., Lu, Z., Kumar, C. C., Kirschmeier, P. T., & Zou, J. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.5.3995 · Cited by 79

Placental glycogen stores and fetal growth: insights from genetic mouse models

Tunster, S. J., Watson, E. D., Fowden, A. L., & Burton, G. J. (2020) · Reproduction · doi:10.1530/rep-20-0007 · Cited by 84

Functional role of Akt in macrophage-mediated innate immunity

Lee, Y. G. (2010) · Frontiers in bioscience · doi:10.2741/3702 · Cited by 77

Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast HTR-8/SVneo cells by down-regulating MMP2 through inhibition of FAK/SRC/PI3K/AKT pathway

Wang, R., Wang, W., Ao, L., Wang, Z., Hao, X., & Zhang, H. (2017) · Toxicology · doi:10.1016/j.tox.2017.05.008 · Cited by 77

Genetic and Pharmacological Inhibition of Rheb1-mTORC1 Signaling Exerts Cardioprotection against Adverse Cardiac Remodeling in Mice

Wu, X., Cao, Y., Nie, J., Liu, H., Lu, S., Hu, X., Zhu, J., Zhao, X., Chen, J., Chen, X., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.02.012 · Cited by 74

Akt2 Mediates TGF-�1-Induced Epithelial to Mesenchymal Transition by Deactivating GSK3�/Snail Signaling Pathway in Renal Tubular Epithelial Cells

Lan, A., Qi, Y., & Du, J. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000363006 · Cited by 72

Focus on FKBP51: A molecular link between stress and metabolic disorders

Häusl, A. S., Balsevich, G., Gassen, N. C., & Schmidt, M. V. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.003 · Cited by 73

Akt‐mediated foxo1 inhibition is required for liver regeneration

Pauta, M., Rotllán, N., Fernández‐Hernando, A., Langhi, C., Ribera, J., Lu, M., Boix, L., Bruix, J., Jiménez, W., Suárez, Y., et al. (2015) · Hepatology · doi:10.1002/hep.28286 · Cited by 72

Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation

Sferruzzi-Perri, A. N., López‐Tello, J., Fowden, A. L., & Constância, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602012113 · Cited by 76

Opposing Functions of Akt Isoforms in Lung Tumor Initiation and Progression

Linnerth-Petrik, N. M., Santry, L. A., Petrik, J., & Wootton, S. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094595 · Cited by 74

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer

Virtakoivu, R., Pellinen, T. S., Rantala, J., Perälä, M., & Ivaska, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-03-0213 · Cited by 71

Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy

Matheson, H., Veerbeek, J. H. W., Charnock‐Jones, D. S., Burton, G. J., & Yung, H. W. (2016) · The Journal of Physiology · doi:10.1113/jp271073 · Cited by 71

Akt2 Deficiency is Associated with Anxiety and Depressive Behavior in Mice

Leibrock, C. B., Ackermann, T. F., Hierlmeier, M., Lang, F. J. W., Borgwardt, S., & Lang, U. E. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000354478 · Cited by 70

FOSL1 Is Integral to Establishing the Maternal-Fetal Interface

Kent, L. N., Rumi, M. A. K., Kubota, K., Lee, D., & Soares, M. J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05780-11 · Cited by 70

Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice

Pantaleon, M., Steane, S. E., McMahon, K., Cuffe, J. S. M., & Moritz, K. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-01666-8 · Cited by 74

Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease

Reyes‐Gordillo, K., Shah, R., Arellanes‐Robledo, J., Cheng, Y., Ibrahim, J., & Tuma, P. L. (2019) · Cells · doi:10.3390/cells8111337 · Cited by 71

Molecular Regulation of Sprouting Angiogenesis

Duran, C. L., Howell, D. W., Dave, J. M., Smith, R. L., Torrie, M. E., Essner, J. J., & Bayless, K. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160048 · Cited by 80

Tipping the balance from angiogenesis to fibrosis in CKD

Ballermann, B. J., & Obeidat, M. (2014) · Kidney International Supplements · doi:10.1038/kisup.2014.9 · Cited by 71

Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells

Maira, G. D., Brustolon, F., Pinna, L. A., & Ruzzene, M. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0108-1 · Cited by 70

Cardioprotection by Vanadium Compounds Targeting Akt-Mediated Signaling

Bhuiyan, M. S., & Fukunaga, K. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.09r01cr · Cited by 70

Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia

Chen, M., Yan, R., Zhou, K., Li, X., Zhang, Y., Liu, C., Jiang, M.-X., Ye, H.-L., Meng, X., Pang, N., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808217115 · Cited by 69

In Vivo Analysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis

Sürücü, B., Bozulic, L., Hynx, D., Parcellier, A., & Hemmings, B. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803053200 · Cited by 70

A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice

Tokuda, S., Mahaffey, C. L., Monks, B., Faulkner, C., Birnbaum, M. J., Danzer, S. C., & Frankel, W. N. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq544 · Cited by 69

N-Carbamylglutamate Enhances Pregnancy Outcome in Rats through Activation of the PI3K/PKB/mTOR Signaling Pathway

Zeng, X., Huang, Z., Mao, X., Wang, J., Wu, G., & Qiao, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041192 · Cited by 67

Protein kinase B (PKB/Akt) is required for the completion of meiosis in mouse oocytes

Hoshino, Y., & Sato, E. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2007.12.005 · Cited by 66

All Akt Isoforms (Akt1, Akt2, Akt3) Are Involved in Normal Hearing, but Only Akt2 and Akt3 Are Involved in Auditory Hair Cell Survival in the Mammalian Inner Ear

Brand, Y., Levano, S., Radojevic, V., Naldi, A. M., Setz, C., Ryan, A. F., Pak, K. K., Hemmings, B. A., & Bodmer, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121599 · Cited by 64

Tumor Necrosis Factor–Like Weak Inducer of Apoptosis Stimulation of Glioma Cell Survival Is Dependent on Akt2 Function

Ensign, S. P. F., Ennis, M. J., Savitch, B. A., Carpentieri, D. F., McDonough, W. S., Winkles, J. A., Loftus, J. C., Kingsley, C. B., Hostetter, G. H., & Tran, N. L. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0194 · Cited by 64

Multiple functions of syncytiotrophoblast mitochondria

Martı́nez, F., Olvera-Sánchez, S., Esparza-Perusquía, M., Gómez-Chang, E., & Flores-Herrera, Ó. (2015) · Steroids · doi:10.1016/j.steroids.2015.09.006 · Cited by 63

Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling

WICKI, A. N., Mandalà, M., Massi, D., Taverna, D., Tang, H., Hemmings, B. A., & Xue, G. (2016) · Physiological Reviews · doi:10.1152/physrev.00024.2015 · Cited by 64

Csf2 Null Mutation Alters Placental Gene Expression and Trophoblast Glycogen Cell and Giant Cell Abundance in Mice1

Sferruzzi-Perri, A. N., Macpherson, A. M., Roberts, C. T., & Robertson, S. A. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.073312 · Cited by 60

Stage-specific Integration of Maternal and Embryonic Peroxisome Proliferator-activated Receptor δ Signaling Is Critical to Pregnancy Success

Wang, H., Xie, H., Sun, X., Tranguch, S. L., Zhang, H., Jia, X.-X., Wang, D., Das, S. K., Desvergne, B., Wahli, W., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706577200 · Cited by 61

Epithelium-Mesenchyme Interactions Control the Activity of Peroxisome Proliferator-Activated Receptor β/δ during Hair Follicle Development

Di‐Poï, N., Ng, C. Y., Tan, N. S., Yang, Z., Hemmings, B. A., Desvergne, B., Michalik, L., & Wahli, W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1696-1712.2005 · Cited by 61

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt

Di, R., Wu, X., Chang, Z., Zhao, X., Feng, Q., Lu, S., Luan, Q., Hemmings, B. A., Li, X., & Yang, Z. (2011) · Biochemical Journal · doi:10.1042/bj20110033 · Cited by 62

