Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216

Oncogenic kinase signalling.

Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K. X., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,616

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,860

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D. J., Lefer, D. J., Sessa, W. C., & Walsh, K. X. (2000) · Nature Medicine · doi:10.1038/79510 · Cited by 1,438

Placental development: Lessons from mouse mutants

Rossant, J., & Cross, J. C. (2001) · Nature Reviews Genetics · doi:10.1038/35080570 · Cited by 1,299

Akt regulates growth by directly phosphorylating Tsc2

Potter, C. J., Pedraza, L. G., & Xu, T. (2002) · Nature Cell Biology · doi:10.1038/ncb840 · Cited by 959

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., & Birnbaum, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100462200 · Cited by 959

Deletion of PKBα/Akt1 Affects Thymic Development

Fayard, E., Gill, J. W., Paolino, M., Hynx, D., Holländer, G. A., & Hemmings, B. A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000992 · Cited by 31

A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206

Chorner, P. M., & Moorehead, R. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193344 · Cited by 30

Knockdown of Akt1 Promotes Akt2 Upregulation and Resistance to Oxidative-Stress-Induced Apoptosis Through Control of Multiple Signaling Pathways

Zhang, L., Sun, S., Zhou, J., Liu, J., Lv, J.-H., Yu, X.-Q., Li, C., Gong, L., Yan, Q., Deng, M., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3560 · Cited by 30

Eupafolin Exhibits Potent Anti-Angiogenic and Antitumor Activity in Hepatocellular Carcinoma

Jiang, H., Wu, D., Xu, D., Yu, H., Zhao, Z., Ma, D., & Jin, J. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.17534 · Cited by 31

AKT Isoforms 1 and 3 Regulate Basal and Epidermal Growth Factor-Stimulated SGHPL-5 Trophoblast Cell Migration in Humans1

Haslinger, P., Haider, S., Sonderegger, S., Otten, J., Pollheimer, J., Whitley, G. S. J., & Knöfler, M. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.112.104778 · Cited by 29

Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis

Zhang, D., Wang, J., Zhou, C., & Xiao, W. (2017) · Mechanisms of Development · doi:10.1016/j.mod.2017.01.004 · Cited by 31

Functional specificity of Akt isoforms in cancer progression

Fortier, A.-M., Asselin, É., & Cadrin, M. (2011) · BioMolecular Concepts · doi:10.1515/bmc.2011.003 · Cited by 28

Akt3 deletion in mice impairs spatial cognition and hippocampal CA 1 long long‐term potentiation through downregulation of mTOR

Zhang, T., Shi, Z., Wang, Y., Wang, L., Zhang, B., Chen, G., Wan, Q., & Chen, L. (2018) · Acta Physiologica · doi:10.1111/apha.13167 · Cited by 28

Progerin modulates the IGF-1R/Akt signaling involved in aging

Jiang, B., Wu, X., Meng, F., Si, L., Cao, S., Dong, Y., Sun, H., Lv, M., Xu, H., Bai, N., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo0322 · Cited by 28

Addressing the Glycine‐Rich Loop of Protein Kinases by a Multi‐Facetted Interaction Network: Inhibition of PKA and a PKB Mimic

Lauber, B. S., Hardegger, L. A., Alam, K. A., Lund, B. A., Dumele∞, O., Harder, M., Kuhn, B., Engh, R. A., & Diederich, F. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201503552 · Cited by 28

Salmonella enteritidis Rck‐mediated invasion requires activation of Rac1, which is dependent on the class I PI 3‐kinases‐Akt signaling pathway

Mijouin, L., Rosselin, M., Bottreau, E., Pizarro‐Cerdá, J., Cossart, P., Velge, P., & Wiedemann, A. (2011) · The FASEB Journal · doi:10.1096/fj.11-189647 · Cited by 27

Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3)

Mouton, V., Toussaint, L., Vertommen, D., Gueuning, M.-A., Maisin, L., Havaux, X., Canedo, C. S., Bertrand, L., Dequiedt, F., Hemmings, B. A., et al. (2010) · Biochemical Journal · doi:10.1042/bj20101089 · Cited by 27

Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart

Klement, G. L., Goukassian, D. A., Hlatky, L., Carrozza, J. P., Morgan, J. P., & Yan, X. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00113 · Cited by 27

Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo

Restuccia, D. F., Hynx, D., & Hemmings, B. A. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.008136 · Cited by 27

Effects of postnatal ethanol exposure at different developmental phases on neurotrophic factors and phosphorylated proteins on signal transductions in rat brain

