Hemmings, Brian A.

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 5,244

Ten years of protein kinase B signalling: a hard Akt to follow

Brazil, D. P., & Hemmings, B. A. (2001) · Trends in Biochemical Sciences

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 1,177

Role of Translocation in the Activation and Function of Protein Kinase B

Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J. C., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., & Hemmings, B. A. (1997) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 1,051

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

Brunet, A., Park, J., Tran, H., Hu, L. S., Hemmings, B. A., & Greenberg, M. E. (2001) · Molecular and Cellular Biology

FOXO transcription factor regulationPI3K/AKT/mTOR signaling in cancer

Cited by 860

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways

Clemens, J. C., Worby, C. A., Simonson-Leff, N., Muda, M., Maehama, T., Hemmings, B. A., & Dixon, J. E. (2000) · Proceedings of the National Academy of Sciences

RNA Interference and Gene DeliveryNeurobiology and Insect Physiology Research

Cited by 843

Phosphorylation and Activation of p70 s6k by PDK1

Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., & Thomas, G. (1998) · Science

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 826

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

Alessi, D. R., Barry Caudwell, F., Andjelkovic, M., Hemmings, B. A., & Cohen, P. (1996) · FEBS Letters

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 628

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

Groves, M. R., Hanlon, N., Turowski, P., Hemmings, B. A., & Barford, D. (1999) · Cell

Protein Structure and DynamicsProtein Tyrosine Phosphatases

Cited by 442

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

Yung, H.-W., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., & Burton, G. J. (2008) · The American Journal of Pathology

Pregnancy and preeclampsia studiesEndoplasmic Reticulum Stress and Disease

Cited by 388

Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth

Yang, Z.-Z., Tschopp, O., Hemmings-Mieszczak, M., Feng, J., Brodbeck, D., Perentes, E., & Hemmings, B. A. (2003) · Journal of Biological Chemistry

Pregnancy and preeclampsia studiesBirth, Development, and Health

Cited by 384

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

Meier, R., Alessi, D. R., Cron, P., Andjelković, M., & Hemmings, B. A. (1997) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 378

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

Hajduch, E., Alessi, D. R., Hemmings, B. A., & Hundal, H. S. (1998) · Diabetes

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 335

Physiological roles of PKB/Akt isoforms in development and disease

Dummler, B., & Hemmings, B. A. (2007) · Biochemical Society Transactions

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 316

Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation

Feng, J., Tamaskovic, R., Yang, Z., Brazil, D. P., Merlo, A., Hess, D., & Hemmings, B. A. (2004) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 294

Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

Hemmings, B. A., Adams-Pearson, C., Maurer, F., Mueller, P., Goris, J., Merlevede, W., Hofsteenge, J., & Stone, S. R. (1990) · Biochemistry

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 243

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα

Götz, J., Probst, A., Ehler, E., Hemmings, B., & Kues, W. (1998) · Proceedings of the National Academy of Sciences

Protein Tyrosine PhosphatasesDevelopmental Biology and Gene Regulation

Cited by 220

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice

Kins, S., Crameri, A., Evans, D. R. H., Hemmings, B. A., Nitsch, R. M., & Götz, J. (2001) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 203

Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A

Stone, S. R., Hofsteenge, J., & Hemmings, B. A. (1987) · Biochemistry

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 168

Regulation of NDR Protein Kinase by Hydrophobic Motif Phosphorylation Mediated by the Mammalian Ste20-Like Kinase MST3

Stegert, M. R., Hergovich, A., Tamaskovic, R., Bichsel, S. J., & Hemmings, B. A. (2005) · Molecular and Cellular Biology

Hippo pathway signaling and YAP/TAZProtein Kinase Regulation and GTPase Signaling

Cited by 152

Centrosome-associated NDR kinase regulates centrosome duplication.

Hergovich, A., Lamla, S., Nigg, E. A., & Hemmings, B. A. (2007) · Molecular Cell

Microtubule and mitosis dynamicsCancer-related Molecular Pathways

Cited by 108

Translation Regulation as a Therapeutic Target in Cancer

Grzmil, M., & Hemmings, B. A. (2012) · Cancer Research

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 103

Tissue‐specific expression of mRNAs encoding α‐ and β‐catalytic subunits of protein phosphatase 2A

Khew-Goodall, Y., & Hemmings, B. A. (1988) · FEBS Letters

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 102

Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.

Cornils, H., Stegert, M. R., Hergovich, A., Hynx, D., Schmitz, D., Dirnhofer, S., & Hemmings, B. A. (2010) · Science Signaling

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 72

Functional expression of human PP2Ac in yeast permits the identification of novel C-terminal and dominant-negative mutant forms

Evans, D. R. H., Myles, T., Hofsteenge, J., & Hemmings, B. A. (1999) · Journal of Biological Chemistry

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 65