Lack of evidence for a role of TRB3/NIPK as an inhibitor of PKB-mediated insulin signalling in primary hepatocytes

Iynedjian, P. B. (2005) · Biochemical Journal · doi:10.1042/bj20041425 · Cited by 60

Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction

Zhou, H., Zhao, C., Wang, P., Yang, W., Zhu, H., & Zhang, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1107182 · Cited by 59

Death effector domain–containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice

Mori, M., Kitazume, M., Ose, R., Kurokawa, J., Koga, K., Osuga, Y., Arai, S., & Miyazaki, T. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44723 · Cited by 60

14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells

Gómez‐Suárez, M., Gutiérrez-Martínez, I. Z., Hernández-Trejo, J. A., Hernández-Ruíz, M., Suárez-Pérez, D., Candelario‐Martínez, A., Kamekura, R., Contreras, O. M., Schnoor, M., Ortiz-Navarrete, V. F., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.163 · Cited by 59

Differential function of Akt1 and Akt2 in human adipocytes

Fischer‐Posovszky, P., Tews, D., Horenburg, S., Debatin, K., & Wabitsch, M. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.03.018 · Cited by 56

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

Green, B. D., Jabbour, A. M., Sandow, J. J., Riffkin, C. D., Masouras, D., Daunt, C. P., Salmanidis, M., Brumatti, G., Hemmings, B. A., Guthridge, M. A., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.63 · Cited by 58

Differential Effects of Protein Kinase B/Akt Isoforms on Glucose Homeostasis and Islet Mass

Buzzi, F., Xu, L., Zuellig, R. A., Boller, S., Spinas, G. A., Hynx, D., Chang, Z., Yang, Z., Hemmings, B. A., Tschopp, O., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00719-09 · Cited by 58

Leptin modulates nitric oxide production and lipid metabolism in human placenta

White, V., Gonzalez, E. T., Capobianco, E., Pustovrh, M. C., Martínez, N., Higa, R., Baier, M., & Jawerbaum, A. (2006) · Reproduction Fertility and Development · doi:10.1071/rd05105 · Cited by 58

Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation

Chang, Z., Zhang, Q., Feng, Q., Xu, J., Teng, T., Luan, Q., Shan, C., Hu, Y., Hemmings, B. A., Gao, X., et al. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.08.033 · Cited by 57

Phosphatase of Regenerating Liver 2 (PRL2) Is Essential for Placental Development by Down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and Activating Akt Protein

Dong, Y., Zhang, L., Zhang, S., Bai, Y., Chen, H., Sun, X., Yong, W., Li, W., Colvin, S. C., Rhodes, S. J., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.393462 · Cited by 56

Maternal Nutrient Restriction Upregulates Growth Signaling Pathways in the Cotyledonary Artery of Cow Placentomes

Zhu, M. J., Du, ‬., Hess, B. W., Means, W. J., Nathanielsz, P. W., & Ford, S. P. (2006) · Placenta · doi:10.1016/j.placenta.2006.04.005 · Cited by 56

Down-Regulation of Growth Signaling Pathways Linked to a Reduced Cotyledonary Vascularity in Placentomes of Over-Nourished, Obese Pregnant Ewes

Zhu, M. J., Du, M., Nijland, M. J., Nathanielsz, P. W., Hess, B. W., Moss, G. E., & Ford, S. P. (2009) · Placenta · doi:10.1016/j.placenta.2009.02.001 · Cited by 54

Cross-talk between the Akt and NF-κB Signaling Pathways Inhibits MEHP-Induced Germ Cell Apoptosis

Rogers, R., Ouellet, G. M., Brown, C. W., Moyer, B., Rasoulpour, T., & Hixon, M. L. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn186 · Cited by 54

PDK1 Regulates Vascular Remodeling and Promotes Epithelial-Mesenchymal Transition in Cardiac Development