Tsuji, R., Fattori, V., Abe, S., Costa, L. G., & Kobayashi, K. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2008.01.004 · Cited by 27

Shifting perspectives from “oncogenic” to oncofetal proteins; how these factors drive placental development

West, R. C., Bouma, G. J., & Winger, Q. A. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0421-3 · Cited by 26

Adaptive changes in structure of skeletal muscles from adult Sod1 homozygous knockout mice

Kostrominova, T. Y., Pasyk, K. A., Remmen, H. V., Richardson, A. G., & Faulkner, J. A. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0297-y · Cited by 26

Autophagy—A Hidden but Important Actor on Oral Cancer Scene

Totan, A., Marina, I. M., Miricescu, D., Ioana, S. I., Bencze, M.-A., Radu, R., Țâncu, A. M. C., Spînu, T. C., & Greabu, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239325 · Cited by 25

microRNA signatures associated with fetal growth restriction: a systematic review

Kochhar, P., Vukku, M., Rajashekhar, R., & Mukhopadhyay, A. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-01041-x · Cited by 26

The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo

Koren, S., DiPilato, L. M., Emmett, M. J., Shearin, A. L., Chu, Q., Monks, B. R., & Birnbaum, M. J. (2015) · Diabetologia · doi:10.1007/s00125-015-3532-9 · Cited by 25

Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain

Wang, L., Cheng, S., Yin, Z., Xu, C., Lu, S., Hou, J., Yu, T., Zhu, X., Zou, X., Peng, Y., et al. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0030-y · Cited by 25

Novel insights for the role of nitric oxide in placental vascular function during and beyond pregnancy

Krause, B. J. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30470 · Cited by 23

Akt3‐mTOR regulates hippocampal neurogenesis in adult mouse

Zhang, T., Ding, H., Wang, Y., Yuan, Z., Zhang, Y., Chen, G., Xu, Y., & Chen, L. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15441 · Cited by 24

TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells

Obeidat, M., Li, L., & Ballermann, B. J. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00070.2014 · Cited by 24

The expression of Akt and ERK1/2 proteins decreased in dexamethasone-induced intrauterine growth restricted rat placental development

Özmen, A., Ünek, G., Kipmen‐Korgun, D., & Korgun, E. T. (2011) · Journal of Molecular Histology · doi:10.1007/s10735-011-9328-4 · Cited by 23

Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle

Zheng, X., & Cartee, G. D. (2016) · Scientific Reports · doi:10.1038/srep39230 · Cited by 22

Lipid droplet deposition in the regenerating liver: A promoter, inhibitor, or bystander?

Hu, Y., Wang, R., Liu, J., Wang, Y., & Dong, J. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000267 · Cited by 22

Expression of endometrial glycogen synthase kinase-3β protein throughout the menstrual cycle and its regulation by progesterone

Salameh, W. A., Helliwell, J. P., Han, G., McPhaul, L., & Khorram, O. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal065 · Cited by 22

Investigation of Sperm and Seminal Plasma Candidate MicroRNAs of Bulls with Differing Fertility and In Silico Prediction of miRNA-mRNA Interaction Network of Reproductive Function

Kasimanickam, V. R., Kumar, N., & Kasimanickam, R. K. (2022) · Animals · doi:10.3390/ani12182360 · Cited by 26

Phosphorylation of the Twist1-Family Basic Helix-Loop-Helix Transcription Factors Is Involved in Pathological Cardiac Remodeling

Lu, S., Nie, J., Luan, Q., Feng, Q., Xiao, Q., Chang, Z., Shan, C., Heß, D., Hemmings, B. A., & Yang, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019251 · Cited by 22

Survival and Size Are Differentially Regulated by Placental and Fetal PKBalpha/AKT1 in Mice1

Plaks, V., Berkovitz, E., Vandoorne, K., Berkutzki, T., Damari, G. M., Haffner, R., Dekel, N., Hemmings, B. A., Neeman, M., & Harmelin, A. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.085951 · Cited by 22

Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation

Morioka, Y., Nam, J., & Ohashi, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171503 · Cited by 21

Aberrant Akt Activation During Implantation Window in Infertile Women With Intramural Uterine Fibroids

Makker, A., Goel, M. M., Nigam, D. K., Mahdi, A. A., Das, V., Ak, A., Pandey, A., & Gautam, A. K. (2017) · Reproductive Sciences · doi:10.1177/1933719117737844 · Cited by 22

SIRT1 negatively regulates invasive and angiogenic activities of the extravillous trophoblast