Feng, Q., Di, R., Tao, F., Chang, Z., Lu, S., Fan, W., Shan, C., Li, X., & Yang, Z. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00420-10 · Cited by 56

Screening of Organophosphate Flame Retardants with Placentation-Disrupting Effects in Human Trophoblast Organoid Model and Characterization of Adverse Pregnancy Outcomes in Mice

Xu, C., Ma, H., Gao, F., Zhang, C., Hu, W., Jia, Y., Xu, J., & Hu, J. (2022) · Environmental Health Perspectives · doi:10.1289/ehp10273 · Cited by 53

Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions

Fukai, A., Kawamura, N., Saito, T., Oshima, Y., Ikeda, T., Kugimiya, F., Higashikawa, A., Yano, F., Ogata, N., Nakamura, K., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27296 · Cited by 53

AKT as a therapeutic target in multiple myeloma

Keane, N. A., Glavey, S. V., Krawczyk, J., & O'Dwyer, M. E. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.924507 · Cited by 55

Placental Glycogen Stores are Increased in Mice with H19 Null Mutations but not in those with Insulin or IGF Type 1 Receptor Mutations

Esquiliano, D. R., Guo, W., Li, L., Dikkes, P., & Lopez, M. F. (2009) · Placenta · doi:10.1016/j.placenta.2009.05.004 · Cited by 53

Glucocorticoid Receptor β Stimulates Akt1 Growth Pathway by Attenuation of PTEN

Stechschulte, L. A., Wuescher, L. M., Marino, J. S., Hill, J. W., Eng, C., & Hinds, T. D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.544072 · Cited by 53

Trimester-specific plasma exosome microRNA expression profiles in preeclampsia

Devor, E. J., Santillan, D. A., Scroggins, S. M., Warrier, A., & Santillan, M. K. (2019) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2019.1569614 · Cited by 51

Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation

Kent, L. N., Konno, T., & Soares, M. J. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-97 · Cited by 52

PI3K Signaling Through the Dual GTPase–Activating Protein ARAP3 Is Essential for Developmental Angiogenesis

Gambardella, L., Hemberger, M., Hughes, B. K., Zudaire, E., Andrews, S. R., & Vermeren, S. (2010) · Science Signaling · doi:10.1126/scisignal.2001026 · Cited by 52

Decreased Spermatogenesis, Fertility, and Altered Slc2A Expression in Akt1−/− and Akt2−/− Testes and Sperm

Kim, S. T., Omurtag, K., & Moley, K. H. (2012) · Reproductive Sciences · doi:10.1177/1933719111424449 · Cited by 50

Akt isoform specific effects in ovarian cancer progression

Linnerth-Petrik, N. M., Santry, L. A., Moorehead, R. A., Jücker, M., Wootton, S. K., & Petrik, J. (2016) · Oncotarget · doi:10.18632/oncotarget.11204 · Cited by 50

Morphology regulation in vascular endothelial cells

Tsuji‐Tamura, K., & Ogawa, M. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0083-8 · Cited by 50

Insulin Regulation of Hepatic Lipid Homeostasis

Uehara, K., Santoleri, D., Whitlock, A. E. G., & Titchenell, P. M. (2023) · Comprehensive Physiology · doi:10.1002/cphy.c220015 · Cited by 49

Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH

Kirkegaard, T., Witton, C. J., Edwards, J., Nielsen, K. V., Jensen, L., Campbell, F., Cooke, T. G., & Bartlett, J. M. S. (2009) · Histopathology · doi:10.1111/j.1365-2559.2009.03467.x · Cited by 48

Hectd1 is required for development of the junctional zone of the placenta

Sarkar, A. A., Nuwayhid, S. J., Maynard, T. M., Ghandchi, F., Hill, J. T., LaMantia, A., & Zohn, I. E. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.05.007 · Cited by 50

Suppression of Inflammatory Responses during Myelin Oligodendrocyte Glycoprotein–Induced Experimental Autoimmune Encephalomyelitis Is Regulated by AKT3 Signaling