Lee, K. M., Seo, H. W., Kwon, M., Han, A. R., & Lee, S. K. (2019) · American Journal of Reproductive Immunology · doi:10.1111/aji.13167 · Cited by 22

Protein kinase B Akt regulation in diabetic kidney disease

Brazil, D. P. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s135 · Cited by 22

Identification and modulation of a caveolae-dependent signal pathway that regulates plasminogen activator inhibitor-1 in insulin-resistant adipocytes

Venugopal, J., Hanashiro, K., Yang, Z., & Nagamine, Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405278101 · Cited by 22

Differential regulation of AKT1 contributes to survival and proliferation in hepatocellular carcinoma cells by mediating Notch1 expression

Chen, J., Liang, J., Liu, S., Song, S., Guo, W., & Shen, F. (2018) · Oncology Letters · doi:10.3892/ol.2018.8193 · Cited by 21

Bisphenol F promotes the secretion of pro-inflammatory cytokines in macrophages by enhanced glycolysis through PI3K-AKT signaling pathway

Zhang, W., Li, L., Chen, H., Zhang, Y., Zhang, Z., Lin, Z., Shi, M., Zhang, W., Li, X., Tang, Z., et al. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.06.011 · Cited by 23

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in DeterminingIn VivoAKT Isoform Substrate Specificity

Lee, R. S., House, C. M., Cristiano, B. E., Hannan, R. D., Pearson, R. B., & Hannan, K. M. (2011) · Enzyme Research · doi:10.4061/2011/720985 · Cited by 20

Akt1 signalling supports acinar proliferation and limits acinar‐to‐ductal metaplasia formation upon induction of acute pancreatitis

Chen, R., Malagola, E., Dietrich, M., Zuellig, R. A., Tschopp, O., Bombardo, M., Saponara, E., Reding, T., Myers, S., Hills, A. P., et al. (2019) · The Journal of Pathology · doi:10.1002/path.5348 · Cited by 21

Akt2 and SGK3 are both determinants of postnatal hair follicle development

Mauro, T. M., McCormick, J. A., Wang, J., Boini, K. M., Ray, L., Monks, B. R., Birnbaum, M. J., Lang, F. J. W., & Pearce, D. (2009) · The FASEB Journal · doi:10.1096/fj.08-123729 · Cited by 21

Antenatal Maternal Long-Term Hypoxia: Acclimatization Responses with Altered Gene Expression in Ovine Fetal Carotid Arteries

Goyal, R., Wickle, J. V., Goyal, D., Matei, N., & Longo, L. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082200 · Cited by 20

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells

Cichon, A.-C., Pickard, A., McDade, S. S., Sharpe, D., Moran, M., James, J. A., & McCance, D. J. (2013) · Oncotarget · doi:10.18632/oncotarget.1078 · Cited by 20

Igf2 ligand dependency of Pten+/− developmental and tumour phenotypes in the mouse

Church, D. N., Phillips, B. R., Stuckey, D. J., Barnes, D., Buffa, F. M., Manek, S., Clarke, K., Harris, A. L., Carter, E. J., & Hassan, A. B. (2011) · Oncogene · doi:10.1038/onc.2011.526 · Cited by 20

Effective angiogenesis requires regulation of phosphoinositide signaling

Davies, E. M., Gurung, R., Le, K. Q., & Mitchell, C. A. (2018) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.11.008 · Cited by 19

Akt1 Is Essential for Postnatal Mammary Gland Development, Function, and the Expression of Btn1a1

LaRocca, J. L., Pietruska, J. R., & Hixon, M. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024432 · Cited by 20

The mechanism of AKT activation in cancer

Meng, F., Li, H., Wang, Y., Zheng, Z., & Chen, Y. (2025) · Cell investigation. · doi:10.1016/j.clnves.2025.100046 · Cited by 18

Akt1/mTORC1 signaling modulates adaptive immune response of Nile tilapia by promoting lymphocyte activation and proliferation

Ai, K., Yan, J., Li, K., Li, C., Zhang, Y., Liang, W., Li, J., Wei, X., & Yang, J. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104042 · Cited by 18

A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health

Rogers, J. M., Heintz, M. M., Thompson, C. M., & Haws, L. C. (2023) · Birth Defects Research · doi:10.1002/bdr2.2185 · Cited by 21

AKT2-mediated nuclear deformation leads to genome instability during epithelial-mesenchymal transition

Fan, J. C., Chang, S.-N., Chu, C., & Chen, H. (2023) · iScience · doi:10.1016/j.isci.2023.106992 · Cited by 18