Tsiperson, V., Gruber, R. C., Goldberg, M. F., Jordan, A., Weinger, J. G., Macián, F., & Shafit‐Zagardo, B. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201387 · Cited by 47

In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1

Nishimoto, M., Katano, M., Yamagishi, T., Hishida, T., Kamon, M., Suzuki, A., Hirasaki, M., Nabeshima, Y., Nabeshima, Y., Katsura, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068119 · Cited by 47

Behavioral effects of developmental methylmercury drinking water exposure in rodents

Bisen-Hersh, E. B., Farina, M., Barbosa, F., da Rocha, J. B. T., & Aschner, M. (2013) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2013.09.008 · Cited by 46

Endometrium On-a-Chip Reveals Insulin- and Glucose-induced Alterations in the Transcriptome and Proteomic Secretome

de Bem, T. H. D., Tinning, H., Vasconcelos, E., Wang, D.-P., & Forde, N. (2021) · Endocrinology · doi:10.1210/endocr/bqab054 · Cited by 40

Influence of peroxisome proliferator-activated receptor activation by its endogenous ligand 15-deoxy 12,14 prostaglandin J2 on nitric oxide production in term placental tissues from diabetic women

Jawerbaum, A. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah090 · Cited by 46

Akt2 is implicated in skeletal muscle differentiation and specifically binds Prohibitin2/REA

Héron‐Milhavet, L., Mamaeva, D. V., Rochat, A., Lamb, N. J. C., & Fernandez, A. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21177 · Cited by 44

AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM‐1

Corum, D. G., Tsichlis, P. N., & Muise‐Helmericks, R. C. (2013) · The FASEB Journal · doi:10.1096/fj.13-235382 · Cited by 44

Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice

López‐Tello, J., Pérez-García, V., Khaira, J., Kusinski, L. C., Cooper, W. N., Andreani, A., Grant, I. D., de Liger, E. F., Lam, B., Hemberger, M., et al. (2019) · eLife · doi:10.7554/elife.45282 · Cited by 47

BMP4 Protects Rat Pulmonary Arterial Smooth Muscle Cells from Apoptosis by PI3K/AKT/Smad1/5/8 Signaling

Wu, J., Yu, Z., & Su, D. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150813738 · Cited by 43

Signaling Pathways Regulating Vascular Smooth Muscle Cell Differentiation

Rzucidlo, E. M. (2009) · Vascular · doi:10.2310/6670.2008.00089 · Cited by 42

Akt3-Mediated Protection Against Inflammatory Demyelinating Disease

DuBois, J. C., Ray, A. K., Gruber, R. C., Zhang, Y., Aflakpui, R., Macián, F., & Shafit‐Zagardo, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01738 · Cited by 41

IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways

Ashida, N., SenBanerjee, S., Kodama, S., Foo, S. Y., Coggins, M. P., Spencer, J. A., Zamiri, P., Shen, D., Li, L., Sciuto, T. E., et al. (2011) · Nature Communications · doi:10.1038/ncomms1317 · Cited by 41

Metabolic syndrome in rats is associated with erectile dysfunction by impairing PI3K/Akt/eNOS activity

Li, R., Cui, K., Liu, K., Li, H., Zhang, Y., Liu, X., Chen, R., Li, M., Wang, T., Wang, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12907-1 · Cited by 41

Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta

Lien, Y., Zhang, Z., Barila, G., Brown, A. G., Elovitz, M. A., & Simmons, R. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.592689 · Cited by 44

Periconceptional Nutrient Restriction in the Ewe Alters MAPK/ERK1/2 and PI3K/Akt Growth Signaling Pathways and Vascularity in the Placentome

Zhu, M. J., Du, M., Hess, B. W., Nathanielsz, P. W., & Ford, S. P. (2007) · Placenta · doi:10.1016/j.placenta.2007.05.004 · Cited by 41

Targeting the Akt, GSK-3, Bcl-2 axis in acute myeloid leukemia

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