Deep Sequence Analysis of Gene Expression Identifies Osteopontin as a Downstream Effector of Integrin-Linked Kinase (ILK) in Cardiac-Specific ILK Knockout Mice

Dai, J., Matsui, T., Abel, E. D., Dedhar, S., Gerszten, R. E., Seidman, C. E., Seidman, J. G., & Rosenzweig, A. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000649 · Cited by 18

The geranyl acetophenone tHGA attenuates human bronchial smooth muscle proliferation via inhibition of AKT phosphorylation

Yap, H. M., Lee, Y. Z., Harith, H. H., Tham, C. L., Cheema, M. S., Shaari, K., & Israf, D. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-34847-0 · Cited by 17

Novel Role for SGK3 in Glucose Homeostasis Revealed in SGK3/Akt2 Double-Null Mice

Yao, L.-J., McCormick, J. A., Wang, J., Yang, K. Y., Kidwai, A., Colussi, G., Boini, K. M., Birnbaum, M. J., Lang, F. J. W., German, M. S., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0329 · Cited by 17

Increased oxidative stress in the placenta tissue and cell culture of tumour-bearing pregnant rats

Toledo, M. T., Ventrucci, G., & Gomes‐Marcondes, M. C. C. (2011) · Placenta · doi:10.1016/j.placenta.2011.08.009 · Cited by 17

An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis

Suyama, K., Yao, J., Liang, H., Benard, O., Loudig, O. D., Amgalan, D., McKimpson, W. M., Phillips, G. R., Segall, J. E., Wang, Y., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-15-1462 · Cited by 17

Placental defects lead to embryonic lethality in mice lacking the Formin and PCP proteins Daam1 and Daam2

Nakaya, M., Gudmundsson, K. O., Komiya, Y., Keller, J. R., Habas, R., Yamaguchi, T. P., & Ajima, R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232025 · Cited by 16

Chronic Akt1 Deficiency Attenuates Adverse Remodeling and Enhances Angiogenesis After Myocardial Infarction

Vandoorne, K., Vandsburger, M. H., Raz, T., Shalev, M., Weisinger, K., Biton, I. E., Brumfeld, V., Raanan, C., Nevo, N., Eilam, R., et al. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000828 · Cited by 17

On the role of IRS2 in the regulation of functional β-cell mass

Nießen, M. (2006) · Archives of Physiology and Biochemistry · doi:10.1080/13813450600711409 · Cited by 17

Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia Through Protein Kinase A

Xiao, W., Zhou, K., Yang, M., Sun, C., Dai, L., Gu, J. H., Yan, R., & Dai, K. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.749930 · Cited by 16

Contrasting effects of G1.2/G2.2 and SOF1/SOF2 embryo culture media on pre- and post-implantation development of non-transgenic and transgenic cloned goat embryos

Hosseini, S. M., Hajian, M., Ostadhosseini, S., Forouzanfar, M., Abedi, P., Jafarpour, F., Gourabi, H., Shahverdi, A., Vosough, A., Ghanaei, H., et al. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.06.008 · Cited by 16

Bone vascularization and trabecular bone formation are mediated by PKBalpha/Akt1 in a gene‐dosage‐dependent manner: In vivo and ex vivo MRI

Vandoorne, K., Magland, J. F., Plaks, V., Sharir, A., Zelzer, E., Wehrli, F. W., Hemmings, B. A., Harmelin, A., & Neeman, M. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22395 · Cited by 16

Molecular and cellular underpinnings of normal and abnormal human placental blood flows

Li, Y., Lorca, R. A., & Su, E. J. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0139 · Cited by 16

Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2–PTEN–AKT Pathway and Placental Cell Proliferation

Lestari, B., Naito, S., Endo, A., Nishihara, H., Kato, A., Watanabe, É. O., Denda, K., Komada, M., & Fukushima, T. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msab371 · Cited by 15

Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway

Cheng, X., Xie, M., Luo, L., Tian, Y., Yu, G., Wu, Q., Fan, X., Yang, D., Mao, X., Gaur, U., et al. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111633 · Cited by 16

Dysregulation of AKT3 along with a small panel of mRNAs stratifies high-grade serous ovarian cancer from both normal epithelia and benign tumor tissues

Yeganeh, P. N., Richardson, C. A., Bahrani-Mostafavi, Z., Tait, D. L., & Mostafavi, M. T. (2017) · Genes & Cancer · doi:10.18632/genesandcancer.164 · Cited by 15

Placental Defects in α7 Integrin Null Mice

Welser, J. V., Lange, N., Flintoff‐Dye, N. L., Burkin, H. R., & Burkin, D. J. (2007) · Placenta · doi:10.1016/j.placenta.2007.08.002 · Cited by 15

Extracellular vesicle-associated miR-515-5p from adipose tissue regulates placental metabolism and fetal growth in gestational diabetes mellitus

Jayabalan, N., Nair, S., Lai, A., Scholz‐Romero, K., Razo-Azamar, M., Ormazábal, V., Lim, R., Carrión, F., Guanzon, D., Rice, G. E., et al. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02739-z · Cited by 17

Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells

Tang, J.-Y., Chuang, Y.-T., Shiau, J., Yang, K., Chang, F., Hou, M., Farooqı, A. A., & Chang, H. (2022) · Cells · doi:10.3390/cells11192940 · Cited by 13

Akt1 regulates phosphorylation and osteogenic activity of Dlx3

Choi, Y. H., Choi, H., Lee, K.-Y., & Oh, J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.155 · Cited by 13

Signalization of Akt/PKB in the Placenta, Skeletal Muscle and Adipose Tissue of Preeclampsia Patients

Orcy, R. B., Schroeder, S., Costa, S. H. D. A. M., Ramos, J. G. L., Schechinger, W., Klein, H., Brum, I. S., Corleta, H. V. E., & Capp, E. (2008) · Gynecologic and Obstetric Investigation · doi:10.1159/000147169 · Cited by 12

Transferase activity function and system development process are critical in cattle embryo development

Adams, H. A., Southey, B. R., Everts, R. E., Marjani, S. L., Tian, C., Lewin, H. A., & Rodriguez‐Zas, S. L. (2010) · Functional & Integrative Genomics · doi:10.1007/s10142-010-0189-9 · Cited by 13

An ex vivo uterine system captures implantation, embryogenesis, and trophoblast invasion via maternal-embryonic signaling

Hiraoka, T., Aikawa, S., Mashiko, D., Nakagawa, T., Shirai, H., Hirota, Y., Kimura, H., & Ikawa, M. (2025) · Nature Communications · doi:10.1038/s41467-025-60610-x · Cited by 12

Both decreased Akt expression and mTOR phosphorylation are related to decreased neuronal differentiation in the hippocampal alveus of aged mice

Yan, B. C., Jiang, D., Wang, J., Zhang, Y., Zhu, X., Xu, P., Yu, X., Won, M., & Su, P. Q. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-017-0833-5 · Cited by 13

Fathers That Are Born Small Program Alterations in the Next-Generation Preimplantation Rat Embryos ,

Master, J. S., Thouas, G. A., Harvey, A. J., Sheedy, J. R., Hannan, N. J., Gardner, D. K., & Wlodek, M. E. (2015) · Journal of Nutrition · doi:10.3945/jn.114.205724 · Cited by 12

Stimulatory Effects of Coumestrol on Embryonic and Fetal Development Through AKT and ERK1/2 MAPK Signal Transduction

Lim, W., & Song, G. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25381 · Cited by 12

Akt Protein Kinase, miR-200/miR-182 Expression and Epithelial-Mesenchymal Transition Proteins in Hibernating Ground Squirrels

Lee, Y.-J., Bernstock, J. D., Klimanis, D., & Hallenbeck, J. M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00022 · Cited by 12

Distinct Actions of Akt1 on Skeletal Architecture and Function

Mukherjee, A., Larson, E. A., Klein, R. F., & Rotwein, P. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093040 · Cited by 13

The AKT1-FOXO4 axis reciprocally regulates hemochorial placentation

Kozai, K., Moreno‐Irusta, A., Iqbal, K., Winchester, M., Scott, R. L., Simon, M. E., Muto, M., Parrish, M. R., & Soares, M. J. (2023) · Development · doi:10.1242/dev.201095 · Cited by 11

Akt phosphorylates and regulates the function of Dlx5

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Identification of circular RNAs as regulators and noninvasive biomarkers for placenta accreta spectrum

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Identifying novel regulators of placental development using time-series transcriptome data

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Multimodal imaging reveals a role for Akt1 in fetal cardiac development

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Impaired Spatial Learning is Associated with Disrupted Integrity of the White Matter in Akt3 Knockout Mice

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Network analysis reveals important genes in human placenta

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Sex-Selective Increase of IGF-2 Expression in the Hypoxic Guinea Pig Placenta of Growth-Restricted Fetuses

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IFPA Gabor Than Award lecture: Molecular control of placental growth: The emerging role of microRNAs

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Survival and Size Are Differentially Regulated by Placental and Fetal PKBalpha/AKT1

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